EKS-MAM-00153
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00153
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK295.85.9E-8891352262
StatusUnreviewed
Ensembl ProteinENSMMUP00000025360
UniProt AccessionF6S3T8;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KB1
Gene Synonyms/Alias RPS6KB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000019305ENSMMUP00000025360ENSMMUT00000027110
OrganismMacaca mulatta
Functional Description
Protein Length525
Protein Sequence
(FASTA)
MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG 60
PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF 120
AMKVLKKPKI CSQKNVSQAR YSDAYLDTWK ESTNSFIRSG LEINIVLSLM FFLFFTGGEL 180
FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC 240
KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK 300
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL 360
LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE 420
SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG 480
IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL 525
Nucleotide Sequence
(FASTA)
ATGAGGCGAC GAAGGAGGCG GGACGGCTTT TACCCAGCGC CGGACTTCCG AGACAGGGAA 60
GCTGAGGACA TGGCAGGAGT GTTTGACATA GACCTGGACC AGCCAGAGGA CGCGGGCTCA 120
GAGGATGAGC TGGAGGAGGG GGGTCAGTTA AATGAAAGCA TGGACCATGG GGGAGTTGGA 180
CCATATGAAC TTGGCATGGA ACATTGTGAG AAATTTGAAA TCTCAGAAAC TAGTGTGAAC 240
AGAGGGCCAG AAAAAATCAG ACCAGAATGT TTTGAGCTAC TTCGGGTACT TGGTAAAGGG 300
GGCTATGGAA AGGTTTTTCA AGTACGAAAA GTAACAGGAG CAAATACTGG GAAAATATTT 360
GCCATGAAGG TGCTTAAAAA GCCTAAAATT TGCAGTCAAA AAAATGTATC TCAAGCCAGG 420
TACAGTGATG CATACCTGGA TACTTGGAAG GAAAGCACAA ACTCTTTCAT TAGAAGTGGG 480
TTGGAAATAA ATATTGTTTT ATCTCTAATG TTTTTTCTTT TCTTTACAGG AGGAGAACTA 540
TTTATGCAGT TAGAAAGAGA GGGAATATTT ATGGAAGACA CTGCCTGCTT TTACTTGGCA 600
GAAATCTCCA TGGCTTTGGG GCATTTACAT CAAAAGGGGA TCATCTACAG AGACCTGAAG 660
CCGGAGAATA TCATGCTTAA TCACCAAGGT CATGTGAAAC TAACAGACTT TGGACTATGC 720
AAAGAATCTA TTCATGATGG AACAGTCACA CACACATTTT GTGGAACAAT AGAATACATG 780
GCCCCTGAAA TCTTGATGAG AAGTGGCCAC AATCGTGCTG TGGATTGGTG GAGTTTGGGA 840
GCATTAATGT ATGACATGCT GACTGGAGCA CCCCCATTCA CTGGGGAGAA CAGAAAGAAA 900
ACAATTGACA AAATCCTCAA ATGTAAACTC AATTTGCCTC CCTACCTCAC GCAAGAAGCC 960
AGAGATCTGC TTAAAAAGCT GCTGAAAAGA AATGCTGCTT CTCGTCTGGG AGCTGGTCCT 1020
GGGGACGCTG GAGAAGTTCA AGCTCATCCA TTCTTTAGAC ACATTAACTG GGAAGAACTT 1080
CTGGCTCGAA AGGTGGAGCC CCCCTTTAAA CCTCTGTTGC AATCTGAAGA GGATGTAAGT 1140
CAGTTTGATT CCAAGTTTAC ACGTCAGACA CCTGTCGACA GCCCAGATGA CTCAACTCTC 1200
AGTGAAAGTG CCAATCAGGT CTTTCTGGGT TTTACATATG TGGCTCCATC TGTACTTGAA 1260
AGTGTAAAAG AAAAGTTTTC CTTTGAACCA AAAATCCGAT CACCTCGAAG ATTTATTGGC 1320
AGCCCACGAA CACCTGTCAG CCCAGTCAAA TTTTCTCCTG GGGATTTCTG GGGAAGAGGT 1380
GCTTCGGCCA GCACAGCAAA TCCTCAGACA CCTGTGGAAT ACCCAATGGA AACAAGTGGC 1440
ATAGAGCAGA TGGATGTGAC AATGAGTGGG GAAGCATCGG CACCACTTCC AATACGACAG 1500
CCGAACTCTG GGCCATACAA AAAACAAGCT TTTCCCATGA TCTCCAAACG GCCAGAGCAC 1560
CTGCGTATGA ATCTATGA 1578
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk.kkkertkeereiLeeve  59
         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkk ++   k+ ++++   + L++ +
Q: 91    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKPKICSqKNVSQARYSDAYLDTWK  150
         89**************************************98566677777777888887
S: 60    hpfivklheafqdekklylv.lellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118
         +     + +  + +  l l+   + +GgeL+++l+++++f+e++a+f+lae+++al +lH
Q: 151   ESTNSFIRSGLEINIVLSLMfFLFFTGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  210
         74333334444444444443134689**********************************
S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178
         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g
Q: 211   QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  269
         *********************************9.9999999******************
S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238
         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k
Q: 270   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  325
         ****************************************..9*****..**********
S: 239   klLkkdpakRlga...taeeikehkfl  262
         klLk++ a+Rlga   +a e+++h+f+
Q: 326   KLLKRNAASRLGAgpgDAGEVQAHPFF  352
         *************9*9*********97
Domain Sequence
(FASTA)
FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKPKI CSQKNVSQAR YSDAYLDTWK 60
ESTNSFIRSG LEINIVLSLM FFLFFTGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120
QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180
NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240
NAASRLGAGP GDAGEVQAHP FF 262
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00147
EKS-ANC-00148
EKS-BOT-00154
EKS-CAJ-00159
EKS-CAF-00162
EKS-CAP-00155
EKS-CHH-00022
EKS-DAR-00441
EKS-EQC-00153
EKS-FEC-00145
EKS-GAG-00132
EKS-GAA-00182
EKS-HOS-00160
EKS-ICT-00151
EKS-LAC-00164
EKS-LOA-00154
EKS-MEG-00122
EKS-MOD-00155
EKS-MUM-00159
EKS-MUP-00159
EKS-MYL-00163
EKS-NOL-00148
EKS-ORN-00191
EKS-ORA-00134
EKS-ORL-00181
EKS-OTG-00160
EKS-PAT-00145
EKS-PES-00137
EKS-POA-00151
EKS-RAN-00152
EKS-SAH-00149
EKS-SOA-00029
EKS-SUS-00135
EKS-TAG-00183
EKS-TAR-00200
EKS-TEN-00193
EKS-TUT-00147
EKS-VIP-00075
EKS-XET-00143
EKS-XIM-00186
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0071363; P:cellular response to growth factor stimulus
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0007281; P:germ cell development
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0045948; P:positive regulation of translational initiation
GO:0043491; P:protein kinase B signaling cascade
GO:0031929; P:TOR signaling cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016238; Ribosomal_S6_kinase.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013