EKS-MAM-00392

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00392

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	310.5	2.0E-92	392	617	226

Status

Unreviewed

Ensembl Protein

ENSMMUP00000024425

UniProt Accession

F6YLW2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K2

Gene Synonyms/Alias

MAP3K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000018568	ENSMMUP00000024425	ENSMMUT00000026102

Organism

Macaca mulatta

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

LDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKSSSPKK QNDVRVKFEH RGEKRILQFP 60

RPVKLEDLRS KAKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV 120

INGSTQATNL EPLPSLEDLD NTVFGAERKK RLSIIGPTSR DRSSPPPGYI PDELHQVARN 180

GSFTSINSEG EFIPESMDQM LDPLSLSSPE NSGSGSCPSL DSPLDGESYP KSRMPRAQSY 240

PDNHQEFSDY DNPIFEKFGK GGTYPRRYHV SYHHQEYNDG RKTFPRARRT QGTSFRSPVS 300

FSPTDHSLST SSGSSIFTPE YDDSRIRRRG SDIDNPTLTV MDISPPSRCN EFLGSDELLK 360

KVGMSGISMV SLLITLDNSL EFFAFTDIVE DLTMNSLFQE VNALECEIQL LKNLLHERIV 420

QYYGCLRDPQ EKTLSIFMEY MPGGSIKDQL KAYGALTENV TRKYTRQILE GVHYLHSNMI 480

VHRDIKGANI LRDSTGNVKL GDFGASKRLQ TICLSGTGMK SVTGTPYWMS PEVISGEGYG 540

RKADIWSVAC TVVEMLTEKP PWAEFEAMAA IFKIATQPTN PKLPPHVSDY TRDFLKRIFV 600

EAKLRPSADE LLRHMFVHYH 620

Nucleotide Sequence
(FASTA)

CTAGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 60

AGTCGACCAG CATTATCCTT GCAGGAAACC AGGAAAGCAA AATCTTCATC ACCAAAAAAA 120

CAGAATGATG TCCGAGTCAA ATTTGAACAT AGGGGAGAAA AAAGAATCCT TCAGTTCCCC 180

AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 240

GATCTACATT ATACCAATAA TGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 300

AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 360

ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 420

AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTTTCTA TAATAGGTCC TACTAGTAGA 480

GATAGAAGTT CTCCTCCCCC AGGATACATT CCAGATGAAT TACACCAGGT TGCCCGAAAT 540

GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAATTCATTC CAGAGAGCAT GGACCAAATG 600

CTGGATCCGT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 660

GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC ACAGAGCTAC 720

CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 780

GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 840

CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTCCGGTC TCCTGTGAGT 900

TTCAGTCCTA CTGATCACTC CTTAAGCACC AGTAGTGGAA GCAGTATCTT TACCCCAGAG 960

TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 1020

ATGGACATCA GCCCACCCAG CCGTTGTAAT GAGTTTTTGG GGTCAGATGA ACTACTCAAA 1080

AAAGTTGGAA TGTCAGGTAT AAGCATGGTA TCACTGTTAA TTACCTTAGA TAATTCTTTA 1140

GAATTTTTTG CTTTTACTGA CATTGTTGAA GACTTAACAA TGAATTCTCT CTTTCAGGAA 1200

GTAAACGCAC TTGAATGTGA AATTCAGTTG CTGAAAAACT TGCTGCATGA GCGAATTGTT 1260

CAGTATTATG GCTGTTTGAG GGATCCCCAG GAAAAAACAC TTTCCATATT TATGGAATAT 1320

ATGCCAGGGG GTTCAATTAA GGACCAATTA AAAGCATATG GCGCTCTTAC TGAGAATGTG 1380

ACTAGGAAAT ACACCCGTCA GATTCTGGAG GGTGTCCATT ATTTGCATAG TAATATGATT 1440

GTCCATAGAG ATATCAAAGG GGCAAATATC CTGAGAGATT CAACAGGCAA TGTCAAACTA 1500

GGAGATTTTG GGGCCAGCAA ACGGCTTCAG ACCATCTGTC TCTCAGGGAC AGGAATGAAG 1560

TCTGTCACGG GCACACCATA CTGGATGAGC CCTGAAGTCA TCAGTGGAGA AGGCTATGGA 1620

AGAAAAGCGG ACATCTGGAG CGTTGCATGT ACTGTGGTAG AAATGCTAAC TGAAAAGCCG 1680

CCTTGGGCTG AATTTGAAGC AATGGCTGCC ATCTTTAAAA TTGCCACTCA GCCAACAAAC 1740

CCAAAGCTGC CACCTCATGT CTCAGACTAT ACTCGAGATT TCCTCAAACG GATTTTTGTA 1800

GAGGCCAAAC TGAGACCTTC AGCTGATGAA CTCTTAAGGC ACATGTTTGT GCATTATCAC 1860

TAG 1863

Domain Profile

S: 36    pekksekkevkalkeEikllkelkHenivkyyGv..eveeeelkiflEyvegGslsslle  93

            +s  +ev+al++Ei+llk+l He+iv+yyG+  + +e++l+if+Ey++gGs++++l+

Q: 392   LTMNSLFQEVNALECEIQLLKNLLHERIVQYYGClrDPQEKTLSIFMEYMPGGSIKDQLK  451

         445555679*************************777899********************

S: 94    kygkleesvikkytkqileglayLHekkivHRDiKgaNilldssgvvklsDFGaskrlae  153

         +yg+l+e+v++kyt+qileg++yLH+++ivHRDiKgaNil ds+g+vkl+DFGaskrl++

Q: 452   AYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQT  511

         ************************************************************

S: 154   lntkaaelesltGtlaymaPEvikkkekgygrkaDiWslgcvviemltgkrPfaeldeel  213

         ++ + + ++s+tGt+++m+PEvi+++  gygrkaDiWs++c+v+emlt+k+P+ae+ e++

Q: 512   ICLSGTGMKSVTGTPYWMSPEVISGE--GYGRKADIWSVACTVVEMLTEKPPWAEF-EAM  568

         ***********************998..****************************.9**

S: 214   aimfkvgakktkPeipeklseegkdflekcleldpkkrpsaeeLLkhefl  263

         a++fk++++ t+P++p ++s+ ++dfl++++ +++k rpsa+eLL+h+f+

Q: 569   AAIFKIATQPTNPKLPPHVSDYTRDFLKRIF-VEAKLRPSADELLRHMFV  617

         *******************************.899*************96

Domain Sequence
(FASTA)

LTMNSLFQEV NALECEIQLL KNLLHERIVQ YYGCLRDPQE KTLSIFMEYM PGGSIKDQLK 60

AYGALTENVT RKYTRQILEG VHYLHSNMIV HRDIKGANIL RDSTGNVKLG DFGASKRLQT 120

ICLSGTGMKS VTGTPYWMSP EVISGEGYGR KADIWSVACT VVEMLTEKPP WAEFEAMAAI 180

FKIATQPTNP KLPPHVSDYT RDFLKRIFVE AKLRPSADEL LRHMFV 226

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666

; PB1; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013