EKS-MAM-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	370.8	8.4E-111	361	620	260

Status

Unreviewed

Ensembl Protein

ENSMMUP00000022020

UniProt Accession

F7AIB6;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 3 isoform 1;

Gene Name

MAP3K3

Gene Synonyms/Alias

MAP3K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000016751	ENSMMUP00000022022	ENSMMUT00000023539
ENSMMUG00000016751	ENSMMUP00000022020	ENSMMUT00000023537

Organism

Macaca mulatta

Functional Description

Protein Length

625

Protein Sequence
(FASTA)

DEQEALNSIM NDLVALQMNR RHRMPGYETM KNKDTGHSNR QSDVRIKFEH NGERRIIAFS 60

RPVKYEDVEH KVTTVFGQPL DLHYMNNELS ILLKNQDDLD KAIDILDRSS SMKSLRILLL 120

SQDRNHNSSS PHSGVSRQVR IKASQSAGDI NTIYQPPEPR SRHLSVSSQN PGRSSPPPGY 180

VPERQQHIAR QGSYTSINSE GEFIPETSEQ CMLDPLSSAE NSLSGSCQSL DRSADSPSFR 240

KSRMSRAQSF PDNRQEYSDR ETQLYDKGVK GGTYPRRYHV SVHHKDYSDG RRTFPRIRRH 300

QGNLFTLVPS SRSLSTNGEN MGLAVQYLDP RGRLRSADSE NALSVQERNV PTKSPSAPIN 360

WRRGKLLGQG AFGRVYLCYD VDTGRELASK QVQFDPDSPE TSKEVSALEC EIQLLKNLQH 420

ERIVQYYGCL RDRAEKTLTI FMEYMPGGSV KDQLKAYGAL TESVTRKYTR QILEGMSYLH 480

SNMIVHRDIK GANILRDSAG NVKLGDFGAS KRLQTICMSG TGMRSVTGTP YWMSPEVISG 540

EGYGRKADVW SLGCTVVEML TEKPPWAEYE AMAAIFKIAT QPTNPQLPSH ISEHGRDFLR 600

RIFVEARQRP SAEELLTHHF AQLMY 625

Nucleotide Sequence
(FASTA)

GACGAACAGG AGGCATTGAA CTCAATCATG AACGATCTGG TGGCCCTCCA GATGAACCGA 60

CGTCACCGGA TGCCTGGATA TGAGACCATG AAGAACAAAG ACACAGGTCA CTCAAATAGG 120

CAGAGTGACG TCAGAATCAA GTTTGAGCAC AATGGGGAGA GGCGAATTAT AGCATTCAGC 180

CGGCCTGTGA AATATGAAGA TGTGGAGCAC AAGGTGACAA CAGTATTTGG ACAACCTCTT 240

GATCTACATT ACATGAACAA TGAGCTCTCC ATCCTGCTGA AAAACCAAGA TGATCTTGAT 300

AAAGCAATTG ACATTTTGGA TAGAAGCTCA AGCATGAAAA GCCTTAGGAT ATTGCTGTTG 360

TCCCAGGACA GAAACCATAA CAGTTCCTCT CCCCACTCTG GGGTGTCCAG ACAGGTGCGG 420

ATCAAGGCTT CCCAGTCTGC AGGGGATATA AATACTATCT ACCAGCCCCC CGAGCCCAGA 480

AGCAGGCACC TCTCCGTCAG CTCCCAGAAC CCTGGCCGAA GCTCACCTCC CCCTGGCTAT 540

GTTCCTGAGC GGCAGCAGCA CATTGCCCGG CAGGGGTCCT ACACCAGCAT CAACAGTGAG 600

GGGGAGTTCA TCCCAGAGAC CAGCGAGCAG TGCATGCTGG ATCCCCTGAG CAGTGCAGAA 660

AATTCCTTGT CTGGAAGCTG CCAATCCTTG GACAGGTCAG CAGACAGCCC GTCCTTCCGG 720

AAATCACGAA TGTCCCGTGC CCAGAGCTTC CCTGACAATA GACAGGAATA CTCAGATCGG 780

GAAACTCAGC TCTATGACAA AGGGGTCAAA GGTGGAACCT ACCCCCGCCG CTACCATGTG 840

TCTGTGCACC ACAAGGACTA CAGTGATGGC AGAAGAACAT TTCCCCGAAT ACGGCGTCAT 900

CAAGGCAACT TGTTCACCCT GGTGCCCTCC AGCCGCTCCC TGAGCACAAA TGGCGAGAAC 960

ATGGGTCTGG CTGTGCAATA CCTGGACCCC CGTGGGCGCC TGCGGAGTGC AGACAGCGAG 1020

AATGCCCTCT CTGTGCAGGA GAGGAATGTG CCAACCAAGT CTCCCAGTGC CCCCATCAAT 1080

TGGCGCCGGG GAAAGCTCCT GGGCCAGGGT GCCTTCGGCA GGGTCTATTT GTGCTATGAC 1140

GTGGACACGG GACGTGAACT TGCTTCCAAG CAGGTCCAGT TTGACCCAGA CAGTCCTGAG 1200

ACAAGCAAGG AGGTGAGTGC TCTGGAGTGC GAGATCCAGT TGCTAAAGAA CTTGCAGCAT 1260

GAGCGCATCG TGCAGTACTA TGGCTGTCTG CGGGACCGTG CTGAGAAGAC CCTGACCATC 1320

TTCATGGAGT ACATGCCAGG GGGCTCGGTG AAAGACCAGT TGAAGGCTTA TGGTGCTCTG 1380

ACAGAGAGCG TGACCCGAAA GTACACGCGG CAGATCCTGG AGGGCATGTC CTACCTGCAC 1440

AGCAACATGA TCGTTCACCG GGACATTAAG GGAGCCAACA TCCTCCGAGA CTCTGCTGGG 1500

AATGTAAAGC TGGGGGACTT TGGGGCCAGC AAACGCCTGC AGACGATCTG TATGTCGGGG 1560

ACGGGCATGC GCTCCGTCAC TGGCACACCC TACTGGATGA GCCCTGAGGT GATCAGCGGC 1620

GAGGGCTATG GAAGGAAAGC AGACGTGTGG AGCCTGGGCT GCACTGTGGT GGAGATGCTG 1680

ACAGAGAAAC CACCATGGGC AGAGTATGAA GCTATGGCCG CCATCTTCAA GATTGCCACC 1740

CAGCCCACCA ATCCTCAGCT GCCCTCCCAC ATCTCTGAAC ATGGCCGGGA CTTCCTGAGG 1800

CGCATTTTTG TGGAGGCTCG CCAGAGACCT TCAGCTGAGG AGCTGCTCAC ACACCACTTT 1860

GCACAGCTCA TGTACTGA 1878

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w++++++g+G+fg+vy+++dvdtg+ la K+v+++p++ +++kev+al++Ei+llk+l+H

Q: 361   WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQH  420

         899*********************************************************

S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118

         e+iv+yyG+  ++ e++l+if+Ey++gGs++++l++yg+l+esv++kyt+qileg++yLH

Q: 421   ERIVQYYGClrDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLH  480

         *********77778999*******************************************

S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         +++ivHRDiKgaNil ds+g+vkl+DFGaskrl++++++ + ++s+tGt+++m+PEvi++

Q: 481   SNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISG  540

         **********************************************************99

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +  gygrkaD+Wslgc+v+emlt+k+P+ae+ e++a++fk++++ t+P++p+++se+g+d

Q: 541   E--GYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD  597

         8..****************************.9***************************

S: 239   flekcleldpkkrpsaeeLLkhef  262

         fl++++ +++++rpsaeeLL+h+f

Q: 598   FLRRIF-VEARQRPSAEELLTHHF  620

         ******.8999***********99

Domain Sequence
(FASTA)

WRRGKLLGQG AFGRVYLCYD VDTGRELASK QVQFDPDSPE TSKEVSALEC EIQLLKNLQH 60

ERIVQYYGCL RDRAEKTLTI FMEYMPGGSV KDQLKAYGAL TESVTRKYTR QILEGMSYLH 120

SNMIVHRDIK GANILRDSAG NVKLGDFGAS KRLQTICMSG TGMRSVTGTP YWMSPEVISG 180

EGYGRKADVW SLGCTVVEML TEKPPWAEYE AMAAIFKIAT QPTNPQLPSH ISEHGRDFLR 240

RIFVEARQRP SAEELLTHHF 260

Keyword

Complete proteome; Kinase; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>