EKS-MAM-00468

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00468

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	334.3	9.9E-100	22	312	291

Status

Unreviewed

Ensembl Protein

ENSMMUP00000022744

UniProt Accession

F7HUF9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000017290	ENSMMUP00000022744	ENSMMUT00000024301

Organism

Macaca mulatta

Functional Description

Protein Length

556

Protein Sequence
(FASTA)

MAEKGDCIAS VYGYDLGGRF VDFQPLGFGV NGLVLSAMDS RACRKVAVKK IALSDARSMK 60

HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELLKFSV AYIVQEYMET DLARLLEQGT 120

LAEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL 240

ILETIPVIRE EDKDELLRVM PSFVSSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDIVLM AANQSQLSNW DTCSSRYPVS 360

LSSDLEWRPD RCQDASEVQR DPRAGSAPLA EDVQVDPRKE SHSSSERFLE QSHSSMERAF 420

EADYGRSCDY KVGSPSYLDK LLWRDNKPHH YSEPKLILDL SHWKQAAGAP PTATGSTDTG 480

AREDEPASLF LEIAQWVKST QGGSTPARPP TTPSTACLPR PPPGPGGRWR QPPVRPGRVH 540

LPRPEALHQA GGPTGQ 556

Nucleotide Sequence
(FASTA)

ATGGCTGAGA AGGGTGACTG CATCGCCAGT GTCTACGGGT ATGACCTCGG TGGGCGCTTT 60

GTTGACTTCC AACCCCTGGG CTTCGGTGTC AATGGTTTGG TGCTGTCGGC CATGGACAGC 120

CGGGCCTGCC GGAAAGTCGC CGTGAAGAAG ATTGCCCTGA GTGATGCCCG CAGCATGAAG 180

CATGCACTCC GAGAGATCAA GATCATTCGG CGTCTGGACC ACGACAACAT CGTCAAAGTG 240

TACGAGGTGC TCGGGCCCAA GGGCACTGAC CTGCAGGGTG AGCTGCTCAA GTTCAGCGTG 300

GCCTACATCG TCCAGGAGTA CATGGAGACT GACCTGGCAC GCCTGCTGGA GCAGGGCACA 360

CTGGCGGAAG AGCATGCCAA GCTGTTCATG TACCAGCTGC TGCGCGGGCT CAAGTACATC 420

CACTCCGCCA ACGTGCTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAG 480

GACCTCGTGC TCAAGATTGG GGATTTCGGG TTGGCAAGGA TTGTTGATCA GCATTACTCC 540

CACAAGGGTT ATCTGTCAGA GGGGTTGGTA ACAAAATGGT ACCGCTCCCC ACGACTGCTC 600

CTCTCCCCCA ATAACTACAC CAAAGCCATC GACATGTGGG CCGCCGGCTG CATCCTGGCT 660

GAGATGCTTA CGGGGAGAAT GCTCTTTGCT GGGGCCCATG AGCTGGAGCA GATGCAGCTC 720

ATCCTGGAGA CCATCCCTGT AATCCGGGAG GAAGACAAGG ACGAGCTGCT CAGGGTGATG 780

CCTTCCTTCG TCAGCAGCAC CTGGGAGGTG AAGAGGCCTC TGCGCAAACT GCTCCCTGAA 840

GTGAACAGCG AAGCCATCGA CTTTCTGGAG AAGATCCTGA CCTTTAACCC CATGGATCGC 900

CTAACAGCTG AGATGGGGCT GCAGCACCCC TACATGAGCC CATACTCGTG CCCTGAGGAT 960

GAGCCCACCT CGCAACACCC CTTCCGCATT GAGGATGAGA TCGATGACAT CGTGCTGATG 1020

GCCGCTAACC AGAGCCAGCT GTCCAACTGG GACACGTGCA GTTCCAGGTA CCCTGTGAGC 1080

CTGTCGTCGG ACCTGGAGTG GCGGCCAGAC CGGTGCCAGG ACGCCAGCGA GGTGCAGCGC 1140

GACCCGCGCG CGGGTTCGGC GCCGCTGGCA GAGGACGTGC AGGTGGACCC GCGCAAGGAA 1200

TCGCACAGCA GCTCCGAGCG CTTCCTAGAG CAGTCACACT CGTCCATGGA GCGCGCCTTC 1260

GAGGCAGACT ACGGGCGCTC CTGCGACTAC AAGGTGGGGT CGCCGTCCTA CCTGGACAAG 1320

CTGCTGTGGC GCGACAACAA GCCGCACCAC TACTCGGAGC CCAAGCTCAT CCTGGACCTA 1380

TCGCACTGGA AACAGGCGGC CGGCGCGCCC CCCACGGCCA CGGGGTCGAC GGACACCGGG 1440

GCGCGCGAGG ACGAGCCGGC CAGCCTCTTC CTGGAGATCG CGCAGTGGGT CAAGAGCACA 1500

CAGGGCGGCA GCACGCCAGC CCGCCCGCCG ACGACCCCGA GCACCGCCTG TCTGCCTCGC 1560

CCCCCGCCCG GCCCCGGTGG ACGGTGGCGC CAGCCCCCAG TTCGACCTGG ACGTGTTCAT 1620

CTCCCGCGCC CTGAAGCTCT GCACCAAGCC GGAGGACCTA CCGGACAATA A 1671

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+sa+d+r+ ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFQPLGFGVNGLVLSAMDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      el +++  Y+v+e+metdL++++++ +l +eh+kl++yq+lrglky

Q: 80    VYEVLGPKGtdlqgELLKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKY  139

         *******9888888899*******************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPSFVSSTWEVKR-PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .9*******99988.9**************************************7

Domain Sequence
(FASTA)

DFQPLGFGVN GLVLSAMDSR ACRKVAVKKI ALSDARSMKH ALREIKIIRR LDHDNIVKVY 60

EVLGPKGTDL QGELLKFSVA YIVQEYMETD LARLLEQGTL AEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI LETIPVIREE DKDELLRVMP 240

SFVSSTWEVK RPLRKLLPEV NSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013