EKS-MAM-00272
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00272
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK446.01.4E-133197525329
StatusUnreviewed
Ensembl ProteinENSMMUP00000026284
UniProt AccessionF7EVF4;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK3
Gene Synonyms/Alias HIPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000019988ENSMMUP00000026284ENSMMUT00000028092
ENSMMUG00000019988ENSMMUP00000011737ENSMMUT00000012515
OrganismMacaca mulatta
Functional Description
Protein Length1191
Protein Sequence
(FASTA)
MASQVLVYPP YVYQTQSSAF CSVKKLKVEP SSCIFQERNY PRTYVNGRNF GNSHPPTKGS 60
AFQTKIPFNR PRGHNFSLQT SAVVLKNTAG ATKVIAAQAQ QAQLQAPQIG AWRNRLHFLE 120
GPQRCGLKRK SEELDNHSSA MQIVDELSIL PAMLQTNMGN PVTVVTTTTG SKQNCTTGEG 180
DYQLVQHEVL CSMKNTYEVL DFLGRGTFGQ VVKCWKRGTN EIVAIKILKN HPSYARQGQI 240
EVSILARLST ENADEYNFVR AYECFQHRNH TCLVFEMLEQ NLYDFLKQNK FSPLPLKVIR 300
PILQQVTTAL KKLKSLGLIH ADLKPENIML VDPVRQPYRV KVIDFGSASH VSKTVCSTYL 360
QSRYYRAPEI ILGLPFCEAI DMWSLGCVIA ELFLGWPLYP GALEYDQIRY ISQTQGLPGE 420
QLLNVGTKST RFFCKETDMS HSGWRLKTLE EHEAETGMKS KEARKYIFNS LDDIAHVNTV 480
MDLEGSDLLA EKADRREFVS LLKKMLLIDA DLRITPAETL NHPFVNMKHL LDFPHSNHVK 540
SCFHIMDICK SHLNLCDTNN HNKTSLLRPV ASSSTATLTA NFTKIGTLRS QALTTSAHSV 600
MNWAWWLRWE DPQVQEIEAT VWIMPLARPC IPATHGKPTS YSIRVDNTVP LVTQAPAVQP 660
LQIRPGVLSQ TWSGRTQQML VPAWQQVTPL APATTTLTSE SVAGSHRLGD WGKMISCSNH 720
YNSVMPQPLL TNQITLSAPQ PVSVGIAHVV WPQPATTKKN KQCQNRSNSL QNTNIPHSAF 780
ISPKIINGKD VEEVSCIETQ DNQNSEGEAR NCCETSVRQD SDSSVSDKQR QTIIIADSPS 840
PAVSVITISS DTDEEETSQR HSLRECKGSL DCEACQSTLN IDRMCSLSSP DSTLSTSSSG 900
QSSPSPCKRP NSMSDEEQES GCDTVDGSPT SDSSGHDSPF AESTFVEDTR ENTELLSSAD 960
TETKPAVCSV VVPPVALENG LSADEHMANT DSICQPLIKG RSAPGRLNQP SAVGTRQQKL 1020
TSAFQQQHLN FSQVQHFGSG HQEWNGNFGH RRQQAYIPTS VTSNPFTLSH GSPNHTAVHA 1080
HLAGNTHLGG QPTLLPYPSS ATLSSAAPVA HLLASPCTSR PMLQHPTYNI SHPSGIVHQV 1140
PVGLNPRLLP SPTIHQTQYK PIFPPHSYIA ASPAYTGFPL SPTKLSQYPY M 1191
Nucleotide Sequence
(FASTA)
ATGGCCTCAC AAGTCTTGGT CTATCCACCA TATGTTTATC AAACTCAGTC AAGTGCCTTT 60
TGTAGTGTGA AGAAACTCAA AGTAGAGCCA AGCAGTTGTA TATTCCAGGA AAGAAACTAT 120
CCACGGACCT ATGTGAATGG TAGAAACTTT GGAAATTCTC ATCCTCCCAC TAAGGGTAGT 180
GCTTTTCAGA CAAAGATACC ATTTAATAGA CCTCGAGGAC ACAACTTTTC ATTGCAGACA 240
AGTGCTGTTG TTTTGAAAAA CACTGCAGGT GCTACAAAGG TCATAGCAGC TCAGGCTCAG 300
CAAGCTCAAT TGCAAGCACC TCAGATTGGG GCGTGGCGAA ACAGATTGCA TTTCCTAGAA 360
GGCCCCCAGC GATGTGGATT GAAGCGCAAG AGTGAGGAGT TGGATAATCA TAGCAGCGCA 420
ATGCAGATTG TCGATGAATT GTCCATACTT CCTGCAATGT TGCAAACCAA CATGGGAAAT 480
CCAGTGACAG TTGTGACAAC TACCACAGGA TCAAAACAGA ATTGTACCAC TGGAGAAGGT 540
GACTATCAGT TAGTGCAGCA TGAAGTCTTA TGCTCCATGA AAAATACTTA TGAAGTCCTT 600
GATTTTCTTG GTCGAGGCAC CTTTGGCCAG GTAGTTAAAT GCTGGAAAAG AGGGACAAAT 660
GAAATTGTAG CAATCAAAAT TTTGAAAAAT CATCCTTCTT ATGCTCGTCA AGGTCAAATA 720
GAAGTGAGCA TATTAGCAAG GCTCAGTACT GAAAATGCTG ATGAATATAA CTTTGTACGA 780
GCTTATGAAT GCTTTCAGCA CCGTAACCAT ACTTGTTTAG TTTTTGAGAT GCTGGAACAA 840
AACTTGTATG ACTTTCTGAA ACAAAATAAA TTTAGTCCCC TGCCACTAAA AGTGATTCGG 900
CCCATTCTTC AGCAAGTGAC CACTGCACTG AAAAAATTGA AAAGTCTTGG TTTAATTCAT 960
GCTGATCTCA AGCCAGAGAA TATTATGTTG GTGGATCCTG TTCGGCAGCC TTACAGGGTT 1020
AAAGTAATAG ACTTTGGGTC GGCCAGTCAT GTATCAAAGA CTGTTTGTTC AACGTATCTA 1080
CAATCTCGGT ACTACAGAGC TCCGGAGATT ATATTGGGGT TGCCATTTTG TGAAGCCATA 1140
GACATGTGGT CATTGGGATG TGTGATTGCA GAATTATTCC TTGGATGGCC GCTCTACCCA 1200
GGAGCCTTGG AGTATGATCA GATTCGATAC ATTTCTCAGA CTCAAGGTTT ACCAGGAGAA 1260
CAGTTGTTAA ATGTGGGTAC TAAATCCACA AGATTTTTTT GCAAAGAAAC AGATATGTCT 1320
CATTCTGGTT GGAGATTAAA GACATTGGAA GAGCATGAGG CAGAGACAGG AATGAAGTCT 1380
AAAGAAGCCA GAAAATACAT TTTCAACAGT CTGGATGACA TAGCGCATGT GAACACAGTG 1440
ATGGATTTGG AAGGAAGTGA TCTTTTGGCT GAGAAAGCTG ATAGAAGAGA ATTTGTTAGT 1500
CTGTTGAAGA AAATGTTGCT GATTGATGCA GATTTAAGAA TTACTCCAGC TGAGACCCTG 1560
AACCATCCTT TTGTTAATAT GAAACATCTT CTAGATTTCC CTCATAGCAA CCACGTAAAG 1620
TCCTGTTTTC ATATTATGGA TATTTGTAAG TCCCACCTAA ATTTATGTGA CACAAATAAT 1680
CACAACAAAA CTTCACTTTT AAGACCAGTT GCTTCAAGCA GTACTGCTAC ACTGACTGCA 1740
AATTTTACTA AAATTGGAAC ATTAAGAAGT CAGGCATTGA CCACATCTGC TCATTCAGTT 1800
ATGAACTGGG CATGGTGGTT GAGGTGGGAG GATCCACAAG TCCAGGAGAT TGAGGCCACA 1860
GTATGGATCA TGCCACTAGC AAGGCCCTGT ATTCCTGCAA CACATGGTAA ACCTACTAGT 1920
TATTCAATAA GGGTAGATAA TACAGTTCCA CTTGTAACTC AGGCCCCAGC TGTGCAGCCA 1980
CTACAGATCC GACCAGGAGT TCTTTCTCAG ACGTGGTCTG GTAGAACACA GCAGATGCTG 2040
GTGCCTGCCT GGCAACAGGT GACACCCCTG GCTCCTGCTA CTACTACACT AACTTCTGAG 2100
AGTGTGGCTG GTTCACACAG GCTTGGAGAC TGGGGGAAGA TGATTTCATG CAGCAATCAT 2160
TATAACTCAG TGATGCCGCA GCCTCTTCTG ACCAATCAGA TAACTTTATC TGCCCCTCAG 2220
CCAGTTAGTG TGGGGATTGC ACATGTTGTC TGGCCTCAAC CTGCCACTAC CAAGAAAAAT 2280
AAACAGTGCC AGAACAGGAG TAATTCATTA CAGAATACCA ATATCCCACA TTCAGCATTT 2340
ATTTCTCCAA AGATAATTAA TGGGAAAGAT GTCGAGGAAG TAAGTTGTAT AGAAACACAG 2400
GACAATCAGA ACTCAGAAGG AGAGGCAAGA AATTGCTGTG AAACATCTGT CAGACAGGAC 2460
TCTGATTCAT CAGTTTCAGA CAAACAGCGA CAAACCATCA TTATTGCTGA CTCCCCGAGT 2520
CCTGCAGTGA GTGTCATCAC TATTAGCAGT GACACTGATG AGGAAGAGAC TTCGCAGAGA 2580
CATTCACTCA GAGAATGTAA AGGTAGTCTA GATTGTGAAG CTTGCCAGAG CACTTTGAAT 2640
ATTGATCGGA TGTGTTCATT AAGTAGTCCT GATAGTACTC TGAGTACCAG CTCCTCAGGG 2700
CAGTCCAGCC CATCCCCCTG CAAGAGACCG AATAGTATGT CAGATGAAGA GCAAGAAAGT 2760
GGTTGTGATA CGGTGGATGG CTCTCCGACA TCCGACTCTT CTGGGCATGA TAGTCCATTT 2820
GCAGAGAGCA CTTTTGTGGA GGACACTCGT GAAAACACAG AACTGTTATC CTCTGCCGAC 2880
ACAGAAACCA AGCCAGCTGT CTGTTCTGTT GTGGTGCCAC CAGTGGCACT AGAAAATGGC 2940
TTAAGTGCCG ATGAGCATAT GGCAAACACA GATTCTATAT GCCAGCCATT AATAAAAGGA 3000
CGATCTGCCC CTGGAAGATT AAACCAGCCT TCCGCAGTGG GTACTCGTCA GCAAAAATTG 3060
ACATCAGCAT TCCAGCAGCA GCATTTGAAC TTTAGTCAGG TTCAGCACTT TGGATCTGGG 3120
CATCAAGAGT GGAATGGAAA CTTTGGGCAT CGAAGACAGC AAGCTTATAT CCCTACTAGT 3180
GTTACCAGTA ATCCATTCAC TCTTTCTCAT GGAAGTCCCA ATCACACAGC AGTGCATGCC 3240
CACCTGGCTG GAAATACACA CCTCGGAGGA CAGCCTACTC TACTTCCATA CCCATCATCA 3300
GCCACCCTCA GTAGTGCTGC ACCAGTGGCC CACCTCTTAG CCTCTCCATG TACCTCAAGA 3360
CCTATGTTAC AGCATCCAAC TTATAATATC TCCCATCCCA GTGGCATAGT TCACCAAGTC 3420
CCAGTGGGCT TAAATCCCCG TCTGTTACCA TCCCCAACCA TTCATCAGAC TCAGTACAAA 3480
CCAATCTTCC CACCACATTC TTACATTGCA GCATCACCTG CATATACTGG ATTTCCACTG 3540
AGTCCAACAA AACTCAGCCA GTATCCATAT ATGTGA 3576
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 197   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  255
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+
Q: 256   YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVTTALKKLKS  315
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 316   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP  375
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+++ff  
Q: 376   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFck  435
         **********************************************************99
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t+++++ ++lkt          ks++++k+++n  ++++++++ ++ e ++ l+ek+d+
Q: 436   eTDMSHSGWRLKTLeeheaetgmKSKEARKYIFNSLDDIAHVNTVMDLEGSDLLAEKADR  495
         8889999999999999*******************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f++llk+ml +d++ Ritp+e+l+hpfv
Q: 496   ReFVSLLKKMLLIDADLRITPAETLNHPFV  525
         99***************************7
Domain Sequence
(FASTA)
YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 60
NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV TTALKKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCKE 240
TDMSHSGWRL KTLEEHEAET GMKSKEARKY IFNSLDDIAH VNTVMDLEGS DLLAEKADRR 300
EFVSLLKKML LIDADLRITP AETLNHPFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00252
EKS-ANC-00259
EKS-BOT-00270
EKS-CAJ-00276
EKS-CAF-00277
EKS-CAP-00305
EKS-DAR-00610
EKS-DIO-00021
EKS-EQC-00262
EKS-FEC-00256
EKS-GAG-00227
EKS-GAA-00333
EKS-GOG-00269
EKS-HOS-00276
EKS-ICT-00259
EKS-LAC-00281
EKS-LOA-00280
EKS-MEG-00215
EKS-MOD-00267
EKS-MUM-00301
EKS-MUP-00267
EKS-MYL-00272
EKS-NOL-00247
EKS-ORN-00349
EKS-ORA-00234
EKS-ORC-00255
EKS-ORL-00325
EKS-OTG-00276
EKS-PAT-00255
EKS-PES-00240
EKS-POA-00260
EKS-RAN-00285
EKS-SAH-00254
EKS-SUS-00232
EKS-TAG-00285
EKS-TAR-00346
EKS-VIP-00012
EKS-XET-00344
EKS-XIM-00341
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009299; P:mRNA transcription
GO:0043508; P:negative regulation of JUN kinase activity
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013