EKS-MAM-00400
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00400
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR612.93.2E-184592949358
StatusUnreviewed
Ensembl ProteinENSMMUP00000020623
UniProt AccessionF6SLY4;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000015707ENSMMUP00000020623ENSMMUT00000022045
OrganismMacaca mulatta
Functional Description
Protein Length1088
Protein Sequence
(FASTA)
MGTSHPAFLV LGCLLTGLSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP 60
MSEEENSDVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTEEN ELEGRHIYIY 120
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LHNSEGVVPA SYNSRQGFNG 180
TFTVGPYICE ATVKGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATREVK 300
EMKRVTISVH EKGFIEIKPT FSQLEAVNLH EVKHFVVEVQ AYPPPRISWK NNLTLIENLT 360
EITTDVEKIQ EIRYRSKLKL IRAKEEDSGH YTIVAQNEDD VKSYTFELLT QVPSSILDLV 420
DDHHGSTGGQ TVRCTAEGMP LPDIEWMICK DIKKCNNETS WTILANNVSN IITEIHPRDR 480
STVEGLVTFA KVEETIAVRC LAKNLLGAEN RELKLVAPTL RSELTVAAAV LVLLVIVIIS 540
LIVLVVIWKQ KPRYEIRWRV IESISPDGHE YIYVDPMQLP YDSRWEFPRD GLVLGRVLGS 600
GAFGKVVEGT AYGLSRSQPV MKVAVKMLKP TARSSEKQAL MSELKIMTHL GPHLNIVNLL 660
GACTKSGPIY IITEYCFYGD LVNYLHKNRD SFLSRHPEKP KKELDIFGLN PADDSTRSYV 720
ILSFENNGDY MDMKQADTTQ YVPMLERKEV SKYSDIQRSL YDRPASYKKK SMLDSEVKNL 780
LSDDNSEGLT LLDLLSFTYQ VARGMEFLAS KNCVHRDLAA RNVLLAQGKI VKICDFGLAR 840
DIMHDSNYVS KGSTFLPVKW MAPESIFDNL YTTLSDVWSY GILLWEIFSL GGTPYPGMMV 900
DSTFYNKIKS GYRMAKPDHA TSEVYEIMVK CWNSESEKRP SFYHLSEIVE NLLPGQYKKS 960
YEKIHLDFLK SDHPAVARMR VDSDNAYIGV TYKNEEDKLK DWEGGLDEQR LSADSGYIIP 1020
LPDIDPVPEE EDLGKRNRHS SQTSEESAIE TGSSSSTFIK REDETIEDID MMDDIGIDSS 1080
DLVEDSFL 1088
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCATCCGGC GTTCCTGGTC TTAGGCTGTC TTCTCACAGG GCTGAGCCTA 60
ATCCTCTGCC AGCTTTCGTT ACCCTCTATC CTTCCAAATG AAAATGAAAA GGTTGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACTC TGATGTGGAA ATCAGAAATG AAGAAAACAA CAGTGGCCTT 240
TTTGTGACAG TCTTGGAAGT GAGCAGTGCC TCGGCGGCCC ACACAGGGCT GTACACTTGC 300
TATTACAACC ACACTCAGAC AGAAGAGAAT GAGCTTGAAG GCAGGCACAT TTACATCTAT 360
GTGCCAGACC CAGATGTAGC CTTTGTACCT CTAGGAATGA CGGATTATTT AGTCATCGTG 420
GAGGACGATG ATTCTGCCAT CATACCTTGT CGCACAACTG ATCCTGAGAC TCCTGTAACT 480
TTACACAACA GTGAGGGGGT GGTACCTGCC TCCTACAACA GCAGACAGGG CTTTAATGGG 540
ACCTTCACTG TAGGGCCCTA TATCTGTGAG GCCACCGTCA AAGGAAAGAA GTTCCAGACC 600
ATCCCATTTA ACGTTTATGC TTTAAAAGCA ACATCAGAGC TGGATCTAGA AATGGAAGCT 660
CTTAAAACCG TGTATAAGTC AGGGGAAACG ATTGTGGTCA CCTGTGCTGT TTTTAACAAT 720
GAGGTGGTTG ACCTTCAGTG GACTTACCCT GGAGAAGTGA AAGGCAAAGG CATCACAATG 780
CTGGAAGAAA TCAAAGTCCC ATCCATCAAA TTGGTGTACA CTTTGACGGT CCCCGAGGCC 840
ACGGTGAAAG ACAGTGGAGA TTACGAATGT GCTGCCCGCC AGGCTACCAG GGAGGTCAAA 900
GAAATGAAGA GAGTCACTAT TTCTGTCCAT GAGAAAGGGT TCATTGAAAT CAAACCCACC 960
TTTAGCCAGT TGGAAGCTGT CAACCTGCAT GAAGTCAAAC ATTTTGTCGT AGAGGTGCAG 1020
GCCTACCCAC CTCCCAGGAT ATCCTGGAAA AACAATCTGA CTCTGATTGA AAACCTCACG 1080
GAGATCACCA CTGATGTGGA AAAGATTCAG GAAATAAGGT ATCGAAGCAA ATTAAAGCTT 1140
ATCCGTGCTA AGGAAGAAGA CAGTGGCCAT TATACTATTG TAGCTCAAAA TGAAGATGAT 1200
GTGAAGAGCT ATACTTTTGA ACTGTTAACT CAAGTTCCTT CATCCATTCT GGACTTGGTC 1260
GATGATCACC ATGGCTCAAC TGGGGGACAG ACGGTGAGGT GCACAGCTGA AGGCATGCCA 1320
CTTCCTGATA TTGAGTGGAT GATATGCAAG GATATTAAGA AATGTAATAA TGAAACTTCC 1380
TGGACGATTT TGGCCAACAA TGTCTCAAAC ATCATCACGG AGATCCACCC CCGAGACAGG 1440
AGTACTGTGG AGGGCCTTGT GACTTTTGCC AAAGTGGAAG AGACCATTGC GGTGAGATGC 1500
CTGGCTAAGA ATCTCCTTGG AGCTGAGAAC CGAGAGCTGA AGCTGGTGGC TCCCACCCTG 1560
CGTTCTGAAC TCACGGTGGC TGCCGCAGTC CTGGTGCTGC TGGTGATTGT GATCATCTCA 1620
CTCATTGTCC TGGTTGTCAT TTGGAAACAG AAACCGAGGT ATGAAATTCG CTGGAGGGTC 1680
ATTGAATCAA TCAGCCCAGA TGGACATGAA TATATTTATG TGGACCCAAT GCAGCTGCCT 1740
TATGACTCGA GATGGGAGTT TCCAAGAGAT GGACTAGTGC TTGGTCGGGT CTTGGGGTCT 1800
GGAGCGTTTG GGAAGGTGGT TGAAGGAACA GCCTATGGAT TAAGCCGGTC CCAACCTGTC 1860
ATGAAAGTTG CAGTGAAGAT GCTAAAACCC ACGGCCAGAT CCAGTGAAAA ACAAGCTCTC 1920
ATGTCTGAAC TGAAGATAAT GACTCACCTG GGGCCACATT TGAACATTGT AAACTTGCTG 1980
GGAGCCTGCA CCAAGTCAGG CCCCATTTAC ATCATCACAG AGTACTGCTT CTACGGAGAT 2040
TTGGTCAACT ATTTGCATAA GAATAGGGAT AGCTTCCTGA GCCGCCACCC AGAGAAGCCA 2100
AAGAAAGAGC TGGATATCTT TGGGTTGAAC CCTGCTGATG ACAGCACACG GAGCTATGTT 2160
ATTTTATCTT TTGAAAACAA TGGTGACTAC ATGGACATGA AGCAGGCTGA TACTACACAG 2220
TATGTCCCTA TGCTAGAAAG GAAAGAGGTT TCTAAATATT CCGACATCCA GAGATCACTG 2280
TATGATCGTC CAGCCTCATA TAAGAAGAAA TCTATGTTAG ACTCAGAAGT CAAAAACCTC 2340
CTTTCAGATG ATAACTCAGA AGGCCTTACT TTGTTGGATT TGTTGAGCTT CACCTATCAA 2400
GTCGCCCGAG GAATGGAGTT TTTGGCTTCA AAAAATTGTG TCCACCGGGA TCTGGCTGCT 2460
CGCAACGTCC TCCTGGCACA AGGAAAAATT GTGAAGATCT GTGACTTTGG CCTGGCCAGA 2520
GACATCATGC ATGATTCGAA CTATGTGTCG AAAGGCAGTA CCTTTCTGCC CGTGAAGTGG 2580
ATGGCTCCTG AGAGCATCTT TGACAACCTC TACACCACAC TGAGTGATGT CTGGTCTTAC 2640
GGCATTCTGC TCTGGGAGAT CTTTTCCCTT GGTGGTACTC CTTACCCTGG CATGATGGTG 2700
GATTCTACTT TCTACAATAA GATCAAGAGT GGGTACCGGA TGGCCAAGCC TGACCATGCT 2760
ACCAGTGAAG TCTACGAGAT CATGGTGAAA TGCTGGAACA GTGAGTCAGA GAAGAGACCC 2820
TCCTTTTACC ACCTGAGTGA GATTGTGGAG AATCTGCTGC CTGGACAATA TAAAAAGAGT 2880
TATGAAAAAA TTCACCTGGA CTTCCTGAAG AGTGACCATC CTGCTGTGGC ACGCATGCGT 2940
GTGGACTCAG ACAATGCGTA CATTGGTGTC ACCTACAAAA ATGAGGAAGA CAAGCTGAAG 3000
GACTGGGAGG GTGGTCTGGA TGAGCAGAGA CTGAGCGCTG ACAGCGGCTA CATCATTCCT 3060
CTGCCTGACA TTGACCCTGT CCCTGAGGAG GAGGACCTGG GCAAGAGGAA CAGACACAGC 3120
TCGCAGACCT CTGAAGAGAG TGCCATTGAG ACGGGTTCCA GCAGTTCCAC CTTCATCAAG 3180
AGAGAGGACG AGACCATTGA AGACATCGAC ATGATGGACG ACATCGGCAT AGACTCTTCA 3240
GACCTGGTGG AAGACAGCTT CCTGTAA 3267
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG+vlGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 592   LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  651
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 652   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEK---PKKELDIFG  708
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 709   LnPADDSTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  768
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 769   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  828
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 829   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  888
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++e+ekrpsf++l+e+
Q: 889   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSESEKRPSFYHLSEI  948
         *********************************************************998
S: 344   l  344
         +
Q: 949   V  949
         6
Domain Sequence
(FASTA)
LVLGRVLGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLNP 120
ADDSTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSESEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013