EKS-MAM-00386
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00386
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11364.85.5E-109527783257
StatusUnreviewed
Ensembl ProteinENSMMUP00000021506
UniProt AccessionF7G2W1;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000016376ENSMMUP00000021506ENSMMUT00000022994
ENSMMUG00000016376ENSMMUP00000021508ENSMMUT00000022996
OrganismMacaca mulatta
Functional Description
Protein Length1219
Protein Sequence
(FASTA)
MSDAFRQPSL FYHLGVRESF SMANNIILYC DTNSDSLQSL KELICQKNTM CTGNYTFVPY 60
MITPHNKVYC CDSSFMKGLT ELMQPNFELL LGPICLPLVD RFIQLLKVAQ ASSSQYFRES 120
ILNDIRKARN LYTGKELAAE LARIRQRVDN IEVLTADIVI NLLLSYRDIQ DYDSIVKLVE 180
TLEKLPTFDL ASHHHVKFHY AFALNRRNLP GDRAKALDIM IPMVQSEGQV ASDMYCLVGR 240
IYKDMFLDSN FTDTESRDHG ASWFKKAFES EPTLQSGINY AVLLLAAGHQ FESSFELRKV 300
GVKLSSLLGK KGNLEKLQSY WEVGFFLGAS VLANDHMRVI QASEKLFKLK TPAWYLKSIV 360
ETILIYKHFV KLTTEQPVAK QELVDFWMDF LVEATKTDVT VVRFPVLILE PTKIYQPSYL 420
SINNEVEEKT ISIWHVLPDD KKGIHEWNFS ASSVRGVSIS KFEERCCFLY VLHNSDDFQI 480
YFCTELHCKK FFEMVNTITE EKGRSTEEGD CESDSLEYDY EYDENGDRVV LGKGTYGIVY 540
AGRDLSNQVR IAIKEIPERD SRYSQPLHEE IALHKHLKHK NIVQYLGSFS ENGFIKIFME 600
QVPGGSLSAL LRSKWGPLKD NEQTIGFYTK QILEGLKYLH DNQIVHRDIK GDNVLINTYS 660
GVLKISDFGT SKRLAGINPC TETFTGTLQY MAPEIIDKGP RGYGKAADIW SLGCTIIEMA 720
TGKPPFYELG EPQAAMFKVG MFKVHPEIPE SMSAEAKAFI LKCFEPDPDK RACANDLLVD 780
EFLKVSSKKK KTQPKLSALS AGSNEYLRSI SLPVPVLVED TSSSSEYGSV SPDTELKADP 840
FSFKTRAKSC GERDVKGIRT LFLGIPDENF EDHSAPPSPE EKDSGFFMLR KDSERRATLH 900
RILTEDQDKV VRNLMESLAQ GSEEPKLKWE HITTLIASLR EFVRSTDRKI IATTLSKLKL 960
ELDFDSHGIS QVQVVLFGFQ DAVNKVLRNH NIKPHWMFAL DSIIRKAVQT AITILVPELR 1020
PHFSLASESD TADQEDLDVE DDHEEQPSNQ TVRRPQPVIE DAVATSGVST LSSTVSHDSQ 1080
SAHRSLNVQL GRMKIETNRL LEELVRKEKE LQALLHRAIE EKDQEIKHLK LKSQPIEIPE 1140
LPVFHLNSPG TNTEDSELTD WLRVNGADED TISRFLAEDY TLLDVLYYVT RDDLKCLRLR 1200
GGMLCTLWKA IIDFRNKQT 1219
Nucleotide Sequence
(FASTA)
ATGAGCGATG CCTTCCGGCA ACCGTCCTTG TTTTACCACC TTGGGGTGAG AGAAAGTTTC 60
AGCATGGCCA ACAACATCAT CCTCTACTGT GATACTAACT CGGACTCTCT GCAGTCGCTG 120
AAGGAACTCA TTTGCCAGAA GAATACTATG TGCACTGGGA ACTACACCTT TGTTCCTTAT 180
ATGATAACGC CACATAACAA GGTCTACTGC TGTGACAGCA GCTTCATGAA GGGGTTGACA 240
GAGCTCATGC AACCGAACTT CGAGCTGCTT CTTGGACCCA TCTGCTTACC TCTTGTGGAT 300
CGTTTTATTC AACTTTTGAA GGTGGCACAA GCAAGTTCTA GCCAGTATTT CCGGGAATCT 360
ATACTCAATG ATATCAGGAA AGCTCGTAAT TTATACACTG GTAAAGAATT GGCAGCTGAG 420
TTGGCAAGAA TTCGGCAGCG AGTAGATAAT ATCGAAGTCT TGACAGCAGA TATTGTCATA 480
AATCTGTTAC TTTCCTACAG AGATATCCAG GACTATGATT CTATTGTGAA GCTGGTAGAG 540
ACTTTAGAAA AACTGCCAAC CTTTGATTTG GCCTCCCATC ACCATGTGAA GTTTCATTAT 600
GCATTTGCAC TGAATAGGAG AAATCTCCCT GGAGACAGAG CAAAAGCTCT TGATATTATG 660
ATTCCCATGG TGCAAAGTGA AGGACAAGTT GCTTCAGATA TGTATTGCCT AGTTGGTCGA 720
ATCTACAAAG ATATGTTTTT GGACTCTAAT TTCACAGACA CGGAAAGCAG AGACCATGGA 780
GCTTCTTGGT TCAAAAAGGC ATTTGAATCT GAGCCAACAC TACAGTCAGG AATTAATTAT 840
GCGGTCCTCC TCCTGGCAGC TGGGCACCAG TTTGAATCTT CCTTTGAGCT CCGGAAAGTT 900
GGGGTGAAGC TAAGTAGTCT TCTTGGTAAA AAGGGAAACT TGGAGAAACT CCAGAGCTAC 960
TGGGAAGTTG GATTTTTTCT GGGGGCCAGT GTCCTAGCCA ATGACCACAT GAGAGTCATT 1020
CAAGCATCTG AAAAGCTTTT TAAACTGAAG ACACCAGCGT GGTACCTCAA GTCTATTGTA 1080
GAGACAATTT TGATATATAA GCATTTTGTG AAACTGACCA CAGAACAGCC TGTGGCCAAG 1140
CAAGAACTTG TGGACTTTTG GATGGATTTC CTGGTCGAGG CCACAAAGAC CGATGTTACT 1200
GTGGTTAGGT TTCCAGTATT AATATTAGAA CCAACCAAAA TCTATCAACC TTCTTATTTG 1260
TCTATCAACA ATGAAGTTGA GGAAAAGACA ATCTCTATTT GGCACGTGCT TCCTGATGAC 1320
AAGAAAGGTA TACATGAGTG GAATTTTAGT GCCTCTTCTG TCAGGGGAGT GAGTATTTCT 1380
AAATTTGAAG AAAGATGCTG CTTTCTTTAT GTGCTCCACA ATTCTGATGA TTTCCAAATC 1440
TATTTCTGTA CAGAACTTCA TTGTAAAAAG TTTTTTGAGA TGGTGAACAC CATTACCGAA 1500
GAGAAGGGGA GAAGCACAGA GGAAGGAGAC TGTGAAAGTG ACTCGCTGGA GTATGACTAT 1560
GAATATGATG AAAATGGTGA CAGAGTCGTT TTAGGAAAAG GCACTTACGG GATAGTCTAC 1620
GCAGGTCGGG ACTTGAGCAA CCAAGTCAGA ATTGCTATTA AGGAAATCCC AGAGAGAGAC 1680
AGCAGATACT CTCAGCCCCT GCATGAAGAA ATAGCATTGC ATAAGCACCT GAAGCACAAA 1740
AATATTGTCC AGTATCTGGG CTCTTTCAGT GAGAATGGTT TCATTAAAAT CTTCATGGAG 1800
CAGGTCCCTG GAGGAAGTCT TTCTGCTCTC CTTCGTTCCA AATGGGGTCC ATTAAAAGAT 1860
AATGAGCAAA CAATTGGCTT TTATACAAAG CAAATACTGG AAGGATTAAA ATATCTCCAT 1920
GACAATCAGA TAGTTCACCG CGACATAAAG GGTGACAATG TGTTGATTAA TACCTACAGT 1980
GGTGTTCTCA AGATCTCTGA CTTCGGGACA TCAAAGAGGC TTGCTGGCAT AAACCCCTGT 2040
ACTGAAACTT TTACTGGTAC CCTCCAGTAT ATGGCACCAG AAATAATAGA TAAAGGACCA 2100
AGAGGCTATG GAAAAGCAGC AGACATCTGG TCTCTGGGCT GTACAATCAT CGAAATGGCC 2160
ACAGGAAAAC CCCCATTTTA TGAACTGGGA GAACCACAAG CAGCTATGTT CAAGGTGGGA 2220
ATGTTTAAAG TCCACCCTGA GATCCCAGAA TCCATGTCTG CAGAGGCCAA GGCATTCATC 2280
CTGAAATGTT TTGAACCAGA CCCTGACAAG AGAGCCTGTG CTAACGACTT GCTTGTTGAT 2340
GAGTTTTTAA AAGTTTCAAG CAAAAAGAAA AAGACACAAC CTAAGCTTTC AGCTCTTTCA 2400
GCTGGATCAA ATGAATATCT CAGGAGTATA TCTTTGCCAG TACCTGTGCT GGTGGAGGAC 2460
ACCAGCAGCA GCAGTGAGTA CGGCTCAGTT TCACCCGACA CGGAGTTGAA AGCGGACCCC 2520
TTCTCTTTCA AAACAAGAGC CAAATCCTGC GGAGAAAGAG ATGTCAAGGG AATTCGGACA 2580
CTCTTTTTGG GCATTCCAGA TGAGAATTTT GAAGATCACA GTGCTCCCCC TTCCCCTGAA 2640
GAAAAAGATT CCGGATTCTT CATGCTGAGG AAGGACAGTG AGAGGCGAGC CACCCTTCAC 2700
AGGATCCTGA CAGAAGACCA AGACAAAGTT GTGAGAAATC TAATGGAATC TTTAGCTCAG 2760
GGGTCTGAAG AACCCAAACT AAAATGGGAA CACATCACAA CCCTCATTGC AAGCCTCAGA 2820
GAATTTGTGA GATCCACTGA CCGAAAAATC ATAGCCACCA CATTGTCAAA GCTGAAACTG 2880
GAGCTGGACT TCGACAGCCA TGGCATTAGC CAAGTCCAGG TGGTGCTCTT TGGTTTTCAA 2940
GATGCTGTCA ATAAAGTTCT TCGGAATCAT AACATCAAGC CGCACTGGAT GTTTGCCTTA 3000
GACAGTATCA TCCGGAAGGC GGTGCAGACA GCCATTACCA TCCTGGTTCC AGAACTAAGG 3060
CCACATTTCA GCCTTGCATC TGAGAGTGAT ACTGCTGATC AAGAAGACTT GGATGTAGAA 3120
GATGACCATG AGGAACAGCC TTCAAATCAA ACTGTCCGAA GACCTCAGCC TGTCATTGAA 3180
GATGCCGTGG CTACCTCAGG CGTGAGCACG CTTAGTTCTA CTGTGTCTCA TGATTCCCAG 3240
AGTGCTCACC GGTCACTGAA TGTACAGCTT GGAAGGATGA AAATAGAAAC CAATAGATTA 3300
CTGGAAGAAT TGGTTCGGAA AGAGAAGGAA TTACAAGCAC TCCTTCATCG AGCTATTGAA 3360
GAAAAAGACC AAGAAATTAA ACACCTGAAG CTTAAGTCCC AACCCATAGA AATTCCTGAA 3420
CTGCCTGTAT TTCACCTAAA TTCTCCTGGC ACAAATACTG AAGATTCTGA GCTTACCGAC 3480
TGGCTGAGAG TGAATGGAGC GGATGAAGAC ACTATAAGCC GGTTTTTGGC TGAAGATTAT 3540
ACACTATTGG ATGTTCTCTA CTATGTTACA CGTGATGACT TAAAATGCTT GAGACTAAGG 3600
GGAGGGATGC TGTGCACACT GTGGAAGGCC ATCATTGACT TTCGAAACAA ACAGACTTGA 3660
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 527   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  581
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 582   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  641
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 642   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  698
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 699   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  758
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ kc+e dp+kr++a++LL +efl
Q: 759   FILKCFEPDPDKRACANDLLVDEFL  783
         **********************996
Domain Sequence
(FASTA)
DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240
DPDKRACAND LLVDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAE-00316
EKS-CAJ-00395
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-DRM-00182
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-ICT-00372
EKS-LAC-00401
EKS-LOA-00395
EKS-MEG-00320
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-SUS-00345
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-XET-00502
EKS-XIM-00493
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013