EKS-MAM-00009
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00009
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph485.74.1E-146612869258
StatusUnreviewed
Ensembl ProteinENSMMUP00000023985
UniProt AccessionF7E018;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2
Gene Synonyms/Alias EPHA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000018245ENSMMUP00000023985ENSMMUT00000025638
OrganismMacaca mulatta
Functional Description
Protein Length974
Protein Sequence
(FASTA)
MELWAARACF VLLWGCALAP ATAAQGKEGD LWDLASSGGE LGWLTHPYGK GWDLMQNIMN 60
DMPIYMYSVC NVMSGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 120
LYYAESDLDY GTNFQKRLFT KIDTIAPDEI TVSSDFEARH VKLNVEERSV GPLTRKGFYL 180
AFQDIGACVA LLSVRVYYKK CPELLQSLAR FPETIAGSDA PSLATVAGTC VDHAVVPPGG 240
EEPRMHCAVD GEWLVPIGQC LCQAGYEKVE DACQACSPGF FKFEVSESPC LECPEHTLPS 300
PEGATSCECE EGFFRAPQDP MSMPCTRPPS APHYLTAVGM GAKVELRWTP PQDSGGREDI 360
VYSVTCEQCW PESGECGPCE SSVRYSEPPH GLTRTSVTVS DLEPHMNYTF TVEARNGVSG 420
LVTSRSFRTA SVSINQTEPP KVRLEGRSTT SLSVSWSIPP PQQSRVWKYE VTYRKKGDSN 480
SYNVRRTEGF SVTLDDLAPD TTYLVQVQAL TQEGQGAGSK VHEFQTLCDP ESGAWAATAG 540
TGLHLTDLPA FGSLWGCFRR KNLRARQSPE DVYFSKSEQL KPLKTYVDPH TYEDPNQAVL 600
KFTTEIHPSC VTRQKVIGAG EFGEVYKGTL KTSSGKKEVP VAIKTLKAGY TEKQRVDFLG 660
EAGIMGQFSH HNIIRLEGVV SKYKPMMIIT EFMENGALDK FLREKDGEFS VLQLVGMLRG 720
IAAGMKYLAN MNYVHRDLAA RNILVNSNLV CKVSDFGLSR VLEDDPEATY TTSGGKIPIR 780
WTAPEAISYR KFTSASDVWS FGIVMWEVMT YGERPYWELS NHEVMKAIND GFRLPTPMDC 840
PSAIYQLMMQ CWQQERARRP KFADIVSILD KLIRAPDSLK TLADFDPRVS IRLPSTSGSE 900
GVPFRTVSEW LESIKMQQYT EHFMAAGYTA IEKVVQMTND DIKRIGVRLP GHQKRIAYSL 960
LGLKDQVNTV GIPI 974
Nucleotide Sequence
(FASTA)
ATGGAGCTCT GGGCAGCCCG CGCCTGCTTC GTCCTGCTGT GGGGCTGTGC GCTGGCCCCG 60
GCCACGGCAG CGCAGGGCAA GGAAGGTGAC CTCTGGGACC TCGCCAGCTC TGGAGGGGAG 120
CTCGGCTGGC TCACACACCC GTATGGCAAA GGGTGGGACC TGATGCAAAA CATCATGAAT 180
GACATGCCGA TCTACATGTA CTCCGTGTGC AACGTGATGT CTGGTGACCA GGACAACTGG 240
CTCCGCACCA ACTGGGTGTA CCGAGGAGAG GCCGAGCGCA TCTTCATTGA ACTCAAGTTT 300
ACTGTGCGCG ACTGCAACAG CTTCCCTGGC GGCGCCAGCT CTTGCAAGGA GACTTTCAAC 360
CTCTACTATG CCGAGTCGGA CCTGGACTAT GGCACCAACT TCCAGAAGCG CCTGTTCACC 420
AAGATTGACA CCATTGCGCC CGATGAGATC ACCGTCAGCA GCGACTTCGA GGCACGCCAC 480
GTGAAACTGA ACGTGGAGGA GCGCTCCGTG GGGCCGCTCA CCCGCAAAGG CTTCTACCTG 540
GCCTTCCAGG ATATCGGTGC CTGTGTGGCG CTGCTCTCCG TCCGTGTCTA CTACAAGAAG 600
TGCCCCGAGC TGCTGCAGAG CCTGGCCCGC TTTCCTGAGA CCATCGCCGG CTCTGATGCA 660
CCCTCCCTGG CCACTGTGGC CGGCACCTGT GTGGACCATG CTGTGGTGCC ACCAGGGGGT 720
GAAGAGCCCC GTATGCACTG CGCAGTGGAT GGCGAGTGGC TGGTGCCCAT TGGGCAGTGC 780
CTGTGCCAGG CAGGCTACGA GAAAGTGGAG GATGCCTGCC AGGCCTGCTC GCCTGGATTC 840
TTTAAGTTTG AGGTGTCTGA GAGCCCCTGC TTGGAGTGCC CTGAGCACAC GCTGCCATCC 900
CCTGAGGGTG CCACCTCCTG CGAGTGTGAG GAAGGCTTCT TCCGGGCACC TCAGGACCCA 960
ATGTCGATGC CCTGCACACG ACCCCCCTCC GCCCCACACT ACCTCACGGC CGTGGGCATG 1020
GGTGCCAAGG TGGAGCTGCG CTGGACACCC CCTCAGGACA GTGGGGGCCG CGAGGACATC 1080
GTCTACAGCG TCACCTGCGA ACAGTGCTGG CCCGAGTCTG GGGAGTGTGG GCCGTGTGAG 1140
TCTAGTGTGC GCTACTCAGA GCCTCCACAC GGACTGACCC GCACCAGTGT GACAGTCAGC 1200
GACCTGGAGC CTCACATGAA CTACACCTTC ACCGTAGAGG CCCGCAACGG CGTCTCAGGC 1260
CTGGTGACCA GCCGCAGCTT CCGTACTGCC AGTGTCAGCA TCAACCAGAC AGAGCCCCCC 1320
AAGGTGAGAC TGGAGGGCCG CAGCACCACC TCGCTTAGCG TCTCCTGGAG CATCCCCCCG 1380
CCGCAGCAGA GCCGCGTGTG GAAGTACGAG GTCACCTACC GCAAGAAGGG AGACTCCAAC 1440
AGCTACAATG TACGCCGCAC CGAGGGTTTC TCCGTGACCC TGGACGACCT GGCTCCGGAC 1500
ACCACCTACC TGGTCCAGGT GCAGGCACTG ACGCAGGAGG GCCAGGGGGC CGGCAGCAAG 1560
GTGCACGAAT TCCAGACACT GTGTGACCCT GAGAGTGGAG CTTGGGCAGC GACAGCGGGG 1620
ACTGGGCTGC ACCTCACTGA CCTCCCTGCA TTTGGTTCCC TGTGGGGCTG TTTCAGGAGG 1680
AAGAACCTGC GTGCCCGCCA GTCCCCGGAG GACGTTTACT TCTCCAAGTC AGAACAACTG 1740
AAACCCCTGA AGACATACGT GGACCCACAC ACATATGAGG ACCCCAACCA AGCTGTGTTG 1800
AAGTTCACCA CCGAGATCCA TCCGTCCTGT GTCACTCGGC AGAAGGTGAT CGGAGCAGGT 1860
GAGTTTGGGG AGGTGTACAA GGGCACGCTG AAGACATCCT CGGGGAAGAA GGAGGTGCCC 1920
GTGGCCATCA AGACACTGAA AGCTGGCTAC ACAGAGAAGC AGCGAGTGGA CTTCCTTGGT 1980
GAGGCTGGCA TCATGGGCCA GTTCAGCCAT CACAACATCA TCCGCCTGGA GGGCGTCGTC 2040
TCCAAATACA AGCCCATGAT GATCATCACT GAGTTCATGG AGAACGGGGC CCTGGACAAG 2100
TTCCTTCGGG AGAAGGATGG CGAGTTCAGC GTGCTGCAGC TGGTGGGCAT GCTGCGGGGC 2160
ATCGCAGCTG GCATGAAGTA CCTGGCCAAC ATGAACTATG TGCATCGTGA CCTGGCTGCC 2220
CGCAACATCC TCGTCAACAG CAACCTGGTC TGCAAGGTGT CTGACTTTGG CCTGTCCCGC 2280
GTGCTGGAGG ACGACCCCGA GGCCACCTAC ACCACCAGTG GTGGCAAGAT CCCGATCCGC 2340
TGGACGGCTC CGGAGGCCAT TTCCTACCGC AAGTTCACCT CTGCCAGTGA CGTGTGGAGC 2400
TTTGGCATTG TCATGTGGGA GGTGATGACC TATGGCGAGC GGCCCTACTG GGAGCTGTCC 2460
AACCATGAGG TGATGAAAGC AATCAACGAT GGCTTCCGGC TCCCCACGCC CATGGACTGC 2520
CCCTCCGCCA TCTACCAGCT CATGATGCAG TGCTGGCAGC AGGAGCGTGC CCGCCGCCCC 2580
AAGTTTGCTG ACATCGTCAG CATCCTGGAC AAGCTCATCC GTGCCCCTGA CTCCCTCAAG 2640
ACCCTGGCTG ACTTCGACCC CCGGGTGTCT ATCCGGCTCC CCAGCACAAG TGGCTCGGAG 2700
GGGGTGCCCT TCCGCACGGT GTCCGAGTGG CTGGAGTCCA TCAAGATGCA GCAGTATACG 2760
GAGCACTTCA TGGCGGCCGG CTACACTGCC ATCGAGAAGG TGGTGCAGAT GACCAACGAC 2820
GACATCAAGA GGATTGGGGT GCGGCTGCCC GGCCACCAGA AGCGCATCGC CTACAGCCTG 2880
CTGGGACTCA AGGACCAGGT GAACACGGTG GGGATCCCCA TCTGA 2925
Domain Profile
S: 2     kiekviGaGefGevcsGrlkl.pgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         + +kviGaGefGev++G+lk+ +gk+e++vaiktlkag+tekqr+dfl ea i+Gqf+h+
Q: 612   TRQKVIGAGEFGEVYKGTLKTsSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHH  671
         6789****************9678************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvv+k kp+mi+te+mengald+flr+kdg+f+v+qlvgmlrGia+gmkyl++m
Q: 672   NIIRLEGVVSKYKPMMIITEFMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANM  731
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrk
Q: 732   NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK  791
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvws+Giv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++c
Q: 792   FTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQC  851
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wq++ra+rpkf++ivsil
Q: 852   WQQERARRPKFADIVSIL  869
         ***************985
Domain Sequence
(FASTA)
TRQKVIGAGE FGEVYKGTLK TSSGKKEVPV AIKTLKAGYT EKQRVDFLGE AGIMGQFSHH 60
NIIRLEGVVS KYKPMMIITE FMENGALDKF LREKDGEFSV LQLVGMLRGI AAGMKYLANM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEATYT TSGGKIPIRW TAPEAISYRK 180
FTSASDVWSF GIVMWEVMTY GERPYWELSN HEVMKAINDG FRLPTPMDCP SAIYQLMMQC 240
WQQERARRPK FADIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAJ-00009
EKS-CAF-00010
EKS-CAP-00007
EKS-DAR-00015
EKS-EQC-00010
EKS-FEC-00007
EKS-GAM-00004
EKS-GAA-00015
EKS-GOG-00009
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAE-00001
EKS-MEG-00012
EKS-MOD-00009
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-ORL-00015
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TAR-00014
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005925; C:focal adhesion
GO:0005887; C:integral to plasma membrane
GO:0031256; C:leading edge membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0032863; P:activation of Rac GTPase activity
GO:0006915; P:apoptotic process
GO:0048320; P:axial mesoderm formation
GO:0046849; P:bone remodeling
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0060326; P:cell chemotaxis
GO:0030216; P:keratinocyte differentiation
GO:0070309; P:lens fiber cell morphogenesis
GO:0033598; P:mammary gland epithelial cell proliferation
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0021915; P:neural tube development
GO:0030182; P:neuron differentiation
GO:0060035; P:notochord cell development
GO:0014028; P:notochord formation
GO:0001649; P:osteoblast differentiation
GO:0030316; P:osteoclast differentiation
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0043491; P:protein kinase B signaling cascade
GO:0045765; P:regulation of angiogenesis
GO:0043535; P:regulation of blood vessel endothelial cell migration
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0010591; P:regulation of lamellipodium assembly
GO:0070848; P:response to growth factor stimulus
GO:0001501; P:skeletal system development
GO:0001570; P:vasculogenesis
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013