EKS-MAM-00091

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00091

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	423.2	1.3E-126	3717	4066	350

Status

Unreviewed

Ensembl Protein

ENSMMUP00000020132

UniProt Accession

F6SP41;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKDC

Gene Synonyms/Alias

PRKDC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000015347	ENSMMUP00000020132	ENSMMUT00000021524
ENSMMUG00000015347	ENSMMUP00000020136	ENSMMUT00000021529

Organism

Macaca mulatta

Functional Description

Protein Length

4126

Protein Sequence
(FASTA)

MAGSGAGVRC SLLRLQETLS AADRCGAALA GHQLIRGLGQ ECVLSSSPAV LALQTSLVFS 60

RDFGLLVFVR KSLNSIEFRE CREEILKFLC IFLEKMGQKI APYCVEIKNT CTSVYTKDRA 120

AKCKIPALDL LIKLLQTFRS SRLMDEFKIG ELFSKFYGEL ALKKKIPDTV LEKVYELLGL 180

LGEVHPSEMI NNAENLFRAF LGELKTQMTS AVREPKLPVL AGCLKGLSSL LCNFTKSMEE 240

DPQTSREIFN FVLKAIRPQI DLKRYAVPSA GLRLFALHAS QFSTCLLDNY VSLFEVLLKW 300

CAHTNVELKK AALSALESFL KQVSNMVAKN AEMHKSKLQY FMEQFYGIIR NVDSNNKELS 360

IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQMFLTQT DTGDDRVYQM PSFLQSVASV 420

LLYLDTVPEV YTPVLEHLVV MQIDSFPQYS PKMQLVCCRA IVKVFLALAA KGPVLRNCIS 480

TVVHQGLIRI CSKPVVLPKG PESESEDYRA SGEVRTGKWK VPTYKDYVDL FRHLLTSDQM 540

MDSILADEAF FSVNSSSESL NHLLYDEFVK SVLKIVEKLD LTLQTQTVGE QENGDEAPGV 600

WMIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKQAE FFEPWVYSFS YELILQSTRL 660

PLISGFYKLL SITVRNAKKI KYFEVSLFCR TLYNCIIKYV IIYIIVFFLV KVAVKMKQYK 720

DELLASCLTF LLSLPHDIIE LDIRAYIPAL QMAFKLGLSY TPLAEVGLNA LEEWSIYIDR 780

HVMQPYYKDI LPCLDGYLKT SALSDETKNN WEVSALSRAA QKGFNKVVLK HLKKTKNLSS 840

NEAISLEEIR IRVVQMLGSL GGQINKNLLT VASSDEMMKS YVAWDREKRL SFAVPFREMK 900

PVIFLDVFLP RVTELALTAS DRQTKVAACE LLHSMVMFML GKATQMPEGG QGAPPMYQLY 960

KRTFPVLLRL ACDVDQVTRQ LYEPLVMQLI HWFTNNKKFE SQDTVALLEA ILDGIVDPVD 1020

STLRDFCGRC IREFLKWSIK QTTPQQQEKS PVNTKSLFKR LYSLALHPNA FKRLGASLAF 1080

NNIYREFREE ESLVEQFVFE ALVIYMESLA LAHADEKSLG TIQQCCDAID HLCRIIEKKH 1140

VSLNKAKKRR LPRGFPPSTS LCLLDLVKWL LAHCGRPQTE CRHKSIELFY KFVPLLPGNR 1200

SPNLWLKDVL KEEGVSFIIN TFEGGGCGQP SGILAQPTLL HLRGPFSLQT TLCWLDLLLA 1260

ALECYNTFIG ERIVGALQVL GTEAHSSLLK AVAFFLESIA MHDIIAAEKC FGTGAAGDRP 1320

SPQEGERYNY SKCTIVVRIM EFTTTLLNTS PEGWKLLKKD LCNTHLMRVL VQTLCEPASV 1380

GFNIGDVQVM AHLPDVCVNL MKALKMSPYK DILETHLREK ITAQSIEELC AVNLYGPDAQ 1440

MDRSRLAAVV SACKQLHRAG LLHSILPSQS TDLHHSIGTE LLSLVYKGIA PGDERQCLPS 1500

LDLSCKQLAS GLLELAFAFG GLCERLVSLL LNPAVLSTPS LGSLQSSVIQ FSHGEYFYSL 1560

FSETINMELL KNLDLAVLEL MQSSVENPKM VSTVLNGMLD QSFRERASQK HQGLKLATTI 1620

LQHWKKCDSW WAKDSPLETK MAVLALLAKI LQIDSSVSFN TSHGSFPEVF TTYISLLADT 1680

KLDLHLKGQA VTLLPFFTSL TGGSLEELRR VLEQLIVAHF PMQSREFPPG TPRFNNYVDC 1740

MKKFLDALEL SQSPMLLELM TEVLCREQQH VMEELFQSSF KRIARRGSCV TQVGLLESVY 1800

EMFRKDDPRL SFTRQSFVDR SLLTLLWHCS LDALREFFST IVVDAIDVLK SRFTKLNEST 1860

FDTQITKKMG YYKILDVMYS RLPKDDVHAK ESKINQVFHG SRITEGNELT KTLIKLCYDA 1920

FTENMAGENQ LLERRRLYHC AAYNCAISVI CCVFNELKFY QGFLFSEKPE KNLLIFENLI 1980

DLKRRYNFPV EVEVPMERKK KYIEIRKEAR EAANGDSDGP SYMSSLSYLA DSTLSEEMSQ 2040

FDFSTGVQSY SYSSQDPRPT TGRFRRREQR DPTVHDDVLE LEMDELNRHE CMAPLTALVK 2100

HMHRSLGPPQ GEEDSVPRDL PPWMKFLHGK LGNPIVSLNI RLFLAKLIIN TEEVFRPYAK 2160

HWLSPLLQLA ASENNGGEGI HYMVVEIVAT ILSWTGLATP TGVPKDEVLA NRLLNFLMKH 2220

VFHPKRAVFR HNLEIIKTLV ECWKDCLSIP YRLIFEKFSG KDPNSKDNSV GIQLLGIVMA 2280

NDLPPYDPQC GIQSSEYFQA LVNNMSFVRY KEVYAAAAEV LGLILRYVME RRNMLEESLC 2340

ELVAKQLKQH QNTMEDKFIV CLNKVTKSFP PLADRFMNAV FFLLPKFHGV LKTLCLEVVL 2400

CRVEAMTELY FQLKSKDFVQ VMRHRDDERQ KVCLDIIYKM MPKLKPVELR ELLNPVVEFV 2460

SHPSATCREQ MYNILMWIHD NYRDPESQTD NDSQEIFKLA KDVLIQGLID ENPGLQLIIR 2520

NFWSHETRLP SNTLDRLLAL NSLYSPKIEV HFLSLATNFL LEMTSLSPDY PNPMFEHPLS 2580

ECEFQEYTID SDWRFRSTVL TPMFVETQAS QGTLQTRTQE GSLSARWPMA GQIRATQQQH 2640

DFTLTQTADG RSSFDWLTGS STDPLVDHSS PSSDSLLFAH KRSERLQRAP LKSVGPDFGK 2700

KRLGLPGDEV DNKVKGAAGR VDLLRLRRRF MRDQEKLSLM YARKGVAEQK REKEIKSELK 2760

MKQDAQVVLY RSYRLGDLPD IQIKHSSLIT PLQAVAQRDP IIAKQLFSSL FSGILKEMDK 2820

FKTLSEKNNI TQKLLQDFNR FLNTTFSFFP PFVSCIQDIS CQHAALLSLD PAAVSAGCLA 2880

SLQQPVGIRL LEEALLRLLP AELPAKRVRG KARLPPDVLR WVELAKLYRS IGEYDVLRGI 2940

FSSEIGTKQI TQNALLAEAR SDYSEAAKQY DEALNKQDWV DGEPTDAEKD FWELASLDCY 3000

NHLAEWKSLE YCSTASVDSE NPPDLNKIWS EPFYQETYLP YMIRSKLKLL LQGEADQSLL 3060

TFIDKAMHGE LQKAILELHY SQELSLLYLL QDDIDRARYY IQNGIQSFMQ NYSSIDVLLH 3120

RSRLTKLQSV QALTEIQEFI SFISKQGNLS SQVPLKRLLN TWTNRYPDAK MDPMNIWDDV 3180

ITNRCFFLSK IEEKLTPLPE DNSMNVDEDG DPSDRMDVQE QEEDISSLIR SCKFSMKMKM 3240

VDSARKQNNF SLAMKLLKEL HKESKTRDDW LVSWVQSYCR LSHCRSRSQG CSEQVLTVLK 3300

TVSLLDENNV SSYLSKNILA SRDQNILLGT TYRIIANALS SEPACLAEIE EDKARRILEL 3360

SGSSSEDSEK VIAGLYQRAF QHLSEAVQAA EEEAQPPSWS CRPAAGVIDA YMTLADFCDQ 3420

QLRKEEENAS VTDSAELQAY PALVVEKMLK ALKLNSNEAR LKFPRLLQII ERYPEETLSL 3480

MTKEISSVPC WQFIGWISHM VALLDKDQAI AVQHTVEEIT DNYPQAIVYP FIISSESYSF 3540

KDTSTGHKNK EFVARIKSKL DQGGVIQDFI NALDQLSNPE LLFKDWSNDV RAELAKTPVN 3600

KKNIEKMYER MYAALGDPKA PGLGAFRRKF IQTFGKEFDK HFGKGGSKLL RMKLSDFNDI 3660

TNMLLLKMNK DSKPPGNLKE CSPWMSDFKV EFLRNELEIP GQYDGRGKPL PEYHVRIAGF 3720

DERVTVMASM RRPKRIIIRG HNEREHPFLV KGGEDLRQDQ RVEQLFQVMN GILAQDSACS 3780

QRALQLRTYS VVPMTSRLGL IEWLENTVTL KDLLLNTMSQ EEKAAYLSDP KAPLCEYRDW 3840

LTKMSGKHDV GAYMLMYKGA NRTETITSFR KRESKVPADL LKRAFVRMST SPEAFLALRS 3900

HFASSHALIC ISHWILGIGD RHLNNFMVAM ETGGMIGIDF GHAFGSATQF LPVPELMPFR 3960

LTRQFINLML PMKEMGLMYS VMVHALRAFR SDPGLLTNTM DVFVKEPSFD WKNFEQKMLK 4020

KGGSWIQEIN VAEKNWYPRQ KICYAKRKLA GANPAVISCD ELLLGHEKAP AFRDYVAVAR 4080

GSKDHNIRAR EPEGGLSEET QVKCLIDQAT DPNILGRTWE GWEPWM 4126

Nucleotide Sequence
(FASTA)

ATGGCGGGCT CCGGAGCCGG TGTGCGTTGC TCCCTGCTGC GGCTGCAGGA GACCTTGTCC 60

GCCGCGGACC GCTGCGGTGC TGCCCTGGCC GGTCATCAGC TGATCCGCGG CCTGGGGCAG 120

GAATGCGTCC TGAGCAGCAG CCCCGCGGTT CTGGCATTAC AGACATCTTT AGTTTTTTCC 180

AGAGATTTCG GTTTGCTTGT ATTTGTCCGG AAGTCACTCA ACAGTATTGA ATTTCGTGAA 240

TGTAGAGAAG AAATCCTAAA GTTTTTATGT ATTTTCTTAG AAAAAATGGG CCAGAAGATC 300

GCGCCTTACT GTGTTGAAAT TAAGAATACT TGTACCAGTG TTTATACAAA AGATAGAGCT 360

GCTAAATGTA AAATTCCAGC CCTGGACCTT CTTATTAAGT TACTTCAGAC TTTTAGAAGT 420

TCTAGACTCA TGGATGAATT TAAAATTGGA GAATTATTTA GTAAATTCTA TGGAGAACTT 480

GCATTGAAAA AAAAAATACC AGATACAGTT TTAGAAAAAG TATATGAGCT CCTGGGATTA 540

TTGGGTGAAG TTCATCCTAG TGAGATGATA AATAATGCAG AAAACCTGTT CCGCGCTTTT 600

CTGGGTGAAC TTAAGACCCA GATGACATCA GCAGTAAGAG AGCCCAAACT ACCTGTTTTG 660

GCAGGATGTC TGAAGGGGTT GTCCTCACTT CTCTGCAACT TCACTAAGTC CATGGAAGAA 720

GATCCCCAGA CATCAAGGGA GATTTTTAAT TTTGTACTAA AGGCAATTCG TCCTCAGATT 780

GATCTGAAGA GATATGCTGT GCCCTCAGCT GGCTTGCGCC TATTTGCCCT GCATGCATCT 840

CAGTTTAGCA CCTGCCTTCT GGACAACTAC GTGTCTCTAT TTGAAGTCTT GTTAAAGTGG 900

TGTGCCCACA CAAATGTAGA GTTGAAAAAA GCTGCACTTT CAGCCCTGGA ATCCTTTCTG 960

AAACAGGTTT CTAATATGGT GGCGAAAAAT GCAGAAATGC ATAAAAGTAA ACTGCAGTAC 1020

TTTATGGAGC AGTTTTATGG AATCATCAGA AATGTGGATT CGAACAACAA GGAGTTATCT 1080

ATTGCTATCC GTGGATATGG ACTTTTTGCA GGACCCTGCA AAGTTATAAA CGCAAAAGAT 1140

GTTGACTTCA TGTATGTTGA GCTCATTCAG CGTTGCAAGC AGATGTTCCT CACCCAGACA 1200

GACACTGGTG ACGACCGTGT TTATCAGATG CCGAGCTTCC TCCAGTCTGT TGCTAGTGTC 1260

TTGCTGTACC TTGACACAGT TCCTGAGGTG TATACTCCAG TTCTGGAGCA CCTTGTGGTG 1320

ATGCAGATAG ACAGTTTCCC ACAGTACAGT CCAAAAATGC AGTTGGTGTG TTGCAGAGCC 1380

ATAGTGAAGG TGTTCCTAGC TTTGGCAGCA AAAGGGCCAG TTCTCAGGAA TTGCATTAGT 1440

ACTGTGGTGC ATCAGGGTTT AATCAGAATA TGTTCTAAAC CAGTGGTCCT TCCAAAGGGC 1500

CCCGAGTCTG AATCTGAAGA CTACCGTGCT TCAGGGGAAG TCAGAACTGG CAAATGGAAG 1560

GTGCCCACAT ACAAAGACTA CGTGGATCTC TTCAGACATC TCCTGACCTC TGACCAGATG 1620

ATGGATTCTA TTTTAGCAGA TGAAGCATTT TTCTCTGTGA ATTCCTCCAG TGAAAGTCTG 1680

AATCATTTAC TTTATGATGA ATTTGTAAAA TCCGTTTTGA AGATTGTTGA GAAATTGGAT 1740

CTTACACTAC AAACACAGAC TGTTGGGGAA CAAGAGAACG GAGATGAGGC TCCTGGTGTT 1800

TGGATGATCC CGACTTCAGA TCCAGCGGCT AACTTGCATC CGGCTAAACC TAAAGATTTT 1860

TCGGCTTTCA TTAACCTGGT GGAATTTTGC AGAGAGATTC TCCCTGAGAA ACAAGCAGAA 1920

TTTTTTGAAC CATGGGTGTA CTCATTTTCA TATGAATTAA TTTTACAGTC TACAAGGTTG 1980

CCCCTCATCA GTGGTTTCTA CAAATTGCTT TCTATTACAG TAAGAAATGC CAAGAAAATA 2040

AAATATTTCG AGGTGAGTCT TTTTTGCAGG ACTTTATATA ACTGTATCAT AAAATATGTG 2100

ATTATATACA TTATTGTCTT CTTTCTTGTT AAGGTGGCAG TTAAAATGAA GCAATACAAA 2160

GATGAACTTT TGGCCTCCTG TTTGACCTTT CTTCTGTCCC TGCCACATGA CATCATCGAA 2220

CTCGATATTA GAGCCTACAT TCCTGCGCTG CAAATGGCTT TCAAACTGGG CCTGAGCTAT 2280

ACCCCCTTGG CAGAAGTAGG CCTGAATGCT CTAGAAGAAT GGTCAATTTA TATCGACAGA 2340

CATGTAATGC AGCCTTATTA CAAAGACATT CTCCCCTGCC TGGATGGCTA CCTGAAGACT 2400

TCAGCCTTGT CAGATGAGAC CAAGAATAAC TGGGAAGTGT CAGCTCTTTC TCGGGCTGCC 2460

CAGAAAGGAT TTAATAAAGT GGTGTTAAAG CATCTGAAGA AGACAAAGAA CCTTTCATCA 2520

AATGAAGCAA TATCCTTAGA AGAAATAAGA ATTAGAGTAG TACAAATGCT TGGATCTCTA 2580

GGAGGACAAA TAAACAAAAA TCTTCTGACA GTCGCTTCCT CTGATGAGAT GATGAAGAGC 2640

TATGTGGCCT GGGACAGAGA GAAGCGGCTG AGCTTTGCAG TGCCCTTTAG AGAGATGAAA 2700

CCTGTCATTT TCCTCGACGT GTTCCTGCCT CGAGTCACAG AATTAGCGCT CACAGCCAGT 2760

GACAGACAAA CTAAAGTTGC AGCCTGTGAA CTTTTACATA GCATGGTTAT GTTTATGTTG 2820

GGCAAAGCCA CGCAGATGCC AGAAGGGGGA CAGGGAGCCC CACCCATGTA CCAGCTCTAT 2880

AAGCGGACGT TTCCTGTGCT GCTTCGACTT GCGTGTGATG TTGATCAGGT GACAAGGCAG 2940

CTGTACGAGC CACTAGTTAT GCAGCTGATT CACTGGTTCA CTAACAATAA GAAATTTGAA 3000

AGTCAGGATA CTGTCGCCTT ACTAGAAGCT ATATTGGATG GAATTGTGGA CCCTGTTGAC 3060

AGTACTTTAA GAGATTTTTG TGGTCGGTGT ATTCGAGAAT TCCTTAAATG GTCCATTAAG 3120

CAAACAACAC CACAGCAGCA GGAGAAGAGT CCAGTAAACA CCAAATCGCT TTTCAAGCGA 3180

CTTTACAGCC TTGCGCTTCA CCCTAATGCT TTCAAGAGGC TGGGAGCGTC ACTCGCCTTT 3240

AATAATATTT ACAGGGAATT CAGGGAAGAA GAGTCTCTGG TGGAACAGTT TGTGTTTGAA 3300

GCCTTGGTGA TATACATGGA GAGTCTGGCC TTAGCACATG CAGATGAGAA GTCCTTAGGT 3360

ACAATTCAAC AGTGTTGTGA TGCCATTGAT CACCTATGCC GCATCATTGA AAAGAAGCAT 3420

GTTTCTTTAA ACAAAGCAAA GAAACGACGT TTGCCACGAG GATTTCCACC TTCCACGTCA 3480

TTGTGTTTAC TGGATCTGGT CAAGTGGCTT TTAGCTCATT GTGGGAGGCC CCAGACAGAA 3540

TGTCGACACA AATCCATTGA ACTCTTTTAT AAATTCGTTC CTTTATTGCC AGGCAACAGA 3600

TCCCCTAATT TGTGGCTGAA AGATGTTCTC AAGGAAGAAG GTGTCTCTTT TATCATCAAC 3660

ACCTTTGAAG GGGGCGGTTG TGGCCAGCCC TCAGGCATCC TGGCCCAGCC CACCCTCTTG 3720

CACCTGCGGG GGCCATTCAG CCTGCAGACC ACGCTGTGCT GGCTGGACCT GCTCCTGGCT 3780

GCGCTGGAGT GCTACAACAC TTTCATTGGC GAGAGAATTG TGGGAGCGCT CCAGGTCTTG 3840

GGTACTGAAG CCCACTCTTC ACTTTTGAAA GCAGTGGCTT TCTTTTTAGA AAGCATTGCC 3900

ATGCATGACA TTATAGCAGC AGAAAAGTGC TTTGGCACTG GGGCAGCAGG TGACAGACCA 3960

AGCCCCCAAG AGGGAGAAAG GTACAACTAC AGCAAATGCA CCATTGTGGT CCGGATTATG 4020

GAGTTCACCA CAACTCTGCT GAACACCTCC CCAGAAGGAT GGAAGCTCCT GAAGAAGGAC 4080

TTGTGTAATA CACACTTGAT GAGAGTCCTG GTGCAGACGC TGTGTGAGCC TGCAAGCGTA 4140

GGTTTCAACA TCGGAGACGT CCAGGTTATG GCTCATCTTC CTGATGTTTG TGTGAACCTG 4200

ATGAAAGCGC TAAAGATGTC CCCATACAAA GATATCCTAG AGACTCATCT GAGAGAGAAA 4260

ATAACAGCAC AGAGCATTGA GGAGCTTTGT GCCGTCAACT TGTATGGCCC TGACGCGCAA 4320

ATGGACAGGA GCAGGCTGGC TGCTGTTGTG TCTGCCTGTA AACAGCTTCA CAGAGCTGGG 4380

CTTCTGCATA GTATATTACC ATCTCAGTCC ACAGATCTGC ATCATTCTAT TGGCACAGAA 4440

CTTCTTTCCC TGGTTTATAA AGGCATTGCC CCCGGAGATG AGAGACAGTG TTTGCCTTCT 4500

CTAGACCTCA GTTGTAAGCA ACTGGCCAGC GGACTTCTGG AGTTAGCCTT TGCTTTCGGA 4560

GGACTGTGTG AGCGCCTCGT GAGTCTTCTC CTGAACCCAG CAGTGCTGTC CACGCCATCC 4620

TTGGGCAGCT TACAGAGCAG CGTCATCCAG TTCTCCCATG GGGAGTATTT CTATAGCTTG 4680

TTCTCAGAAA CGATCAACAT GGAATTATTG AAAAATCTGG ATCTTGCTGT ATTGGAGCTC 4740

ATGCAGTCAT CAGTGGAAAA TCCCAAAATG GTGAGTACTG TTTTGAATGG CATGTTAGAC 4800

CAGAGCTTCA GGGAGCGAGC AAGCCAGAAA CACCAAGGAC TGAAACTTGC GACTACAATT 4860

CTGCAACACT GGAAGAAGTG TGATTCCTGG TGGGCTAAAG ATTCCCCTCT CGAAACTAAA 4920

ATGGCAGTGC TGGCCTTACT GGCAAAAATT TTACAGATTG ATTCATCTGT ATCTTTTAAT 4980

ACAAGTCATG GTTCATTCCC TGAAGTCTTT ACAACATATA TTAGTCTACT TGCTGACACA 5040

AAACTGGATC TACATTTAAA GGGCCAAGCT GTCACTCTTC TTCCATTCTT CACCAGCCTC 5100

ACCGGAGGCA GTCTGGAGGA ACTTAGGCGT GTTCTGGAGC AGCTCATCGT TGCTCACTTC 5160

CCCATGCAGT CCAGAGAATT TCCCCCAGGA ACTCCGCGGT TCAATAATTA TGTGGACTGC 5220

ATGAAAAAGT TTCTAGATGC ATTGGAATTA TCTCAAAGCC CTATGTTGTT GGAATTGATG 5280

ACAGAAGTTC TTTGTCGGGA ACAGCAGCAT GTCATGGAAG AATTATTTCA ATCCAGTTTC 5340

AAGAGGATTG CCAGAAGGGG TTCATGCGTC ACACAAGTAG GCCTTCTGGA AAGTGTGTAT 5400

GAAATGTTCA GGAAGGATGA CCCCCGCCTA AGTTTCACAC GCCAATCCTT TGTGGACCGC 5460

TCTCTCCTTA CTCTGCTGTG GCACTGTAGC CTGGATGCTT TGAGAGAATT CTTTAGCACA 5520

ATTGTGGTGG ATGCCATTGA TGTGTTGAAG TCCAGGTTTA CAAAGCTAAA TGAATCTACC 5580

TTTGATACTC AAATCACGAA GAAGATGGGC TACTATAAGA TTCTAGATGT GATGTATTCT 5640

CGTCTTCCCA AAGATGATGT TCACGCTAAG GAATCTAAAA TTAATCAAGT TTTCCATGGC 5700

TCGCGTATTA CAGAAGGAAA TGAACTTACA AAGACACTGA TTAAATTGTG CTACGATGCA 5760

TTTACAGAGA ACATGGCAGG AGAGAATCAG CTGCTGGAGA GGAGAAGACT TTACCATTGT 5820

GCAGCATACA ACTGCGCCAT ATCTGTCATC TGCTGTGTCT TCAATGAGTT AAAATTTTAC 5880

CAAGGTTTTC TGTTTAGTGA AAAACCAGAA AAGAACTTGC TTATTTTTGA AAATCTGATC 5940

GACCTGAAGC GCCGCTATAA TTTTCCTGTA GAAGTTGAGG TTCCTATGGA AAGAAAGAAA 6000

AAGTACATTG AAATTAGGAA GGAAGCCAGA GAAGCAGCAA ATGGGGACTC AGATGGTCCT 6060

TCCTATATGT CTTCCCTGTC ATATTTGGCA GACAGTACCC TGAGTGAAGA AATGAGTCAA 6120

TTTGATTTCT CAACCGGAGT TCAGAGCTAT TCATACAGCT CCCAAGACCC TAGACCTACC 6180

ACTGGTCGTT TTCGGAGACG GGAGCAGCGG GACCCCACGG TGCATGATGA TGTGCTGGAG 6240

CTGGAGATGG ATGAGCTCAA TCGGCACGAG TGTATGGCAC CCCTGACGGC CCTGGTGAAG 6300

CATATGCACA GAAGTCTGGG CCCGCCTCAA GGAGAAGAGG ATTCAGTGCC AAGAGATCTT 6360

CCTCCTTGGA TGAAATTCCT CCATGGCAAA CTGGGAAATC CAATAGTATC ATTAAATATC 6420

CGTCTCTTCT TAGCCAAGCT TATTATTAAT ACAGAAGAGG TCTTTCGCCC TTACGCGAAG 6480

CACTGGCTTA GCCCCTTGTT GCAGCTGGCT GCTTCTGAAA ACAATGGAGG AGAAGGAATT 6540

CACTACATGG TGGTTGAGAT AGTGGCCACT ATTCTTTCAT GGACAGGCTT GGCCACTCCG 6600

ACAGGGGTTC CTAAGGATGA AGTGTTAGCA AATCGATTGC TTAATTTCCT AATGAAACAT 6660

GTCTTTCATC CAAAAAGAGC TGTGTTTAGA CACAACCTTG AAATTATAAA GACCCTTGTC 6720

GAGTGCTGGA AGGATTGTTT ATCCATCCCT TATAGGTTAA TATTTGAAAA GTTTTCCGGT 6780

AAAGATCCTA ATTCTAAAGA CAACTCAGTA GGGATTCAAT TGCTAGGCAT CGTGATGGCC 6840

AATGACCTGC CTCCCTATGA CCCGCAGTGT GGCATTCAGA GTAGCGAATA CTTTCAGGCT 6900

TTGGTGAATA ATATGTCCTT TGTAAGATAT AAAGAAGTGT ATGCTGCTGC AGCAGAAGTT 6960

TTAGGACTTA TACTTCGATA TGTTATGGAG AGAAGAAACA TGCTGGAGGA GTCTCTGTGT 7020

GAACTGGTTG CGAAACAATT GAAGCAACAT CAAAATACCA TGGAGGACAA GTTTATTGTG 7080

TGCTTAAACA AAGTGACCAA GAGCTTCCCT CCTCTTGCAG ACAGGTTCAT GAATGCTGTG 7140

TTCTTTCTGC TGCCAAAATT TCATGGAGTG TTGAAAACAC TCTGTCTGGA GGTGGTACTT 7200

TGTCGTGTGG AGGCAATGAC AGAGCTGTAC TTCCAGTTAA AGAGCAAGGA CTTCGTTCAA 7260

GTCATGAGAC ATAGAGATGA TGAAAGACAA AAAGTATGTT TGGACATAAT TTATAAGATG 7320

ATGCCAAAAT TAAAACCAGT AGAACTCCGA GAACTTCTGA ACCCTGTTGT GGAATTCGTT 7380

TCCCATCCTT CTGCAACATG TAGGGAACAA ATGTATAATA TTCTCATGTG GATTCATGAC 7440

AATTACAGAG ATCCAGAAAG TCAGACAGAT AATGACTCCC AGGAAATATT TAAGTTGGCA 7500

AAAGATGTGC TGATTCAAGG ATTGATCGAT GAGAACCCTG GACTTCAATT AATTATTCGA 7560

AATTTCTGGA GCCATGAAAC TAGGTTACCT TCAAATACTT TGGACCGGTT GCTGGCACTA 7620

AATTCCTTAT ATTCTCCTAA GATAGAAGTG CACTTTTTAA GTTTAGCAAC AAATTTTCTG 7680

CTTGAAATGA CCAGCCTGAG CCCAGATTAT CCAAATCCCA TGTTCGAACA TCCTCTGTCA 7740

GAATGTGAAT TTCAGGAATA TACCATTGAT TCTGATTGGC GTTTCCGAAG TACTGTTCTC 7800

ACTCCAATGT TTGTGGAGAC CCAGGCCTCC CAGGGCACTC TCCAGACCCG TACCCAGGAA 7860

GGGTCCCTCT CAGCTCGCTG GCCAATGGCA GGGCAGATAA GGGCCACCCA GCAGCAGCAT 7920

GACTTCACAC TGACACAGAC TGCAGATGGA AGAAGCTCAT TTGATTGGCT GACCGGGAGC 7980

AGCACTGACC CGCTGGTCGA CCACTCCAGT CCGTCATCTG ACTCTTTGCT GTTTGCCCAC 8040

AAGAGGAGTG AAAGGTTACA GAGAGCACCC TTGAAGTCAG TGGGGCCTGA TTTTGGGAAA 8100

AAAAGGCTGG GCCTTCCAGG GGATGAGGTG GATAACAAAG TGAAAGGTGC GGCTGGCCGA 8160

GTGGACCTAC TGCGACTGCG CAGACGGTTT ATGAGGGACC AAGAGAAGCT CAGTTTGATG 8220

TATGCCAGAA AAGGCGTTGC TGAGCAAAAA CGAGAGAAGG AAATCAAGAG TGAGTTAAAA 8280

ATGAAGCAGG ATGCCCAGGT CGTTCTGTAC AGAAGCTACC GGCTGGGAGA CCTTCCTGAC 8340

ATTCAAATCA AGCACAGCAG CCTCATCACC CCATTACAGG CCGTGGCCCA GAGAGACCCA 8400

ATAATTGCAA AACAGCTCTT TAGCAGCTTG TTTTCCGGAA TTTTGAAAGA GATGGATAAA 8460

TTTAAGACGC TGTCTGAAAA AAACAACATC ACTCAAAAGT TGCTCCAAGA CTTCAATCGT 8520

TTTCTTAATA CCACCTTCTC TTTCTTTCCA CCTTTTGTCT CTTGTATTCA GGACATCAGC 8580

TGCCAGCACG CAGCCCTGCT GAGCCTTGAC CCAGCAGCTG TTAGCGCTGG TTGCCTGGCT 8640

AGCCTACAGC AGCCCGTGGG CATCCGCCTG CTGGAGGAGG CTCTGCTCCG CCTGCTGCCT 8700

GCTGAGCTGC CTGCCAAGCG AGTCCGCGGG AAGGCCCGCC TCCCTCCTGA TGTCCTCAGA 8760

TGGGTGGAGC TTGCTAAACT GTATAGATCA ATTGGAGAAT ACGACGTCCT CCGTGGGATT 8820

TTTAGCAGTG AGATAGGAAC AAAGCAAATC ACTCAGAATG CATTGTTAGC AGAAGCCAGA 8880

AGTGATTATT CTGAAGCTGC TAAGCAGTAT GATGAGGCTC TCAATAAACA AGACTGGGTA 8940

GATGGTGAGC CCACAGACGC CGAGAAGGAT TTTTGGGAAC TTGCATCCCT TGACTGTTAC 9000

AACCACCTTG CTGAGTGGAA ATCACTTGAA TACTGTTCTA CAGCCAGTGT AGACAGTGAG 9060

AACCCCCCAG ATCTAAATAA AATCTGGAGT GAACCATTTT ATCAGGAAAC GTATCTACCT 9120

TACATGATCC GCAGCAAGCT GAAGCTGCTG CTCCAGGGAG AGGCTGACCA GTCCCTGCTG 9180

ACATTTATTG ACAAAGCTAT GCATGGGGAG CTCCAGAAGG CGATTTTAGA GCTTCATTAC 9240

AGTCAAGAGC TGAGTCTACT TTACCTCCTG CAAGATGATA TTGACAGAGC CAGATACTAC 9300

ATTCAAAATG GCATTCAGAG TTTTATGCAG AATTATTCTA GTATTGATGT CCTCTTACAC 9360

CGAAGTAGAC TCACCAAATT GCAGTCTGTA CAGGCTTTAA CAGAAATTCA GGAGTTCATC 9420

AGCTTTATAA GCAAACAAGG CAATTTATCA TCTCAAGTTC CCCTTAAGAG ACTTCTGAAC 9480

ACCTGGACAA ACAGATATCC AGATGCTAAA ATGGACCCAA TGAACATCTG GGATGACGTC 9540

ATCACAAATC GATGTTTCTT TCTCAGCAAA ATAGAGGAGA AGCTTACCCC TCTTCCAGAA 9600

GATAATAGTA TGAATGTGGA TGAAGATGGA GACCCCAGTG ACAGGATGGA CGTGCAAGAG 9660

CAGGAAGAAG ATATCAGCTC CTTGATCAGG AGCTGCAAGT TTTCCATGAA AATGAAGATG 9720

GTAGACAGTG CCCGGAAGCA GAACAATTTC TCACTTGCCA TGAAACTACT GAAGGAGCTG 9780

CATAAAGAGT CAAAAACCAG AGACGATTGG CTGGTGAGCT GGGTGCAGAG CTACTGCCGC 9840

TTGAGCCACT GCCGGAGCCG ATCCCAGGGC TGCTCTGAGC AGGTGCTCAC TGTGCTGAAA 9900

ACAGTCTCTT TGTTGGATGA GAACAACGTG TCAAGCTACT TAAGCAAAAA TATTCTGGCT 9960

TCCCGTGACC AGAACATTCT CTTGGGTACA ACTTACAGGA TCATAGCTAA TGCTCTCAGC 10020

AGTGAGCCAG CCTGCCTTGC TGAAATCGAG GAGGACAAGG CTAGAAGAAT CTTAGAGCTT 10080

TCTGGATCCA GTTCAGAGGA TTCGGAGAAG GTGATCGCGG GTCTGTACCA GAGAGCATTC 10140

CAGCACCTCT CTGAGGCTGT GCAGGCAGCT GAGGAGGAGG CCCAGCCTCC CTCCTGGAGC 10200

TGTAGGCCTG CAGCTGGAGT GATTGATGCT TACATGACGC TGGCAGATTT CTGTGACCAA 10260

CAGCTGCGCA AGGAAGAAGA GAATGCATCA GTTACTGATT CTGCAGAACT GCAGGCGTAT 10320

CCAGCACTTG TGGTGGAGAA AATGTTGAAA GCTTTAAAAT TAAATTCCAA TGAAGCCAGA 10380

TTGAAGTTTC CTAGATTACT TCAGATCATA GAACGGTATC CAGAGGAGAC TTTGAGTCTC 10440

ATGACAAAAG AGATCTCTTC CGTTCCCTGC TGGCAGTTCA TCGGCTGGAT CAGCCACATG 10500

GTGGCCTTAC TGGACAAAGA CCAAGCCATT GCTGTTCAGC ACACCGTGGA AGAAATCACT 10560

GATAACTACC CGCAGGCTAT TGTTTATCCC TTCATCATAA GCAGCGAAAG CTATTCCTTC 10620

AAGGATACTT CTACTGGTCA TAAGAATAAA GAGTTTGTGG CAAGGATTAA AAGTAAGTTG 10680

GATCAAGGAG GAGTGATTCA AGATTTTATT AACGCCTTAG ATCAGCTCTC TAATCCTGAA 10740

CTGCTCTTTA AGGATTGGAG CAATGATGTA AGAGCTGAAC TAGCAAAAAC CCCTGTAAAT 10800

AAAAAAAACA TTGAAAAAAT GTATGAAAGA ATGTATGCAG CGTTGGGTGA CCCAAAAGCT 10860

CCAGGCCTGG GGGCCTTTAG AAGGAAGTTT ATTCAGACTT TTGGAAAAGA ATTTGATAAA 10920

CATTTTGGGA AAGGAGGTTC TAAGCTACTG AGAATGAAGC TCAGTGACTT CAATGACATT 10980

ACCAACATGC TACTTTTGAA AATGAACAAA GACTCAAAAC CCCCTGGGAA TCTGAAAGAA 11040

TGTTCGCCCT GGATGAGCGA CTTCAAAGTG GAGTTCCTGA GAAATGAGCT GGAGATTCCT 11100

GGTCAGTATG ACGGTAGGGG AAAGCCGTTG CCAGAGTACC ACGTGCGAAT CGCCGGGTTT 11160

GATGAGCGGG TGACAGTCAT GGCGTCTATG CGAAGGCCCA AGCGCATCAT CATCCGTGGC 11220

CACAATGAGA GGGAGCACCC TTTCCTGGTG AAGGGTGGCG AGGACCTGCG GCAGGACCAG 11280

CGTGTGGAGC AGCTCTTCCA GGTCATGAAT GGGATCCTGG CCCAAGACTC CGCCTGCAGC 11340

CAGAGGGCCC TGCAGCTGAG GACCTACAGC GTGGTGCCCA TGACTTCCAG GTTAGGATTA 11400

ATTGAGTGGC TTGAAAATAC TGTTACCTTG AAGGACCTTC TTTTGAACAC CATGTCCCAA 11460

GAGGAGAAGG CGGCTTACCT GAGTGATCCC AAGGCACCGC TGTGTGAATA TAGAGATTGG 11520

CTGACAAAAA TGTCAGGAAA ACATGATGTT GGAGCTTACA TGCTAATGTA TAAGGGAGCT 11580

AATCGTACTG AAACAATCAC CTCTTTTAGA AAACGAGAAA GTAAAGTGCC TGCCGATCTC 11640

TTAAAGCGGG CCTTTGTGAG GATGAGTACA AGCCCCGAGG CTTTCCTGGC CCTCCGCTCC 11700

CACTTTGCCA GCTCTCATGC TCTGATATGC ATCAGCCACT GGATCCTCGG GATTGGAGAC 11760

AGACATCTGA ACAACTTTAT GGTGGCCATG GAGACTGGCG GCATGATTGG GATCGACTTT 11820

GGGCATGCAT TTGGATCCGC TACACAGTTT CTGCCAGTCC CTGAGTTGAT GCCTTTTCGG 11880

CTAACTCGCC AGTTTATCAA TCTGATGTTA CCAATGAAAG AAATGGGCCT TATGTACAGC 11940

GTCATGGTAC ACGCGCTCCG GGCCTTCCGC TCAGACCCTG GCCTGCTCAC CAACACCATG 12000

GATGTGTTTG TCAAGGAGCC TTCCTTTGAC TGGAAAAATT TTGAACAGAA AATGCTGAAA 12060

AAAGGAGGAT CATGGATTCA AGAAATAAAT GTTGCTGAAA AAAATTGGTA TCCCCGACAG 12120

AAAATATGTT ACGCTAAGAG AAAGTTAGCA GGTGCCAATC CAGCAGTCAT TAGTTGTGAT 12180

GAGCTGCTAC TGGGTCACGA GAAGGCGCCT GCTTTCAGAG ACTATGTGGC TGTGGCACGA 12240

GGAAGCAAAG ATCACAACAT TCGTGCCCGA GAACCAGAGG GTGGGCTTTC AGAAGAAACT 12300

CAAGTGAAGT GCTTGATTGA CCAGGCAACA GACCCCAACA TCCTTGGCAG AACCTGGGAA 12360

GGATGGGAGC CCTGGATGTG A 12381

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfderv+++as ++pk++++rG++++e+p+Lvkg eDlrqd+rv+qlf+++N +La+d

Q: 3717  IAGFDERVTVMASMRRPKRIIIRGHNEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD  3776

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkkl..vekkavlldqpi..syr  116

         +++s+r+L++rty+Vvp+++r+gliew+entv+Lk+ll ++  +e+ka++l++p+   ++

Q: 3777  SACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTmsQEEKAAYLSDPKapLCE  3836

         ***************************************998999*********9999**

S: 117   ykdlstvqarkpklkhlkls.........levfkevlenlvpkdllkklllekfpspeew  167

         y d+ t+++ k+++ +++l+         +++f++++++ vp+dllk++++++++spe++

Q: 3837  YRDWLTKMSGKHDVGAYMLMykganrtetITSFRKRESK-VPADLLKRAFVRMSTSPEAF  3895

         ***************************************.********************

S: 168   felrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpe  227

         ++lr+++++s+A+i+++++iLg+gdrhl+n+++++etg ++ idfg+af++a+++l+vpe

Q: 3896  LALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGMIGIDFGHAFGSATQFLPVPE  3955

         ************************************************************

S: 228   kvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk..  285

          +PFRLTr+++n++ ++++ G++++ ++++lr++r+++  l+++++vf+++p++dwk+

Q: 3956  LMPFRLTRQFINLMLPMKEMGLMYSVMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNfe  4015

         ************************************************************

S: 286   ....kkktsketeeelaekakaealkikkllskvekaenavatrdllllee  332

             kk++s+++e+++aek++++++ki+++++k+++a++av+ +d+lll++

Q: 4016  qkmlKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVISCDELLLGH  4066

         **9999****************************************99987

Domain Sequence
(FASTA)

IAGFDERVTV MASMRRPKRI IIRGHNEREH PFLVKGGEDL RQDQRVEQLF QVMNGILAQD 60

SACSQRALQL RTYSVVPMTS RLGLIEWLEN TVTLKDLLLN TMSQEEKAAY LSDPKAPLCE 120

YRDWLTKMSG KHDVGAYMLM YKGANRTETI TSFRKRESKV PADLLKRAFV RMSTSPEAFL 180

ALRSHFASSH ALICISHWIL GIGDRHLNNF MVAMETGGMI GIDFGHAFGS ATQFLPVPEL 240

MPFRLTRQFI NLMLPMKEMG LMYSVMVHAL RAFRSDPGLL TNTMDVFVKE PSFDWKNFEQ 300

KMLKKGGSWI QEINVAEKNW YPRQKICYAK RKLAGANPAV ISCDELLLGH 350

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005958	; C:DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006915	; P:apoptotic process
GO:0002326	; P:B cell lineage commitment
GO:0007420	; P:brain development
GO:0032869	; P:cellular response to insulin stimulus
GO:0006303	; P:double-strand break repair via nonhomologous end joining
GO:0035234	; P:germ cell programmed cell death
GO:0007507	; P:heart development
GO:0033152	; P:immunoglobulin V(D)J recombination
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0002328	; P:pro-B cell differentiation
GO:0031648	; P:protein destabilization
GO:0010332	; P:response to gamma radiation
GO:0001756	; P:somitogenesis
GO:0033077	; P:T cell differentiation in thymus
GO:0002360	; P:T cell lineage commitment
GO:0033153	; P:T cell receptor V(D)J recombination
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013