EKS-MAM-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	247.2	3.3E-73	41	309	269

Status

Unreviewed

Ensembl Protein

ENSMMUP00000022257

UniProt Accession

F7CHX7;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000016919	ENSMMUP00000022257	ENSMMUT00000023780
ENSMMUG00000016919	ENSMMUP00000022260	ENSMMUT00000023783
ENSMMUG00000016919	ENSMMUP00000022261	ENSMMUT00000023784
ENSMMUG00000016919	ENSMMUP00000024500	ENSMMUT00000026178
ENSMMUG00000016919	ENSMMUP00000022247	ENSMMUT00000023770

Organism

Macaca mulatta

Functional Description

Protein Length

1307

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV 60

GSGREYALKR LLSNEEEKNR AIIQEVCFMK HALSGRVSSL QLSSADTVGI RSSRCGEAVL 120

CLSVSLCCAA AAALGERCLQ RALAVSHTRA LSLKSCICLR QVHGLSSGIL QVENLLLSNQ 180

GTIKLCDFGS ATTISHYPDY SWSAQRRALV EEEITRNTTP MYRTPEIIDL YSNFPIGEKQ 240

DIWALGCILY LLCFRQHPFE DGAKLRIVNG KYSIPPHDTQ YTVFHSLIRA MLQVNPEERL 300

SIAEVVHQLQ EIAAARNVNP KSPITELLEQ NGGYGSTVLS RGPPPLVGPA GSGYSGGLAL 360

AEYDQPYGGF LDILRGGTER LFTNLKDTSS KVIQSVANYA KGDLDISYIT SRIAVMSFPA 420

EGVESALKNN IEDVRLFLDS KHPGHYAVYN LSPRTYRPSR FHNRVSECGW AARRAPHLHT 480

LYNICRNMHA WLRQDHKNVC VVHCMDGRAA SAVAVCSFLC FCRLFSTAEA AVYMFSMKRC 540

PPGIWPSHKR YIEYMCDMVA EEPITPHSKP ILVRAVVMTP VPLFSKQRSG CRPFCEVYVG 600

DERVASTSQE YDKMRDFKIE DGKAVIPLGV TVQGDVLIVI YHARSTLGGR LQAKMASMKM 660

FQIQFHTGFV PRNATTVKFA KYDLDACDIQ EKYPDLFQVN LEVEVEPRDR LSREAPPWEN 720

SSMRGLNPKI LFSSREEQQD ILSKFGKPEL PRQPGSTAQY DAGAGSPEAE PTDSDSPPSS 780

SADTSRFLHT LDWQEEKEAE TGAANASPKE SESALMEDRD ESEVSDEGGS PVSSEGQEPR 840

ADPEPPGLTA GLVQQDVAFE VGTPAVLPEP VPQEDGVDLL GLHSEVGAGP AVAPQALQAP 900

SSNTDLLSCL LGPPEATSQG PPEDLLGEAP LLLASPAPPL SMQSTPGGGP PAAADPFGPL 960

LLSSDSDSQP CSNPDLFGEF LNSDSAAVPP SFPSAHSAPP PSSSADFLHL GDLPGEPSKM 1020

TASSSNPDLL GGWAAWTETA ASAVAPTPAT EGPLFSPGGQ LAPCGPQASW TKSQNPDPFA 1080

DLGDLSSGLQ GSPAGFPPGG FIPKTATTAK GSGSWQTSRP PAQGASWPPQ AKPPLKACTQ 1140

PRPNYAANFS VIGAREERGV RAPSFAQKPK VSENDFEDLL SNQGFSSRSD KKGPKTIAEM 1200

RKQDLAKDTD PLKLKLLDWI EGKERNIRAL LSTLHTVLWD GESRWTPVGM ADLVAPEQVK 1260

KHYRRAVLAV HPDKAAGQPY EQHAKMIFME LNDAWSEFEN QGSRPLF 1307

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TGCAGTCGGC GCTCGACTTC TTGGCGGGTC CAGGCTCCCT GGGCGGTGCT 60

TCCGGCCGCG ACCAGAGTGA TTTCGTGGGG CAGACGGTGG AACTGGGCGA GCTGCGGCTG 120

CGGGTGCGGC GGGTCCTGGC CGAAGGAGGG TTTGCATTTG TGTATGAAGC TCAAGATGTG 180

GGGAGTGGCA GAGAGTATGC ATTAAAGAGG CTATTATCCA ATGAAGAGGA AAAGAACAGA 240

GCCATCATTC AAGAAGTTTG CTTCATGAAG CATGCCCTGT CGGGCAGGGT CTCCTCTCTG 300

CAGCTTTCCT CAGCTGACAC TGTGGGGATA AGATCCTCGC GATGTGGTGA GGCTGTGCTG 360

TGTCTGTCTG TCAGTCTCTG TTGTGCTGCA GCCGCGGCCC TGGGCGAGCG CTGTCTGCAA 420

AGGGCCCTGG CTGTGTCTCA TACCCGTGCG CTTTCCCTGA AGTCCTGTAT CTGTCTACGC 480

CAAGTTCATG GGCTGTCTTC TGGAATTTTA CAGGTTGAGA ACCTGTTGCT TAGTAATCAA 540

GGGACCATTA AGCTGTGTGA CTTTGGCAGT GCCACGACCA TCTCGCACTA CCCGGACTAC 600

AGCTGGAGCG CCCAGAGGCG AGCCCTGGTG GAGGAAGAGA TCACGAGGAA TACGACACCA 660

ATGTATAGAA CGCCAGAAAT CATAGACTTG TATTCCAACT TCCCGATCGG CGAGAAGCAG 720

GATATCTGGG CCCTGGGCTG CATCTTGTAC CTGCTGTGCT TCCGGCAGCA CCCTTTTGAG 780

GATGGAGCGA AACTTCGAAT AGTCAATGGG AAGTACTCGA TTCCCCCGCA CGACACGCAG 840

TACACGGTCT TCCACAGCCT CATCCGCGCC ATGCTGCAGG TGAACCCGGA GGAGCGGCTG 900

TCCATCGCTG AGGTAGTGCA CCAGCTGCAG GAGATTGCGG CCGCGCGCAA CGTGAACCCC 960

AAGTCTCCCA TCACAGAGCT TCTGGAGCAG AATGGAGGCT ATGGGAGCAC CGTGCTGTCC 1020

CGAGGGCCAC CCCCTCTTGT GGGCCCCGCT GGCAGTGGCT ACAGTGGAGG CCTGGCCCTG 1080

GCGGAGTACG ACCAGCCCTA CGGCGGCTTC CTGGACATTC TGCGGGGTGG GACGGAGCGG 1140

CTCTTCACCA ACCTCAAGGA CACCTCCTCC AAGGTCATAC AGTCCGTCGC TAATTACGCA 1200

AAGGGTGACC TGGACATATC TTACATCACG TCCAGAATTG CAGTAATGTC GTTCCCGGCA 1260

GAAGGTGTGG AGTCAGCGCT CAAAAACAAC ATCGAAGACG TGCGGTTGTT CCTGGACTCC 1320

AAGCACCCGG GGCACTATGC CGTCTACAAC CTGTCCCCCA GGACCTACCG GCCTTCCAGG 1380

TTCCACAACC GGGTCTCCGA GTGTGGCTGG GCAGCGCGGC GGGCCCCGCA CCTGCACACC 1440

CTGTACAACA TCTGCAGGAA CATGCATGCC TGGCTGCGGC AGGACCACAA GAACGTCTGT 1500

GTCGTGCACT GCATGGACGG GAGAGCCGCG TCTGCTGTGG CTGTCTGCTC CTTCCTGTGC 1560

TTCTGCCGTC TCTTCAGCAC CGCAGAGGCC GCCGTGTACA TGTTCAGCAT GAAGCGCTGC 1620

CCGCCAGGCA TCTGGCCGTC CCACAAAAGG TACATCGAAT ACATGTGCGA CATGGTGGCG 1680

GAGGAGCCCA TCACACCCCA CAGCAAGCCC ATCCTGGTGA GGGCTGTGGT CATGACGCCC 1740

GTTCCGCTGT TCAGCAAGCA GAGGAGCGGC TGCAGGCCCT TCTGCGAGGT CTACGTGGGG 1800

GATGAGCGCG TGGCCAGCAC CTCCCAGGAG TACGATAAGA TGCGGGATTT TAAGATTGAG 1860

GATGGTAAAG CCGTCATTCC CCTGGGCGTC ACGGTGCAAG GAGATGTGCT CATCGTCATC 1920

TATCACGCCC GGTCCACCCT GGGCGGCCGG CTGCAGGCCA AGATGGCATC CATGAAGATG 1980

TTCCAGATTC AGTTCCACAC GGGGTTTGTG CCTCGGAACG CCACCACTGT GAAATTTGCC 2040

AAGTATGACC TGGACGCCTG TGACATTCAA GAGAAATACC CGGACTTATT TCAAGTGAAC 2100

CTAGAAGTGG AGGTGGAGCC CAGGGACAGG CTGAGCCGGG AAGCCCCACC GTGGGAGAAC 2160

TCGAGCATGA GGGGGCTGAA CCCCAAAATC CTGTTTTCCA GCCGGGAGGA GCAGCAAGAC 2220

ATTCTGTCTA AGTTTGGGAA GCCGGAGCTC CCCCGGCAGC CCGGCTCCAC GGCTCAGTAT 2280

GATGCTGGGG CAGGTTCCCC GGAAGCCGAG CCCACGGACT CCGACTCACC ACCAAGTAGC 2340

AGCGCGGACA CCAGCCGCTT CCTGCACACA CTGGACTGGC AGGAAGAGAA GGAGGCAGAG 2400

ACTGGTGCAG CAAATGCCTC TCCCAAGGAG AGCGAGTCTG CCCTGATGGA GGACAGAGAC 2460

GAGAGCGAGG TGTCGGACGA AGGGGGTTCC CCGGTCTCCA GCGAGGGCCA GGAGCCCCGG 2520

GCCGATCCGG AGCCCCCCGG CCTGACAGCA GGGCTGGTGC AGCAGGACGT GGCTTTTGAG 2580

GTGGGGACGC CAGCTGTGCT CCCGGAGCCT GTGCCACAGG AAGACGGGGT TGACCTCCTG 2640

GGCCTGCACT CCGAGGTGGG CGCAGGGCCA GCTGTAGCCC CGCAGGCCCT CCAGGCCCCC 2700

TCCAGCAACA CCGACCTGCT CAGCTGCCTC CTTGGGCCCC CGGAGGCCAC CTCCCAGGGG 2760

CCCCCGGAGG ATCTGCTCGG CGAGGCCCCC CTGCTCCTGG CAAGCCCGGC CCCTCCCCTG 2820

AGCATGCAGA GCACCCCAGG AGGAGGGCCC CCTGCTGCTG CTGACCCCTT TGGCCCGCTC 2880

CTGCTGTCTT CAGACAGCGA CTCCCAGCCC TGCTCCAATC CTGATCTCTT CGGCGAATTT 2940

CTCAATTCGG ACTCTGCGGC CGTCCCACCA TCCTTCCCGT CTGCCCACAG TGCTCCGCCC 3000

CCGTCCTCCA GCGCTGACTT CCTGCACCTG GGGGATCTGC CAGGAGAGCC CAGCAAGATG 3060

ACGGCCTCGT CCAGCAACCC AGACCTGCTG GGAGGATGGG CTGCCTGGAC CGAGACGGCA 3120

GCGTCGGCAG TGGCCCCCAC GCCAGCCACG GAAGGCCCCC TCTTCTCTCC TGGAGGTCAG 3180

CTGGCCCCTT GTGGCCCTCA GGCCAGCTGG ACCAAGTCTC AGAACCCGGA CCCATTTGCT 3240

GACCTTGGCG ACCTCAGCTC CGGCCTCCAA GGCTCACCAG CTGGATTCCC TCCTGGTGGC 3300

TTCATTCCCA AAACGGCCAC CACAGCCAAA GGCAGTGGCT CCTGGCAGAC AAGTCGGCCG 3360

CCAGCCCAGG GCGCCTCATG GCCCCCTCAG GCCAAGCCGC CCCTCAAAGC CTGCACACAG 3420

CCAAGGCCTA ACTATGCTGC GAACTTCAGT GTGATCGGGG CACGAGAGGA GCGGGGGGTC 3480

CGCGCACCCA GCTTTGCTCA AAAGCCAAAA GTGTCTGAGA ACGACTTTGA AGATCTGTTG 3540

TCCAATCAAG GCTTCTCCTC CAGGTCTGAC AAGAAGGGGC CAAAGACCAT TGCGGAGATG 3600

AGGAAGCAGG ACCTGGCTAA AGACACAGAC CCGCTCAAGC TGAAGCTCCT GGACTGGATT 3660

GAGGGCAAGG AGCGGAACAT CCGGGCCCTG CTGTCCACAC TGCACACAGT GCTGTGGGAC 3720

GGGGAGAGCC GCTGGACGCC CGTGGGCATG GCCGACCTGG TGGCCCCGGA GCAGGTGAAG 3780

AAGCACTACC GCCGCGCGGT GCTGGCCGTG CACCCCGACA AGGCCGCGGG GCAGCCGTAT 3840

GAGCAGCACG CCAAGATGAT CTTCATGGAG CTGAATGACG CCTGGTCAGA GTTTGAGAAC 3900

CAGGGCTCCC GGCCCCTCTT CTGA 3924

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkk.lsghkniv  60

         r+++vlaeGGfa+vy a+d+ +g++yalKr+l+neee++++i++E+++mk+ lsg    +

Q: 41    RVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKHaLSGRVSSL  100

         89***********************************************97477777777

S: 61    klvdssvkeekdng..skevlllleyckkgslvdllnkrlekgelseaeilkilldvtra  118

         +l ++ +   ++++  ++ ++l + +c +   +  l +r  ++ l  ++   + l+ +

Q: 101   QLSSADTVGIRSSRcgEAVLCLSVSLCCA--AAAALGERCLQRALAVSHTRALSLKSCIC  158

         77755544444444115666666677765..7888888888888999999999999999*

S: 119   vaalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeei  175

         + ++H ls ++    l+veN+lls++g+++lcD+GSatt+++ ++   s+q+++ ++eei

Q: 159   LRQVHGLSSGI----LQVENLLLSNQGTIKLCDFGSATTISHYPDyswSAQRRALVEEEI  214

         *****999998....89***************************999999**********

S: 176   eknttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysi  235

         ++ntt++yr+PE+idlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngkysi

Q: 215   TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSI  274

         ************************************************************

S: 236   PensryseklkslikkmlevdpeeRptiaqvlell  270

         P+++++++ ++sli++ml+v+peeR++ia+v+++l

Q: 275   PPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL  309

         *******************************9986

Domain Sequence
(FASTA)

RVRRVLAEGG FAFVYEAQDV GSGREYALKR LLSNEEEKNR AIIQEVCFMK HALSGRVSSL 60

QLSSADTVGI RSSRCGEAVL CLSVSLCCAA AAALGERCLQ RALAVSHTRA LSLKSCICLR 120

QVHGLSSGIL QVENLLLSNQ GTIKLCDFGS ATTISHYPDY SWSAQRRALV EEEITRNTTP 180

MYRTPEIIDL YSNFPIGEKQ DIWALGCILY LLCFRQHPFE DGAKLRIVNG KYSIPPHDTQ 240

YTVFHSLIRA MLQVNPEERL SIAEVVHQL 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013