EKS-MAM-00466

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00466

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	375.1	3.8E-112	129	415	287

Status

Unreviewed

Ensembl Protein

ENSMMUP00000024630

UniProt Accession

G7NGI5;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase NLK;

Gene Name

NLK

Gene Synonyms/Alias

NLK; EGK_08311;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000018719	ENSMMUP00000024630	ENSMMUT00000026312

Organism

Macaca mulatta

Functional Description

Protein Length

497

Protein Sequence
(FASTA)

MAAYNGGTSA AAAGHHHHHH HHLPHLPPPH LHHHHHPQHH LHPGSAAAVH PVQQHTSSAA 60

AAAAAAAAAA AMLNPGQQQP YFPSPAPGQA PGPAAAAPAQ VQAAAAATVK AHHHQHSHHP 120

QQQLDIEPDR PIGYGAFGVV WSVTDPRDGK RVALKKMPNV FQNLVSCKRV FRELKMLCFF 180

KHDNVLSALD ILQPPHIDYF EEIYVVTELM QSDLHKIIVS PQPLSSDHVK VFLYQILRGL 240

KYLHSAGILH RDIKPGNLLV NSNCVLKICD FGLARVEELD ESRHMTQEVV TQYYRAPEIL 300

MGSRHYSNAI DIWSVGCIFA ELLGRRILFQ AQSPIQQLDL ITDLLGTPSL EAMRTACEGA 360

KAHILRGPHK QPSLPVLYTL SSQATHEAVH LLCRMLVFDP SKRISAKDAL AHPYLDEGRL 420

RYHTCMCKCC FSTSTGRVYT SDFEPVTNPK FDDTFEKNLS SVRQVKEIIH QFILEQQKGN 480

RVPLCINPQS AAFKSFI 497

Nucleotide Sequence
(FASTA)

ATGGCGGCTT ACAATGGCGG TACATCTGCA GCAGCAGCAG GTCACCACCA CCACCATCAC 60

CACCACCTTC CACACCTCCC TCCTCCTCAC CTGCACCACC ACCACCACCC TCAACACCAT 120

CTTCATCCGG GGTCGGCTGC CGCTGTACAC CCTGTACAGC AGCACACCTC TTCGGCAGCT 180

GCGGCAGCCG CAGCAGCGGC TGCAGCTGCA GCCATGTTAA ACCCTGGGCA ACAACAGCCA 240

TATTTCCCAT CACCGGCACC GGGGCAGGCT CCTGGACCAG CTGCAGCAGC CCCAGCTCAG 300

GTACAGGCTG CCGCAGCTGC TACAGTTAAG GCGCACCATC ATCAGCACTC GCATCATCCA 360

CAACAGCAGC TGGATATTGA GCCGGATAGA CCTATTGGAT ATGGAGCCTT TGGTGTTGTC 420

TGGTCAGTAA CAGATCCAAG AGATGGAAAG AGAGTAGCAC TCAAAAAGAT GCCCAACGTC 480

TTCCAGAATC TGGTCTCTTG CAAAAGGGTC TTCCGGGAAT TGAAGATGTT GTGTTTTTTT 540

AAGCATGATA ATGTACTCTC TGCCCTTGAC ATACTCCAAC CTCCACACAT TGACTATTTT 600

GAAGAAATAT ATGTTGTCAC AGAATTGATG CAGAGTGACC TACATAAAAT TATCGTCTCT 660

CCTCAACCAC TCAGCTCAGA TCATGTCAAA GTTTTTCTTT ATCAGATTTT GCGAGGTTTG 720

AAATATCTCC ATTCAGCTGG CATTTTACAT CGAGACATTA AGCCAGGGAA TCTCCTTGTG 780

AACAGCAACT GTGTTCTAAA GATTTGTGAT TTTGGATTGG CCAGAGTGGA AGAATTAGAT 840

GAATCCCGTC ATATGACTCA GGAAGTTGTT ACTCAGTATT ACCGGGCTCC GGAAATCCTG 900

ATGGGCAGCC GTCATTACAG CAATGCTATT GACATCTGGT CTGTGGGATG TATCTTTGCA 960

GAACTACTAG GACGAAGAAT ATTGTTTCAG GCACAGAGTC CCATTCAGCA GTTGGATTTG 1020

ATCACGGATC TGTTGGGCAC ACCATCACTG GAAGCAATGA GGACAGCTTG TGAAGGCGCT 1080

AAGGCACATA TACTCAGGGG TCCTCATAAA CAGCCATCTC TTCCTGTACT CTATACCCTG 1140

TCTAGCCAGG CTACACATGA AGCTGTTCAT CTCCTTTGCA GGATGTTGGT CTTTGATCCA 1200

TCCAAAAGAA TATCCGCTAA GGATGCCTTA GCCCACCCCT ACCTAGATGA AGGGCGACTA 1260

CGATATCACA CATGTATGTG TAAATGTTGC TTTTCCACCT CTACTGGAAG AGTTTATACC 1320

AGTGACTTTG AGCCTGTTAC CAATCCCAAA TTTGATGACA CTTTTGAGAA GAACCTCAGT 1380

TCTGTCCGAC AGGTTAAAGA AATTATTCAT CAGTTCATTT TGGAACAGCA GAAAGGAAAC 1440

AGAGTGCCTC TCTGCATCAA CCCTCAGTCT GCTGCTTTTA AGAGCTTTAT T 1491

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 129   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  188

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 189   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  247

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 248   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  307

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 308   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  366

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 367   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  415

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004707	; F:MAP kinase activity
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0033136	; P:serine phosphorylation of STAT3 protein
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013