EKS-MAM-00405
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00405
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK407.55.1E-122165443279
StatusUnreviewed
Ensembl ProteinENSMMUP00000021862
UniProt AccessionF6TPI1;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK3
Gene Synonyms/Alias IRAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000016625ENSMMUP00000021862ENSMMUT00000023365
OrganismMacaca mulatta
Functional Description
Protein Length596
Protein Sequence
(FASTA)
MAGNCGVRGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK 60
YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNHGAVLS PSEKSYQEGG 120
FPNILLKETA SVTVDNVLIP EHNGKGILPK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY 180
RVEIQNLTYA VKLFKQEKKM QCKKHWKSFL SELEVLLLFH HPNILELTAY FTETEKFCLV 240
YPYMRNGTLF DRLQCVGDTA PLPWHVRISI LIGISKAIHY LHNVQPCSVI CGSISSANIL 300
LDDQFQPKLT DFAMAHFRSH VEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF 360
GIVIMEVLTG CRVVLDDPKH IQLRDLLIEL MEKRGLDSCL SFLDKKVPPC PRNFSIKLFC 420
LAGQCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE 480
DDESQNNHLL SSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSRE 540
ESWFPKYIVP SQDLRPFKVN MDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQHKKE 596
Nucleotide Sequence
(FASTA)
ATGGCGGGGA ACTGCGGGGT CCGCGGCGCG CTGTCGGCGC ACACCCTGCT GTTCGACCTG 60
CCGCCCGCGC TGCTGGGGGA GCTGTGCGCG GTGCTGGACA GCTGCGACGG CGCGCTGGGC 120
TGGCGCGGCC TGGCAGAGAG ACTTTCAAGC AGCTGGCTGG ATGTTCGTCA TATTGAAAAG 180
TATGTAGACC AAGGTAAAAG TGGAACAAGA GAATTACTTT GGTCCTGGGC ACAGAAAAAC 240
AAGACCATCG GTGACCTTTT ACAGGTCCTC CAGGAGATGG GGCATCGTCG AGCTATTCAT 300
TTAATTACAA ACCATGGAGC AGTCTTGAGT CCTTCAGAGA AGAGTTATCA GGAAGGTGGA 360
TTTCCAAACA TATTACTCAA GGAAACAGCC AGTGTCACAG TGGATAATGT TCTTATTCCT 420
GAACATAATG GAAAAGGAAT ACTGCCTAAA TCTTCAATCA GCTTTCAAAA CATCATAGAA 480
GGAACTAGAA ATTTCCACAA AGACTTCCTA ATTGGAGAAG GAGAGATTTT TGAGGTATAC 540
AGAGTGGAGA TTCAAAACCT AACATACGCT GTCAAATTAT TTAAACAGGA GAAAAAAATG 600
CAATGTAAGA AGCATTGGAA GAGTTTTTTA TCTGAGCTTG AAGTCTTACT ACTGTTTCAC 660
CATCCAAACA TACTCGAGTT GACTGCATAT TTTACAGAGA CTGAGAAGTT CTGTCTGGTT 720
TATCCATACA TGAGAAATGG AACACTTTTT GACAGATTGC AGTGTGTAGG TGACACGGCC 780
CCACTCCCTT GGCACGTTCG AATCAGTATA TTAATAGGAA TATCTAAAGC CATTCACTAC 840
CTGCACAACG TTCAACCATG CTCGGTCATC TGTGGCAGTA TATCAAGTGC AAACATCCTT 900
TTGGATGATC AGTTTCAACC CAAACTAACT GATTTTGCCA TGGCACACTT CCGGTCCCAC 960
GTAGAACATC AGAGTTGTAC CATAAATATG ACCAGCAGCA GCAGTAAACA TCTGTGGTAC 1020
ATGCCAGAAG AGTACATCAG ACAGGGGAAA CTTTCCATTA AAACAGACGT CTACAGCTTT 1080
GGAATTGTCA TAATGGAAGT TCTGACAGGA TGTAGAGTAG TGTTAGATGA TCCAAAACAT 1140
ATCCAGCTGC GGGATCTCCT TATAGAATTG ATGGAGAAGA GAGGCCTGGA TTCATGTCTC 1200
TCATTTCTAG ATAAGAAGGT GCCTCCCTGC CCTCGGAATT TCTCCATCAA GCTCTTCTGT 1260
TTGGCAGGCC AGTGTGCTGC AACGCGGGCA AAGTTAAGAC CATCAATGGA TGAAGTTCTA 1320
AATACTCTTG AAAGTACTCA AGCCAGCTTG TATTTTGCTG AAGATCCTCC CACGTCACTA 1380
AAGTCCTTCA GGTGTCCTTC TCCTCTATTC CTGGAGAATG TACCAAGTAT TCCAGTGGAA 1440
GATGATGAAA GCCAGAATAA CCATTTACTG TCTTCTGATG AAGGCTTGAG GATAGACAGA 1500
ATGACTCAGA AAACTCCTTT TGAATGCAGC CAGTCTGAGG TTATGTTTCT GAGCTTGGAC 1560
AAAAAGCCAG AGAGCAAGAG AAATGAGGAA GCTTGCAACA TGCCCAGTTC TTCTCGTGAA 1620
GAAAGTTGGT TCCCAAAGTA TATAGTTCCA TCCCAGGACT TAAGGCCTTT TAAGGTAAAT 1680
ATGGATCCTT CTTCAGAAGC TCCAGGCCAT TCTTGCAGGA GCAGGCCAGT GGAGAGCAGC 1740
TGTTCCTCCA AATTTTCCTG GGACGAATAT GAACAACACA AAAAAGAATA A 1791
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         f++d+ igeG+++evyr+e++n+++avk +k+e+++++k++++sfl+El+vl+ f+H+ni
Q: 165   FHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKSFLSELEVLLLFHHPNI  224
         89**********************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120
         lel +y++e+ek+cLvY+ym+nG+L+drLqc ++++pL+W++R+sil+G+++ai++LH++
Q: 225   LELTAYFTETEKFCLVYPYMRNGTLFDRLQCVGDTAPLPWHVRISILIGISKAIHYLHNV  284
         ************************************************************
S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179
         +p s+i+g+i+saNiLLD++++pKl+Df++a+f+++ e+qs+t+++ts+ +++l+Y+pee
Q: 285   QPcSVICGSISSANILLDDQFQPKLTDFAMAHFRSHVEHQSCTINMTSSSSKHLWYMPEE  344
         ************************************************************
S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239
         +ir+g+l++k+DvySfGiV++EvltG+r+v +d+k+ +L+dll e +e+++++++ +fld
Q: 345   YIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLIELMEKRGLDSCLSFLD  404
         ************************************************************
S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278
         kk+++++++++ +l++la++c+a++ak rP+m++vl++l
Q: 405   KKVPPCPRNFSIKLFCLAGQCAATRAKLRPSMDEVLNTL  443
         ***********************************9987
Domain Sequence
(FASTA)
FHKDFLIGEG EIFEVYRVEI QNLTYAVKLF KQEKKMQCKK HWKSFLSELE VLLLFHHPNI 60
LELTAYFTET EKFCLVYPYM RNGTLFDRLQ CVGDTAPLPW HVRISILIGI SKAIHYLHNV 120
QPCSVICGSI SSANILLDDQ FQPKLTDFAM AHFRSHVEHQ SCTINMTSSS SKHLWYMPEE 180
YIRQGKLSIK TDVYSFGIVI MEVLTGCRVV LDDPKHIQLR DLLIELMEKR GLDSCLSFLD 240
KKVPPCPRNF SIKLFCLAGQ CAATRAKLRP SMDEVLNTL 279
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00378
EKS-ANC-00394
EKS-BOT-00407
EKS-CAJ-00410
EKS-CAF-00407
EKS-CAP-00435
EKS-DAR-00794
EKS-ECT-00006
EKS-EQC-00399
EKS-ERE-00006
EKS-FEC-00390
EKS-GAA-00494
EKS-GOG-00398
EKS-HOS-00413
EKS-ICT-00386
EKS-LAC-00422
EKS-LOA-00416
EKS-MIM-00062
EKS-MOD-00398
EKS-MUM-00439
EKS-MUP-00401
EKS-MYL-00402
EKS-NOL-00370
EKS-OCP-00086
EKS-ORN-00520
EKS-ORA-00355
EKS-ORC-00382
EKS-OTG-00409
EKS-PAT-00385
EKS-PEM-00222
EKS-POA-00397
EKS-RAN-00421
EKS-SAH-00378
EKS-SUS-00359
EKS-TAR-00515
EKS-TUT-00121
EKS-VIP-00063
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0045824; P:negative regulation of innate immune response
GO:0010936; P:negative regulation of macrophage cytokine production
GO:0043407; P:negative regulation of MAP kinase activity
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177; P:negative regulation of protein catabolic process
GO:0043242; P:negative regulation of protein complex disassembly
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0010933; P:positive regulation of macrophage tolerance induction
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0043330; P:response to exogenous dsRNA
GO:0032496; P:response to lipopolysaccharide
GO:0032494; P:response to peptidoglycan
KEGG
mcc:717845;
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00531; Death; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00005; DEATH; 1.
Prosites
PS50017; DEATH_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013