EKS-MAM-00414

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00414

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	429.0	1.1E-128	63	321	259

Status

Unreviewed

Ensembl Protein

ENSMMUP00000025013

UniProt Accession

F6RAJ6;

Protein Name

Protein Synonyms/Alias

Gene Name

STK17A

Gene Synonyms/Alias

STK17A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000019022	ENSMMUP00000025013	ENSMMUT00000026732

Organism

Macaca mulatta

Functional Description

Protein Length

414

Protein Sequence
(FASTA)

MIPLEKPGSG SSSPAATSGS GRAGRGLSVP CRPPPPPQAR GLLTEIRAAV RTEPFQDSYS 60

LCPGRELGRG KFAVVRKCIK KDSGIEFAAK FMRKRRKGQD CRMEIIHEIA VLELAQDNPW 120

VINLHEVYET ASEMILVLEY AAGGEIFDQC VADREEAFKE KDVQRLMRQI LEGVHFLHTH 180

DVVHLDLKPQ NILLTSESPL GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI 240

SMATDMWSIG VLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAHDFIRT 300

LLVKKPEDRA TAEECLKHPW LTQSSIQEPS FRMEKALEEA NALQEGHSVP EINSDTDKSE 360

TEESIVTEEL IVVTSYTLGQ CRQSEKEKME QKAISKRFKF EEPLLQEIPG EFIY 414

Nucleotide Sequence
(FASTA)

ATGATCCCTC TGGAGAAGCC GGGCAGCGGC AGCTCCTCCC CAGCCGCCAC CTCAGGCTCG 60

GGCCGGGCCG GCCGGGGTCT GAGCGTGCCG TGCCGGCCGC CGCCGCCGCC ACAGGCCCGC 120

GGGCTGCTGA CAGAGATCCG CGCCGCGGTG CGCACCGAGC CCTTCCAGGA CAGCTACAGC 180

CTGTGCCCGG GCCGGGAGCT GGGCAGGGGG AAATTTGCAG TGGTGAGGAA ATGTATAAAG 240

AAAGATTCTG GGATAGAATT TGCTGCAAAG TTCATGAGAA AAAGAAGAAA AGGCCAAGAT 300

TGTCGGATGG AAATAATTCA TGAAATTGCT GTACTTGAAC TAGCACAGGA CAATCCTTGG 360

GTCATTAATT TACATGAAGT TTATGAGACT GCATCAGAAA TGATCTTAGT TCTGGAATAT 420

GCTGCTGGGG GTGAAATCTT TGACCAGTGT GTTGCAGACA GAGAGGAAGC CTTTAAAGAA 480

AAAGATGTTC AGAGACTTAT GCGACAGATT CTAGAAGGTG TTCACTTTTT ACACACTCAT 540

GATGTAGTTC ATCTTGATTT GAAGCCTCAG AATATTCTGT TGACAAGCGA ATCTCCATTG 600

GGTGACATTA AGATTGTTGA TTTTGGCCTT TCAAGAATAT TGAAGAACAG TGAAGAGCTC 660

CGAGAAATTA TGGGTACCCC TGAATATGTG GCTCCTGAAA TTCTTAGTTA CGATCCTATA 720

AGCATGGCAA CAGATATGTG GAGCATTGGA GTGTTAACAT ATGTCATGCT TACAGGAATA 780

TCGCCTTTCT TAGGCAATGA TAAACAAGAA ACATTCTTAA ACATCTCACA GATGAATTTA 840

AGTTATTCTG AGGAAGAATT TGATGTTTTG TCTGAGTCAG CTCATGACTT CATCAGGACA 900

CTTTTAGTTA AGAAACCTGA GGATCGAGCC ACTGCTGAAG AATGTCTAAA GCACCCCTGG 960

TTGACACAGA GCAGTATTCA AGAGCCTTCT TTCAGAATGG AAAAGGCACT AGAAGAAGCA 1020

AATGCCCTCC AAGAAGGTCA TTCTGTGCCT GAAATTAATT CAGATACTGA CAAATCAGAA 1080

ACCGAGGAAT CCATTGTAAC TGAGGAGTTA ATTGTAGTTA CTTCATATAC TCTAGGACAG 1140

TGCAGACAGT CTGAAAAAGA GAAAATGGAG CAAAAGGCCA TTTCCAAACG ATTTAAATTT 1200

GAGGAACCTT TGCTACAAGA AATTCCAGGA GAATTTATCT ACTGA 1245

Domain Profile

S: 3     tgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirse  62

          g+elg+Gkfavvrkc++k++G e+aakf++krr    +++++r+ei +e+avl++++++

Q: 63    PGRELGRGKFAVVRKCIKKDSGIEFAAKFMRKRR----KGQDCRMEIIHEIAVLELAQDN  118

         689*******************************....**********************

S: 63    pnvinlhevyenksdvililelvaGGelfd..llaekeslseeeatellkqilegvkylh  120

         p+vinlhevye++s++il+le++aGGe+fd  +++++e+++e+++++l++qilegv++lh

Q: 119   PWVINLHEVYETASEMILVLEYAAGGEIFDqcVADREEAFKEKDVQRLMRQILEGVHFLH  178

         ******************************988999************************

S: 121   skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny  180

         ++++vhldlkP+nill++++ p gdik++dfGlsr +++++el+ei+GtPe+vaPei++y

Q: 179   THDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSY  237

         ********************.***************************************

S: 181   eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf  240

         +p+s++tdmwsiGv+ty++l+g+sPflG++kqet+lnis++nl++see f+ +se+a+df

Q: 238   DPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAHDF  297

         ************************************************************

S: 241   irrllvkdpekrltieeclehswl  264

         ir+llvk+pe+r+t+eecl+h+wl

Q: 298   IRTLLVKKPEDRATAEECLKHPWL  321

         ***********************7

Domain Sequence
(FASTA)

PGRELGRGKF AVVRKCIKKD SGIEFAAKFM RKRRKGQDCR MEIIHEIAVL ELAQDNPWVI 60

NLHEVYETAS EMILVLEYAA GGEIFDQCVA DREEAFKEKD VQRLMRQILE GVHFLHTHDV 120

VHLDLKPQNI LLTSESPLGD IKIVDFGLSR ILKNSEELRE IMGTPEYVAP EILSYDPISM 180

ATDMWSIGVL TYVMLTGISP FLGNDKQETF LNISQMNLSY SEEEFDVLSE SAHDFIRTLL 240

VKKPEDRATA EECLKHPWL 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:2000377	; P:regulation of reactive oxygen species metabolic process

KEGG

mcc:701091

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013