EKS-MAM-00012
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00012
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph382.31.4E-114652896245
StatusUnreviewed
Ensembl ProteinENSMMUP00000021314
UniProt AccessionI2CUL1;
Protein Name
Protein Synonyms/Alias Ephrin type-B receptor 6;
Gene NameEPHB6
Gene Synonyms/Alias EPHB6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000016218ENSMMUP00000021314ENSMMUT00000022788
OrganismMacaca mulatta
Functional Description
Protein Length1003
Protein Sequence
(FASTA)
MVCSLWVLLL VSSVLALEEV LLDTTGETSE IGWLTYPPGG WDEVSVLDDQ RRLTRTFEAC 60
HVAGAPPGTG QDNWLQTHFV ERRGAQRAHI RLHFSVRACS SLGVSGGTCR ETFTLYYRQA 120
EEPDSPESVS SWHLKRWTKV DTIAADESFP SSSSSSSSAA WAVGPHGAGQ RAGLQLNVKE 180
RSFGPLTQRG FYVAFQDTGA CLALVAVRLF SYTCPAVLRS FASFPETQAS GAGGASLVAA 240
VGTCVAHAEP EEDGVGGQAG GSPPRLHCNG EGKWMVAVGG CLCQPGHQPA RGDKACQACP 300
RGLYKASAGN VPCSPCPARS HAPNPAAPVC PCLEGFYRAS SDPPEAPCTG PPSAPQELWF 360
EVQGSALMLH WRLPRELGGR GDLLFNVVCK ECEGRQEPAS GGGGTCRRCR DEVHFDPRQR 420
GLTESRVLVG GLRAHVPYIL EVQAVNGVSE LSPDPPQAAA INVSTSHEVP SAVPVVHQVS 480
RASNSITVSW PQPDQTNGNI LDYQLRYYDQ AEDESHSFTL TSETNTATVT QLSPGHIYGF 540
QVRARTAAGH GPYGGKVYFQ TLPQGELSSQ LPERLSLVIG SILGALAFLL LAAITVLAVV 600
FQRKRRGTGY MEQLQQYSSP GPGVKYYIDP STYEDPCQAI RELAREIDPA YIKIEEVIGT 660
GSFGEVRRGR LQPRGRREQT VAIQALWAGG AESLQMTFLG RAAVLGQFQH PNILRLEGVV 720
TKSRPLMVLT EFMELGPLDS FLRQREGQFS SLQLVAMQRG VAAAMQYLSS FAFVHRSLSA 780
HSVLVNSHLV CKVARLGHSP QGPSCLLRWA APEVIAHGKH TASSDVWSFG ILMWEVMSYG 840
ERPYWDMSEQ EVLNAIEQEF RLPPPPGCPP GLHLLMLDTW QKDRARRPHF DQLVAAFDKM 900
IRKPDTLQAG GDPGERPSQA LLTPVALDFP CLDSPQAWLS AIGLECYQDN FSKFGLCTFS 960
DVAQLSLEDL PALGITLAGH QKKLLHHIQL LQQHLRQQGS VEV 1003
Nucleotide Sequence
(FASTA)
ATGGTTTGTA GCCTATGGGT GCTGCTCCTG GTGTCTTCAG TTCTGGCTCT GGAAGAGGTA 60
TTGCTGGACA CCACCGGAGA GACATCTGAG ATTGGCTGGC TCACCTACCC ACCAGGGGGG 120
TGGGACGAGG TGAGTGTTCT GGACGACCAG CGACGCCTGA CTCGGACCTT TGAGGCATGT 180
CATGTGGCAG GGGCCCCTCC AGGCACCGGG CAGGACAATT GGTTGCAGAC ACACTTTGTG 240
GAGCGGCGCG GGGCCCAGAG GGCACACATT CGACTCCACT TCTCTGTGCG GGCGTGCTCC 300
AGCCTGGGCG TGAGCGGCGG CACCTGCCGG GAGACCTTCA CCCTTTACTA CCGCCAGGCT 360
GAGGAGCCCG ACAGCCCCGA GAGCGTTTCC TCCTGGCACC TCAAACGCTG GACCAAGGTG 420
GACACAATTG CAGCAGACGA GAGCTTTCCC TCCTCCTCCT CCTCTTCTTC CTCTGCAGCG 480
TGGGCTGTGG GACCCCACGG GGCTGGGCAG CGGGCTGGAC TGCAGCTGAA CGTCAAAGAG 540
CGGAGCTTTG GGCCTCTCAC CCAACGTGGC TTCTACGTGG CCTTCCAGGA CACGGGGGCC 600
TGCCTGGCCC TGGTAGCTGT CAGGCTCTTC TCCTACACCT GCCCTGCCGT GCTCCGATCC 660
TTTGCCTCCT TTCCAGAGAC GCAGGCCAGT GGGGCTGGGG GGGCCTCCCT GGTGGCAGCT 720
GTGGGCACCT GTGTGGCTCA TGCAGAGCCA GAGGAGGATG GAGTAGGGGG CCAGGCAGGA 780
GGCAGCCCCC CGAGGCTGCA CTGCAACGGG GAGGGCAAGT GGATGGTAGC TGTCGGGGGC 840
TGCCTGTGCC AGCCTGGACA CCAACCAGCA CGAGGAGACA AGGCCTGCCA AGCCTGCCCA 900
CGGGGGCTCT ATAAGGCTTC TGCTGGGAAT GTTCCCTGCT CACCATGCCC TGCCCGCAGC 960
CACGCTCCCA ATCCAGCAGC CCCAGTTTGC CCCTGCCTGG AGGGCTTCTA CCGGGCCAGT 1020
TCCGACCCAC CAGAGGCCCC CTGCACTGGT CCTCCATCGG CTCCCCAGGA GCTTTGGTTT 1080
GAGGTGCAAG GCTCAGCACT CATGCTACAC TGGCGCCTGC CTCGGGAGCT GGGGGGTCGA 1140
GGGGACCTGC TCTTCAACGT CGTGTGCAAG GAGTGTGAAG GCCGCCAGGA GCCTGCCAGC 1200
GGTGGTGGGG GCACTTGTCG CCGCTGCAGG GATGAGGTCC ACTTTGACCC TCGCCAGAGA 1260
GGCCTGACTG AGAGCCGAGT GTTAGTGGGG GGGCTCCGAG CACATGTACC CTACATCTTA 1320
GAGGTGCAGG CTGTCAATGG GGTGTCTGAG CTCAGCCCTG ACCCTCCTCA GGCTGCAGCT 1380
ATCAATGTCA GCACCAGCCA TGAAGTGCCC TCTGCAGTCC CTGTGGTGCA CCAGGTGAGC 1440
CGGGCATCCA ACAGCATCAC AGTGTCCTGG CCGCAGCCCG ACCAGACCAA TGGGAACATC 1500
TTGGACTATC AGCTCCGCTA CTATGACCAG GCAGAAGACG AATCCCACTC CTTCACCCTG 1560
ACCAGCGAGA CCAACACTGC CACCGTGACA CAGCTGAGCC CTGGCCACAT CTATGGTTTC 1620
CAGGTGCGAG CCCGGACTGC TGCCGGCCAC GGCCCCTACG GGGGCAAAGT CTATTTCCAG 1680
ACGCTTCCTC AAGGGGAGCT GTCCTCCCAG CTTCCGGAGA GACTCTCCTT GGTGATTGGC 1740
TCCATCCTGG GGGCCTTGGC CTTCCTCCTG CTGGCAGCCA TCACCGTGCT GGCGGTCGTC 1800
TTCCAGCGGA AGCGGCGTGG GACTGGCTAT ATGGAGCAGC TGCAGCAATA CAGCAGCCCA 1860
GGACCTGGGG TGAAGTATTA CATCGACCCC TCCACCTACG AGGACCCCTG CCAGGCCATC 1920
CGAGAACTTG CCCGGGAGAT CGATCCTGCC TATATCAAGA TTGAGGAGGT CATTGGGACA 1980
GGCTCTTTTG GCGAAGTGCG CCGGGGCCGC CTACAGCCAC GGGGACGGAG GGAGCAGACT 2040
GTGGCCATCC AGGCCCTGTG GGCCGGGGGC GCCGAAAGCC TGCAGATGAC CTTCCTGGGC 2100
CGGGCTGCGG TGCTGGGTCA GTTCCAGCAC CCCAACATCC TGCGGCTGGA GGGTGTGGTC 2160
ACCAAGAGCC GACCCCTCAT GGTGTTGACG GAGTTCATGG AGCTTGGCCC CCTGGACAGC 2220
TTCCTCAGGC AGCGGGAGGG CCAGTTCAGC AGCCTGCAGC TGGTGGCCAT GCAACGGGGA 2280
GTGGCTGCTG CCATGCAGTA CCTGTCCAGC TTTGCCTTCG TCCATCGCTC GCTCTCTGCC 2340
CACAGCGTGC TGGTAAATAG CCACTTGGTG TGCAAGGTGG CCCGTCTTGG CCACAGTCCT 2400
CAGGGCCCAA GTTGTTTGCT TCGCTGGGCA GCCCCAGAGG TCATTGCACA CGGAAAGCAT 2460
ACAGCATCCA GTGACGTCTG GAGCTTTGGG ATACTCATGT GGGAAGTGAT GAGTTATGGA 2520
GAACGGCCTT ACTGGGACAT GAGTGAACAG GAGGTACTAA ATGCAATAGA GCAGGAGTTC 2580
CGGCTGCCCC CACCTCCAGG CTGTCCTCCT GGATTACATC TACTTATGTT GGACACTTGG 2640
CAGAAGGACC GTGCCCGGCG GCCTCATTTT GACCAGCTGG TGGCTGCATT TGACAAGATG 2700
ATCCGCAAGC CGGATACCCT GCAGGCTGGC GGAGACCCAG GGGAAAGGCC TTCCCAGGCC 2760
CTTCTGACCC CTGTGGCCCT GGACTTTCCT TGTCTGGACT CACCCCAGGC CTGGCTTTCA 2820
GCCATTGGAC TGGAGTGCTA CCAGGACAAC TTCTCCAAGT TTGGCCTCTG TACCTTCAGT 2880
GATGTGGCTC AGCTCAGCCT GGAAGACCTG CCTGCCCTGG GCATCACCCT GGCTGGCCAC 2940
CAGAAGAAGC TGCTGCACCA CATCCAGCTC CTTCAGCAAC ACCTGAGGCA GCAGGGCTCA 3000
GTGGAGGTCT GA 3012
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kie+viG+G+fGev++Grl+ +g+re++vai++l+ag +e+ +++fl +a++lGqf+hp
Q: 652   IKIEEVIGTGSFGEVRRGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHP  711
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         ni+rleGvvtks+p+m++te+me g ldsflr+++gqf+++qlv+m+rG+a++m+yls++
Q: 712   NILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSF  771
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         ++vhr+l+a+++lvns+lvckv+++G+s++            g ++ +rw+ape+ia++k
Q: 772   AFVHRSLSAHSVLVNSHLVCKVARLGHSPQ------------GPSCLLRWAAPEVIAHGK  819
         ****************************98............999***************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         +t++sdvws+Gi++wev+syGerpywdms+q+v++aie+++rlppp +cp +l+ lmld+
Q: 820   HTASSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDT  879
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqkdra+rp+f+q+v++
Q: 880   WQKDRARRPHFDQLVAA  896
         **************986
Domain Sequence
(FASTA)
IKIEEVIGTG SFGEVRRGRL QPRGRREQTV AIQALWAGGA ESLQMTFLGR AAVLGQFQHP 60
NILRLEGVVT KSRPLMVLTE FMELGPLDSF LRQREGQFSS LQLVAMQRGV AAAMQYLSSF 120
AFVHRSLSAH SVLVNSHLVC KVARLGHSPQ GPSCLLRWAA PEVIAHGKHT ASSDVWSFGI 180
LMWEVMSYGE RPYWDMSEQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ KDRARRPHFD 240
QLVAA 245
KeywordATP-binding; Membrane; Nucleotide-binding; Receptor; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00013
EKS-CAJ-00013
EKS-CAF-00013
EKS-CAP-00012
EKS-EQC-00013
EKS-FEC-00010
EKS-GOG-00014
EKS-HOS-00014
EKS-ICT-00014
EKS-MOD-00012
EKS-MUM-00013
EKS-MUP-00014
EKS-NOL-00013
EKS-ORC-00013
EKS-OTG-00014
EKS-PAT-00011
EKS-POA-00012
EKS-RAN-00013
EKS-SAH-00012
EKS-SUS-00012
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0055074; P:calcium ion homeostasis
GO:0035898; P:parathyroid hormone secretion
KEGG
mcc:704886;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013