EKS-MAM-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	496.0	3.4E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSMMUP00000026112

UniProt Accession

F7GTI6;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2; EGK_15739;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000019859	ENSMMUP00000026112	ENSMMUT00000027910

Organism

Macaca mulatta

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH SKHPDGHSGN LTTDALRNKV TELERELRRK DAEIQEREYN LKELREQLSK 60

QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASPDK VPLEVHRKTS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 720

ARSLPSPLQR ELNGPIDHSY FDKYPPEKGM PPDELSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCTAAACAT TCCAAGCACC CAGATGGACA CTCTGGGAAC 60

CTCACCACTG ACGCTCTGCG GAACAAGGTG ACAGAGCTGG AGAGAGAGTT GAGGAGGAAG 120

GATGCTGAGA TCCAGGAGCG GGAGTACAAT TTGAAGGAGC TGCGGGAGCA GCTGTCGAAG 180

CAGACCGTGG CCATTGCTGA ACTCACAGAA GAGCTCCAGA ACAAGTGCAT CCAGCTGAAC 240

AAGCTGCAGG ATGTGGTGCA TATGCAGGGA GGAAGCCCGC TTCAGGCTTC TCCAGATAAA 300

GTGCCTCTTG AGGTCCACCG GAAGACCTCT GGATTGGTCT CTCTCCATAG CAGGAGGGGA 360

GCAAAGGCTG GCGTGTCTGC TGAGCCAACA ACCCGGACCT ATGACCTCAA CAAACCCCCT 420

GAATTTTCCT TTGAGAAAGC AAGAGTCAGA AAAGACTCCA GTGAGAAGAA GCTCATTACA 480

GACGCCCTTA ATAAAAATCA GTTTCTGAAA AGACTGGATC CTCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTATGGGAG AAACTATCAG CAAGGGAGTT ACATTATTAA GCAAGGAGAA 600

CCAGGAAACC ATATCTTTGT GCTGGCAGAG GGTCGACTAG AGGTGTTTCA AGGGGAGAAA 660

TTGCTGTCCT CCATCCCTAT GTGGACCACA TTTGGGGAGC TTGCCATTTT ATACAACTGT 720

ACAAGGACTG CCTCTGTGAA AGCTATTACC AATGTTAAAA CATGGGCACT AGATCGAGAG 780

GTATTCCAGA ATATAATGAG GAGAACAGCC CAAGCTAGAG ATGAACAATA CAGAAACTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAATTTA CCTGAAGATA AATTAACCAA GATCATTGAC 900

TGCTTGGAAG TGGAATACTA TGATAAAGGA GATTACATCA TTAGAGAGGG CGAGGAAGGA 960

AGTACCTTTT TCATTTTGGC AAAAGGAAAG GTAAAAGTAA CACAGAGTAC AGAAGGCCAT 1020

GATCAACCAC AGCTGATAAA AACACTGCAG AAAGGAGAAT ACTTTGGAGA AAAAGCTCTT 1080

ATCAGTGATG ATGTCAGGTC AGCTAACATT ATTGCTGAAG AAAATGATGT TGCATGCCTG 1140

GTTATAGATC GAGAAACATT CAACCAAACT GTTGGTACAT TTGAAGAGCT GCAAAAATAC 1200

CTTGAAGGAT ATGTGGCAAA CCTGAACCGT GATGATGAAA AAAGACATGC AAAGCGGTCC 1260

ATGTCTAACT GGAAGCTGTC CAAAGCACTC TCTCTGGAAA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCATC ATCCCCATTC CAGAACCTTG AGATTATTGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTAAAAA ATGAGAATGT CGCTTTTGCT 1440

ATGAAGTGTA TAAGGAAGAA GCACATAGTT GACACCAAGC AGCAGGAGCA TGTCTACTCA 1500

GAGAAGAGGA TCTTAGAGGA GCTGTGCTCT CCATTCATTG TGAAATTATA TCGTACTTTC 1560

AAGGACAATA AGTATGTATA CATGCTTCTG GAGGCCTGCT TAGGTGGGGA GCTATGGAGT 1620

ATATTAAGGG ACAGAGGCAG CTTTGATGAA CCCACCTCCA AATTCTGCGT TGCTTGTGTG 1680

ACAGAAGCAT TTGATTACCT GCATCGACTA GGTATTATCT ACAGAGACTT AAAACCAGAA 1740

AACTTAATTC TAGATGCTGA GGGTTACCTT AAATTGGTTG ACTTTGGATT TGCGAAGAAA 1800

ATAGGGTCTG GACAGAAAAC ATGGACATTC TGTGGGACTC CAGAATATGT AGCTCCTGAA 1860

GTCATTCTCA ACAAAGGACA TGACTTCAGT GTGGATTTCT GGTCACTGGG AATTCTAGTG 1920

TATGAGCTTC TAACGGGCAA CCCACCCTTT TCTGGGATTG ACCAAATGAT GACCTACAAT 1980

TTGATTCTCA AAGGAATTGA AAAAATGGAT TTTCCCAGGA AGATAACACG ACGACCTGAG 2040

GATTTGATTC GAAGGCTTTG CAGGCAAAAT CCAACAGAAA GGCTGGGAAA TCTGAAGAAT 2100

GGAATAAATG ACATTAAGAA ACACAGGTGG TTAAATGGTT TTAATTGGGA GGGACTGAAA 2160

GCACGGAGCC TTCCATCGCC TTTACAAAGA GAGCTCAATG GACCCATAGA TCACAGCTAC 2220

TTTGACAAAT ACCCTCCTGA AAAGGGAATG CCTCCAGATG AGCTATCAGG CTGGGATAAA 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGINDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013