EKS-MAM-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	294.1	1.6E-87	463	719	257

Status

Unreviewed

Ensembl Protein

ENSMMUP00000025611

UniProt Accession

F7D3I9;

Protein Name

Protein Synonyms/Alias

Gene Name

708767

Gene Synonyms/Alias

708767;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000019488	ENSMMUP00000039918	ENSMMUT00000046887
ENSMMUG00000019488	ENSMMUP00000004710	ENSMMUT00000005001
ENSMMUG00000019488	ENSMMUP00000039917	ENSMMUT00000046886
ENSMMUG00000019488	ENSMMUP00000025611	ENSMMUT00000027382

Organism

Macaca mulatta

Functional Description

Protein Length

835

Protein Sequence
(FASTA)

MGNYKSRPTQ TCTDEWKKKV SESYVITIER LEDDLQIKEK ELTELRHIFS SDEAFSKVNL 60

NYRTENGLSL LHLCCICGGN KSHIRTLMLK GLRPSRLSRN GFTALHLAVY KDNAELITSL 120

LHSGADIQQV GYGGLTALHI ATIAGHPEAA DVLLQHGANV NIQDAVFFTP LHIAAYYGHE 180

QVTRLLLKFG ADVNVSGEVG DRPLHLASAK GFLNIAKLLM EEGSKADVNA QDNEDHVPLH 240

FCSRFGHHDI VKYLLQSDLE VQPHAVNIYG DTPLHLACYN GKFEVAKEII QISGTESLTK 300

ENIFSETAFH SACTYGKRID LVKFLLDQNV ININHQGRDG HTGLHSACYH GHIRLVQFLL 360

DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGNDAIVTL LKHYKRPQDE LLCNEYSQPG 420

GDGSYVSVPS PLGKIKSMTK EKADILLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG 480

RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCQLNHPC VIQFVGACLN DPSQFAIVTQ 540

YISGGSLFSL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG 600

HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWEILT 660

GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPVSSLLIR GWNACPEGRP EFSEVVTKLE 720

ECLCNIELMS PASSNSSGSL SPSSSSDCLV SRGGPGRSHV AALRSRFELE YALNARSYAA 780

LSQSAGQHSS QGLSLEEMKR SLQYSPIDKY GYVSDPMSPM HFHFCRNSSS FEDSS 835

Nucleotide Sequence
(FASTA)

ATGGGAAATT ATAAATCTAG ACCAACCCAA ACTTGTACTG ATGAATGGAA GAAAAAAGTC 60

AGTGAATCAT ATGTTATCAC AATAGAAAGA TTAGAAGATG ACCTGCAGAT CAAGGAAAAA 120

GAACTGACAG AACTAAGGCA TATATTTAGC TCTGATGAAG CCTTCAGTAA AGTCAATTTA 180

AATTACCGCA CTGAAAATGG GCTGTCTCTA CTTCATTTAT GTTGCATTTG TGGAGGCAAC 240

AAATCACATA TTCGAACTCT TATGTTAAAA GGGCTCCGCC CATCTCGACT GTCAAGAAAT 300

GGATTTACAG CCTTGCATTT GGCAGTTTAC AAGGATAATG CAGAATTGAT CACTTCTCTG 360

CTTCACAGTG GAGCTGATAT ACAGCAGGTT GGATATGGTG GCCTCACTGC CCTCCATATT 420

GCTACAATAG CTGGCCACCC AGAGGCTGCT GATGTGCTGT TGCAACATGG AGCTAATGTC 480

AATATTCAAG ATGCAGTTTT TTTCACTCCA TTGCACATTG CAGCCTACTA TGGGCATGAA 540

CAGGTAACTC GCCTTCTTTT GAAATTTGGT GCTGATGTAA ATGTAAGTGG TGAAGTTGGA 600

GATAGACCCC TCCACCTAGC ATCCGCAAAA GGATTCTTGA ATATTGCAAA ACTCTTGATG 660

GAAGAAGGCA GCAAAGCAGA TGTGAATGCT CAAGATAATG AAGACCATGT CCCTCTCCAT 720

TTCTGTTCTC GATTTGGACA CCATGATATA GTTAAGTATC TGCTGCAAAG TGATTTGGAA 780

GTTCAACCTC ATGCTGTTAA TATCTATGGA GATACCCCCT TGCACCTGGC ATGCTACAAT 840

GGCAAATTTG AAGTTGCCAA GGAAATCATC CAAATATCAG GAACAGAAAG TCTGACTAAG 900

GAAAACATCT TCAGTGAAAC TGCTTTTCAT AGTGCTTGTA CCTATGGCAA GAGAATTGAC 960

CTAGTCAAAT TTCTTCTTGA TCAGAACGTC ATAAACATCA ACCACCAAGG AAGGGATGGG 1020

CACACTGGAT TACACTCTGC TTGCTACCAC GGTCACATTC GCCTGGTTCA GTTCTTACTG 1080

GATAATGGAG CTGATATGAA TCTAGTGGCT TGTGATCCCA GCAGGTCTAG TGGTGAAAAA 1140

GATGAGCAGA CATGTTTGAT GTGGGCTTAT GAAAAAGGGA ATGATGCCAT TGTCACACTC 1200

CTGAAGCATT ATAAGAGACC GCAAGATGAA TTGCTCTGTA ATGAATATTC TCAGCCTGGA 1260

GGAGATGGCT CCTATGTGTC TGTTCCATCC CCCTTGGGGA AGATTAAAAG CATGACAAAA 1320

GAGAAGGCAG ATATTCTCCT CCTAAGAGCA GGATTGCCTT CACATTTCCA TCTTCAGCTC 1380

TCAGAAATTG AGTTCCATGA GATTATCGGC TCAGGTTCTT TTGGGAAAGT ATATAAAGGA 1440

CGATGCAGAA ATAAAATAGT GGCTATAAAA CGTTATCGAG CCAATACCTA CTGCTCCAAG 1500

TCAGATGTGG ATATGTTTTG CCGAGAGGTG TCCATTCTCT GCCAGCTCAA TCATCCCTGT 1560

GTAATTCAGT TTGTGGGCGC TTGCTTGAAT GATCCCAGCC AGTTTGCCAT TGTCACTCAA 1620

TACATATCAG GGGGTTCTCT GTTCTCCCTC CTTCATGAGC AGAAAAGGAT TCTTGATTTG 1680

CAGTCTAAAT TAATTATTGC AGTAGATGTT GCCAAAGGCA TGGAGTACCT TCACAACTTG 1740

ACACAGCCAA TTATACATCG TGACTTGAAC AGTCACAATA TTCTTCTCTA TGAGGACGGG 1800

CATGCTGTGG TGGCAGATTT TGGAGAATCA AGATTTCTAC AGTCTCTGGA TGAAGACAAC 1860

ATGACAAAAC AACCTGGGAA CCTCCGTTGG ATGGCTCCTG AGGTGTTCAC GCAGTGCACT 1920

CGGTACACCA TCAAAGCAGA CGTCTTCAGC TACGCTCTGT GTCTGTGGGA AATTCTCACT 1980

GGCGAAATTC CATTCGCTCA TCTCAAGCCA GCGGCTGCGG CAGCAGACAT GGCTTACCAC 2040

CACATCAGAC CTCCCATTGG CTATTCCATT CCCAAGCCTG TATCATCTCT GCTGATACGA 2100

GGGTGGAACG CATGTCCTGA AGGAAGACCC GAGTTTTCTG AAGTTGTCAC GAAGTTAGAA 2160

GAGTGTCTCT GCAACATTGA GCTGATGTCT CCTGCATCAA GTAACAGCAG TGGCTCTCTC 2220

TCACCTTCTT CTTCTTCTGA TTGCCTGGTG AGCCGGGGAG GACCTGGCCG GAGTCATGTG 2280

GCAGCTTTAA GAAGTCGTTT CGAATTGGAA TATGCTCTAA ATGCAAGGTC CTATGCTGCT 2340

TTGTCCCAAA GTGCTGGACA ACATTCCTCT CAAGGTCTGT CTTTGGAGGA GATGAAAAGA 2400

AGTCTTCAAT ACTCACCCAT TGACAAATAT GGCTATGTAT CCGATCCCAT GAGCCCTATG 2460

CATTTTCATT TTTGCCGAAA TAGTAGCAGC TTTGAGGACA GCAGCTGA 2508

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 463   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCQLNHPCVI  522

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++A+Gm+YLh+ +

Q: 523   QFVGACLNDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT  581

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 582   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  639

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWe+lt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 640   TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPVSSLLI  699

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 700   RGWNACPEGRPEFSEVVTKL  719

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCQLNHPCVI 60

QFVGACLNDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWEILTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PVSSLLIRGW 240

NACPEGRPEF SEVVTKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

mcc:100533987

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 3.
PF12796	; Ank_2; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013