EKS-MAM-00143
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00143
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Csk472.44.3E-142195440246
StatusUnreviewed
Ensembl ProteinENSMMUP00000020019
UniProt AccessionF7GRP2;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase CSK;
Gene NameCSK
Gene Synonyms/Alias CSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000015267ENSMMUP00000033422ENSMMUT00000040354
ENSMMUG00000015267ENSMMUP00000020019ENSMMUT00000021405
OrganismMacaca mulatta
Functional Description
Protein Length450
Protein Sequence
(FASTA)
MSAIQASWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 180
DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420
NCWHLDAAMR PSFLQLREQL EHIKTHELHL 450
Nucleotide Sequence
(FASTA)
ATGTCAGCAA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60
CACGGCACCG CCGAGCAAGA CCTGCCTTTC TGCAAAGGAG ACGTGCTCAC CATTGTGGCC 120
GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAGG TGGGCCGTGA GGGCATCATC 180
CCAGCCAACT ACGTCCAGAA GCGGGAGGGC GTGAAGGCGG GTACCAAACT CAGCCTCATG 240
CCTTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCTGAGC GGCTTCTGTA CCCGCCGGAG 300
ACAGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC GCTGTGCGTG 360
AGCTGCGACG GCAAGGTGGA GCACTACCGC ATCATGTACC ATGCCAGCAA GCTCAGCATC 420
GACGAGGAGG TGTACTTTGA GAATCTCATG CAGCTGGTGG AGCACTACAC CTCAGACGCA 480
GATGGACTCT GTACGCGCCT CATTAAACCA AAGGTCATGG AGGGCACGGT GGCGGCCCAG 540
GATGAGTTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AGCTGAAGCT ACTGCAGACC 600
ATTGGGAAGG GGGAGTTCGG AGATGTGATG CTGGGCGATT ACCGAGGGAA CAAAGTCGCT 660
GTCAAGTGCA TTAAGAACGA CGCCACCGCC CAGGCCTTCC TGGCTGAAGC TTCAGTCATG 720
ACGCAACTGC GGCATAGCAA CCTGGTGCAG CTCCTGGGCG TGATCGTGGA GGAGAAGGGC 780
GGGCTCTACA TCGTCACTGA GTACATGGCC AAGGGGAGCC TCGTGGACTA CCTGCGGTCT 840
CGGGGTCGGT CAGTGCTGGG CGGAGACTGT CTCCTCAAGT TCTCGCTAGA TGTCTGCGAG 900
GCCATGGAAT ACCTGGAGGG CAACAACTTC GTGCATCGAG ACCTGGCTGC CCGCAACGTG 960
CTGGTGTCTG AGGACAACGT GGCCAAGGTC AGCGACTTTG GTCTCACCAA GGAGGCGTCC 1020
AGCACCCAGG ACACGGGCAA GCTGCCAGTC AAGTGGACAG CCCCTGAGGC CCTGAGAGAG 1080
AAGAAATTCT CCACTAAGTC TGACGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAC 1140
TCCTTTGGGC GAGTGCCTTA TCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAG 1200
AAGGGCTACA AGATGGATGC CCCCGATGGC TGCCCGCCCG CAGTCTATGA GGTCATGAAG 1260
AACTGCTGGC ACCTGGACGC CGCCATGCGG CCATCCTTCC TACAGCTCCG AGAGCAGCTT 1320
GAGCACATCA AAACCCATGA GCTGCACCTG TGA 1353
Domain Profile
S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60
         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv
Q: 195   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254
         6899********************************************************
S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119
         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd
Q: 255   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  314
         *****99*****************************************************
S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179
         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi
Q: 315   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  374
         ************************************************************
S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239
         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf 
Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFL  434
         ************************************************************
S: 240   klkekl  245
         +l+e+l
Q: 435   QLREQL  440
         ***997
Domain Sequence
(FASTA)
LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60
IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120
LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180
LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAAMRPSFL 240
QLREQL 246
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00137
EKS-ANC-00139
EKS-BOT-00146
EKS-CAE-00119
EKS-CAJ-00150
EKS-CAF-00152
EKS-CAP-00145
EKS-CII-00089
EKS-CIS-00181
EKS-DAR-00430
EKS-DIO-00081
EKS-DRM-00070
EKS-EQC-00143
EKS-FEC-00136
EKS-GAM-00074
EKS-GAG-00123
EKS-GAA-00170
EKS-GOG-00145
EKS-HOS-00150
EKS-ICT-00139
EKS-LAC-00154
EKS-LOA-00144
EKS-MAE-00056
EKS-MEG-00113
EKS-MOD-00144
EKS-MUM-00149
EKS-MUP-00149
EKS-MYL-00155
EKS-NOL-00139
EKS-ORN-00178
EKS-ORL-00168
EKS-OTG-00150
EKS-PAT-00135
EKS-PES-00130
EKS-POA-00141
EKS-PRC-00025
EKS-PTV-00137
EKS-RAN-00143
EKS-SAH-00139
EKS-SOA-00023
EKS-SUS-00127
EKS-TAG-00173
EKS-TAR-00188
EKS-TEN-00180
EKS-TUT-00144
EKS-XET-00133
EKS-XIM-00172
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005813; C:centrosome
GO:0005794; C:Golgi apparatus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0008285; P:negative regulation of cell proliferation
GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport
KEGG
mcc:702868;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013