EKS-MAM-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC196.89.0E-58252431180
StatusUnreviewed
Ensembl ProteinENSMMUP00000024882
UniProt AccessionF6ZZK4;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCZ
Gene Synonyms/Alias PRKCZ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000018911ENSMMUP00000040668ENSMMUT00000047645
ENSMMUG00000018911ENSMMUP00000024882ENSMMUT00000026588
OrganismMacaca mulatta
Functional Description
Protein Length592
Protein Sequence
(FASTA)
MPSRTSPKMD GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL HQQHPLTLKW 60
VDSEGDPCTV SSQMELEEAF RLARQRRDEG LIIHVFPSTP EQPGLPCPGE DKSIYRRGAR 120
RWRKLYRANG HLFQAKRFNR RAYCGQCSER IWGLARQGYR CINCKLLVHK RCHGLVPLTC 180
RKHMDSVMPS QEPPVDDKNE DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG 240
IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEVESWPRAA 300
SHVSFRVADT HVCLPGLEHC VKGCVWLPLR IPGEGGGSGE KGRQRGRGSP PRRAGFYAAE 360
ICIALNFLHE RGIIYRDLKL DNVLLDADGH IKLTDYGMCK EGLGPGDTTS TFCGTPNYIA 420
PEILRGEEYG ECRGRPLSEH TGPETASRLA QRRGRGFADH LPPKSHTLFR SRMSSSGLSP 480
FFEFLKTSHF LGSFLSVSFC DSSACGQSGR DDARAELTLL ALFSKLEKKQ ALPPFQPQIT 540
DNYGLDNFDT QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV 592
Nucleotide Sequence
(FASTA)
ATGCCCAGCA GGACCAGCCC CAAGATGGAC GGGAGCGGCG GCCGCGTCCG CCTCAAGGCG 60
CATTACGGAG GGGACATCTT CATCACCAGC GTGGACGCCG CCACAACCTT CGAGGAGCTC 120
TGCGAGGAAG TGAGAGACAT GTGCCGTCTG CACCAGCAGC ACCCGCTCAC CCTCAAGTGG 180
GTGGACAGCG AAGGTGACCC TTGCACGGTG TCCTCCCAGA TGGAGCTGGA AGAGGCTTTC 240
CGCCTGGCCC GTCAGCGCAG GGACGAAGGC CTCATCATTC ATGTTTTCCC GAGCACCCCT 300
GAGCAGCCAG GACTGCCGTG TCCAGGAGAA GACAAATCCA TCTACCGCCG GGGAGCCAGA 360
AGATGGAGGA AGCTGTACCG TGCCAACGGC CATCTCTTCC AAGCCAAGCG CTTTAACAGG 420
AGAGCGTACT GCGGTCAGTG CAGCGAGAGG ATATGGGGCC TCGCGAGGCA AGGCTACAGG 480
TGCATCAACT GCAAACTGCT GGTCCATAAG CGCTGCCACG GCCTCGTCCC GCTGACCTGC 540
AGGAAGCATA TGGATTCTGT CATGCCTTCC CAAGAGCCTC CAGTAGATGA CAAGAACGAG 600
GACGCCGACC TTCCTTCCGA GGAGACAGAT GGAATTGCTT ACATTTCCTC ATCCCGGAAA 660
CATGACAGCA TTAAAGACGA CTCTGAGGAC CTTAAGCCAG TTATCGATGG GATGGATGGA 720
ATCAAAATCT CTCAGGGGCT CGGGCTGCAG GACTTCGACC TAATCAGAGT CATAGGGCGC 780
GGGAGCTACG CCAAGGTTCT CCTGGTGCGG TTGAAGAAGA ATGACCAAAT TTACGCCATG 840
AAAGTGGTGA AGAAAGAGCT GGTGCATGAC GACGAGGTAG AGTCCTGGCC TCGGGCTGCC 900
TCCCACGTGT CCTTTCGTGT TGCGGACACC CATGTTTGCC TTCCAGGGCT CGAACACTGT 960
GTGAAGGGAT GCGTGTGGCT GCCACTTCGC ATTCCTGGAG AGGGTGGGGG GAGTGGCGAG 1020
AAGGGGCGGC AGCGAGGACG GGGCTCACCT CCTAGGAGGG CAGGGTTCTA CGCGGCCGAG 1080
ATCTGCATCG CCCTCAACTT CCTACACGAG AGGGGGATCA TCTACCGGGA CCTGAAGCTG 1140
GACAACGTCC TCCTGGACGC GGACGGGCAC ATCAAGCTCA CAGACTACGG CATGTGCAAG 1200
GAAGGCCTGG GCCCTGGCGA CACAACAAGC ACTTTCTGCG GAACCCCGAA CTACATCGCC 1260
CCCGAAATCC TGCGGGGTGA AGAGTACGGT GAGTGCCGCG GCCGTCCCCT CTCGGAGCAC 1320
ACGGGGCCAG AAACAGCTTC GCGCCTCGCC CAGCGGCGGG GGAGAGGTTT CGCTGACCAT 1380
CTTCCACCCA AAAGCCACAC ACTCTTTCGC AGCCGGATGT CATCATCTGG TCTCAGCCCC 1440
TTCTTTGAAT TCTTGAAAAC CTCCCATTTT CTAGGTTCTT TTCTCAGTGT TTCATTCTGT 1500
GATTCAAGTG CATGCGGACA ATCTGGTAGG GATGATGCCC GCGCGGAGCT GACCCTTCTT 1560
GCCTTGTTTT CCAAGCTGGA GAAGAAGCAG GCGCTCCCTC CATTCCAGCC ACAGATCACG 1620
GACAACTACG GTCTGGACAA CTTTGACACA CAGTTCACCA GCGAGCCCGT GCAGCTGACC 1680
CCAGACGATG AGGATGCCAT AAAGAGGATC GACCAGTCGG AGTTCGAAGG CTTCGAGTAC 1740
ATCAACCCAT TACTGCTGTC CACCGAGGAG TCGGTGTGA 1779
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrv.lalaskk  59
         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+   + ++  +v + +a+ +
Q: 252   FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEVESWPRAASHVsFRVADTH  311
         89***********************************9988888999999986788999*
S: 60    pflvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhek  119
           l  l  c +    l + +    GG      q+ r  + +ra fyaaei++al+flhe+
Q: 312   VCLPGLEHCVKGCVWLPLRIPGEGGGSGEKGRQRGRGSPPRRAGFYAAEICIALNFLHER  371
         *************9999999999999999999999999**********************
S: 120   giiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygk  179
         giiyrdlkldnvllda+Ghikl+d+G+cke++  g+ttstfcGtP+yiaPeil++eeyg+
Q: 372   GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGE  431
         **********************************************************96
Domain Sequence
(FASTA)
FDLIRVIGRG SYAKVLLVRL KKNDQIYAMK VVKKELVHDD EVESWPRAAS HVSFRVADTH 60
VCLPGLEHCV KGCVWLPLRI PGEGGGSGEK GRQRGRGSPP RRAGFYAAEI CIALNFLHER 120
GIIYRDLKLD NVLLDADGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP EILRGEEYGE 180
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00165
EKS-ANC-00167
EKS-BOT-00174
EKS-CAE-00132
EKS-CAJ-00178
EKS-CAF-00181
EKS-CAP-00175
EKS-DAR-00466
EKS-DIO-00088
EKS-EQC-00172
EKS-ERE-00041
EKS-FEC-00166
EKS-GAM-00090
EKS-GAG-00149
EKS-GAA-00210
EKS-GOG-00173
EKS-HOS-00179
EKS-ICT-00168
EKS-LAC-00182
EKS-LOA-00172
EKS-MEG-00138
EKS-MOD-00171
EKS-MUM-00178
EKS-MUP-00178
EKS-NOL-00166
EKS-OCP-00108
EKS-ORN-00218
EKS-ORC-00159
EKS-ORL-00205
EKS-OTG-00179
EKS-PAT-00164
EKS-PES-00153
EKS-POA-00172
EKS-RAN-00170
EKS-SAH-00165
EKS-TAG-00201
EKS-TAS-00058
EKS-TEN-00219
EKS-TUT-00155
EKS-XET-00161
EKS-XIM-00213
Gene Ontology
GO:0045179; C:apical cortex
GO:0016324; C:apical plasma membrane
GO:0035748; C:myelin sheath abaxonal region
GO:0005635; C:nuclear envelope
GO:0016363; C:nuclear matrix
GO:0043234; C:protein complex
GO:0005923; C:tight junction
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0035556; P:intracellular signal transduction
GO:0000226; P:microtubule cytoskeleton organization
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333; P:negative regulation of protein complex assembly
GO:0018105; P:peptidyl-serine phosphorylation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:2001181; P:positive regulation of interleukin-10 secretion
GO:2000667; P:positive regulation of interleukin-13 secretion
GO:0032753; P:positive regulation of interleukin-4 production
GO:2000664; P:positive regulation of interleukin-5 secretion
GO:2000553; P:positive regulation of T-helper 2 cell cytokine production
GO:0045630; P:positive regulation of T-helper 2 cell differentiation
GO:0072659; P:protein localization to plasma membrane
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013