EKS-MAM-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph516.31.9E-155559815257
StatusUnreviewed
Ensembl ProteinENSMMUP00000019514
UniProt AccessionF6U3X2;
Protein Name
Protein Synonyms/Alias
Gene NameLOC707295
Gene Synonyms/Alias LOC707295;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000014867ENSMMUP00000019514ENSMMUT00000020857
OrganismMacaca mulatta
Functional Description
Protein Length924
Protein Sequence
(FASTA)
MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG 60
LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTRDCNS LPGDVGACIA 120
LVSVKVYYKK CWSIIENLAI FPDTVTGSEF SSLVEVRGTC VSSAEEEAEN SPRMHCSAEG 180
EWLVPIGKCI CKAGYQQKGD TCEPCGRGFY KSSSQDLQCS RCPTHSFSDK EGSSRCECED 240
GYYRAPSDPP YVACTRPPSA PQNLIFNINQ TTVSLEWSPP ADNGGRNDVT YRILCKRCSW 300
EQGECVPCGS NIGYMPQQTG LEDNYVTVMD LLAHANYTFE VEAVNGVSDL SRSQRLFAAV 360
SITTGQAAPS QVSGVMKERV LQRSVELSWQ EPEHPNGVIT EYEIKYYEKD QRERTYSTVK 420
TKSTSASINN LKPGTVYVFQ IRAFTAAGYG NYSPRLDVAT LEEATGKMFE ATAVSSEQNP 480
VIIIAVVAVA GTIILVFMVF GFIIGRRHCG YSKADQEGDE ELYFHFKFPG TKTYIDPETY 540
EDPNRAVHQF AKELDASCIK IERVIGAGEF GEVCSGRLKL PGKRDVAVAI KTLKVGYTEK 600
QRRDFLCEAS IMGQFDHPNV VHLEGVVTRG KPVMIVIEFM ENGALDAFLR KHDGQFTVIQ 660
LVGMLRGIAA GMRYLADMGY VHRDLAARNI LVNSNLVCKV SDFGLSRVIE DDPEAVYTTT 720
GGKIPVRWTA PEAIQYRKFT SASDVWSYGI VMWEVMSYGE RPYWDMSNQD VIKAIEEGYR 780
LPAPMDCPAG LHQLMLDCWQ KERAERPKFE QIVGILDKMI RNPNSLKTPL GTCSRPISPL 840
LDQNTPDFTT FCSVGEWLQA IKMERYKDNF TAAGYNSLES VARMTIEDVM SLGITLVGHQ 900
KKIMSSIQTM RAQMLHLHGT GIQV 924
Nucleotide Sequence
(FASTA)
ATGGTTTTTC AAACTCGGTA CCCTTCATGG ATTATTTTAT GCTACATCTG GCTGCTCCGC 60
TTTGCACACA CGGGGGAGGC GCAGGCTGCG AAGGAAGTAC TACTGCTGGA TTCTAAAGCA 120
CAACAAACAG AGTTGGAGTG GATTTCCTCT CCACCCAATG GGTGGGAAGA AATTAGTGGT 180
TTGGATGAGA ACTATACCCC GATACGAACA TACCAGGTGT GCCAAGTCAT GGAGCCCAAC 240
CAAAACAACT GGCTGCGGAC TAACTGGATT TCTAAAGGCA ATGCACAAAG GATTTTTGTA 300
GAATTGAAAT TCACCAGGGA TTGTAACAGT CTTCCTGGAG ATGTAGGGGC TTGCATAGCT 360
TTGGTTTCTG TCAAAGTATA CTACAAGAAG TGCTGGTCCA TTATTGAGAA CTTAGCTATC 420
TTTCCAGATA CAGTGACTGG TTCAGAATTT TCCTCTTTAG TCGAGGTTCG AGGGACATGT 480
GTCAGCAGTG CAGAGGAAGA GGCGGAAAAC TCCCCCAGGA TGCACTGCAG TGCAGAAGGA 540
GAATGGTTAG TGCCCATTGG AAAATGTATC TGCAAGGCGG GCTACCAGCA AAAAGGGGAC 600
ACTTGTGAAC CCTGTGGCCG TGGGTTCTAC AAGTCTTCCT CTCAAGATCT TCAGTGCTCT 660
CGTTGTCCAA CTCACAGTTT TTCTGATAAA GAAGGCTCCT CCAGATGTGA ATGTGAAGAT 720
GGGTATTACA GGGCTCCATC TGACCCACCG TACGTTGCAT GCACAAGGCC TCCATCTGCA 780
CCACAGAACC TCATTTTCAA CATCAACCAA ACCACAGTAA GTTTGGAATG GAGTCCTCCT 840
GCAGACAATG GAGGAAGAAA CGATGTGACC TACAGAATAT TGTGTAAGCG GTGCAGTTGG 900
GAGCAAGGCG AATGTGTTCC GTGTGGGAGT AACATTGGAT ACATGCCCCA GCAGACTGGA 960
TTAGAGGATA ACTATGTCAC TGTCATGGAC CTGCTAGCCC ACGCTAATTA TACTTTTGAA 1020
GTTGAAGCTG TAAATGGAGT TTCTGACTTA AGCCGATCCC AGAGGCTCTT TGCGGCTGTC 1080
AGTATCACCA CTGGTCAAGC AGCTCCCTCG CAAGTGAGCG GAGTAATGAA GGAGAGAGTG 1140
CTGCAGCGGA GTGTCGAGCT TTCCTGGCAG GAACCAGAGC ATCCCAATGG AGTCATCACA 1200
GAATATGAAA TCAAGTATTA CGAGAAAGAT CAAAGGGAAC GGACCTACTC AACAGTAAAA 1260
ACCAAGTCTA CTTCAGCCTC CATTAATAAT CTGAAACCAG GAACAGTGTA TGTTTTCCAG 1320
ATTCGGGCTT TTACTGCTGC TGGTTATGGA AACTACAGTC CCAGACTTGA TGTTGCTACA 1380
CTAGAGGAAG CTACAGGTAA AATGTTTGAA GCTACAGCTG TCTCCAGTGA ACAGAATCCT 1440
GTCATTATCA TTGCTGTGGT TGCTGTGGCT GGGACCATCA TTTTGGTGTT CATGGTCTTT 1500
GGCTTCATCA TTGGGAGAAG GCACTGTGGT TATAGCAAAG CTGACCAAGA AGGGGATGAA 1560
GAGCTTTACT TTCATTTTAA ATTTCCAGGC ACCAAAACCT ACATTGACCC TGAAACCTAT 1620
GAGGACCCAA ATAGAGCTGT CCATCAATTC GCCAAGGAGC TAGATGCCTC CTGTATTAAA 1680
ATTGAGCGTG TGATTGGTGC AGGAGAATTT GGTGAAGTCT GCAGTGGCCG TTTGAAACTT 1740
CCAGGGAAAA GAGACGTTGC AGTAGCCATA AAAACCCTGA AAGTTGGTTA CACAGAAAAA 1800
CAAAGGAGAG ACTTTTTATG TGAAGCAAGC ATCATGGGGC AGTTTGACCA CCCAAATGTT 1860
GTCCATTTGG AAGGCGTTGT TACAAGAGGG AAACCAGTCA TGATTGTAAT AGAGTTCATG 1920
GAAAATGGAG CCCTAGATGC ATTTCTCAGG AAACATGATG GGCAATTTAC AGTCATTCAG 1980
TTAGTAGGAA TGCTGAGAGG AATTGCTGCT GGAATGAGAT ATTTGGCTGA TATGGGATAT 2040
GTTCACAGGG ACCTTGCAGC TCGCAATATT CTTGTCAACA GCAATCTTGT TTGTAAAGTG 2100
TCAGATTTTG GCCTGTCCCG AGTTATAGAG GATGATCCAG AAGCTGTCTA TACAACTACT 2160
GGTGGAAAAA TTCCAGTAAG GTGGACAGCA CCCGAAGCCA TCCAGTACCG GAAATTCACA 2220
TCAGCCAGTG ATGTATGGAG CTATGGAATA GTCATGTGGG AAGTTATGTC TTATGGAGAA 2280
AGACCTTATT GGGACATGTC AAATCAAGAT GTTATAAAAG CAATAGAAGA AGGTTATCGT 2340
TTACCAGCAC CCATGGACTG CCCAGCTGGC CTTCACCAGC TAATGTTGGA TTGTTGGCAA 2400
AAGGAGCGTG CTGAAAGGCC AAAATTTGAA CAGATAGTTG GAATTCTTGA CAAAATGATT 2460
CGAAACCCAA ATAGTCTGAA AACTCCCCTG GGAACTTGTA GTAGGCCAAT AAGCCCTCTT 2520
CTGGATCAAA ACACTCCCGA TTTCACTACC TTTTGTTCAG TTGGAGAATG GCTGCAAGCT 2580
ATTAAGATGG AAAGATATAA AGATAACTTC ACAGCAGCTG GCTACAATTC CCTTGAATCA 2640
GTAGCCAGGA TGACTATTGA GGATGTGATG AGTTTAGGGA TCACACTGGT TGGCCATCAA 2700
AAGAAAATCA TGAGCAGCAT TCAGACTATG AGAGCACAAA TGCTACATTT ACATGGAACT 2760
GGCATTCAAG TGTGA 2775
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kie+viGaGefGevcsGrlklpgkr++avaiktlk g+tekqrrdfl+easi+Gqfdhp
Q: 559   IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP  618
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+++leGvvt++kpvmiv+e+mengald+flrk+dgqftviqlvgmlrGia+gm+yl+dm
Q: 619   NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM  678
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnilvnsnlvckvsdfGlsrv+edd+ea+ytt+ggkip+rwtapeai+yrk
Q: 679   GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK  738
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlp+pmdcpa+l+qlmldc
Q: 739   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC  798
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqk+raerpkfeqiv i
Q: 799   WQKERAERPKFEQIVGI  815
         **************987
Domain Sequence
(FASTA)
IKIERVIGAG EFGEVCSGRL KLPGKRDVAV AIKTLKVGYT EKQRRDFLCE ASIMGQFDHP 60
NVVHLEGVVT RGKPVMIVIE FMENGALDAF LRKHDGQFTV IQLVGMLRGI AAGMRYLADM 120
GYVHRDLAAR NILVNSNLVC KVSDFGLSRV IEDDPEAVYT TTGGKIPVRW TAPEAIQYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPAPMDCP AGLHQLMLDC 240
WQKERAERPK FEQIVGI 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00003
EKS-BOT-00010
EKS-CAJ-00004
EKS-CAF-00004
EKS-CAP-00003
EKS-DAR-00005
EKS-EQC-00004
EKS-FEC-00002
EKS-GAG-00004
EKS-GOG-00003
EKS-HOS-00004
EKS-LAC-00004
EKS-LOA-00004
EKS-MEG-00003
EKS-MOD-00004
EKS-MUM-00004
EKS-MUP-00003
EKS-MYL-00004
EKS-NOL-00014
EKS-ORN-00005
EKS-ORA-00004
EKS-ORC-00003
EKS-ORL-00002
EKS-OTG-00002
EKS-PAT-00003
EKS-POA-00008
EKS-RAN-00004
EKS-SOA-00002
EKS-SUS-00003
EKS-TAG-00003
EKS-TEN-00018
EKS-TUT-00003
EKS-VIP-00001
EKS-XET-00004
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0045499; F:chemorepellent activity
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007420; P:brain development
GO:0048755; P:branching morphogenesis of a nerve
GO:0043525; P:positive regulation of neuron apoptotic process
GO:0022407; P:regulation of cell-cell adhesion
GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0031952; P:regulation of protein autophosphorylation
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013