EPS-MAM-00020

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00020

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	273.3	4.2E-81	61	373	313

Status

Unreviewed

Ensembl Protein

ENSMMUP00000023722

UniProt Accession

F7HUA9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1D

Gene Synonyms/Alias

PPM1D;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000018049	ENSMMUP00000023722	ENSMMUT00000025356
ENSMMUG00000018049	ENSMMUP00000034728	ENSMMUT00000041710

Organism

Macaca mulatta

Functional Description

Protein Length

605

Protein Sequence
(FASTA)

MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLS LRPSPPAPAG 60

GEVSGKGPAV AAREARDPPP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 120

WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 180

RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 240

VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 300

LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 360

RMLRADNTSA IVICISPEVD NQGNFTNEDE LYLNLTDSPS YNSQETCVMT PSPCSTPPVK 420

SLEEDPWPRL NSKDHIPALV RSNAFSENFL EVSAEIARGN VQGVVIPSKD PEPLEENCAK 480

ALTLRIHDSL NNSLPVGLVP TNSTNTVMDQ KNLKMSTPGQ MKAQEIERTP PTNFKRTLEE 540

SNSGPLMKKH RRNGLSRSSG AQPASLPTTS QRKNSVKLTM RRRLRGQKKI GNPLLHQHRK 600

TVCVC 605

Nucleotide Sequence
(FASTA)

ATGGCGGGGC TGTACTCGCT GGGAGTGAGC GTCTTCTCCG ACCAGGGCGG GAGGAAGTAC 60

ATGGAGGACG TTACTCAGAT CGTTGTGGAG CCTGAACCGA CGGCTGAAGA AAAGCCCTCG 120

CCGCGGCGGT CGCTGTCTCA GCCGTTGTCT CTGCGGCCGT CGCCGCCCGC CCCTGCCGGC 180

GGCGAAGTCT CGGGGAAAGG CCCAGCGGTG GCAGCCCGAG AGGCTCGCGA CCCTCCCCCG 240

GACGCCGGGG CCTCGCCTGC ACCCAGCCGC TGCTGCCGCC GCCGTTCCTC CGTGGCCTTT 300

TTCGCCGTGT GCGACGGGCA CGGCGGGCGG GAGGCGGCAC AGTTTGCCCG GGAGCACTTG 360

TGGGGTTTTA TCAAGAAGCA GAAGGGTTTC ACGTCATCCG AGCCGGCTAA GGTTTGCGCT 420

GCCATCCGCA AAGGCTTTCT CGCTTGTCAC CTCGCCATGT GGAAGAAACT GGCGGAATGG 480

CCAAAGACTA TGACAGGTCT TCCCAGCACA TCAGGAACAA CTGCCAGTGT GGTCATCATA 540

CGGGGCATGA AGATGTATGT AGCTCACGTA GGTGACTCAG GGGTGGTTCT TGGAATTCAG 600

GATGACCCAA AGGATGACTT TGTCAGAGCT GTGGAGGTGA CACAGGACCA TAAGCCAGAA 660

CTTCCCAAGG AAAGAGAACG AATCGAAGGA CTTGGCGGGA GTGTGATGAA CAAGTCTGGG 720

GTGAATCGTG TAGTTTGGAA ACGACCTCGG CTCACTCACA ATGGACCTGT TAGAAGAAGC 780

ACAGTTATTG ACCAGATTCC TTTTCTGGCA GTAGCAAGAG CACTTGGTGA TTTGTGGAGC 840

TATGATTTCT TCAGTGGTGA GTTTGTGGTG TCACCTGAAC CAGACACAAG TGTCCACACT 900

CTTGACCCTC AGAAGCACAA GTATATTATA TTGGGGAGTG ATGGGCTTTG GAATATGATT 960

CCACCACAAG ATGCCATCTC AATGTGCCAG GACCAAGAGG AGAAAAAATA CCTGATGGGT 1020

GAGCACGGAC AATCTTGTGC CAAAATGCTT GTGAATCGAG CATTGGGCCG CTGGAGGCAG 1080

CGTATGCTCC GAGCAGATAA CACTAGTGCC ATAGTAATCT GCATCTCTCC AGAAGTGGAC 1140

AATCAGGGAA ACTTTACCAA TGAAGATGAG TTGTACCTGA ACCTGACTGA TAGCCCTTCC 1200

TATAATAGTC AAGAAACCTG TGTGATGACT CCTTCCCCAT GTTCTACACC ACCAGTCAAG 1260

TCCCTGGAGG AGGATCCATG GCCAAGGCTG AACTCTAAGG ACCATATACC TGCCCTGGTT 1320

CGTAGCAATG CCTTCTCAGA GAATTTTTTA GAGGTTTCAG CTGAGATAGC TCGAGGGAAT 1380

GTCCAGGGTG TAGTCATACC CTCAAAAGAT CCAGAACCGC TTGAAGAAAA TTGCGCTAAA 1440

GCCCTGACTT TAAGGATACA TGATTCTTTG AATAATAGCC TTCCAGTTGG CCTTGTGCCT 1500

ACTAACTCAA CAAACACTGT CATGGACCAA AAAAATTTGA AGATGTCAAC TCCTGGCCAA 1560

ATGAAAGCCC AAGAAATTGA AAGAACCCCT CCAACAAACT TTAAAAGGAC ACTAGAAGAG 1620

TCCAATTCTG GCCCCCTGAT GAAGAAACAT AGACGAAATG GCTTAAGTCG AAGTAGTGGT 1680

GCTCAGCCTG CAAGTCTCCC CACAACCTCA CAGCGAAAGA ACTCTGTTAA ACTTACCATG 1740

CGACGCAGAC TTAGGGGCCA GAAGAAAATT GGAAATCCTT TACTTCATCA ACACAGGAAA 1800

ACTGTTTGTG TTTGCTGA 1818

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr......laffgvyDGhggsevakfcsekl  57

         g vs++g+    ++a+++ p++++sp+ +++      +aff+v+DGhgg+e+a+f++e+l

Q: 61    GEVSGKGPAVAAREARDPPPDAGASPAPSRCcrrrssVAFFAVCDGHGGREAAQFAREHL  120

         78999************************99*****************************

S: 58    heilaeelesseseerkvkkalakaFlstdeel.....kvleeksldidksGstavvali  112

         + ++++++ +++se +kv++a++k+Fl+++ ++     +++++++  +++sG+ta+v++i

Q: 121   WGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMwkklaEWPKTMTGLPSTSGTTASVVII  180

         ************************************************************

S: 113   kdsklyvanvGdSravLcrngk.......avelssdHkpsredEleRieeaggsvilkdg  165

         +++k+yva+vGdS++vL+ +++       ave+++dHkp+ ++E+eRie  ggsv++k+g

Q: 181   RGMKMYVAHVGDSGVVLGIQDDpkddfvrAVEVTQDHKPELPKERERIEGLGGSVMNKSG  240

         *******************77656999999******************************

S: 166   a.Rv.....................lGvLavsRalGdlylk......pyvtpePevtshr  197

         + Rv                     +++Lav+RalGdl+++      ++v+peP++++h+

Q: 241   VnRVvwkrprlthngpvrrstvidqIPFLAVARALGDLWSYdffsgeFVVSPEPDTSVHT  300

         ************************************************************

S: 198   ltsede.fliLasDGlwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargsk  252

         l+++++ ++iL+sDGlw+++++++a+s+++d++e    ++e+ q++ak+Lv++al r+++

Q: 301   LDPQKHkYIILGSDGLWNMIPPQDAISMCQDQEEkkylMGEHGQSCAKMLVNRALGRWRQ  360

         ************************************************************

S: 253   .....dnvsaivv  260

              dn+saiv+

Q: 361   rmlraDNTSAIVI  373

         ***********97

Domain Sequence
(FASTA)

GEVSGKGPAV AAREARDPPP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 60

WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 120

RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 180

VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 240

LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 300

RMLRADNTSA IVI 313

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0009617	; P:response to bacterium

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013