EKS-MAM-00103

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00103

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	489.8	2.5E-147	402	652	251

Status

Unreviewed

Ensembl Protein

ENSMMUP00000025714

UniProt Accession

F7BGK5;

Protein Name

Protein Synonyms/Alias

Gene Name

BTK

Gene Synonyms/Alias

BTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000019573	ENSMMUP00000040920	ENSMMUT00000047887
ENSMMUG00000019573	ENSMMUP00000025714	ENSMMUT00000027493
ENSMMUG00000019573	ENSMMUP00000040921	ENSMMUT00000047888
ENSMMUG00000019573	ENSMMUP00000025713	ENSMMUT00000027492
ENSMMUG00000019573	ENSMMUP00000040918	ENSMMUT00000047885
ENSMMUG00000019573	ENSMMUP00000040919	ENSMMUT00000047886
ENSMMUG00000019573	ENSMMUP00000040924	ENSMMUT00000047891
ENSMMUG00000019573	ENSMMUP00000040925	ENSMMUT00000047892
ENSMMUG00000019573	ENSMMUP00000040922	ENSMMUT00000047889
ENSMMUG00000019573	ENSMMUP00000040923	ENSMMUT00000047890

Organism

Macaca mulatta

Functional Description

Protein Length

659

Protein Sequence
(FASTA)

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK 60

ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180

HRKTKKPLPP TPEEDQVYRE LGSQQPCNPI TFSLCRPGLS IIAQSRLTAT STSQLRKGDE 240

YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300

EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360

YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420

WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480

CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540

GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600

FTNSETAEHI AQGLRLYRPH LASEKVYTIM YSCWHEKADE RPTFKILLSN ILDVMDEES 659

Nucleotide Sequence
(FASTA)

ATGGCTGCAG TGATTCTGGA GAGCATCTTT CTGAAGCGAT CCCAACAGAA AAAGAAAACA 60

TCACCTCTAA ACTTCAAGAA GCGCCTGTTT CTCTTGACCG TGCACAAACT CTCCTACTAT 120

GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA CGTTGAGAAG 180

ATCACTTGCG TTGAAACAGT GGTTCCTGAA AAAAATCCTC CTCCTGAAAG ACAGATTCCG 240

AGAAGAGGTG AAGAGTCCAG TGAAATGGAG CAAATTTCAA TCATTGAAAG ATTCCCTTAT 300

CCCTTCCAGG TTGTATATGA TGAAGGGCCT CTCTACGTCT TCTCCCCAAC TGAAGAACTA 360

AGGAAGCGGT GGATTCACCA GCTCAAAAAC GTAATCCGGT ACAACAGTGA TCTGGTTCAG 420

AAATACCACC CTTGCTTCTG GATCGATGGG CAGTATCTCT GCTGCTCTCA GACAGCCAAA 480

AATGCTATGG GCTGCCAAAT TTTGGAAAAC AGGAATGGAA GCTTAAAACC TGGGAGTTCT 540

CACCGGAAGA CAAAAAAGCC TCTTCCCCCA ACGCCTGAGG AGGACCAGGT ATACAGGGAA 600

CTGGGCTCTC AGCAACCCTG TAATCCAATC ACCTTCTCGC TCTGTCGCCC AGGCTTGAGT 660

ATAATAGCAC AATCTCGGCT CACTGCAACC TCCACCTCCC AGCTGCGGAA GGGCGACGAA 720

TATTTTATCT TGGAGGAAAG CAACTTACCA TGGTGGCGAG CACGAGATAA AAATGGGCAA 780

GAAGGCTATA TTCCTAGTAA CTACGTCACT GAAGCCGAAG ACTCCATAGA AATGTATGAG 840

TGGTATTCCA AACACATGAC TCGGAGTCAG GCTGAGCAAC TGCTAAAGCA AGAGGGGAAA 900

GAAGGAGGTT TCATTGTCAG AGACTCCAGC AAAGCTGGCA AATATACAGT GTCTGTGTTT 960

GCTAAATCCA CAGGGGACCC TCAAGGGGTG ATACGTCATT ATGTTGTGTG TTCCACACCT 1020

CAAAGCCAGT ATTACCTGGC TGAGAAGCAC CTTTTCAGCA CCATCCCTGA GCTCATTAAC 1080

TACCATCAGC ACAACTCTGC GGGACTCATA TCCAGGCTCA AATATCCAGT GTCTCAACAA 1140

AACAAGAATG CACCTTCCAC GGCAGGCCTG GGATATGGAT CATGGGAAAT TGATCCAAAG 1200

GACCTGACCT TCTTGAAGGA GCTGGGGACT GGACAATTTG GGGTAGTGAA GTATGGGAAA 1260

TGGAGAGGCC AGTATGATGT GGCCATCAAG ATGATCAAAG AAGGCTCCAT GTCTGAAGAT 1320

GAATTCATTG AAGAAGCCAA AGTCATGATG AATCTTTCCC ATGAGAAGCT GGTGCAGTTG 1380

TATGGCGTCT GCACCAAGCA GCGCCCCATC TTCATCATCA CTGAATACAT GGCCAATGGC 1440

TGCCTCCTGA ACTACCTGAG GGAGATGCGC CACCGCTTCC AGACTCAGCA GCTGCTGGAG 1500

ATGTGCAAGG ATGTCTGTGA AGCCATGGAA TACCTGGAGT CAAAGCAGTT CCTTCACCGA 1560

GACCTGGCAG CTCGAAACTG TTTGGTAAAC GATCAAGGAG TTGTTAAAGT ATCTGATTTC 1620

GGCCTGTCCA GGTATGTCCT GGATGATGAA TACACCAGCT CAGTAGGCTC CAAATTTCCA 1680

GTCCGGTGGT CCCCACCGGA AGTCCTGATG TATAGCAAGT TCAGCAGCAA ATCTGACATT 1740

TGGGCTTTTG GAGTTTTGAT GTGGGAAATT TACTCCCTGG GGAAGATGCC ATATGAGAGA 1800

TTTACTAACA GTGAGACTGC TGAACACATT GCCCAAGGCC TACGTCTCTA CAGGCCTCAT 1860

CTGGCTTCAG AGAAGGTATA TACCATCATG TACAGTTGTT GGCATGAGAA AGCAGATGAA 1920

CGTCCCACTT TCAAAATTCT TCTGAGCAAT ATTCTAGATG TCATGGATGA AGAATCCTGA 1980

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly

Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  461

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd

Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w

Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las+kvy++m+scw+ek++er

Q: 582   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADER  641

         ************************************************************

S: 241   ptfkellsale  251

         ptfk lls++

Q: 642   PTFKILLSNIL  652

         ********996

Domain Sequence
(FASTA)

LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60

GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120

LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180

AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASEKVYTIMY SCWHEKADER 240

PTFKILLSNI L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031410	; C:cytoplasmic vesicle
GO:0005829	; C:cytosol
GO:0045121	; C:membrane raft
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005547	; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0048469	; P:cell maturation
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013