EKS-MAM-00373
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00373
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src382.12.0E-114241490250
StatusUnreviewed
Ensembl ProteinENSMMUP00000025241
UniProt AccessionF6QQC0;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000019206ENSMMUP00000025241ENSMMUT00000026980
OrganismMacaca mulatta
Functional Description
Protein Length505
Protein Sequence
(FASTA)
MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDPPPLPP LVVFNHLTPP PPKEHLEEDE 60
HFVVALYDYA AMNDRDLQML KGEKLQVLKG TGDWWLAKSL VTGREGYVPS NFVARVESLE 120
VERWFFRSLS RKEAERQLLA PINKTGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR 180
SLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VSLAPQNPWA QDEWEIPRQS 240
LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 300
AVVTKEPIYI VTEYMARGGR EGQARREGGT GWAWSFTMCL FPQIAEGMAY IERMNSIHRD 360
LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 420
FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPETC PPELYRGVIA ECWRSRPEER 480
PTFEFLQSVL EDFYTATERQ YELQP 505
Nucleotide Sequence
(FASTA)
ATGGGGCTAG TAAGCAGCAA AAAACCGGAC AAGGAAAAGC CGATCAAGGA GAAGGACAAG 60
GGCCAATGGA GCCCCCTGAA GGTCAGCGCC CAAGACAAGG ACCCCCCGCC ACTGCCGCCA 120
CTGGTTGTCT TCAACCACCT TACTCCTCCA CCGCCCAAAG AGCACCTGGA AGAAGACGAG 180
CATTTCGTGG TAGCCCTGTA TGACTACGCT GCCATGAATG ACCGGGACCT GCAGATGCTG 240
AAGGGGGAGA AGCTACAAGT CCTGAAGGGA ACTGGAGACT GGTGGTTGGC CAAGTCGCTC 300
GTCACAGGAA GAGAAGGCTA CGTGCCCAGC AACTTTGTGG CCCGAGTGGA GAGCCTGGAA 360
GTGGAAAGGT GGTTCTTTAG ATCACTGAGC CGGAAGGAGG CCGAGAGGCA GCTTCTGGCT 420
CCAATCAACA AGACCGGCTC CTTTCTTATC AGAGAGAGTG AAACCAACAA AGGTGCCTTC 480
TCCCTGTCTG TGAAGGACGT CACCACCCAG GGGGAGCTGA TCAAGCACTA TAAGATCCGC 540
TCCCTGGACG AAGGGGGTTA CTACATCTCC CCCCGGATCA CCTTCCCCTC GCTCCAGGCC 600
CTGGTGCAGC ACTATTCTAA GAAGGGGGAT GGTCTATGCC AGAGGCTGAC CCTGCCCTGT 660
GTGAGCCTGG CCCCACAGAA CCCCTGGGCC CAGGATGAAT GGGAAATCCC CCGGCAGTCT 720
CTCAGGCTGG TCAGGAAACT CGGGTCTGGA CAATTTGGCG AAGTCTGGAT GGGTTATTAC 780
AAAAACAACA TGAAGGTGGC CATTAAGACG CTGAAGGAGG GAACCATGTC TCCAGAAGCC 840
TTTCTGGGCG AGGCCAACGT GATGAAGGCC CTGCAGCATG AGCGGCTGGT CCGACTCTAC 900
GCCGTGGTCA CCAAGGAGCC CATCTATATT GTCACCGAGT ACATGGCCAG AGGTGGGAGG 960
GAGGGGCAGG CACGGAGGGA GGGGGGCACG GGGTGGGCTT GGTCCTTTAC CATGTGCCTG 1020
TTCCCTCAGA TTGCCGAAGG GATGGCTTAC ATCGAGCGCA TGAATTCCAT CCACCGCGAC 1080
CTGCGGGCGG CCAACATTCT AGTATCCGAG GCCTTGTGCT GCAAAATTGC TGATTTTGGC 1140
TTGGCTCGAA TCATCGACAG TGAATACACG GCCCAAGAGG GGGCCAAGTT CCCCATCAAG 1200
TGGACAGCCC CAGAAGCCAT CCACTTCGGG GTCTTCACCA TCAAAGCAGA CGTGTGGTCG 1260
TTTGGAGTCC TCCTGATGGA AGTTGTCACT TATGGGCGGG TACCATACCC AGGGATGAGC 1320
AACCCCGAGG TCATCCGCAA CCTGGAGCGC GGCTACCGCA TGCCGCGCCC CGAAACCTGC 1380
CCGCCCGAGC TGTACCGCGG CGTCATCGCC GAGTGCTGGC GCAGCCGGCC CGAGGAGCGG 1440
CCCACCTTCG AGTTCCTGCA GTCGGTGCTG GAGGACTTCT ACACGGCCAC CGAGCGGCAG 1500
TACGAGCTGC AGCCCTAG 1518
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+lv+klG+GqfGevw+g++k+++kva+ktlkegt+speafl ea+++k l+he+lv+ly
Q: 241   LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY  300
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+ma+G      ++e g+    +  + l  q+aeGmay+e++n ihr
Q: 301   AVVTK-EPIYIVTEYMARGGREGQARREGGTGWAWSFTMCLFPQIAEGMAYIERMNSIHR  359
         ****9.******************************9***********************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv
Q: 360   DLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  418
         **************************.899******************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239
         WsfG+ll+e+vt+G+vPypGm+n ev++++ergyr+prpe+cp ely+ +++ecw+++pe
Q: 419   WSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPETCPPELYRgVIAECWRSRPE  478
         ************************************************9***********
S: 240   erPtfetlqevl  251
         erPtfe+lq+vl
Q: 479   ERPTFEFLQSVL  490
         ********9986
Domain Sequence
(FASTA)
LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 60
AVVTKEPIYI VTEYMARGGR EGQARREGGT GWAWSFTMCL FPQIAEGMAY IERMNSIHRD 120
LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180
FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPETC PPELYRGVIA ECWRSRPEER 240
PTFEFLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-EQC-00363
EKS-FEC-00359
EKS-GAG-00314
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LOA-00381
EKS-MEG-00304
EKS-MOD-00360
EKS-MUM-00404
EKS-MUP-00366
EKS-NOL-00339
EKS-ORC-00351
EKS-OTG-00375
EKS-PAT-00352
EKS-PES-00329
EKS-POA-00361
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-SUS-00325
EKS-TAG-00443
EKS-TUT-00099
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013