EKS-MAM-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	865.0	3.0E-260	80	653	574

Status

Unreviewed

Ensembl Protein

ENSMMUP00000024412

UniProt Accession

F6YMJ8;

Protein Name

Protein Synonyms/Alias

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000018557	ENSMMUP00000023965	ENSMMUT00000025614
ENSMMUG00000018557	ENSMMUP00000024410	ENSMMUT00000026086
ENSMMUG00000018557	ENSMMUP00000024412	ENSMMUT00000026088

Organism

Macaca mulatta

Functional Description

Protein Length

655

Protein Sequence
(FASTA)

MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN 60

DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET 120

ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN 180

YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR 240

SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ 300

KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIGQDQ TLMERDTEGG AAEINCNGVI 360

EVINYTQNSN SETLRHKEDL HNANDCEVQN LNQESSFLSS QNGDSSTSQE TDSCTPIKSE 420

VSDTMVCQSS STIDQSFSEQ HISQLQESIR AEIPCEDEQE QEHNGPLDNK GKSTAGNFLV 480

NPLEPKNAEK LKVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM 540

AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI 600

TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAAECLRH PWLNS 655

Nucleotide Sequence
(FASTA)

ATGGAGCGGA AAGTGCTTGC GCTCCAGGCC CGAAAGAAAA GGACCAAGGC CAAGAAGGAC 60

AAAGCCCAAA GGAAATCTGA AACTCAGCAC CGAGGCTCTG CTCCCCACTC TGAGAGTGAT 120

CTACCAGAGC AAGAAGAGGA GATTCTGGGA TCTGATGATG ATGAGCAGGA AGATCCTAAT 180

GATTATTGTA AAGGAGGTTA TCATCTTGTG AAAATTGGAG ATCTATTCAA TGGGAGATAT 240

CATGTGATCC GAAAGTTAGG CTGGGGACAC TTTTCAACAG TATGGTTATC ATGGGATATT 300

CAGGGGAAGA AATTTGTGGC AATGAAAGTA GTTAAAAGTG CTGAACATTA CACCGAAACA 360

GCACTCGATG AAATCCGGTT GCTGAAGTCA GTTCGCAATT CAGACCCTAA TGATCCAAAC 420

AGAGAGATGG TTGTTCAACT ACTAGATGAC TTTAAAATAT CAGGAGTTAA TGGAACACAT 480

ATCTGCATGG TATTTGAAGT TTTGGGGCAC CATCTGCTCA AGTGGATCAT CAAGTCCAAT 540

TATCAGGGGC TTCCACTGCC TTGTGTCAAA AAAATTATTC AGCAAGTGTT ACAGGGTCTT 600

GATTACTTAC ATACCAAGTG CCGTATCATC CACACTGACA TTAAACCAGA GAACATCTTA 660

TTGTCAGTGA ATGAGCAGTA CATTCGGAGG CTGGCTGCAG AAGCAACAGA ATGGCAGCGA 720

TCTGGAGCTC CTCCGCCTTC CGGATCTGCA GTCAGTACTG CTCCCCAACC TAAACCAGCT 780

GACAAAATGT CAAAGAATAA GAAGAAGAAA TTGAAGAAGA AGCAGAAGCG CCAGGCAGAA 840

TTACTAGAGA AGCGAATGCA GGAAATTGAG GAAATGGAGA AAGAGTCGGG CCCTGGGCAA 900

AAAAGACCAA ACAAGCAAGA AGAATCAGAG AGTCCTGTTG AAAGACCCTT GAAAGAGAAC 960

CCACCTAATA AAATGACCCA AGAAAAACTT GAAGAGTCAA GTACCATTGG CCAGGATCAA 1020

ACACTTATGG AACGTGATAC AGAGGGTGGT GCAGCAGAAA TTAATTGCAA TGGAGTGATT 1080

GAAGTCATTA ATTATACTCA GAACAGTAAT AGTGAAACAT TGAGACATAA AGAGGATCTA 1140

CATAATGCTA ATGACTGTGA GGTCCAAAAT TTGAATCAGG AATCTAGTTT CCTAAGCTCC 1200

CAAAATGGAG ACAGCAGCAC ATCTCAAGAA ACAGACTCTT GTACACCTAT AAAATCTGAG 1260

GTGTCAGACA CCATGGTGTG CCAGTCTTCC TCAACTATAG ATCAGTCATT CAGTGAACAA 1320

CACATTAGCC AACTTCAAGA AAGCATTCGG GCAGAGATAC CCTGTGAAGA TGAACAAGAG 1380

CAAGAACATA ATGGACCACT GGACAATAAA GGAAAATCCA CGGCTGGAAA TTTTCTTGTT 1440

AATCCCCTTG AGCCAAAAAA TGCAGAAAAG CTCAAGGTGA AGATTGCTGA TCTTGGAAAT 1500

GCTTGTTGGG TGCACAAACA TTTCACTGAA GATATTCAAA CAAGGCAGTA TCGTTCCTTG 1560

GAAGTTCTGA TAGGATCTGG CTATAATACC CCTGCTGACA TTTGGAGCAC AGCATGCATG 1620

GCCTTTGAAC TGGCCACAGG TGACTATTTG TTTGAACCTC ATTCAGGGGA AGAGTACACT 1680

CGAGATGAAG ATCACATTGC ATTGATCATA GAACTTCTGG GGAAGGTGCC TCGCAAGCTC 1740

ATTGTGGCAG GAAAATATTC CAAGGAATTT TTCACCAAAA AAGGTGACCT TAAACATATC 1800

ACGAAGCTGA AACCTTGGGG CCTTTTTGAG GTTCTAGTGG AGAAGTATGA GTGGTCTCAG 1860

GAAGAGGCAG CTGGCTTCAC AGATTTCTTA CTGCCCATGT TGGAGCTGAT CCCCGAGAAG 1920

AGAGCCACTG CCGCCGAGTG TCTTCGGCAC CCTTGGCTTA ACTCCTAA 1968

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWL+wd+q+k+fva+kvvksaehytetaldei+llksvr+sdp+dp

Q: 80    YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDP  139

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         +re+vvqllddfkisGvnG+h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 140   NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG  199

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+++yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 200   LDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  259

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 260   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkesgpgqkrpnkqeesespverplke  319

         ************************************************************

S: 215   ..........aaeanseaedqelkedaekgeleeieadveeevanedeaseeee......  258

                   ++e++++ +dq+l+e++++g+++ei+++ ++ev+n++++s++e+

Q: 320   nppnkmtqekLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNSETlrhked  379

         *********9999************************************99999999999

S: 259   ..............essltsssdaesksgelseastellsesleqlacgsvls.......  297

                       ess++ss++ +s+++++++++t++ se++++++c+s+++

Q: 380   lhnandcevqnlnqESSFLSSQNGDSSTSQETDSCTPIKSEVSDTMVCQSSSTidqsfse  439

         99999999999999************************************9999******

S: 298   ........................................vnplepknadkikvkiadLG  317

                                                 vnplepkna+k+kvkiadLG

Q: 440   qhisqlqesiraeipcedeqeqehngpldnkgkstagnflVNPLEPKNAEKLKVKIADLG  499

         ************************************************************

S: 318   naCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfephsgedy  377

         naCwvhkhftediqtrqyrslevliG+gy+tpadiWstaC+afeLatGdyLfephsge+y

Q: 500   NACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEY  559

         ************************************************************

S: 378   srdedhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLlevLvekyews  437

         +rdedhia iiellGk+Prkli++Gkys+eff+kkg+L+hitkLkpw+L+evLvekyews

Q: 560   TRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWS  619

         ************************************************************

S: 438   keeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         +eeaa f+dfLlPmlel+pekra+aaecl+hpwL

Q: 620   QEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL  653

         *********************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLSWD IQGKKFVAMK VVKSAEHYTE TALDEIRLLK SVRNSDPNDP 60

NREMVVQLLD DFKISGVNGT HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIQQVLQG 120

LDYLHTKCRI IHTDIKPENI LLSVNEQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKESGPG QKRPNKQEES ESPVERPLKE 240

NPPNKMTQEK LEESSTIGQD QTLMERDTEG GAAEINCNGV IEVINYTQNS NSETLRHKED 300

LHNANDCEVQ NLNQESSFLS SQNGDSSTSQ ETDSCTPIKS EVSDTMVCQS SSTIDQSFSE 360

QHISQLQESI RAEIPCEDEQ EQEHNGPLDN KGKSTAGNFL VNPLEPKNAE KLKVKIADLG 420

NACWVHKHFT EDIQTRQYRS LEVLIGSGYN TPADIWSTAC MAFELATGDY LFEPHSGEEY 480

TRDEDHIALI IELLGKVPRK LIVAGKYSKE FFTKKGDLKH ITKLKPWGLF EVLVEKYEWS 540

QEEAAGFTDF LLPMLELIPE KRATAAECLR HPWL 574

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013