EKS-MAM-00227

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00227

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	392.2	2.1E-117	102	367	266

Status

Unreviewed

Ensembl Protein

ENSMMUP00000026088

UniProt Accession

F7FU91;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000019842	ENSMMUP00000026088	ENSMMUT00000027885

Organism

Macaca mulatta

Functional Description

Protein Length

399

Protein Sequence
(FASTA)

MAAPSPSGGG GSGGGSGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN PPFKSTARFT 60

LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE DLKDLGEIGR GAYGSVNKMV 120

HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD VVMRSSDCPY IVQFYGALFR EGDCWICMEL 180

MSTSFDKFYK YVYSVLDDVI PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS 240

GNIKLCDFGI SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL 300

ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK DESKRPKYKE 360

LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD 399

Nucleotide Sequence
(FASTA)

ATGGCGGCTC CGAGCCCGAG CGGCGGCGGC GGCTCCGGGG GCGGCAGCGG CAGCGGCACC 60

CCGGGCCCCG TAGGGTCCCC GGCGCCGGGC CACCCGGCCG TCAGCAGCAT GCAGGGTAAA 120

CGCAAAGCAC TGAAGTTGAA TTTTGCAAAT CCACCTTTCA AATCTACAGC AAGGTTTACT 180

CTGAATCCCA ATCCTACAGG AGTTCAAAAC CCACACATAG AGAGACTGAG AACACACAGC 240

ATTGAGTCAT CAGGAAAACT GAAGATCTCC CCTGAACAAC ACTGGGATTT CACTGCAGAG 300

GACTTGAAAG ACCTTGGAGA AATTGGACGA GGAGCTTATG GTTCTGTCAA CAAAATGGTC 360

CACAAACCAA GTGGGCAAAT AATGGCAGTT AAAAGAATTC GGTCAACAGT GGATGAAAAA 420

GAACAAAAAC AACTTCTTAT GGATTTGGAT GTAGTAATGC GGAGTAGTGA TTGCCCATAC 480

ATCGTTCAGT TTTATGGTGC ACTCTTCAGA GAGGGTGACT GTTGGATCTG TATGGAACTC 540

ATGTCTACCT CGTTTGATAA GTTTTACAAA TATGTATATA GTGTATTAGA TGATGTTATT 600

CCAGAAGAAA TTTTAGGCAA AATCACTTTA GCAACTGTGA AAGCACTAAA CCACTTAAAA 660

GAAAACTTGA AAATTATTCA CAGAGATATC AAACCTTCCA ATATTCTTCT GGACAGAAGT 720

GGAAATATTA AACTCTGTGA CTTCGGCATC AGTGGACAGC TTGTGGACTC TATTGCCAAG 780

ACAAGAGATG CTGGCTGTAG GCCATACATG GCACCTGAAA GAATAGACCC AAGCGCATCA 840

CGACAAGGAT ATGATGTCCG CTCTGATGTC TGGAGTTTGG GGATCACATT GTATGAGTTG 900

GCCACAGGCC GATTTCCTTA TCCAAAGTGG AATAGTGTAT TTGATCAACT AACACAAGTC 960

GTGAAAGGAG ATCCTCCGCA GCTGAGTAAT TCTGAGGAAA GGGAATTCTC CCCAAGTTTC 1020

ATCAACTTTG TCAACTTGTG CCTTACGAAG GATGAATCCA AAAGGCCAAA GTATAAAGAG 1080

CTTCTGAAAC ATCCCTTTAT TTTGATGTAT GAAGAACGTG CCGTTGAGGT CGCATGCTAT 1140

GTTTGTAAAA TCCTGGATCA AATGCCAGCT ACTCCCAGCT CTCCCATGTA TGTCGATTGA 1200

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 102   LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  161

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 162   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  220

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 221   ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  280

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 281   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF  340

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 341   INFVNLCLTKDESKRPKYKELLKHPFI  367

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0000165	; P:MAPK cascade

KEGG

mcc:718155

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013