EPS-MAM-00137

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00137

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	281.1	1.7E-83	131	337	207

Status

Unreviewed

Ensembl Protein

ENSMMUP00000020636

UniProt Accession

F6SFD1;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2

Gene Synonyms/Alias

PPEF2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000015716	ENSMMUP00000020636	ENSMMUT00000022059
ENSMMUG00000015716	ENSMMUP00000020632	ENSMMUT00000022055

Organism

Macaca mulatta

Functional Description

Protein Length

600

Protein Sequence
(FASTA)

MGSGTSTRHH SAFQNAERTF KAAALIQRWY RRYVARLEMR RRCTWSIFQS IEYAGQQDQV 60

KLHDFFSYLM DHFIPSSHNE REFLTRMFTE DRFTQDSEME KCSDYESIEV PDSYTGPRLS 120

FPLLPDHATA LIEAFRLKQQ LHARYVLNLL YETKKHLVQL PNINRVSTCY SEEITVCGDL 180

HGQLDDLIFI FYKNGLPSPE RSYVFNGDFV DRGKDSVEIL MILFAFMLVY PKEFHLNRGN 240

HEDHMVNLRY GFTKEVMNKY KIHGKEILRT LQDVFCWLPL ATLIDEKVLI FHGGVSDITD 300

LELLDKIERN KIVSTMRCKT RQKSEKQMEE KGKANRNSSA QEPIPWFLPQ SRSLPSSPLR 360

LSSYKAHKTN RSSSIPCGGC LDGRELSRQV RSSVELELER CRQQAGLLVT GQKEEPSRSA 420

SEADSEAGEL QKPTQEEWRQ VVDILWSDPM AQEGCKANTI RGGGCYFGPD VTQQLLQKYN 480

LQFLIRSHEC KPEGYEFCHN RKVLTIFSAS NYYEVGSNRG AYVKLGPALT PHIVQYQANK 540

VTNTLTMRQR QDFSMMEESA LRALREKLFA HSSDLLSEFK KHDADKIHLA SNQLCHYQQK 600

Nucleotide Sequence
(FASTA)

ATGGGAAGCG GCACCTCTAC CCGACATCAT TCTGCTTTCC AGAATGCAGA GAGAACCTTC 60

AAGGCAGCAG CCCTGATCCA GAGATGGTAC CGGCGCTACG TGGCCCGCCT GGAGATGAGG 120

CGGCGTTGCA CCTGGAGCAT CTTCCAATCT ATAGAATATG CTGGGCAGCA AGACCAAGTC 180

AAGCTCCATG ACTTCTTCAG CTATCTCATG GATCACTTCA TCCCCAGCAG CCACAACGAG 240

AGGGAATTCC TGACCCGCAT GTTCACTGAG GACAGATTCA CCCAGGACTC TGAGATGGAG 300

AAATGCAGTG ACTATGAGTC CATAGAGGTA CCCGACAGTT ACACGGGGCC ACGCCTCTCC 360

TTCCCGCTCC TGCCTGACCA TGCAACTGCC CTGATAGAAG CATTCAGACT GAAACAACAG 420

CTCCATGCTC GCTACGTCTT GAACCTTTTG TATGAAACCA AGAAACATCT GGTGCAGCTG 480

CCAAACATCA ACCGGGTCTC AACCTGTTAC AGCGAGGAGA TCACAGTGTG TGGAGACTTA 540

CACGGCCAAT TGGATGACTT AATATTTATA TTTTATAAGA ATGGCCTCCC ATCACCAGAA 600

CGGTCCTATG TGTTCAACGG TGACTTTGTG GATCGAGGCA AAGATTCAGT AGAGATCCTG 660

ATGATTCTTT TTGCCTTCAT GCTGGTTTAC CCCAAAGAGT TCCATCTTAA CAGAGGAAAC 720

CATGAGGACC ATATGGTGAA CTTACGATAT GGCTTCACCA AGGAAGTGAT GAACAAATAC 780

AAGATACATG GGAAGGAAAT ACTAAGAACC CTGCAAGATG TTTTCTGTTG GCTTCCACTG 840

GCCACTCTGA TAGATGAGAA AGTTTTAATT TTTCATGGTG GGGTGTCAGA CATAACTGAT 900

TTGGAGCTTT TGGACAAAAT AGAGAGGAAC AAGATAGTTT CCACCATGAG GTGCAAAACG 960

AGACAGAAGA GTGAGAAGCA GATGGAGGAG AAGGGAAAAG CCAACCGGAA CAGCTCTGCA 1020

CAGGAACCCA TCCCATGGTT TCTCCCACAA AGCCGCTCTC TTCCCTCTTC ACCCCTTCGG 1080

CTCAGCTCCT ACAAGGCCCA CAAAACCAAC AGGTCCTCCA GCATCCCCTG CGGCGGTTGC 1140

CTGGACGGGC GGGAGCTCTC CCGGCAGGTG CGGAGCTCGG TGGAACTGGA GCTGGAGCGG 1200

TGCCGGCAGC AAGCAGGCCT CCTGGTGACC GGACAGAAAG AGGAGCCCTC CCGCTCTGCC 1260

TCAGAAGCAG ACTCTGAAGC CGGAGAGTTG CAGAAGCCCA CTCAGGAGGA GTGGAGGCAG 1320

GTTGTAGATA TCCTGTGGAG TGATCCCATG GCTCAAGAGG GCTGCAAGGC CAACACTATT 1380

CGAGGAGGAG GCTGTTATTT TGGGCCTGAT GTGACACAAC AGTTGCTACA AAAATACAAC 1440

CTGCAATTCC TGATCCGTTC ACACGAATGC AAACCTGAAG GCTATGAATT CTGTCACAAC 1500

CGCAAGGTAC TAACGATCTT TTCTGCCTCC AACTACTATG AAGTTGGCAG CAACAGAGGG 1560

GCCTATGTCA AACTGGGGCC AGCCCTGACC CCACATATCG TGCAGTATCA AGCTAACAAG 1620

GTGACCAACA CACTCACCAT GAGGCAAAGG CAAGACTTTT CAATGATGGA GGAGTCGGCT 1680

CTGAGAGCTC TGAGGGAGAA GCTGTTTGCT CATTCTTCAG ATCTTCTCAG TGAATTTAAG 1740

AAGCATGATG CAGATAAAAT TCACCTAGCT TCCAACCAAC TTTGCCACTA CCAACAAAAA 1800

TAG 1803

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         l+e+f+ k++lha+yvl++l+e+kk l qlpni++vst+ s+e+tv+GdlhG+lddl+++

Q: 131   LIEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFI  190

         89**********************************************************

S: 64    lkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnary  123

         ++knGlPs +++yvfnGdfvdrGk ++e+l++l +++lv+P++ +lnrGnhed+++n+ry

Q: 191   FYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRY  250

         ************************************************************

S: 124   GfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksverk  183

         Gf+kev++kyk +gk ilr+l++v+ wlPl++++d++vl+ hGG+s+ t+l+ll ++er+

Q: 251   GFTKEVMNKYKIHGKEILRTLQDVFCWLPLATLIDEKVLIFHGGVSDITDLELLDKIERN  310

         ************************************************************

S: 184   krksvllpPeessrdlgrldtdgepres  211

         k +s ++  +  ++   +++++g+++++

Q: 311   KIVSTMRCKT-RQKSEKQMEEKGKANRN  337

         *****99877.44455566777666554

Domain Sequence
(FASTA)

LIEAFRLKQQ LHARYVLNLL YETKKHLVQL PNINRVSTCY SEEITVCGDL HGQLDDLIFI 60

FYKNGLPSPE RSYVFNGDFV DRGKDSVEIL MILFAFMLVY PKEFHLNRGN HEDHMVNLRY 120

GFTKEVMNKY KIHGKEILRT LQDVFCWLPL ATLIDEKVLI FHGGVSDITD LELLDKIERN 180

KIVSTMRCKT RQKSEKQMEE KGKANRN 207

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception
GO:0043409	; P:negative regulation of MAPK cascade
GO:0010801	; P:negative regulation of peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013