EKS-MAM-00298

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00298

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	436.4	7.8E-131	15	288	274

Status

Unreviewed

Ensembl Protein

ENSMMUP00000024306

UniProt Accession

F6X938;

Protein Name

Protein Synonyms/Alias

Gene Name

CHUK

Gene Synonyms/Alias

CHUK; EGK_19974;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000018476	ENSMMUP00000024306	ENSMMUT00000025976

Organism

Macaca mulatta

Functional Description

Protein Length

745

Protein Sequence
(FASTA)

MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH 60

EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ 120

ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKII HKIIDLGYAK DVDQGSLCTS 180

FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK 240

CIFACEEMSG EVRFSSHLPQ PNSLCSLIVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC 300

FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI 360

SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDSKIQLPI 420

VQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTLI SASQQLKAKL 480

EFFHKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHAE 540

IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV 600

LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI WHLLKIACTQ 660

SSARSLVGSS LEGAVTPQTS VWLPPTSAEH DHSLSCVVTP QDGDTSAQMI EENLNCLGHL 720

STIIHEANEE QGNSMMNLDW SWLTE 745

Nucleotide Sequence
(FASTA)

ATGGAGCGGC CCCCGGGGCT GCGGCCGGGC GCGGGCGGGC CCTGGGAGAT GCGGGAGCGG 60

TTGGGCACCG GCGGCTTCGG GAACGTCTGT CTGTACCAGC ATCGGGAACT TGATCTCAAA 120

ATAGCAATTA AGTCTTGTCG CCTAGAGCTA AGTACCAAAA ACAGAGAACG ATGGTGCCAC 180

GAAATCCAGA TTATGAAGAA GTTGAACCAT GCCAACGTTG TAAAGGCCTG TGATGTTCCT 240

GAAGAATTGA ATATTTTGAT TCATGATGTG CCTCTTCTAG CAATGGAATA CTGTTCTGGA 300

GGAGATCTCC GAAAGCTGCT CAACAAACCA GAAAATTGTT GTGGACTTAA AGAAAGCCAG 360

ATACTTTCTT TACTAAGTGA TATAGGGTCT GGGATTCGAT ATTTGCATGA AAACAAAATT 420

ATACATCGAG ATCTAAAACC TGAAAACATA GTTCTTCAGG ACGTTGGTGG AAAGATAATA 480

CATAAAATAA TTGATCTGGG ATATGCCAAA GATGTTGATC AAGGAAGTCT GTGTACATCT 540

TTTGTGGGAA CACTGCAGTA TCTGGCCCCA GAGCTCTTTG AGAATAAGCC TTACACAGCC 600

ACTGTTGATT ATTGGAGCTT TGGGACCATG GTATTTGAAT GTATTGCTGG ATATAGGCCT 660

TTTTTGCATC ATCTGCAGCC ATTTACCTGG CATGAGAAGA TTAAGAAGAA GGATCCAAAG 720

TGTATATTTG CATGTGAAGA GATGTCAGGA GAAGTTCGGT TTAGTAGCCA TTTACCTCAA 780

CCAAATAGCC TTTGTAGTTT AATAGTAGAA CCCATGGAAA ACTGGCTACA GTTGATGTTG 840

AATTGGGACC CTCAGCAGAG AGGAGGACCT GTTGACCTTA CTTTGAAGCA GCCAAGATGT 900

TTTGTACTAA TGGATCACAT TTTGAATTTG AAGATAGTAC ACATCCTAAA TATGACTTCT 960

GCAAAGATAA TTTCTTTTCT GTTACCACCT GATGAAAGTC TTCATTCACT ACAGTCTCGT 1020

ATTGAGCGTG AAACTGGAAT AAATACTGGT TCTCAAGAAC TTCTTTCAGA GACAGGAATT 1080

TCTCTGGATC CTCGGAAACC AGCCTCTCAA TGTGTTCTAG ATGGAGTTAG AGGCTGTGAT 1140

AGCTATATGG TTTATTTGTT TGATAAAAGT AAAACTGTGT ATGAAGGGCC ATTTGCTTCC 1200

AGAAGTTTAT CTGATTGTGT AAATTATATT GTACAGGACA GCAAAATACA GCTTCCAATT 1260

GTACAGCTGC GTAAAGTGTG GGCTGAAGCA GTGCACTATG TGTCTGGACT AAAAGAAGAC 1320

TACAGCAGGC TCTTTCAGGG ACAAAGGGCA GCAATGTTAA GTCTTCTTAG ATATAATGCT 1380

AACTTAACAA AAATGAAGAA CACTTTGATC TCAGCATCAC AACAACTGAA AGCTAAATTG 1440

GAGTTTTTTC ACAAAAGCAT TCAGCTTGAC TTGGAGAGAT ACAGCGAGCA GATGACGTAT 1500

GGGATATCTT CAGAAAAAAT GCTAAAAGCA TGGAAAGAAA TGGAAGAAAA GGCCATCCAC 1560

TATGCTGAGG TTGGTGTCAT TGGATACCTG GAGGATCAGA TTATGTCTTT GCATGCTGAA 1620

ATCATGGAGC TACAGAAGAG CCCCTATGGA AGACGTCAGG GAGACTTGAT GGAATCTCTG 1680

GAACAGCGTG CTATTGATCT ATATAAGCAG TTAAAACACA GACCTTCAGA TCACTCCTAC 1740

AGTGACAGCA CAGAGATGGT GAAAATCATT GTGCACACTG TGCAGAGTCA GGACCGTGTG 1800

CTCAAGGAGC TGTTTGGTCA TTTGAGCAAG TTGTTGGGCT GTAAGCAGAA GATTATTGAT 1860

CTACTCCCTA AGGTGGAAGT GGCCCTCAGT AACATCAAAG AAGCTGATAA TACTGTCATG 1920

TTCATGCAGG GAAAAAGGCA GAAAGAAATA TGGCATCTCC TTAAAATTGC CTGTACACAG 1980

AGTTCTGCCC GGTCCCTTGT AGGATCCAGT CTAGAAGGTG CAGTAACCCC TCAGACGTCA 2040

GTATGGCTGC CCCCGACTTC AGCAGAACAT GATCATTCTC TGTCATGTGT GGTAACTCCT 2100

CAAGATGGGG ATACTTCAGC ACAAATGATA GAAGAAAATT TGAACTGCCT TGGCCATTTA 2160

AGCACTATTA TTCATGAGGC AAATGAGGAA CAGGGCAATA GTATGATGAA TCTTGATTGG 2220

AGTTGGTTAA CAGAATGA 2238

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         We++e+LG+G+fgnv+ +++++ + kia+k+++ e+s+++re++++e+++++klnh+n+v

Q: 15    WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV  74

         ************************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         k++dv+eeln++ +++++l++eyCsgGdlrk+L++pen++GLkes++l++Lsd+ +g+ry

Q: 75    KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY  134

         ************************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         L+enki+hRDlkPenivl+++ +gk i+k++DlG+a+++d++++++s+vGt++YlaPel+

Q: 135   LHENKIIHRDLKPENIVLQDV-GGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF  193

         ********************9.**************************************

S: 181   eqkkytatvDlWsiGvllyeaitGslPflpfegprrlykkitkkpakaiagtekangeve  240

         e+k ytatvD+Ws+G++++e+i+G++Pfl++ +p+++++ki+kk++k+i+++e+++gev+

Q: 194   ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVR  253

         ************************************************************

S: 241   fssslPlsaslssglqeklekllanllevdeekrw  275

         fss+lP+++sl+s+++e +e++l+++l++d+++r+

Q: 254   FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRG  288

         ********************************986

Domain Sequence
(FASTA)

WEMRERLGTG GFGNVCLYQH RELDLKIAIK SCRLELSTKN RERWCHEIQI MKKLNHANVV 60

KACDVPEELN ILIHDVPLLA MEYCSGGDLR KLLNKPENCC GLKESQILSL LSDIGSGIRY 120

LHENKIIHRD LKPENIVLQD VGGKIIHKII DLGYAKDVDQ GSLCTSFVGT LQYLAPELFE 180

NKPYTATVDY WSFGTMVFEC IAGYRPFLHH LQPFTWHEKI KKKDPKCIFA CEEMSGEVRF 240

SSHLPQPNSL CSLIVEPMEN WLQLMLNWDP QQRG 274

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0008384	; F:IkappaB kinase activity
GO:0007252	; P:I-kappaB phosphorylation
GO:0007595	; P:lactation
GO:0060749	; P:mammary gland alveolus development
GO:0033598	; P:mammary gland epithelial cell proliferation
GO:0002011	; P:morphogenesis of an epithelial sheet
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0030316	; P:osteoclast differentiation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade

KEGG

mcc:709511

;

InterPros

IPR022007	; IKKbetaNEMObind.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12179	; IKKbetaNEMObind; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013