EKS-MAM-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	308.5	5.8E-92	754	1015	262

Status

Unreviewed

Ensembl Protein

ENSMMUP00000021937

UniProt Accession

F6VT69;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1B

Gene Synonyms/Alias

BUB1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000016686	ENSMMUP00000021937	ENSMMUT00000023445

Organism

Macaca mulatta

Functional Description

Protein Length

1048

Protein Sequence
(FASTA)

MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR 60

AFESEIRFYT GHDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR 120

FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ 180

QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA 240

PIIRVGGALK APSQNRGLQN PFPQQMQSNS RITVFDENAD EASIAELSKP TVQPWIAPPV 300

PRAKENELQA GPWNTGRSLE YRPRGNTASL MAVPAVLPSF TPYVEETAQQ PVMTPCKIEP 360

SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF 420

RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL 480

RIASESQEMP GMTLSSSACQ VNSCAKETSL AENIWQEQPH SKGPSIPFSI FDEFLLSEKK 540

NKSPPADPPR VLTQRRPLAV LKTSESITSN EDVSPDVCDE FTEIEPLSED AIITGFRNVT 600

ICPNPEDTCD FARAARFVST PFHEIMSLKN LPSDPERLLQ EEDLDVKTSE DQQAACGTIY 660

SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSATAPAT 720

SYTTNWQIYQ CLCSLNQEVK ARGLYMFTVI FKWNQTLSTG NEDYCIKREY LICEDYKLFW 780

VAPRNSAELT IIKVSSQPVP WDFYINLKLK ERLNEAFDHL CSCYQYQDGC IVWHQYINCF 840

TLQDLLQHSE YITHEIAVLI IYNLLTIVEK LHKAEIVHGD LSPRSLILRN RIHDPYDCNE 900

NNQALKIVDF SYSVDLRVQL DVFTLSGFRT VQILEGQKIL ANCSSPYQVD LFGIADLAHL 960

LLFKEHLQVF WDGSFWKLSQ NISELKDGEL WNKFFVRILN ANDEATVSVL RELAAEMNGV 1020

FDTTFQSHLN KALWKVGKLT SPGALLFQ 1048

Nucleotide Sequence
(FASTA)

ATGGCGGCGG TGAAGAAGGA AGGGGGTGCT CTGAGTGAAG CCATGTCCCT GGAGGGAGAT 60

GAATGGGAAC TGAGTAAAGA AAATGTACAA CCTTTAAGGC AAGGGCGGAT CATGTCCACA 120

CTTCAGGGAG CATTGGCACA AGAATCTGCC TGTAACAATA CTCTTCAGCA GCAGAAACGG 180

GCATTTGAAT CTGAAATTCG ATTTTACACT GGACATGACC CTCTGGATGT TTGGGATAGG 240

TATATCAGCT GGACAGAGCA GAACTATCCT CAAGGTGGGA AGGAGAGTAA TATGTCAACG 300

TTATTAGAAA GAGCTGTAGA AGCACTACAA GGAGAAAAAC GATATTATAG TGATCCTCGA 360

TTTCTCAATC TCTGGCTTAA ATTAGGGCGT TTATGCAATG AGCCTTTGGA TATGTACAGT 420

TACTTGCACA ACCAAGGGAT TGGTGTTTCA CTTGCTCAGT TCTATATCTC ATGGGCAGAA 480

GAATATGAAG CTAGAGAAAA CTTTAGGAAA GCAGATGCGA TATTTCAGGA AGGGATTCAA 540

CAGAAGGCTG AACCACTAGA AAGACTACAG TCCCAGCACC GACAATTCCA AGCTCGAGTG 600

TCTCGACAAA CTCTGTTGGC ACTTGAGAAA GAAGAAGAGG AGGAAGTTTT TGAGTCTTCT 660

GTACCACAAC GAAGCACACT AGCTGAACTA AAGAGCAAAG GGAAAAAGAC AGCAAGAGCT 720

CCAATCATCC GTGTAGGAGG TGCTCTCAAG GCTCCAAGCC AGAACAGAGG ACTCCAAAAT 780

CCATTTCCTC AACAGATGCA AAGTAATAGT AGAATTACTG TTTTTGATGA AAATGCTGAT 840

GAGGCTTCTA TAGCAGAGTT GTCTAAGCCT ACAGTCCAGC CATGGATAGC ACCCCCGGTG 900

CCCAGGGCCA AAGAGAATGA GCTGCAAGCA GGCCCTTGGA ACACAGGCAG GTCCTTGGAA 960

TACAGGCCTC GTGGCAATAC AGCGTCACTG ATGGCTGTAC CCGCTGTGCT TCCCAGTTTT 1020

ACACCATATG TGGAAGAGAC TGCACAACAG CCAGTTATGA CACCATGTAA AATTGAACCT 1080

AGTATAAACC ACATCCTCAG CACCAGAAAG CCTGGAAAGG AAGAAGGAGA TCCTCTACAA 1140

AGGGTTCAGA GCCATCAGCA AGCATCTGAG GAGAAGAAAG AGAAAATGAT GTATTGTAAG 1200

GAGAAGATTT ATGCAGGAGT GGGGGAATTC TCCTTTGAAG AAATCCGGGC TGAAGTTTTC 1260

CGGAAGAAAT TAAAAGAGCA AAGGGAAGCC GAGCTATTGA CCAGTGCAGA GAAGAGAGCA 1320

GAAATGCAGA AACAGATTGA AGAGATGGAA AAGAAGCTAA AAGAAATCCA AACTACTCAG 1380

CAAGAAAGAA CAGGTGATCA GCAAGAAGAG ACGATGCCTA CCAAGGAGAC AACTAAACTG 1440

CGAATTGCTT CCGAGTCTCA GGAAATGCCA GGAATGACTC TATCCAGTTC TGCTTGTCAA 1500

GTAAACTCTT GTGCCAAAGA AACTTCACTT GCGGAGAACA TTTGGCAGGA ACAACCTCAT 1560

TCTAAAGGTC CCAGTATACC TTTCTCCATT TTTGATGAGT TTCTTCTTTC AGAAAAGAAG 1620

AATAAAAGTC CTCCTGCAGA TCCCCCACGA GTTTTAACTC AACGAAGACC CCTTGCAGTT 1680

CTCAAAACCT CAGAAAGCAT CACCTCAAAT GAAGATGTGT CTCCAGATGT TTGTGATGAA 1740

TTTACGGAAA TTGAACCCTT GAGTGAGGAT GCCATTATCA CAGGCTTCAG AAATGTAACA 1800

ATTTGTCCTA ACCCAGAAGA CACTTGTGAC TTTGCCAGAG CAGCTCGTTT TGTATCCACT 1860

CCTTTTCATG AGATAATGTC CTTGAAGAAT CTCCCTTCTG ATCCTGAGAG ACTGTTACAG 1920

GAAGAGGATC TAGATGTAAA GACCTCTGAG GACCAGCAGG CAGCTTGTGG CACTATCTAC 1980

AGTCAGACTC TCAGCATCAA GAAGCTGAGC CCAATTATTG AAGACAGTCG TGAAGCCACA 2040

CACTCCTCTG GCTTCTCTGG TTCTTCTGCC TCGGTTGCAA GCACCTCCTC CATCAAATGT 2100

CTTCAGATTC CTGAGAAACT AGAACTTACT AATGAGACTT CAGCCACCGC GCCCGCCACT 2160

TCATATACTA CTAACTGGCA AATATACCAG TGCCTCTGTT CCTTAAACCA GGAGGTAAAA 2220

GCTAGAGGGC TGTATATGTT CACAGTGATT TTTAAATGGA ATCAAACTTT ATCAACAGGT 2280

AATGAGGATT ACTGCATTAA ACGAGAATAC CTAATATGTG AAGATTACAA GTTATTCTGG 2340

GTGGCACCAA GAAACTCTGC AGAATTAACC ATAATAAAGG TATCTTCTCA ACCTGTCCCA 2400

TGGGACTTTT ATATCAACCT CAAGTTAAAG GAACGTTTAA ATGAGGCCTT TGATCATTTG 2460

TGCAGCTGTT ATCAATATCA AGATGGCTGT ATTGTTTGGC ACCAATATAT AAACTGCTTC 2520

ACCCTTCAGG ATCTTCTCCA ACACAGTGAA TATATTACCC ATGAAATAGC AGTGTTGATT 2580

ATTTATAACC TTTTGACAAT AGTGGAGAAG CTTCACAAAG CAGAAATAGT CCATGGTGAC 2640

TTGAGTCCAA GGAGTCTGAT TCTCAGAAAC AGAATCCACG ATCCCTATGA TTGTAACGAG 2700

AACAATCAAG CTTTGAAGAT AGTGGACTTT TCCTACAGTG TTGACCTTAG GGTACAGCTA 2760

GATGTTTTTA CCCTCAGCGG CTTTCGGACT GTACAGATCC TGGAAGGACA AAAGATCCTG 2820

GCTAACTGTT CTTCTCCCTA CCAGGTAGAC CTGTTTGGTA TAGCAGATTT AGCACATTTA 2880

CTTTTGTTCA AGGAACACCT ACAGGTCTTC TGGGATGGGT CCTTCTGGAA ACTTAGCCAA 2940

AATATTTCTG AGCTAAAAGA TGGTGAATTG TGGAATAAAT TCTTTGTGCG GATTCTGAAT 3000

GCCAATGATG AGGCCACAGT GTCTGTTCTG AGGGAGCTTG CAGCAGAAAT GAATGGGGTT 3060

TTTGACACTA CATTCCAAAG TCACCTGAAC AAAGCCTTAT GGAAGGTAGG GAAGTTAACT 3120

AGTCCTGGGG CTTTGCTCTT TCAGTGA 3147

Domain Profile

S: 4     ekeigeGayakvykaeh....dsk........sgelvalKvekpansWefYIclqlkeRl  51

         ++ +  G++++++k+e+    d+k        s+el+++Kv++++++W+fYI+l+lkeRl

Q: 754   NQTLSTGNEDYCIKREYliceDYKlfwvaprnSAELTIIKVSSQPVPWDFYINLKLKERL  813

         577899***********999988899999999****************************

S: 52    keeellksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivq  111

         +e      +++++s++++qd+++++++y++++tl+dl+++++++t     +e+ vl+i++

Q: 814   NEA-----FDHLCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYIT-----HEIAVLIIYN  863

         *87.....*************************************.....**********

S: 112   llkiveklHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgt  171

         ll+iveklH++eI+HgDl+P++++l+nri+d++d+++++++lk++Df++s+D+++++d++

Q: 864   LLTIVEKLHKAEIVHGDLSPRSLILRNRIHDPYDCNENNQALKIVDFSYSVDLRVQLDVF  923

         ************************************************************

S: 172   kfkgkaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkik  231

         +++g+++++++e++++la++s++YqvDlfg+a+++h+llf+++l+v+++g+ wkl+q+i+

Q: 924   TLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNIS  983

         ************************************************************

S: 232   rllkkelwekiferlLNisdastlpsleelve  263

         +l++ elw+k+f+r+LN++d++t+++l el++

Q: 984   ELKDGELWNKFFVRILNANDEATVSVLRELAA  1015

         *****************************986

Domain Sequence
(FASTA)

NQTLSTGNED YCIKREYLIC EDYKLFWVAP RNSAELTIIK VSSQPVPWDF YINLKLKERL 60

NEAFDHLCSC YQYQDGCIVW HQYINCFTLQ DLLQHSEYIT HEIAVLIIYN LLTIVEKLHK 120

AEIVHGDLSP RSLILRNRIH DPYDCNENNQ ALKIVDFSYS VDLRVQLDVF TLSGFRTVQI 180

LEGQKILANC SSPYQVDLFG IADLAHLLLF KEHLQVFWDG SFWKLSQNIS ELKDGELWNK 240

FFVRILNAND EATVSVLREL AA 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0000940	; C:condensed chromosome outer kinetochore
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0007091	; P:mitotic metaphase/anaphase transition
GO:0034501	; P:protein localization to kinetochore

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013