EKS-MAM-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	348.8	3.8E-104	865	1137	273

Status

Unreviewed

Ensembl Protein

ENSMMUP00000024423

UniProt Accession

F6YLX1;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1; EGK_00847;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000018566	ENSMMUP00000024423	ENSMMUT00000026100

Organism

Macaca mulatta

Functional Description

Protein Length

1144

Protein Sequence
(FASTA)

MAFCAKMRSS KKTEVNLEVP EPGVEVIFYM SDREPLRLGS GEYTAEELCI RAAQACRISP 60

LCHNLFALYD ENTKLWYAPN RTITVDDKMS LRLHYRMRFY FTNWHGTNDN EQSVWRHSPK 120

KQKNGYEKKK VPDATPLLDA SSLEYLFAQG QYDLVKCLAP IRDPKTEQDG HDIENECLGM 180

AVLAISHYAM MKKMQLPELP KDISYKRYIP ETLNKSIRQR NLLTRMRINN VFKDFLKEFN 240

NKTICDSSVS THDLKVKYLA TLETLTKHYG AEIFETSMLL ISSENEMNWF HSNDSGNVLY 300

YEVMVTGNLG IQWRHKPNVV SVEKEKNKLK RKKLENKHKK DEEKNKIREE WNNFSYFPEI 360

THIVIKESVV SINKQDNKKM ELKLSSHEEA LSFVSLVDGY FRLTADAHHY LCTDVAPPLI 420

VHNIQNGCHG PICTEYAINK LRQEGSEEGM YVLRWSCTDF DNILMTVTCF EKSEQGQGAQ 480

KQFKNFQIEV QKGRYSLHGS DRSFPSLGDL MSHLKKQILR TDNISFMLKR CCQPKPREIS 540

NLLVATKKAQ EWQPVYPMSQ LSFDRIFKKD LVQGEHLGRG TRTHIYSGTL MDYKDDEGTS 600

EEKKIKVILK VLDPSHRDIS LASAFFEAAS MMRQVSHKHI VYLYGVCVRD VENIMVEEFV 660

EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS ALSYLEDKDL VHGNVCTKNL LLAREGIDSE 720

CGPFIKLSDP GIPITVLSRQ ECIERIPWIA PECVEDSKNL SVAADKWSFG TTLWEICYNG 780

EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA IMRDINKLEE 840

QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN TGEQVAVKSL 900

KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN GIKLIMEFLP SGSLKEYLPK 960

NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG DFGLTKAIET 1020

DKEYYTVKDD RDSPVFWYAP ECLMQSKFYI ASDVWSFGVT LHELLTYCDS DSSPMALFLK 1080

MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT SFQNLIEGFE 1140

ALLK 1144

Nucleotide Sequence
(FASTA)

ATGGCTTTCT GTGCTAAAAT GAGGAGCTCC AAGAAGACTG AGGTGAACCT GGAGGTCCCT 60

GAGCCAGGGG TGGAAGTGAT CTTCTATATG TCGGACAGGG AGCCCCTCCG GCTGGGCAGT 120

GGAGAGTATA CAGCAGAGGA ACTGTGCATC AGGGCTGCAC AGGCATGCCG TATCTCTCCT 180

CTTTGTCACA ACCTCTTTGC CCTGTATGAT GAGAACACCA AGCTCTGGTA TGCTCCAAAT 240

CGCACTATCA CCGTTGATGA CAAGATGTCC CTCCGACTCC ACTACCGGAT GAGGTTCTAT 300

TTCACCAATT GGCACGGAAC CAACGACAAT GAGCAGTCAG TGTGGCGTCA TTCTCCAAAG 360

AAGCAGAAAA ATGGCTACGA GAAAAAAAAG GTTCCAGATG CAACCCCTCT CCTTGATGCC 420

AGCTCACTGG AGTATCTGTT TGCTCAGGGA CAGTATGATT TGGTGAAATG CCTGGCTCCC 480

ATTCGAGACC CCAAGACCGA GCAGGATGGG CATGATATTG AAAACGAGTG TCTGGGGATG 540

GCTGTCCTGG CCATCTCACA CTATGCCATG ATGAAGAAGA TGCAGTTGCC AGAACTGCCC 600

AAGGACATCA GCTACAAGCG ATATATTCCA GAAACATTGA ATAAGTCCAT CAGACAGAGG 660

AACCTTCTCA CCAGGATGCG GATAAATAAT GTTTTCAAGG ATTTCCTAAA GGAATTTAAC 720

AACAAGACCA TTTGTGACAG CAGCGTGTCC ACGCATGACC TGAAGGTGAA ATACTTGGCT 780

ACCTTGGAAA CTTTGACAAA ACATTATGGC GCTGAAATAT TTGAGACTTC CATGTTGCTG 840

ATTTCATCAG AAAATGAGAT GAATTGGTTT CATTCGAATG ACAGTGGAAA CGTTCTGTAC 900

TATGAAGTGA TGGTGACTGG GAATCTTGGA ATCCAGTGGA GGCATAAACC AAATGTTGTT 960

TCTGTTGAAA AGGAAAAAAA TAAACTGAAG CGGAAAAAAC TGGAAAATAA ACACAAGAAG 1020

GATGAGGAGA AAAACAAGAT CCGGGAAGAG TGGAATAATT TTTCTTACTT CCCTGAAATC 1080

ACTCACATTG TAATAAAGGA GTCTGTGGTC AGCATTAACA AGCAGGACAA CAAGAAAATG 1140

GAACTGAAGC TCTCTTCCCA TGAGGAGGCC TTGTCCTTTG TGTCACTGGT AGATGGCTAC 1200

TTCCGGCTCA CCGCAGACGC CCATCATTAC CTCTGCACCG ACGTGGCCCC CCCGTTGATC 1260

GTCCACAACA TACAGAATGG CTGTCATGGT CCAATCTGTA CAGAATATGC CATCAATAAA 1320

TTGCGGCAAG AAGGAAGCGA GGAGGGGATG TACGTGCTGA GGTGGAGCTG CACCGACTTT 1380

GACAACATCC TCATGACCGT CACCTGCTTT GAGAAGTCTG AGCAGGGGCA GGGTGCCCAG 1440

AAGCAGTTCA AGAACTTTCA GATCGAGGTG CAGAAGGGCC GCTACAGCCT GCATGGTTCA 1500

GACCGCAGCT TCCCCAGCTT GGGAGACCTC ATGAGCCACC TCAAGAAGCA GATCCTGCGC 1560

ACGGATAACA TCAGCTTCAT GTTGAAACGC TGCTGCCAGC CCAAGCCCCG AGAAATCTCC 1620

AACCTGCTGG TGGCTACTAA GAAAGCCCAG GAGTGGCAGC CCGTCTACCC CATGAGCCAG 1680

CTGAGTTTTG ATCGGATTTT CAAGAAGGAT CTGGTGCAGG GCGAGCACCT TGGGAGAGGC 1740

ACGAGAACAC ACATCTACTC TGGGACCCTG ATGGATTACA AGGATGACGA AGGAACTTCT 1800

GAAGAGAAGA AGATAAAAGT GATCCTCAAA GTCTTAGACC CCAGCCACAG GGATATTTCC 1860

CTGGCAAGTG CCTTCTTCGA GGCAGCCAGC ATGATGAGAC AGGTCTCCCA CAAACACATC 1920

GTGTACCTCT ATGGCGTCTG TGTCCGCGAC GTGGAGAATA TCATGGTGGA AGAGTTTGTG 1980

GAAGGGGGTC CTCTGGATCT CTTCATGCAC CGGAAAAGCG ATGTCCTTAC TACACCCTGG 2040

AAATTCAAAG TTGCCAAACA GCTTGCCAGT GCCCTGAGCT ACTTGGAAGA TAAAGACCTG 2100

GTCCATGGAA ATGTGTGTAC TAAAAACCTC CTCCTGGCCC GTGAGGGCAT CGACAGCGAG 2160

TGTGGTCCGT TCATCAAGCT CAGTGACCCT GGCATCCCCA TTACGGTGCT GTCTAGGCAA 2220

GAGTGCATTG AACGAATCCC GTGGATTGCT CCCGAGTGTG TTGAGGACTC CAAGAACCTG 2280

AGTGTGGCTG CTGACAAGTG GAGCTTTGGA ACTACGCTCT GGGAAATCTG CTACAATGGC 2340

GAGATCCCCT TGAAAGACAA GACACTGATT GAGAAAGAGA GATTCTATGA AAGCCGGTGC 2400

AGGCCAGTGA CACCATCATG TAAGGAGCTG GCTGACCTCA TGACCCGCTG CATGAACTAC 2460

GACCCCAATC AGAGGCCCTT CTTCCGAGCC ATCATGAGAG ACATTAATAA GCTTGAAGAG 2520

CAGAATCCAG ATATTGTTTC AGAAAAAAAG CCAGCAACTG AAGTGGACCC CACGCATTTT 2580

GAGAAGCGCT TCCTAAAGAG GATCCGTGAC TTGGGAGAGG GCCACTTTGG GAAGGTTGAG 2640

CTCTGCAGGT ATGACCCCGA AGGGGACAAT ACAGGGGAGC AGGTGGCTGT CAAATCTCTG 2700

AAGCCTGAGA GTGGAGGTAA CCACATAGCT GATCTGAAAA AGGAAATCGA GATCTTAAGG 2760

AACCTCTATC ATGAGAACAT TGTGAAGTAC AAAGGAATCT GCACGGAAGA CGGAGGAAAT 2820

GGTATTAAGC TCATCATGGA ATTTCTGCCT TCGGGAAGCC TTAAGGAGTA TCTTCCAAAG 2880

AATAAGAACA AAATTAACCT CAAACAGCAG CTAAAATATG CCGTTCAGAT TTGTAAGGGG 2940

ATGGACTATT TGGGTTCTCG GCAATATGTT CACCGTGACT TGGCAGCAAG AAATGTCCTT 3000

GTTGAGAGTG AACACCAAGT GAAAATTGGA GACTTCGGTT TAACCAAAGC AATTGAAACC 3060

GATAAGGAGT ATTACACCGT CAAGGATGAC CGGGACAGCC CTGTGTTTTG GTATGCTCCA 3120

GAATGTTTAA TGCAATCTAA ATTTTATATC GCCTCTGACG TCTGGTCTTT TGGAGTCACT 3180

CTGCATGAGC TGCTGACTTA CTGTGACTCA GATTCTAGTC CCATGGCTTT GTTCCTGAAA 3240

ATGATAGGCC CAACCCATGG CCAGATGACA GTCACAAGAC TTGTGAATAC ATTAAAAGAA 3300

GGAAAACGCC TGCCGTGCCC GCCTAACTGT CCAGATGAGG TTTATCAACT TATGAGGAAA 3360

TGCTGGGAAT TCCAACCATC CAATCGGACA AGCTTTCAGA ACCTTATTGA AGGATTTGAA 3420

GCACTTTTAA AATAA 3435

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 865   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  924

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 925   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  984

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 985   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1038

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++++

Q: 1039  APECLMQSK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLVNT  1097

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+++lm++c++ +ps+r+sF++++e

Q: 1098  LKEGKRLPCPPnCPDEVYQLMRKCWEFQPSNRTSFQNLIE  1137

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLM 180

QSKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPNCPDEV YQLMRKCWEF QPSNRTSFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013