EKS-MAM-00104
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00104
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec481.68.0E-145271521251
StatusUnreviewed
Ensembl ProteinENSMMUP00000024503
UniProt AccessionF7ADL9;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000018627ENSMMUP00000024503ENSMMUT00000026181
OrganismMacaca mulatta
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MTCFSDNTIQ SVFCCCCCCS VQKRQVRTQI SLSPDEELPE KHTQHRRPWL SQLSNKKQSN 60
TGCVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW 120
KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA ERLLRQESKE GAFIVRDSRH 180
LGSYTISVFI GARRSTEAAI KHYQIKKNDS GQWYVTERHV FQSVPELIWY HQHNAAGLMT 240
RLRYPVGLMG SCLPATAGFS YEKWEIDPSE LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA 300
INEGSMSEED FIEEAKVMMK LSHSKLVQLY GVCTQWKPLY IVTEFMENGC LLNYLRENKG 360
KLRKEMLLSV CQDICEGMEY LERNGYIHRD LAARNCLVSS TCTVKISDFG MTRYVLDDEY 420
VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS 480
EGFRLYRPHL APMSIYEVMY SCWHEKPKGR PTFAELLRAL TELAETW 527
Nucleotide Sequence
(FASTA)
ATGACCTGCT TTTCAGATAA CACCATCCAG TCGGTTTTCT GTTGCTGCTG TTGCTGTTCA 60
GTGCAGAAGC GACAAGTGAG AACACAGATA AGCCTGAGCC CAGATGAAGA GCTTCCAGAA 120
AAACACACCC AGCATCGCAG GCCATGGCTC AGTCAATTGT CAAATAAGAA GCAATCCAAC 180
ACGGGCTGTG TGCAGCCGTC AAAACGAAAG CCACTGCCTC CCCTCCCACC CTCTGAGGTT 240
GCTGAAGAGA AGATTCAAGT CAAGGCACTT TATGATTTTC TGCCCAGAGA ACCCTGTAAT 300
TTAGCCTTAA GGAGAGCAGA AGAATACCTG ATACTGGAGA AATATAATCC TCATTGGTGG 360
AAGGCAAGAG ACCGTTTGGG GAATGAAGGC TTAATCCCAA GCAACTATGT GACTGAAAAC 420
AAAATAACTA ATTTAGAAAT ATATGAGTGG TACCATAGAA ACATTACCAG AAATCAGGCA 480
GAACGTCTGT TGAGACAAGA GTCTAAAGAA GGTGCATTTA TTGTCAGAGA TTCAAGACAT 540
TTAGGATCCT ACACAATTTC CGTATTTATA GGAGCTAGAA GAAGTACAGA GGCTGCCATA 600
AAACATTATC AGATAAAAAA GAATGACTCA GGACAGTGGT ATGTGACTGA AAGACACGTC 660
TTTCAATCAG TCCCCGAGTT AATCTGGTAT CACCAGCACA ATGCGGCCGG TCTCATGACC 720
CGTCTCCGAT ATCCAGTTGG GCTGATGGGC AGTTGTTTAC CAGCCACAGC TGGGTTTAGC 780
TACGAAAAGT GGGAGATAGA TCCATCTGAG TTGGCTTTTA TAAAGGAGAT TGGAAGTGGT 840
CAATTTGGAG TGGTCCATTT AGGTGAATGG CGGTCACATA TCCAGGTAGC TATCAAGGCC 900
ATCAATGAAG GCTCCATGTC TGAAGAGGAT TTCATTGAAG AGGCCAAAGT GATGATGAAA 960
TTATCTCATT CAAAGCTAGT GCAACTTTAT GGGGTCTGTA CACAGTGGAA GCCCCTTTAC 1020
ATTGTGACAG AGTTCATGGA AAATGGCTGC CTGCTTAACT ATCTCAGGGA GAATAAAGGA 1080
AAGCTTAGAA AGGAAATGCT ACTGAGTGTA TGCCAGGATA TATGTGAAGG AATGGAATAT 1140
CTGGAGAGGA ATGGCTATAT TCATAGGGAT TTGGCGGCAA GGAATTGTTT GGTCAGTTCA 1200
ACATGCACAG TAAAAATTTC GGACTTTGGA ATGACAAGGT ATGTTTTGGA TGATGAGTAT 1260
GTCAGTTCTT TTGGAGCCAA GTTCCCAATC AAGTGGTCCC CTCCTGAAGT TTTTCTTTTC 1320
AATAAGTACA GCAGTAAATC TGATGTCTGG TCATTTGGAG TTTTAATGTG GGAAGTTTTT 1380
ACAGAAGGAA AAATGCCTTT TGAAAATAAG TCAAATTTGC AAGTCGTGGA AGCTATTTCT 1440
GAAGGCTTCA GGTTATATCG CCCTCACCTA GCACCAATGT CCATATATGA AGTTATGTAC 1500
AGCTGCTGGC ATGAGAAACC CAAAGGCCGC CCTACGTTTG CAGAGCTGCT GCGGGCTCTC 1560
ACAGAGCTTG CGGAAACCTG GTAA 1584
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         l+++ke+gsgqfgvv+lg+wr++i+vaikai+eg+mseedfieeakvmmklsh+klvqly
Q: 271   LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLY  330
         68**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++ kp+yivte++engcllnylre+k+kl+ke+ll++c+d+cegmeyler+ +ihrd
Q: 331   GVCTQWKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRD  390
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++++vk+sdfg++ryvldd+yvss gakfp+kwsppev+ ++kyssksdvw
Q: 391   LAARNCLVSSTCTVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVW  450
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e+ksn +vve++s+g+rlyrp+la++++yevm+scw+ekp++r
Q: 451   SFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPKGR  510
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+al+
Q: 511   PTFAELLRALT  521
         ********986
Domain Sequence
(FASTA)
LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA INEGSMSEED FIEEAKVMMK LSHSKLVQLY 60
GVCTQWKPLY IVTEFMENGC LLNYLRENKG KLRKEMLLSV CQDICEGMEY LERNGYIHRD 120
LAARNCLVSS TCTVKISDFG MTRYVLDDEY VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW 180
SFGVLMWEVF TEGKMPFENK SNLQVVEAIS EGFRLYRPHL APMSIYEVMY SCWHEKPKGR 240
PTFAELLRAL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013