EKS-MAM-00387

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00387

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	363.6	1.2E-108	127	379	253

Status

Unreviewed

Ensembl Protein

ENSMMUP00000022826

UniProt Accession

F7HBG6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000017339	ENSMMUP00000022826	ENSMMUT00000024388

Organism

Macaca mulatta

Functional Description

Protein Length

784

Protein Sequence
(FASTA)

MACLTHRNET NARMEFYSLF HKGNKAGVQW HDLGSLQPLP PGFKRFSCLS FQSSWDLSKF 60

DERCCFLYVH DNSDDFQIYF STEEQCSRFF SLVKEMITNT AGSTVELEGE TDGDTLEYEY 120

DHDANGERVV LGKGTYGIVY AGRDLSNQVR IAIKEIPERD SRQPLHEEIA LHKYLKHRNI 180

VQYLGSVSEN GYIKIFMEQV PGGDLSALLR SKWGPMKEPT IKFYTKQILE GLKYLHENQI 240

VHRDIKGDNV LVNTYSGVVK ISDFGTSKRL AGVNPCTETF TGTLQYMAPE IIDQGPRGYG 300

APADIWSLGC TIIEMATSKP PFHELGEPQA AMFKVGMFKI HPEIPEALSA EARAFILSCF 360

EPDPHKRATA AELLRERFLR QVNKAKKNRI AFKPSEGPRG VVLALPTQGE PMATSSSEHS 420

SVSPDSDAQP DALFERTRAP RHHLGHLLSV PDESSALEDR GLASSPEDRD PGLFLLRKDS 480

ERRAILYKIL WEEQNQVVSN LQECVAQSSE ELHLSVGHIK QIIGILRDFI RSPEHRVMAT 540

TISKLKVDLD FDSSSISQIH LVLFGFQDAV NKILRNHLIR PHWMFAMDNI IRRAVQAAVT 600

ILIPELQAHF EPTCETEGVD KDMDEAEEGY PPAARPGQEA QPHQQHLSLQ LGELRQETNR 660

LLEHLVEKER EYQNLLRQTL EQKTQELYHL QLKLKSNCIT ENPAGPYGQR TDKELIDWLR 720

LQGADAKTIE KIVEEGYTLS DILNEITKED LRYLRLRGGL LCRLWSAVSQ YRRAQEASET 780

KDEA 784

Nucleotide Sequence
(FASTA)

ATGGCATGTC TCACCCACAG AAATGAAACA AATGCACGAA TGGAATTTTA CAGCCTCTTC 60

CATAAAGGGA ATAAGGCTGG AGTACAGTGG CATGATCTCG GCTCACTGCA ACCTCTGCCT 120

CCCGGGTTCA AGCGATTCTC CTGCCTCAGC TTCCAGAGTA GCTGGGACCT ATCAAAGTTT 180

GATGAACGGT GTTGTTTTCT TTATGTCCAT GATAATTCTG ATGACTTTCA AATCTACTTT 240

TCCACCGAAG AGCAGTGCAG TAGATTTTTC TCTTTGGTCA AAGAGATGAT AACCAATACA 300

GCAGGCAGTA CAGTGGAGCT GGAGGGAGAG ACTGATGGAG ACACCTTGGA GTATGAGTAT 360

GACCATGATG CAAATGGTGA GAGAGTTGTC TTGGGGAAAG GCACGTATGG GATTGTGTAT 420

GCTGGCCGAG ATCTGAGCAA TCAAGTGCGA ATAGCCATCA AAGAAATTCC GGAGAGAGAT 480

AGCAGGCAAC CACTGCATGA GGAGATAGCC CTGCACAAGT ACCTGAAGCA CCGCAATATC 540

GTTCAGTACC TGGGCTCTGT TTCAGAGAAT GGCTACATTA AGATATTTAT GGAGCAGGTG 600

CCTGGAGGTG ACCTTTCGGC TCTTCTGCGA TCCAAATGGG GGCCGATGAA GGAACCGACG 660

ATCAAGTTTT ACACCAAACA GATCCTGGAG GGCCTTAAGT ATCTCCATGA AAACCAGATC 720

GTGCACAGAG ACATAAAGGG CGATAATGTT CTGGTGAACA CCTACAGTGG AGTGGTGAAA 780

ATCTCCGATT TTGGGACCTC AAAACGTCTT GCGGGTGTGA ACCCCTGCAC AGAGACTTTT 840

ACTGGCACCC TGCAGTACAT GGCACCTGAG ATAATTGACC AAGGGCCTCG TGGGTATGGT 900

GCCCCAGCCG ATATCTGGTC CCTGGGCTGC ACCATCATCG AGATGGCCAC CAGCAAGCCT 960

CCGTTCCATG AGCTCGGTGA GCCGCAGGCA GCGATGTTCA AAGTGGGCAT GTTTAAGATC 1020

CACCCTGAGA TTCCAGAAGC TCTTTCAGCT GAAGCCCGAG CCTTCATTTT ATCCTGTTTC 1080

GAGCCTGACC CCCACAAACG CGCCACCGCC GCTGAGCTAC TGAGAGAGCG TTTCTTAAGG 1140

CAGGTGAACA AGGCCAAGAA GAACCGAATT GCCTTCAAGC CCTCAGAAGG TCCCCGGGGT 1200

GTCGTCCTGG CCCTGCCCAC ACAGGGGGAG CCCATGGCCA CCAGCAGCAG TGAGCACAGC 1260

TCCGTCTCCC CGGACTCCGA CGCCCAGCCT GACGCACTCT TTGAGAGGAC CCGGGCGCCC 1320

AGGCATCACC TTGGCCACCT TCTCAGTGTT CCAGACGAAA GCTCAGCCTT GGAAGACCGC 1380

GGCTTGGCCT CATCCCCGGA GGACAGGGAC CCAGGCCTCT TCCTGCTGCG CAAGGACAGT 1440

GAGCGCCGCG CCATCCTGTA CAAAATCCTC TGGGAGGAGC AGAACCAGGT GGTTTCCAAC 1500

CTGCAGGAGT GCGTGGCCCA GAGTTCCGAA GAGTTGCATC TCTCAGTTGG CCACATCAAG 1560

CAAATCATTG GGATCCTGAG GGACTTCATC CGCTCCCCAG AGCACCGGGT GATGGCGACC 1620

ACAATCTCAA AGCTCAAGGT GGACCTGGAC TTTGACAGCT CGTCCATCAG TCAGATTCAC 1680

CTGGTGCTGT TCGGATTTCA GGATGCTGTA AATAAAATTT TGAGGAACCA CTTAATTAGG 1740

CCCCACTGGA TGTTTGCAAT GGACAACATC ATCCGCCGAG CGGTGCAGGC CGCGGTCACC 1800

ATTCTCATCC CAGAGCTCCA AGCCCACTTT GAGCCTACCT GTGAGACTGA AGGGGTAGAT 1860

AAGGACATGG ATGAAGCAGA AGAGGGCTAT CCCCCAGCGG CCAGACCTGG CCAGGAGGCC 1920

CAGCCCCACC AGCAGCACCT GAGCCTCCAG CTGGGTGAGC TCAGGCAGGA GACCAACAGA 1980

CTTTTGGAAC ACCTAGTTGA AAAAGAGAGA GAGTACCAGA ATCTTCTGCG GCAAACTCTA 2040

GAACAGAAAA CTCAAGAATT GTATCACCTT CAGTTAAAAT TAAAATCAAA TTGTATTACA 2100

GAGAACCCAG CAGGGCCCTA TGGGCAGAGA ACAGATAAAG AGCTTATAGA CTGGTTGCGG 2160

CTGCAAGGAG CCGATGCAAA GACAATTGAA AAGATTGTTG AAGAGGGTTA TACACTTTCT 2220

GATATTCTTA ATGAGATCAC TAAGGAAGAT CTAAGATACC TTCGACTACG GGGTGGTCTC 2280

CTCTGCAGGC TCTGGAGTGC AGTCTCCCAG TACAGAAGGG CTCAGGAGGC CTCAGAAACC 2340

AAAGATGAGG CTTGA 2355

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+    ++l+eEi+l+k lkH+n

Q: 127   ERVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR----QPLHEEIALHKYLKHRN  179

         6899**************************...787775....9****************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gG ls+ll+ k+g+++e +ik+ytkqilegl+yLHe++

Q: 180   IVQYLGSVSENGYIKIFMEQVPGGDLSALLRsKWGPMKEPTIKFYTKQILEGLKYLHENQ  239

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e++tGtl+ymaPE+i+++

Q: 240   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDQGP  296

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+t+k+Pf+el+e++a+mfkvg+ k++Peipe+ls+e+++f+

Q: 297   RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI  356

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

          +c+e dp+kr++a+eLL++ fl

Q: 357   LSCFEPDPHKRATAAELLRERFL  379

         *******************9996

Domain Sequence
(FASTA)

ERVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRQPLH EEIALHKYLK HRNIVQYLGS 60

VSENGYIKIF MEQVPGGDLS ALLRSKWGPM KEPTIKFYTK QILEGLKYLH ENQIVHRDIK 120

GDNVLVNTYS GVVKISDFGT SKRLAGVNPC TETFTGTLQY MAPEIIDQGP RGYGAPADIW 180

SLGCTIIEMA TSKPPFHELG EPQAAMFKVG MFKIHPEIPE ALSAEARAFI LSCFEPDPHK 240

RATAAELLRE RFL 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Monodelphis domestica"; ?>Oryzias latipes"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013