EKS-MAM-00137

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00137

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.9	8.5E-152	148	405	258

Status

Unreviewed

Ensembl Protein

ENSMMUP00000037508

UniProt Accession

F7FNH8;

Protein Name

Protein Synonyms/Alias

RAC-gamma serine/threonine-protein kinase isoform 1;

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000019995	ENSMMUP00000026292	ENSMMUT00000028102
ENSMMUG00000019995	ENSMMUP00000037509	ENSMMUT00000044491
ENSMMUG00000019995	ENSMMUP00000037508	ENSMMUT00000044490

Organism

Macaca mulatta

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120

PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240

RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300

ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360

EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 420

PFKPQVTSET DTRYFDEEFT AQTITITPPE KCQQSDCGML GNWKK 465

Nucleotide Sequence
(FASTA)

ATGAGCGATG TTACCATTGT GAAAGAAGGT TGGGTTCAGA AGAGGGGAGA ATATATAAAA 60

AACTGGAGGC CAAGATATTT CCTTTTGAAG ACAGATGGCT CATTCATAGG ATATAAAGAG 120

AAACCTCAAG ATGTGGATTT ACCTTATCCC CTCAACAACT TTTCAGTGGC AAAATGCCAA 180

TTAATGAAAA CAGAACGACC AAAGCCAAAC ACATTTATAA TCAGATGTCT CCAGTGGACC 240

ACTGTTATAG AGAGAACATT TCATGTAGAT ACTCCAGAGG AAAGGGAAGA ATGGACAGAA 300

GCTATCCAGG CTGTAGCGGA CAGACTGCAG AGGCAAGAAG AGGAGAGAAT GAATTGTAGT 360

CCAACTTCAC AAATTGATAA TATAGGAGAG GAAGAGATGG ATGCTTCTAC AACCCATCAT 420

AAAAGAAAGA CAATGAATGA TTTTGACTAT TTGAAACTAC TAGGTAAAGG CACTTTTGGG 480

AAAGTTATTT TGGTTCGAGA GAAGGCAAGT GGAAAATATT ATGCTATGAA GATTCTGAAG 540

AAAGAAGTCA TTATTGCAAA GGATGAAGTG GCACACACTC TTACTGAAAG CAGAGTATTA 600

AAGAACACTA GACATCCCTT TTTAACATCC TTGAAATATT CCTTCCAGAC AAAAGACCGT 660

TTGTGTTTTG TGATGGAATA TGTTAATGGG GGCGAGCTGT TTTTCCATTT GTCGAGAGAG 720

CGGGTGTTCT CTGAGGACCG CACACGTTTC TATGGTGCAG AAATTGTCTC TGCCTTGGAC 780

TATCTACATT CCGGAAAGAT CGTGTACCGT GATCTCAAGT TGGAGAATCT AATGCTGGAT 840

AAAGATGGCC ACATAAAAAT TACAGATTTT GGACTTTGCA AAGAAGGGAT CACAGATGCA 900

GCCACCATGA AGACGTTCTG TGGCACTCCA GAATATCTGG CACCAGAGGT GTTAGAAGAT 960

AATGACTATG GCCGAGCAGT AGACTGGTGG GGCCTAGGGG TTGTCATGTA TGAAATGATG 1020

TGTGGGAGGT TACCTTTCTA CAACCAGGAC CATGAGAAAC TTTTTGAATT AATATTAATG 1080

GAAGACATTA AGTTTCCTCG AACACTCTCT TCAGATGCAA AATCATTGCT TTCAGGGCTC 1140

TTGATAAAGG ATCCAAATAA ACGCCTTGGT GGAGGACCAG ATGATGCAAA AGAAATTATG 1200

AGACACAGTT TCTTTTCTGG AGTAAACTGG CAAGATGTAT ATGATAAAAA GCTTGTACCT 1260

CCTTTTAAAC CTCAAGTAAC ATCTGAGACA GATACTAGAT ATTTTGATGA AGAATTTACA 1320

GCTCAGACTA TTACAATAAC ACCACCTGAA AAATGTCAGC AATCAGATTG TGGCATGCTG 1380

GGTAACTGGA AAAAATAA 1398

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  267

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 268   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  327

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 328   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  387

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 388   RLGGGPDDAKEIMRHSFF  405

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000002	; P:mitochondrial genome maintenance
GO:0007165	; P:signal transduction

KEGG

mcc:714717

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013