EKS-MAM-00167
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00167
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC478.97.8E-144339597259
StatusUnreviewed
Ensembl ProteinENSMMUP00000024164
UniProt AccessionF7H1C6;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCA
Gene Synonyms/Alias PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000018378ENSMMUP00000024164ENSMMUT00000025827
OrganismMacaca mulatta
Functional Description
Protein Length672
Protein Sequence
(FASTA)
MADVFPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA 180
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 300
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360
TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420
NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480
DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540
EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600
DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660
PQFVHPILQS AV 672
Nucleotide Sequence
(FASTA)
ATGGCTGACG TTTTCCCGGC CAACGACTCC ACCGCGTCTC AGGACGTGGC CAACCGCTTC 60
GCCCGCAAAG GGGCGCTGAG GCAGAAGAAC GTGCACGAGG TGAAGGACCA CAAATTCATC 120
GCGCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGGTTT 180
GGGAAACAGG GCTTCCAGTG CCAAGTTTGC TGTTTTGTGG TCCACAAGAG GTGCCATGAA 240
TTTGTTACTT TTTCTTGTCC GGGTGCAGAT AAGGGACCCG ACACTGATGA CCCCAGGAGC 300
AAGCACAAGT TCAAAATCCA CACTTACGGA AGCCCCACCT TCTGCGATCA CTGTGGGTCC 360
CTGCTGTATG GACTTATCCA CCAAGGGATG AAATGTGACA CCTGCGATAT GAACGTTCAC 420
AAGCAATGCG TCATCAATGT CCCCAGCCTC TGCGGAATGG ATCACACAGA GAAGAGGGGG 480
CGGATTTACC TAAAGGCTGA GGTTGCTGAT GAAAAGCTCC ATGTCACAGT ACGAGATGCA 540
AAAAATCTAA TCCCTATGGA TCCAAACGGG CTTTCAGATC CTTATGTGAA GCTGAAACTT 600
ATTCCTGATC CCAAGAATGA AAGCAAACAA AAAACCAAAA CCATCCGCTC CACACTAAAT 660
CCCCAGTGGA ATGAGTCCTT TACATTCAAA CTGAAACCTT CAGACAAAGA CCGACGACTG 720
TCTGTAGAAA TCTGGGACTG GGATCGAACA ACAAGGAATG ACTTCATGGG ATCCCTTTCC 780
TTTGGGGTTT CGGAACTAAT GAAGATGCCA GCCAGTGGAT GGTACAAGTT GCTTAACCAA 840
GAAGAAGGTG AGTACTACAA TGTACCCATT CCAGAAGGGG ACGAAGAAGG AAACATGGAA 900
CTCAGGCAGA AATTCGAGAA AGCCAAGCTT GGCCCTGCTG GCAACAAAGT CATCAGTCCC 960
TCTGAAGACA GGAAACAGCC TTCCAACAAC CTGGACCGAG TGAAACTCAC CGACTTCAAT 1020
TTCCTCATGG TGCTGGGGAA GGGGAGTTTT GGAAAGGTGA TGCTTGCCGA CAGGAAGGGC 1080
ACAGAAGAAC TGTATGCAAT CAAAATCCTG AAGAAGGATG TGGTGATTCA GGATGACGAC 1140
GTGGAGTGCA CCATGGTAGA AAAACGAGTC TTGGCCCTGC TTGACAAACC CCCGTTCTTG 1200
ACGCAGCTGC ACTCCTGCTT CCAGACAGTG GATCGGCTGT ACTTCGTCAT GGAATATGTC 1260
AACGGTGGGG ACCTCATGTA CCACATTCAG CAAGTAGGAA AATTTAAGGA ACCACAAGCA 1320
GTATTCTATG CGGCAGAGAT TTCCATCGGA TTGTTCTTTC TTCATAAAAG AGGAATCATT 1380
TATAGGGATC TGAAGTTAGA TAACGTCATG TTGGATTCAG AAGGACATAT CAAAATTGCT 1440
GACTTTGGGA TGTGCAAGGA ACATATGATG GATGGAGTCA CGACCAGGAC CTTCTGTGGG 1500
ACTCCAGATT ACATCGCCCC AGAGATTATC GCTTATCAGC CATATGGAAA ATCTGTGGAC 1560
TGGTGGGCCT ATGGCGTCCT GTTGTATGAA ATGCTTGCCG GGCAGCCTCC ATTTGATGGT 1620
GAAGATGAAG ACGAGCTGTT TCAGTCTATC ATGGAGCACA ACGTTTCCTA TCCAAAATCC 1680
TTGTCCAAGG AGGCTGTTTC CATCTGCAAA GGACTAATGA CCAAACACCC AGCCAAGCGG 1740
CTGGGCTGCG GGCCTGAGGG GGAGAGGGAC GTGAGAGAAC ATGCTTTCTT CCGGAGGATC 1800
GACTGGGAAA AACTGGAGAA CAGGGAGATC CAGCCACCGT TCAAGCCCAA AGTGTGCGGC 1860
AAAGGAGCAG AAAACTTTGA CAAGTTCTTC ACACGAGGGC AGCCCGTCTT AACGCCGCCT 1920
GATCAGCTGG TTATCGCTAA CATAGACCAG TCTGATTTTG AAGGGTTCTC GTATGTCAAC 1980
CCCCAGTTTG TGCACCCCAT CTTACAGAGT GCGGTATGA 2019
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 339   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  398
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 399   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  458
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks
Q: 459   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  518
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+
Q: 519   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  578
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+d++ehaff
Q: 579   KRLGCGPEGERDVREHAFF  597
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240
KRLGCGPEGE RDVREHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-ANC-00165
EKS-BOT-00169
EKS-CAE-00131
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-CII-00114
EKS-CIS-00205
EKS-DAR-00460
EKS-DRM-00084
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-ICT-00164
EKS-LAC-00179
EKS-LOA-00168
EKS-MEG-00134
EKS-MOD-00168
EKS-MUM-00174
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-OTG-00175
EKS-PAT-00160
EKS-PES-00149
EKS-POA-00171
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-TAG-00197
EKS-TAR-00221
EKS-XIM-00207
Gene Ontology
GO:0005829; C:cytosol
GO:0030425; C:dendrite
GO:0005783; C:endoplasmic reticulum
GO:0005739; C:mitochondrion
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0001750; C:photoreceptor outer segment
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004698; F:calcium-dependent protein kinase C activity
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0008270; F:zinc ion binding
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0002062; P:chondrocyte differentiation
GO:0000188; P:inactivation of MAPK activity
GO:0050930; P:induction of positive chemotaxis
GO:0035556; P:intracellular signal transduction
GO:0008285; P:negative regulation of cell proliferation
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0030593; P:neutrophil chemotaxis
GO:0045766; P:positive regulation of angiogenesis
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0045785; P:positive regulation of cell adhesion
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0050729; P:positive regulation of inflammatory response
GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0001934; P:positive regulation of protein phosphorylation
GO:0006937; P:regulation of muscle contraction
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0090330; P:regulation of platelet aggregation
GO:0002026; P:regulation of the force of heart contraction
GO:0070555; P:response to interleukin-1
KEGG
mcc:718412;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013