EKS-MAM-00144
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00144
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR556.71.2E-167360636277
StatusUnreviewed
Ensembl ProteinENSMMUP00000026227
UniProt AccessionF7FZS3;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000019945ENSMMUP00000026226ENSMMUT00000028032
ENSMMUG00000019945ENSMMUP00000026225ENSMMUT00000028031
ENSMMUG00000019945ENSMMUP00000026227ENSMMUT00000028033
ENSMMUG00000019945ENSMMUP00000027281ENSMMUT00000029158
OrganismMacaca mulatta
Functional Description
Protein Length694
Protein Sequence
(FASTA)
MGAPACALAL CVAVAIVAGA SSESLGTEQR VVGRVAEVSG PEPSQQEQLV FGSGDAVELS 60
CPPPGGGPMG PTVWVKDGAG LVPSERVLVG PQRLQVLNAS HEDSGAYSCR QRLTQLVLCH 120
FSVRVTDAPS SGDDEDGEDE AEDTGVDTGA PYWTRPERMD KKLLAVPAAN TVRFRCPAAG 180
NPTPSISWLK NGKEFRGEHR IGGIKLRHQQ WSLVMESVVP SDRGNYTCVV ENKFGSIRQT 240
YTLDVLERSP HRPILQAGLP ANQTAVLGSD VEFHCKVYSD AQPHIQWLKH VEVNGSKVGP 300
DGTPYVTVLK VSLESNASMS SNTPLVRIAR LSSGEGPTLA NVSELELPAD PKWELSRARL 360
TLGKPLGEGC FGQVVMAEAI GIDKDRAAKP VTVAVKMLKD DATDKDLSDL VSEMEMMKMI 420
GKHKNIINLL GACTQGGPLY VLVEYAAKGN LREFLRARRP PGLDYSFDTC KPPEEQLTFK 480
DLVSCAYQVA RGMEYLASQK CIHRDLAARN VLVTEDNVMK IADFGLARDV HNLDYYKKTT 540
NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LLWEIFTLGG SPYPGIPVEE LFKLLKEGHR 600
MDKPANCTHD LYMIMRECWH AAPSQRPTFK QLVEDLDRVL TVTSTDEYLD LSAPFEQYSP 660
GGQDTPSSSS SGDDSVFAHD LLPPAPPSSG GSRT 694
Nucleotide Sequence
(FASTA)
ATGGGCGCCC CTGCCTGCGC CCTCGCGCTC TGCGTGGCAG TGGCCATCGT GGCCGGCGCC 60
TCCTCGGAGT CCTTGGGGAC GGAGCAGCGC GTCGTGGGGC GAGTGGCAGA AGTGTCCGGC 120
CCGGAGCCCA GCCAGCAGGA GCAGTTGGTC TTCGGCAGCG GGGACGCTGT GGAGCTGAGC 180
TGTCCCCCGC CCGGGGGTGG TCCCATGGGG CCCACTGTCT GGGTCAAGGA TGGCGCAGGG 240
CTGGTGCCCT CGGAGCGTGT CCTGGTGGGG CCCCAGCGGC TGCAGGTGCT GAATGCCTCC 300
CACGAGGACT CTGGGGCCTA CAGCTGCCGG CAGCGGCTCA CACAGCTCGT ACTGTGCCAC 360
TTCAGTGTGC GGGTGACAGA TGCTCCATCC TCGGGAGATG ACGAAGACGG GGAGGACGAG 420
GCTGAGGACA CAGGTGTGGA CACAGGGGCC CCTTACTGGA CTCGGCCCGA GCGGATGGAC 480
AAGAAGCTGC TGGCTGTGCC GGCCGCCAAC ACCGTCCGCT TCCGCTGCCC GGCTGCCGGC 540
AACCCCACTC CCTCCATCTC CTGGCTGAAG AATGGCAAGG AGTTCCGCGG CGAGCACCGC 600
ATTGGCGGCA TCAAGCTTCG GCACCAGCAG TGGAGCCTGG TCATGGAAAG CGTGGTGCCC 660
TCGGACCGCG GCAACTACAC CTGCGTGGTG GAGAACAAGT TTGGCAGCAT CCGGCAGACA 720
TACACGCTGG ACGTGCTGGA GCGCTCCCCG CACCGGCCCA TCCTGCAGGC GGGGCTGCCG 780
GCCAACCAGA CGGCGGTGCT GGGCAGCGAT GTGGAGTTTC ACTGCAAGGT GTACAGTGAT 840
GCGCAGCCCC ACATCCAGTG GCTCAAGCAC GTGGAGGTGA ATGGCAGCAA GGTGGGCCCC 900
GACGGCACAC CCTACGTCAC CGTGCTCAAG GTGTCCCTGG AGTCCAACGC GTCCATGAGC 960
TCCAACACAC CGCTGGTGCG CATCGCAAGG CTGTCCTCAG GGGAGGGTCC CACGCTGGCC 1020
AATGTCTCCG AGCTTGAGCT GCCTGCTGAC CCCAAATGGG AGCTGTCTCG GGCCCGGCTG 1080
ACCCTGGGCA AGCCCCTTGG GGAGGGCTGC TTCGGCCAGG TGGTCATGGC GGAGGCTATC 1140
GGCATTGACA AGGACCGGGC CGCCAAGCCT GTCACCGTAG CCGTGAAGAT GCTGAAAGAT 1200
GATGCCACTG ACAAGGACCT GTCAGACCTG GTGTCTGAGA TGGAGATGAT GAAGATGATT 1260
GGGAAACACA AGAACATTAT CAACCTGCTG GGCGCCTGCA CGCAGGGCGG GCCCCTGTAC 1320
GTGCTGGTGG AGTACGCGGC CAAGGGCAAC CTGAGGGAGT TTCTGCGGGC GCGGCGGCCC 1380
CCGGGCCTGG ACTACTCCTT CGACACCTGC AAGCCGCCTG AGGAGCAACT CACCTTCAAG 1440
GACCTGGTGT CCTGTGCCTA CCAGGTGGCC CGAGGCATGG AGTACCTCGC CTCCCAGAAG 1500
TGCATCCACA GGGACCTGGC TGCTCGAAAT GTGCTGGTGA CCGAGGACAA CGTGATGAAG 1560
ATCGCAGACT TCGGGCTGGC CCGCGACGTG CACAACCTTG ACTACTACAA GAAGACAACC 1620
AACGGCCGGC TGCCCGTGAA GTGGATGGCG CCTGAGGCCC TGTTTGACCG AGTCTACACC 1680
CACCAGAGTG ACGTCTGGTC CTTTGGGGTC CTGCTCTGGG AGATCTTCAC GCTGGGGGGC 1740
TCTCCGTACC CCGGCATCCC TGTGGAGGAG CTCTTCAAGC TGCTGAAGGA GGGTCACCGG 1800
ATGGACAAGC CGGCCAACTG CACACACGAC CTGTACATGA TCATGCGGGA GTGCTGGCAT 1860
GCTGCGCCCT CCCAGAGGCC CACCTTCAAG CAGCTGGTGG AGGACCTGGA CCGTGTCCTC 1920
ACTGTGACGT CCACCGACGA GTACCTGGAC CTGTCAGCGC CCTTCGAGCA GTACTCCCCC 1980
GGCGGCCAGG ACACCCCGAG CTCCAGCTCC TCAGGGGATG ACTCCGTGTT TGCCCACGAC 2040
CTGCTGCCCC CGGCCCCACC CAGCAGTGGG GGCTCGCGGA CGTGA 2085
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datdkdl+dlvseme++k+
Q: 360   LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  419
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veyaakGnlreflrarrp+g ++s d++k +eeqlt+
Q: 420   IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTF  479
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt
Q: 480   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  539
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 540   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  599
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl
Q: 600   RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL  636
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQGGPL YVLVEYAAKG NLREFLRARR PPGLDYSFDT CKPPEEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH DLYMIMRECW HAAPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Homo sapiens"; ?>
EKS-CAE-00120
EKS-CAJ-00154
EKS-DAR-00433
EKS-HOS-00153
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0009898; C:internal side of plasma membrane
GO:0005764; C:lysosome
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0061144; P:alveolar secondary septum development
GO:0060385; P:axonogenesis involved in innervation
GO:0060349; P:bone morphogenesis
GO:0051216; P:cartilage development
GO:0022010; P:central nervous system myelination
GO:0090102; P:cochlea development
GO:0048546; P:digestive tract morphogenesis
GO:0072148; P:epithelial cell fate commitment
GO:0060113; P:inner ear receptor cell differentiation
GO:0070307; P:lens fiber cell development
GO:0002089; P:lens morphogenesis in camera-type eye
GO:0000165; P:MAPK cascade
GO:0002009; P:morphogenesis of an epithelium
GO:0043066; P:negative regulation of apoptotic process
GO:0048712; P:negative regulation of astrocyte differentiation
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0045879; P:negative regulation of smoothened signaling pathway
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597; P:positive regulation of cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518; P:positive regulation of phospholipase activity
GO:0031398; P:positive regulation of protein ubiquitination
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777; P:protein autophosphorylation
GO:0048678; P:response to axon injury
GO:0035019; P:somatic stem cell maintenance
GO:0021762; P:substantia nigra development
KEGG
mcc:712829;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013