EKS-MAM-00388
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00388
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11349.03.5E-104651907257
StatusUnreviewed
Ensembl ProteinENSMMUP00000024083
UniProt AccessionF7HFE8;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K6
Gene Synonyms/Alias MAP3K6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000018318ENSMMUP00000024083ENSMMUT00000025743
ENSMMUG00000018318ENSMMUP00000024086ENSMMUT00000025746
OrganismMacaca mulatta
Functional Description
Protein Length1303
Protein Sequence
(FASTA)
MAGQCPRSGA ERAGSCWQDP LAVALSRGRP LAATPGRGCA RSRPLSVVYV LTREPQPGLE 60
PGEGTEAEPL PLRCLREACA QLPRPRPPPQ LRSLPFGTLA LGDTAALDAF YNADVVVLEV 120
SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ ADLPDLQALR EDVFQKNSDC VGSYTLIPYV 180
VTATGRVLCG DAGLLRGLAD GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR 240
QDIRQARERF SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL 300
QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALAVLLP LVQLEGSVAP DLYCMCGRIY 360
KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV LLIAAGQHFE DSKELRLIGM 420
KLGCLLARKG CVEKMQYYWD VGFYLGAQIL ANDPTQVVLA AEQLYKLNAP IWYLVSVMET 480
FLLYQHFRPM PAEPRGGPPR RAHFWLHFLL QSCQPFKMAC PQGDQCLVLV LEMNKVLLPA 540
NLEVRGTDPV STVTLSLLEP ETQDIPSSWT FPVASICGVS ASKRDERCCF LYALPPAQDV 600
QLCFPSVGHC QWFCGLIQAL VTNPDSTAPA EEAEGVGEVL EFDYEYTETG ERLVLGKGTY 660
GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL GSASQGGYLK 720
IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL GYLHDNHIVH RDIKGDNVLI 780
NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA ADIWSLGCTV 840
IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPSSLSAEA QAFLLRTFEP DPRLRASAQA 900
LLGDPFLQPG KRSRSPSSPQ HVPRPSDAPS ASPIPSADST TQSQTFPRPQ APSQHPPSPP 960
KRCLSYGGIS QLRVPEEPAA EEPASPEESS GLSLLHQESK RRAMLAAVLE QELPALAENL 1020
HQEQEQEQEQ EQEQGSRLGR NYVEELLRCL GAHIHTPNRR QLAQELRALQ GRLRAQGLGP 1080
ALLHGPLFAF PDAVKQILRR RQIRPHWMFV LDSLLSRAVR AALAVLGPEV EKEAVSLRSE 1140
ELSKEGDSQQ RPQQSPGQQS LLPVEPEQGP APLMVQLSLL RAETDRLREV LAEKEREYQA 1200
LVQRALQRLN EEVRTYALAP EPPATLSTDQ GLVQWLQELN VDSGTIQMLL NHSFTLHTLL 1260
TYATRDDLIY TRIRGGMVCR IWRAILAQRA GSTPVTPGPR EAE 1303
Nucleotide Sequence
(FASTA)
ATGGCGGGGC AGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 60
CTGGCCGTGG CGCTGAGCCG GGGCCGGCCG CTCGCGGCGA CCCCGGGCCG GGGCTGTGCG 120
CGGAGCCGGC CGCTCAGCGT GGTCTATGTG CTGACCCGGG AGCCGCAGCC CGGGCTGGAG 180
CCTGGAGAGG GAACCGAGGC AGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 240
CAGCTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGCA 300
CTAGGCGACA CCGCTGCGCT GGATGCCTTC TACAACGCGG ACGTGGTGGT GCTGGAGGTG 360
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 420
ATGACCAACA ACGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 480
GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGTT ACACACTGAT CCCCTATGTG 540
GTGACGGCCA CTGGTCGGGT GCTGTGTGGC GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 600
GGGCTGGTAC AGGCTGGAGT GGGGACCGAG GCTCTGCTCA CTCCCCTGGT GGGCCGGCTT 660
GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 720
CAGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCGC AGCTGCGGCA GGAGCTGGCT 780
CGGCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 840
CTGCTCTCCT ACCGCGATGT GCAAGACTAC TCAGCCATCA TTGAGCTGGT GGAGACGCTG 900
CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA TTACACTTTT 960
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGGCCGT GCTGCTGCCA 1020
CTGGTACAGC TTGAGGGCTC CGTGGCACCT GATCTGTACT GCATGTGTGG CCGTATCTAC 1080
AAGGACATGT TCTTCAGTTC AGGTTTCCAG GATGCCGGGC ACCGGGAGCA GGCCTATCAC 1140
TGGTATCGCA AGGCTTTTGA TGTAGAGCCC AGCCTCCACT CGGGCATCAA TGCAGCTGTG 1200
CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAGG AGCTCCGGCT AATAGGCATG 1260
AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 1320
GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 1380
GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 1440
TTCCTGCTCT ACCAGCACTT TAGGCCCATG CCAGCAGAGC CCCGTGGAGG GCCACCACGC 1500
CGTGCCCACT TCTGGCTCCA CTTCTTGCTA CAGTCCTGCC AACCATTCAA GATGGCCTGT 1560
CCCCAGGGTG ACCAGTGCTT GGTGCTGGTC CTGGAGATGA ACAAGGTGCT GCTGCCTGCA 1620
AATCTCGAGG TTCGGGGTAC TGACCCAGTG AGCACAGTGA CCCTGAGCTT GCTGGAGCCT 1680
GAGACCCAGG ACATTCCCTC CAGCTGGACC TTCCCAGTCG CCTCCATATG TGGAGTCAGC 1740
GCCTCCAAGC GCGACGAGCG CTGCTGCTTC CTCTATGCAC TGCCCCCAGC TCAGGACGTC 1800
CAGCTGTGCT TCCCCAGCGT AGGGCATTGC CAGTGGTTCT GCGGCCTGAT CCAGGCCTTG 1860
GTGACGAACC CGGATTCCAC GGCGCCCGCG GAGGAGGCAG AGGGCGTGGG GGAGGTGTTG 1920
GAGTTTGATT ATGAGTACAC GGAGACGGGC GAGCGGCTGG TGCTGGGCAA GGGCACGTAT 1980
GGGGTGGTGT ACGCGGGCCG TGATCGCCAC ACGAGGGTGC GCATCGCCAT CAAGGAGATC 2040
CCGGAGCGGG ACAGCAGGTT TTCTCAGCCC CTGCATGAAG AAATCGCTCT TCACAAACGC 2100
CTGCGCCACA AGAACATAGT GCGCTATCTG GGCTCAGCTA GCCAGGGCGG CTACCTTAAG 2160
ATCTTTATGG AGGAAGTGCC TGGAGGCAGC CTGTCATCCT TGCTGCGGTC AGTGTGGGGA 2220
CCCCTGAAGG ACAACGAGAG CACCATCAGT TTCTACACCC GCCAGATCCT GCAGGGACTT 2280
GGCTATTTGC ACGACAACCA CATCGTACAC AGGGACATTA AGGGGGACAA TGTGCTGATC 2340
AACACCTTCA GTGGGCTGCT CAAGATTTCT GACTTTGGCA CCTCCAAGCG ACTGGCAGGA 2400
ATCACACCTT GCACTGAGAC CTTCACAGGA ACTCTGCAGT ATATGGCCCC AGAAATCATT 2460
GACCAGGGCC CACGCGGGTA TGGGAAAGCG GCTGACATCT GGTCACTGGG CTGCACTGTC 2520
ATTGAGATGG CCACGGGTCG CCCCCCCTTC CATGAGCTAG GGAGCCCACA GGCTGCCATG 2580
TTTCAGGTGG GTATGTACAA GGTCCATCCA CCAATGCCCA GCTCTCTGTC GGCTGAGGCC 2640
CAAGCCTTTC TCCTTCGAAC TTTTGAGCCA GACCCCCGCC TCCGAGCCAG CGCCCAGGCA 2700
CTGCTGGGGG ACCCCTTCCT GCAGCCTGGG AAAAGGAGCC GCAGCCCCAG CTCCCCCCAA 2760
CATGTTCCAC GGCCCTCAGA TGCCCCTTCC GCCAGTCCCA TTCCTTCAGC CGACTCAACC 2820
ACCCAGTCTC AGACATTCCC GCGCCCTCAG GCACCGTCTC AGCACCCGCC CAGCCCCCCG 2880
AAGCGCTGCC TCAGTTATGG GGGCATCAGC CAGCTCCGGG TGCCCGAGGA GCCTGCGGCC 2940
GAGGAGCCTG CATCTCCGGA GGAGAGTTCG GGGCTGAGCC TGCTACACCA GGAAAGCAAG 3000
CGTCGGGCCA TGCTGGCCGC GGTGCTGGAG CAGGAGCTGC CAGCGCTGGC GGAGAATCTG 3060
CACCAGGAGC AGGAGCAAGA GCAGGAGCAG GAGCAGGAGC AGGGGTCCCG TCTGGGCAGA 3120
AACTATGTGG AAGAGCTGCT GCGATGCCTC GGGGCACACA TCCACACTCC CAACCGCCGG 3180
CAGCTGGCCC AGGAGCTGCG GGCTCTGCAA GGACGGCTGA GGGCCCAGGG CCTTGGGCCT 3240
GCACTTCTGC ACGGACCGCT CTTTGCCTTC CCGGATGCGG TGAAGCAGAT CCTCCGCAGG 3300
CGCCAGATCC GTCCACACTG GATGTTCGTT CTGGACTCAC TGCTCAGCCG TGCTGTGCGG 3360
GCAGCCCTGG CTGTGCTGGG CCCGGAGGTG GAGAAGGAGG CGGTCTCACT GAGGTCGGAG 3420
GAGCTGAGTA AAGAAGGGGA CTCCCAGCAG AGGCCACAGC AGAGCCCAGG CCAGCAGAGC 3480
CTGCTTCCAG TGGAGCCTGA GCAGGGCCCC GCTCCTCTGA TGGTGCAGCT GAGCCTCTTG 3540
AGGGCAGAGA CTGATCGGCT GCGGGAAGTC CTGGCGGAGA AGGAACGGGA GTACCAGGCC 3600
CTGGTGCAGC GGGCTCTACA GCGGCTGAAT GAGGAAGTCC GGACCTATGC CCTGGCCCCA 3660
GAGCCCCCAG CCACTCTTTC AACGGACCAG GGCCTGGTGC AATGGCTACA GGAACTGAAT 3720
GTGGATTCAG GCACCATCCA AATGCTGTTG AACCATAGCT TCACCCTCCA TACCCTGCTC 3780
ACCTATGCCA CTCGAGATGA CCTCATCTAT ACCCGCATCA GGGGAGGGAT GGTATGCCGC 3840
ATCTGGAGGG CCATCTTGGC ACAGCGAGCA GGATCCACGC CAGTCACCCC TGGACCCCGA 3900
GAGGCTGAAT GA 3912
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n
Q: 651   ERLVLGKGTYGVVYAGRDRHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  705
         5779**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl yLH+
Q: 706   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLKdnESTISFYTRQILQGLGYLHD  765
         *******************************99****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++
Q: 766   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  822
         *****************9*********************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p++ls+e+++
Q: 823   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA  882
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl +++e dp+ r+sa+ LL ++fl
Q: 883   FLLRTFEPDPRLRASAQALLGDPFL  907
         **********************996
Domain Sequence
(FASTA)
ERLVLGKGTY GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60
GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL GYLHDNHIVH 120
RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180
ADIWSLGCTV IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPSSLSAEA QAFLLRTFEP 240
DPRLRASAQA LLGDPFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00364
EKS-ANC-00380
EKS-BOT-00391
EKS-CAJ-00392
EKS-CAF-00391
EKS-CAP-00420
EKS-EQC-00382
EKS-FEC-00381
EKS-GAA-00477
EKS-HOS-00398
EKS-ICT-00368
EKS-LOA-00400
EKS-MAE-00046
EKS-MIM-00057
EKS-MOD-00378
EKS-MUM-00422
EKS-MUP-00384
EKS-MYL-00387
EKS-ORC-00368
EKS-OTG-00392
EKS-PAT-00368
EKS-POA-00382
EKS-RAN-00404
EKS-SUS-00342
EKS-TUT-00109
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
KEGG
mcc:715911;
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013