EKS-MAM-00403
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00403
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR581.01.6E-174610943334
StatusUnreviewed
Ensembl ProteinENSMMUP00000036456
UniProt AccessionF6Y6U1;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000016139ENSMMUP00000036456ENSMMUT00000043454
ENSMMUG00000016139ENSMMUP00000036455ENSMMUT00000043453
ENSMMUG00000016139ENSMMUP00000021228ENSMMUT00000022691
OrganismMacaca mulatta
Functional Description
Protein Length993
Protein Sequence
(FASTA)
MPALARGGGR LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP 60
EDLGCALRPQ SAGTVYEAAT VEVDVSASIT LQVLVDTPGN VSCLWVFKHS SLNCQPHFDV 120
QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLFTLRR PYFRKMENQD 180
ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE 240
CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGSYFEM 300
STYSTNRTMI RILFAFVSSV ARNNTGYYTC SSSKHPSQSA LVTIVEKGFI NATNSSEDYE 360
IDQYEEFCFS VRFKAYPQIR CTWTFSRKAF PCEQKALDDG YSVSKFCNHK HQPGEYIFHA 420
ENGDAQFTKM FTLNIRRKPQ VLAEASASQA SCSSDGYPLP SWTWKKCSDK SPNCTEDIPE 480
GVWNRKANRK VFGQWVSSST LNMSEAMKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD 540
SISFYATIGV CLLFIVVLTM LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFRDCDYD 600
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS 660
ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE 720
HNFSFYPTFQ SHPNSSMPGS RDVQIHPHSD PISGLHGNSF HSEDEIEYEN QKRLEEEEDL 780
NVLTFEDLLC FAYQVAKGME FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS 840
NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 900
LIRNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPHLT SFLGCQLEDA EEAMYQNVDG 960
RVSERPHIYQ NRRPFSREMD SGPLSPKAQV EDS 993
Nucleotide Sequence
(FASTA)
ATGCCGGCGT TGGCGCGCGG CGGCGGCCGG CTGCCGCTGC TCGTTGTTTT TTCTGCAATG 60
ATATTTGGGA CTATTACAAA TCAAGATCTG CCTGTGATCA AGTGTGTTTT AATCAATCAT 120
AAGAACAATG ATTCATCAGT GGGGAAGTCA TCATCATATC CCATGGTGTC AGAATCCCCA 180
GAAGACCTCG GGTGTGCATT GAGACCCCAG AGCGCAGGGA CAGTGTATGA AGCCGCCACG 240
GTGGAAGTGG ATGTATCTGC TTCCATCACA TTGCAAGTGC TGGTCGACAC CCCAGGGAAC 300
GTTTCCTGTC TCTGGGTCTT TAAGCACAGC TCCCTGAATT GTCAGCCACA TTTTGATGTA 360
CAAAATAGAG GAGTTGTTTC CATGGTCATT TTGAAAATGA CAGAAACCCA AGCTGGAGAA 420
TACCTACTTT TTATTCAGAG TGAAGCTACC AATTACACAA TATTGTTTAC AGTGAGTATA 480
AGAAATACCC TGCTTTTCAC ATTAAGAAGA CCTTACTTTA GAAAAATGGA AAACCAGGAC 540
GCCCTGGTCT GCATATCTGA GAGCGTTCCA GAGCCGATCG TGGAATGGGT GCTTTGCGAT 600
TCACAGGGGG AAAGTTGTAA AGAAGAAAGT CCAGCAGTTG TTAAAAAGGA GGAGAAAGTG 660
CTTCATGAAT TATTTGGGAC GGACATAAGG TGCTGTGCCA GAAATGAACT GGGCAGGGAA 720
TGCACCAGGC TGTTCACAAT AGATCTAAAT CAAACTCCTC AGACCACATT GCCACAATTA 780
TTTCTTAAAG TGGGGGAACC CTTATGGATA AGGTGCAAAG CTGTTCATGT GAACCATGGA 840
TTCGGGCTCA CCTGGGAATT AGAAAACAAA GCACTTGAGG AGGGCAGCTA CTTTGAGATG 900
AGTACCTATT CAACAAACAG AACTATGATA CGGATTCTGT TTGCTTTTGT ATCATCAGTG 960
GCAAGAAACA ACACGGGATA CTACACTTGT TCCTCTTCAA AGCATCCCAG TCAATCCGCT 1020
TTGGTTACCA TCGTAGAAAA GGGATTTATA AATGCTACCA ATTCAAGTGA AGATTATGAA 1080
ATTGACCAAT ATGAAGAGTT TTGTTTTTCC GTCAGGTTTA AAGCCTACCC ACAAATCAGA 1140
TGTACATGGA CCTTCTCTCG AAAAGCATTT CCTTGTGAGC AAAAGGCTCT CGATGACGGA 1200
TACAGCGTAT CCAAGTTTTG CAATCATAAG CACCAGCCAG GAGAATATAT ATTCCATGCA 1260
GAAAATGGTG ATGCCCAATT TACCAAAATG TTCACGCTGA ATATAAGAAG GAAACCTCAA 1320
GTGCTCGCGG AAGCATCAGC GAGTCAGGCG TCCTGTTCCT CGGATGGATA CCCATTACCA 1380
TCTTGGACCT GGAAGAAGTG TTCAGACAAG TCTCCTAACT GCACAGAAGA CATCCCAGAA 1440
GGAGTCTGGA ATAGAAAGGC TAACAGAAAA GTGTTTGGAC AGTGGGTGTC CAGCAGTACT 1500
CTAAACATGA GTGAAGCCAT GAAAGGGTTC CTGGTCAAGT GCTGTGCATA CAATTCCCTT 1560
GGCACATCTT GTGAGACGAT CCTTTTAAAC TCTCCAGGCC CCTTCCCTTT CATCCAAGAC 1620
AGCATCTCAT TCTATGCAAC AATTGGTGTT TGTCTCCTCT TCATTGTCGT TTTAACCATG 1680
CTGATTTGTC ACAAGTACAA AAAGCAATTT AGGTATGAAA GCCAGCTACA GATGGTACAG 1740
GTGACCGGCT CCTCAGATAA TGAGTACTTC TACGTTGATT TCAGAGACTG TGACTATGAT 1800
CTCAAATGGG AGTTTCCAAG AGAAAATTTA GAGTTTGGGA AGGTGCTAGG ATCAGGGGCT 1860
TTTGGAAAAG TGATGAACGC AACAGCTTAT GGAATTAGCA AAACAGGAGT CTCAATCCAG 1920
GTTGCAGTCA AAATGCTGAA AGAAAAAGCA GACAGCTCTG AAAGAGAGGC ACTCATGTCA 1980
GAACTCAAGA TGATGACCCA GCTGGGAAGC CACGAGAATA TTGTGAACCT GCTGGGGGCG 2040
TGCACGCTGT CAGGACCAAT TTACTTGATT TTTGAATATT GTTGCTATGG TGATCTTCTC 2100
AACTATCTAA GAAGTAAAAG AGAAAAATTT CACAGGACTT GGACAGAGAT TTTCAAGGAA 2160
CACAATTTCA GTTTTTACCC CACTTTCCAA TCACATCCAA ATTCCAGCAT GCCTGGTTCA 2220
AGAGACGTTC AGATACACCC GCACTCGGAT CCAATCTCAG GGCTTCATGG GAATTCATTT 2280
CACTCTGAAG ATGAAATTGA ATATGAAAAC CAAAAAAGGC TGGAAGAAGA GGAGGACTTG 2340
AATGTGCTTA CATTTGAAGA TCTTCTTTGC TTTGCATATC AAGTTGCCAA AGGAATGGAA 2400
TTTCTGGAAT TTAAGTCGTG TGTTCACAGA GACCTGGCCG CCAGGAACGT GCTTGTCACC 2460
CACGGGAAAG TGGTGAAGAT ATGTGACTTT GGATTGGCTC GAGATATCAT GAGTGATTCC 2520
AACTATGTTG TCAGGGGCAA TGCCCGTCTG CCTGTAAAAT GGATGGCCCC TGAAAGCCTA 2580
TTTGAAGGGA TCTATACCAT TAAGAGTGAT GTCTGGTCAT ACGGAATATT ACTGTGGGAA 2640
ATCTTCTCAC TTGGTGTGAA TCCTTACCCT GGCATTCCGG TTGATGCTAA CTTCTACAAA 2700
CTGATTCGAA ATGGATTTAA AATGGATCAG CCATTTTATG CTACAGAAGA AATATACATT 2760
ATAATGCAAT CCTGCTGGGC TTTTGACTCA AGGAAGCGGC CATCCTTCCC TCATTTGACT 2820
TCATTTTTAG GATGTCAGCT GGAGGATGCG GAAGAAGCGA TGTATCAGAA TGTGGATGGC 2880
CGTGTTTCGG AACGTCCTCA CATCTACCAA AACAGGCGAC CTTTCAGCAG AGAGATGGAT 2940
TCAGGGCCAC TCTCTCCAAA GGCTCAGGTC GAAGATTCAT AG 2982
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk++++lG
Q: 610   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLG  669
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 670   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  728
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s++ v+++++++ +s  + ++++se++ +++++++   +eeed
Q: 729   ------FQSHPNSSMPGSRD-VQIHPHSDPISGLHGNSFHSEDEIEYENQKRL--EEEED  779
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardim+d
Q: 780   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD  839
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 840   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  899
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 900   KLIRNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPHLTSFL  943
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTQLG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPG SRDVQIHPHS DPISGLHGNS FHSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDIMSD SNYVVRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIRNGFKMD 300
QPFYATEEIY IIMQSCWAFD SRKRPSFPHL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
mcc:721712;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013