EKS-MAM-00443

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00443

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	460.3	3.5E-138	78	346	269

Status

Unreviewed

Ensembl Protein

ENSMMUP00000021625

UniProt Accession

F7GBY9;

Protein Name

Protein Synonyms/Alias

Gene Name

DMPK

Gene Synonyms/Alias

DMPK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000016457	ENSMMUP00000021622	ENSMMUT00000023113
ENSMMUG00000016457	ENSMMUP00000021623	ENSMMUT00000023114
ENSMMUG00000016457	ENSMMUP00000021621	ENSMMUT00000023112
ENSMMUG00000016457	ENSMMUP00000021624	ENSMMUT00000023115
ENSMMUG00000016457	ENSMMUP00000031564	ENSMMUT00000038464
ENSMMUG00000016457	ENSMMUP00000021625	ENSMMUT00000023116

Organism

Macaca mulatta

Functional Description

Protein Length

572

Protein Sequence
(FASTA)

MGGQFWPEPY TVFMWGSSWE ADSPRVKLRG REKGRQGGVF PLVSSAFSGD PRFFSPTTPP 60

AEPIVVRLKE VRLHRDDFEI LKVIGRGAFS EVAVVKMKQT GQVYAMKIMN KWDMLKRGEV 120

SCFREERDVL VNGDRRWITQ LHFAFQDENY LYLVMEYYVG GDLLTLLSKF GERIPAEMAR 180

FYLAEIVMAI DSVHRLGYVH RDIKPDNILL DRCGHIRLAD FGSCLKLQAD GTVRSLVAVG 240

TPDYLSPEIL QAVGGGPGTG SYGPECDWWA LGVFAYEMFY GQTPFYADST AETYGKIVHY 300

KEHLSLPLAD EGVPEEAQDL IQRLLCPPET RLGRGGAGDF RTHPFFFGLD WDGLRDSMPP 360

FTPDFEGATD TCNFDLVEDG LTAMVSGGGE TLSDIREGAP LGVHLPFVGY SYSCMALRDS 420

EVPGPTPMEL EAEQLLEPHV QVPSLESSVS PRDETAEVAV PAAIPAAEAE AEVTLRELQE 480

ALEEEVLTRQ SLSREMEAIR MANQNFASQL REAEARNRDL EAHVRQLQER MELLRAEGAT 540

GEWPPGRGSG PVPAGGARPH APPPPAAPCQ GT 572

Nucleotide Sequence
(FASTA)

ATGGGAGGGC AGTTTTGGCC AGAACCTTAC ACAGTGTTTA TGTGGGGAAG CTCTTGGGAA 60

GCAGACAGTC CTAGGGTGAA GCTGAGAGGC AGAGAGAAGG GGAGACAGGG TGGGGTTTTT 120

CCCCTTGTCT CCAGTGCCTT TTCTGGTGAC CCTCGGTTCT TTTCCCCCAC CACGCCCCCA 180

GCGGAGCCCA TCGTGGTGAG GCTTAAGGAG GTCCGACTGC ACAGGGACGA CTTCGAGATT 240

CTGAAGGTGA TCGGACGCGG GGCGTTCAGT GAGGTAGCGG TGGTGAAGAT GAAGCAGACG 300

GGCCAGGTGT ACGCCATGAA GATCATGAAC AAGTGGGACA TGCTGAAGAG GGGCGAGGTG 360

TCGTGCTTCC GTGAGGAGAG GGACGTGTTG GTGAATGGGG ACCGGCGGTG GATCACGCAG 420

CTGCATTTCG CCTTCCAGGA TGAGAACTAC CTGTACCTGG TCATGGAGTA TTACGTGGGT 480

GGGGACCTGC TGACACTGCT GAGCAAGTTT GGGGAGCGGA TTCCGGCTGA GATGGCGCGC 540

TTCTACCTGG CGGAGATTGT CATGGCCATA GATTCGGTGC ACCGGCTCGG CTACGTGCAC 600

AGGGACATCA AACCCGACAA CATCCTGCTG GACCGCTGTG GCCACATCCG CCTGGCTGAC 660

TTCGGCTCCT GTCTCAAGCT GCAGGCAGAT GGAACGGTGC GGTCACTGGT GGCTGTGGGC 720

ACCCCAGACT ACCTGTCCCC CGAGATCCTG CAGGCTGTGG GCGGTGGGCC TGGGACAGGC 780

AGCTACGGGC CAGAGTGTGA CTGGTGGGCG CTGGGTGTGT TCGCCTATGA AATGTTCTAC 840

GGGCAGACGC CCTTCTACGC GGATTCCACG GCGGAGACCT ACGGCAAGAT CGTCCACTAC 900

AAGGAGCACC TCTCTCTGCC GCTGGCAGAT GAAGGGGTCC CTGAGGAGGC TCAAGACCTC 960

ATCCAGCGTC TGCTGTGTCC CCCGGAGACA CGGCTGGGCC GGGGTGGAGC AGGTGACTTC 1020

CGGACACATC CCTTCTTCTT TGGCCTCGAC TGGGATGGTC TCCGAGACAG CATGCCCCCC 1080

TTTACACCGG ATTTCGAAGG TGCCACCGAC ACATGCAACT TCGACTTGGT GGAGGACGGG 1140

CTCACTGCCA TGGTGAGCGG GGGCGGGGAG ACGCTGTCGG ACATTCGGGA AGGTGCGCCA 1200

CTGGGGGTCC ACCTGCCTTT TGTGGGCTAC TCCTACTCCT GCATGGCCCT CAGGGACAGT 1260

GAGGTCCCGG GCCCCACACC CATGGAACTG GAGGCCGAGC AGCTGCTTGA GCCACACGTG 1320

CAAGTGCCTA GCCTGGAGTC CTCAGTGTCC CCAAGGGATG AAACAGCTGA AGTGGCAGTT 1380

CCAGCGGCTA TCCCTGCGGC AGAGGCTGAG GCCGAGGTGA CGCTGCGGGA GCTCCAGGAG 1440

GCCCTGGAGG AGGAGGTGCT CACCCGGCAG AGCCTGAGCC GGGAGATGGA GGCCATCCGC 1500

ATGGCCAACC AGAACTTTGC CAGTCAACTA CGCGAGGCAG AGGCTCGGAA CCGGGACCTA 1560

GAGGCGCACG TACGGCAGTT GCAGGAGCGG ATGGAGTTGC TGCGGGCAGA GGGAGCCACA 1620

GGCGAATGGC CCCCCGGCCG TGGCTCTGGG CCAGTGCCCG CTGGTGGGGC CAGGCCCCAT 1680

GCACCGCCGC CACCTGCTGC TCCCTGCCAG GGTACG 1716

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGaf+evavv++k+t++vyamki++k+++lkr e+++freerdvlv++d++w

Q: 78    FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRW  137

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i+ql++afqde+ylylvmey+vGGdlltllsk+++++p+e+arfylae+v+a+dsvh+lg

Q: 138   ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLG  197

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee..  178

         yvhrdikpdnilld++Ghi+ladfGsclkl++dgtv+s vavGtpdy+spe+l+a++

Q: 198   YVHRDIKPDNILLDRCGHIRLADFGSCLKLQADGTVRSLVAVGTPDYLSPEILQAVGGgp  257

         ********************************************************9978

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseea  237

         g+g+yg+ecdww+lGv++ye+++g+tpfya+s++ety+ki+++ke+l++p  +  v+eea

Q: 258   GTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLADeGVPEEA  317

         899***********************************************76549*****

S: 238   kdlikklltsreerlgregiedlkkhpff  266

         +dli++ll+ +e+rlgr g  d+++hpff

Q: 318   QDLIQRLLCPPETRLGRGGAGDFRTHPFF  346

         ****************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER DVLVNGDRRW 60

ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG 120

YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QADGTVRSLV AVGTPDYLSP EILQAVGGGP 180

GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP LADEGVPEEA 240

QDLIQRLLCP PETRLGRGGA GDFRTHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0031307	; C:integral to mitochondrial outer membrane
GO:0031965	; C:nuclear membrane
GO:0005886	; C:plasma membrane
GO:0033017	; C:sarcoplasmic reticulum membrane
GO:0005524	; F:ATP binding
GO:0017020	; F:myosin phosphatase regulator activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006874	; P:cellular calcium ion homeostasis
GO:0010657	; P:muscle cell apoptotic process
GO:0006998	; P:nuclear envelope organization
GO:0014853	; P:regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
GO:0008016	; P:regulation of heart contraction
GO:0010830	; P:regulation of myotube differentiation
GO:0014722	; P:regulation of skeletal muscle contraction by calcium ion signaling
GO:0002028	; P:regulation of sodium ion transport
GO:0051823	; P:regulation of synapse structural plasticity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013