EKS-MAM-00211

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00211

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	485.2	8.2E-146	4	286	283

Status

Unreviewed

Ensembl Protein

ENSMMUP00000021881

UniProt Accession

F6TVA3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL3

Gene Synonyms/Alias

CDKL3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000016639	ENSMMUP00000021881	ENSMMUT00000023385

Organism

Macaca mulatta

Functional Description

Protein Length

592

Protein Sequence
(FASTA)

MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE IKFLKQFHHE 60

NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIDYLHSNN 120

IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDIYTDY VATRWYRAPE LVLKDTSYGK 180

PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP 240

QVQHPKNARK KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK 300

AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE KKPKEIKVRV 360

IKVKGGRGDI SEPKKKEYEG GLCQQDANEN VHPMSPDTKL VTIEPPNPIN PSTNCNGLKE 420

NPHCGGSMTM PPINLTNSNL MAANLNSNLF HPSVRLTERA KKRRTSSQSI GQVMPNSRQE 480

DPGPIQSQME KGIFNERTGH SDQMSNENKR KLNFSRSDRK EFHFPELPVT IQPKDTKGME 540

VKQIKMLKRE SKKTDSSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW 592

Nucleotide Sequence
(FASTA)

ATGGAGATGT ATGAAACCCT TGGAAAAGTG GGAGAGGGAA GTTACGGAAC AGTCATGAAA 60

TGTAAACATA AGAATACTGG GCAGATAGTG GCCATTAAGA TATTTTATGA GAGACCAGAA 120

CAATCTGTCA ACAAAATTGC GATGAGAGAA ATAAAGTTTC TAAAGCAATT TCATCATGAA 180

AACCTGGTCA ATCTGATTGA AGTTTTTAGA CAGAAAAAGA AAATTCATTT GGTATTTGAA 240

TTTATTGACC ACACAGTATT AGATGAGTTA CAACATTATT GTCATGGACT AGAGAGTAAA 300

CGACTTAGAA AATACCTCTT CCAGATCCTT CGAGCAATTG ACTATCTTCA CAGTAATAAT 360

ATCATTCATC GCGATATAAA ACCTGAGAAT ATTTTAGTAT CCCAGTCAGG AATTACTAAG 420

CTCTGTGATT TTGGTTTTGC ACGAACACTA GCAGCTCCTG GGGACATTTA TACGGACTAT 480

GTGGCCACAC GCTGGTATAG AGCTCCAGAA TTAGTATTAA AAGATACTTC TTATGGAAAA 540

CCTGTGGATA TCTGGGCTTT GGGCTGTATG ATCATTGAGA TGGCGACTGG AAATCCCTAT 600

CTTCCTAGTA GCTCTGATTT GGATTTACTC CATAAAATTG TTTTGAAAGT GGGCAATTTG 660

TCACCTCACT TGCAGAATAT CTTTTCCAAG AGCCCCATTT TTGCTGGGGT AGTTCTTCCT 720

CAAGTTCAAC ACCCCAAAAA TGCAAGAAAA AAATATCCAA AGCTTAATGG ATTGTTGGCA 780

GATATAGTTC ATGCTTGTTT ACAAATTGAT CCTGCTGACA GGATATCATC TAGTGATCTT 840

TTGCATCATG AGTATTTTAC TAGAGATGGA TTTATTGAAA AATTCATGCC AGAACTGAAA 900

GCTAAATTAC TGCAGGAAGC AAAAGTCAAT TCATTAATAA AGCCAAAAGA GAGTTCTAAA 960

GAAAATGAAC TCAGGAAAGA TGAAAGAAAA ACAGTTTATA CCAATACACT GCTAAGTAGT 1020

TCAGTTTTGG GAAAGGAAAT AGAAAAAGAG AAAAAGCCCA AGGAGATTAA AGTCAGAGTT 1080

ATTAAAGTCA AAGGAGGAAG AGGAGATATC TCAGAACCAA AAAAGAAAGA GTATGAAGGT 1140

GGACTTTGTC AACAGGATGC AAATGAAAAT GTTCATCCTA TGTCTCCAGA TACAAAACTT 1200

GTAACCATTG AACCGCCAAA CCCTATCAAT CCCAGCACTA ACTGTAATGG CTTGAAAGAA 1260

AATCCACATT GCGGAGGTTC TATGACAATG CCACCCATCA ATCTAACTAA TAGTAATTTG 1320

ATGGCTGCAA ATCTCAATTC AAATCTCTTT CACCCCAGTG TGAGGTTAAC TGAAAGAGCA 1380

AAAAAGAGAC GCACTTCTTC ACAATCTATT GGACAAGTTA TGCCTAATAG CAGGCAAGAG 1440

GATCCAGGTC CTATTCAAAG CCAAATGGAG AAGGGTATAT TTAATGAGCG AACAGGTCAC 1500

AGTGACCAAA TGTCTAATGA GAACAAAAGG AAGCTGAATT TTTCCAGATC TGACAGGAAA 1560

GAATTCCATT TTCCAGAATT GCCTGTCACA ATACAGCCAA AAGATACGAA AGGAATGGAA 1620

GTTAAACAGA TAAAAATGCT GAAGAGGGAG TCAAAGAAAA CAGATTCATC TAAGATACCA 1680

ACTTTACTTA ATGTGGATCA AAATCAAGAA AAACAAGAGG GTGGAGATGG CCATTGTGAG 1740

GGGAAGAATT TGAAGAGAAA CAGGTTTTTT TTCTGGTAG 1779

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lgkvGeGsyG+v+kc++k+tgqivaik f+e+++ ++v+kia+reik+lkq++henl

Q: 4     YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHHENL  62

         9***********************************9.99********************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfr+kkk++lvfe++d+tvldel++y++G+e+++++k+l+qil+ai+++h+nnii

Q: 63    VNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNII  122

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sg++klcdfGfar+laapgd+ytdyvatrwyrapel+++dt+yGk+v

Q: 123   HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPV  182

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+wa+Gc+++e++tG+p++p++sd+d l+ki+ ++G+l+p+ q+ifsk+++faGv+lp+v

Q: 183   DIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQV  242

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++++++kkypkln +l+d++++cl++dpa+r+s+++ll+heyf

Q: 243   QHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF  286

         *******************************************9

Domain Sequence
(FASTA)

YETLGKVGEG SYGTVMKCKH KNTGQIVAIK IFYERPEQSV NKIAMREIKF LKQFHHENLV 60

NLIEVFRQKK KIHLVFEFID HTVLDELQHY CHGLESKRLR KYLFQILRAI DYLHSNNIIH 120

RDIKPENILV SQSGITKLCD FGFARTLAAP GDIYTDYVAT RWYRAPELVL KDTSYGKPVD 180

IWALGCMIIE MATGNPYLPS SSDLDLLHKI VLKVGNLSPH LQNIFSKSPI FAGVVLPQVQ 240

HPKNARKKYP KLNGLLADIV HACLQIDPAD RISSSDLLHH EYF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mcc:710586

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013