EKS-MAM-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	383.4	7.3E-115	42	293	252

Status

Unreviewed

Ensembl Protein

ENSMMUP00000024574

UniProt Accession

F6ZYB5;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK4

Gene Synonyms/Alias

MARK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000018672	ENSMMUP00000024575	ENSMMUT00000026254
ENSMMUG00000018672	ENSMMUP00000031570	ENSMMUT00000038469
ENSMMUG00000018672	ENSMMUP00000024573	ENSMMUT00000026252
ENSMMUG00000018672	ENSMMUP00000024574	ENSMMUT00000026253

Organism

Macaca mulatta

Functional Description

Protein Length

545

Protein Sequence
(FASTA)

HGTLGSGRSS DKGPSWSSRS LGARCRNSIA SCPEEQPHVG NYRLLRTIGK GNFAKVKLAR 60

HILTGREVAI KIIDKTQLNP SSLQKLFREV RIMKGLNHPN IVKLFEVIET EKTLYLVMEY 120

ASAGEVFDYL VSHGRMKEKE ARAKFRQIVS AVHYCHQKNI VHRDLKAENL LLDAEANIKI 180

ADFGFSNEFT LGSKLDTFCG SPPYAAPELF QGKKYDGPEV DIWSLGVILY TLVSGSLPFD 240

GHNLKELRER VLRGKYRVPF YMSTDCESIL RRFLVLNPAK RCTLEQIMKD KWINIGYEGE 300

ELKPYTEPEE DFGDTKRIEV MVGMGYTREE IKEALTSQKY NEVTATYLLL GRKTEEGGDR 360

GAPGLALARV RAPSDTTNGT SSSKGTSHSK GQRSSSSTYH RQRRHSDFCG PSPAPLHPKR 420

SPTSTGEAEL KEERLPGRKA SCSAAGSGSR GLPPSSPMVS SAHNPNKAEI PERRKDSTST 480

PNNLPPSMMT RRNTYVCTER PGAERPSLLP NGKENSSGTP RVPPASPSSH SLAPPSGERS 540

RLARG 545

Nucleotide Sequence
(FASTA)

CATGGCACCT TGGGCAGTGG CCGCTCCTCG GACAAAGGCC CGTCCTGGTC CAGCCGCTCA 60

CTGGGTGCCC GTTGCCGGAA CTCCATCGCC TCCTGTCCCG AGGAGCAGCC CCATGTGGGC 120

AACTACCGCC TGCTGAGGAC CATCGGGAAG GGCAACTTTG CCAAAGTCAA GCTGGCTCGG 180

CACATCCTCA CTGGTCGGGA GGTTGCCATC AAGATCATCG ACAAAACCCA GCTGAATCCC 240

AGCAGCCTGC AGAAGCTGTT CCGAGAAGTC CGCATCATGA AGGGCCTAAA CCACCCCAAC 300

ATCGTGAAGC TCTTCGAGGT GATTGAGACT GAGAAGACGC TGTACCTGGT GATGGAGTAT 360

GCAAGTGCCG GAGAAGTGTT TGACTACCTC GTGTCGCATG GCCGCATGAA GGAGAAGGAA 420

GCTCGAGCCA AGTTCCGACA GATCGTTTCG GCTGTGCACT ATTGTCACCA GAAAAACATT 480

GTACACAGGG ACCTGAAGGC TGAGAACCTC TTGCTGGACG CCGAGGCCAA CATCAAGATC 540

GCTGACTTTG GCTTCAGCAA CGAGTTCACG CTGGGCTCAA AGCTGGACAC GTTCTGTGGG 600

AGCCCCCCAT ACGCTGCCCC GGAGCTGTTT CAGGGCAAGA AGTACGACGG GCCGGAGGTG 660

GACATCTGGA GCCTGGGAGT CATCCTGTAC ACCCTCGTCA GCGGCTCCCT GCCCTTCGAC 720

GGGCACAACC TCAAGGAGCT GCGGGAGCGA GTCCTCAGAG GGAAGTACCG GGTCCCTTTC 780

TACATGTCAA CAGACTGTGA GAGCATCCTG CGGAGATTTT TGGTGCTGAA CCCAGCTAAA 840

CGCTGTACTC TCGAGCAAAT CATGAAAGAC AAATGGATCA ACATCGGCTA TGAGGGTGAG 900

GAATTGAAGC CATACACAGA GCCCGAGGAG GACTTCGGGG ACACCAAGAG AATTGAGGTG 960

ATGGTGGGTA TGGGCTACAC GCGGGAAGAA ATCAAAGAGG CCTTGACCAG CCAGAAGTAC 1020

AACGAAGTGA CCGCCACCTA CCTCCTGCTG GGCAGGAAGA CTGAGGAGGG TGGGGACCGG 1080

GGCGCCCCAG GGCTGGCCCT GGCACGGGTG CGGGCGCCCA GCGACACCAC CAATGGAACA 1140

AGTTCCAGCA AAGGCACCAG CCACAGCAAA GGGCAACGGA GTTCCTCTTC CACCTACCAC 1200

CGTCAGCGCA GGCATAGCGA TTTCTGTGGC CCATCCCCTG CACCCCTGCA CCCCAAACGC 1260

AGCCCGACGA GCACGGGGGA AGCAGAGCTG AAGGAGGAGC GGCTGCCAGG CCGGAAGGCG 1320

AGCTGCAGTG CCGCGGGGAG CGGGAGTCGA GGGCTGCCCC CCTCCAGCCC CATGGTCAGC 1380

AGCGCCCACA ACCCCAACAA GGCAGAGATC CCAGAGCGGC GGAAGGACAG CACAAGCACC 1440

CCCAACAACC TCCCTCCCAG CATGATGACC CGCAGAAACA CCTACGTTTG CACAGAACGC 1500

CCGGGGGCTG AGCGCCCGTC ACTGTTGCCA AATGGGAAAG AAAACAGCTC AGGCACCCCA 1560

CGGGTGCCCC CTGCCTCCCC CTCCAGTCAC AGCCTGGCAC CCCCATCAGG GGAGCGGAGC 1620

CGCCTGGCAC GCGGC 1635

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+ll+t+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k l+hpni

Q: 42    YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI  101

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyas ge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 102   VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV  161

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld++ nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 162   HRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  221

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGv+Ly+lv+g+lPfd++nlkel+e++l+gk+++p+++s+++es+lr++Lv +p+kR

Q: 222   IWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKR  281

         ************************************************************

S: 241   atieeilkhewl  252

         +t+e+i+k++w+

Q: 282   CTLEQIMKDKWI  293

         ***********7

Domain Sequence
(FASTA)

YRLLRTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPS SLQKLFREVR IMKGLNHPNI 60

VKLFEVIETE KTLYLVMEYA SAGEVFDYLV SHGRMKEKEA RAKFRQIVSA VHYCHQKNIV 120

HRDLKAENLL LDAEANIKIA DFGFSNEFTL GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

IWSLGVILYT LVSGSLPFDG HNLKELRERV LRGKYRVPFY MSTDCESILR RFLVLNPAKR 240

CTLEQIMKDK WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000930	; C:gamma-tubulin complex
GO:0005874	; C:microtubule
GO:0043005	; C:neuron projection
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050321	; F:tau-protein kinase activity
GO:0001578	; P:microtubule bundle formation
GO:0007399	; P:nervous system development
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.
PF00627	; UBA; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013