EKS-MAM-00254
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00254
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL292.93.1E-871201201
StatusUnreviewed
Ensembl ProteinENSMMUP00000026374
UniProt AccessionH9Z5L7;
Protein Name
Protein Synonyms/Alias Serine/threonine-protein kinase SIK1;
Gene NameSIK1
Gene Synonyms/Alias SIK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000020050ENSMMUP00000026374ENSMMUT00000028189
OrganismMacaca mulatta
Functional Description
Protein Length706
Protein Sequence
(FASTA)
MKLLNHPHII KLYQVMETKD MLYIVTEFAK NGEMFDYLTS NGHLSENEAR KKFWQILSAV 60
EYCHDHHIVH RDLKTENLLL DGNMDIKLAD FGFGNFYKSG EPLSTWCGSP PYAAPEVFEG 120
KEYEGPQLDI WSLGVVLYVL VCGSLPFDGP NLPTLRQRVL EGRFRIPFFM SQDCESLIRR 180
MLVVDPARRI TIAQIRQHRW MRAEPCLPGP ACSTFSAHSY SSNLGDYDEQ ALGIMQTLGV 240
DRQRTVESLQ NSSYNHFAAI YYLLLERLKE YRNAQCARPG PARQPRPRSS DLSGLEVPQE 300
GLSTDPFRPA LLCPQPQTLV QSVLQAELDC ELQSSLQWPL FFPVDASCSG VFRPRPVSPS 360
SLLDTAISEE ARQGPGLEEE QDVQESLPSS TGRRHTLAEV STRLSPLTAP CIVVSPSASA 420
SPAEGTSSDS CLTFSASKSP VGLSGTPATQ GLLGACSPVR LASPFLGSQS ATPVLPTQGG 480
LGGAVLLPVS FQEGRRASDT SLTQGLKAFR QQLRKTTRTK GFLGLNKIKG LARQMCQAPA 540
SRASRGGLSP FHAPAQSPGL HGVAAGSREG RSLLEEVLEQ QRLLQLQHHP AAAPGCSQAA 600
QPAPAQFVIA PCDGPGAAPL PSTLLMSGLP LLQPPLLQTG VSPVASAAQL LDTHLHIGAG 660
PTTLPAAPPP RLARLAPGCE PLGLLQGDCE MEDLTPCPLG TFVLVQ 706
Nucleotide Sequence
(FASTA)
ATGAAGCTTC TGAACCATCC ACATATCATA AAGCTCTACC AGGTTATGGA AACAAAGGAT 60
ATGCTTTACA TCGTCACTGA ATTTGCTAAA AATGGAGAAA TGTTTGATTA TTTGACTTCC 120
AACGGGCACC TGAGTGAGAA CGAGGCACGG AAGAAGTTCT GGCAAATACT GTCAGCCGTG 180
GAGTACTGTC ACGACCATCA CATCGTCCAC CGGGACCTCA AGACCGAGAA CCTCCTGCTG 240
GATGGCAACA TGGACATCAA GCTAGCAGAT TTTGGATTTG GGAATTTCTA CAAGTCAGGA 300
GAGCCTCTGT CCACGTGGTG TGGGAGCCCC CCATATGCCG CCCCGGAAGT CTTTGAGGGG 360
AAGGAGTATG AAGGCCCCCA GCTGGACATC TGGAGCCTGG GTGTGGTGCT GTACGTCCTG 420
GTCTGTGGTT CTCTCCCCTT TGACGGGCCT AACCTGCCGA CGCTGAGACA GCGGGTGCTG 480
GAGGGCCGCT TCCGCATCCC CTTCTTCATG TCTCAAGACT GTGAGAGCCT GATCCGCCGC 540
ATGCTGGTGG TGGACCCTGC CAGGCGCATC ACCATCGCCC AGATCCGGCA GCACCGGTGG 600
ATGCGGGCTG AGCCCTGCTT GCCAGGACCC GCCTGCTCCA CCTTCTCCGC GCACAGCTAC 660
AGCTCCAACC TGGGCGACTA CGACGAGCAG GCGCTGGGTA TCATGCAGAC GCTGGGCGTC 720
GACCGGCAGA GGACGGTGGA GTCGCTGCAA AACAGCAGCT ATAACCACTT CGCTGCCATT 780
TATTACCTCC TCCTCGAGCG GCTCAAGGAG TATCGGAATG CCCAGTGTGC CCGCCCCGGG 840
CCTGCCAGGC AGCCGCGACC TCGGAGCTCG GACCTCAGCG GTTTGGAGGT GCCTCAGGAA 900
GGCCTTTCCA CTGACCCTTT CCGCCCCGCC CTGCTGTGCC CGCAGCCGCA GACCTTGGTG 960
CAGTCTGTCC TGCAGGCCGA GCTGGACTGT GAGCTCCAGA GCTCGCTGCA GTGGCCCTTG 1020
TTCTTCCCGG TGGATGCCAG CTGCAGCGGC GTGTTCCGGC CCCGGCCCGT GTCCCCCAGC 1080
AGCCTGCTGG ACACAGCCAT CAGTGAGGAG GCCAGGCAGG GGCCAGGCCT AGAGGAGGAG 1140
CAGGACGTGC AGGAGTCCCT GCCCAGCAGC ACGGGCCGGA GACACACCCT GGCCGAGGTC 1200
TCCACCCGCC TCTCCCCACT CACCGCTCCA TGTATAGTCG TCTCCCCCTC CGCCTCGGCA 1260
AGTCCTGCAG AGGGAACCAG CTCTGACAGT TGTCTGACCT TCTCTGCAAG CAAAAGCCCT 1320
GTGGGGCTCA GTGGCACCCC GGCCACTCAG GGGCTGTTGG GCGCCTGCTC CCCGGTCAGG 1380
CTGGCCTCAC CCTTCCTGGG GTCGCAGTCC GCCACCCCGG TGCTGCCGAC TCAGGGGGGC 1440
TTGGGAGGAG CTGTGCTGCT CCCTGTCAGC TTCCAGGAGG GACGGCGGGC ATCAGACACC 1500
TCACTGACTC AGGGGCTGAA GGCCTTTCGG CAGCAGCTGA GGAAGACCAC GCGGACCAAA 1560
GGGTTTCTGG GACTGAACAA AATCAAGGGG CTGGCTCGCC AGATGTGCCA GGCCCCTGCC 1620
AGCCGGGCCA GCAGGGGCGG CCTGAGCCCC TTCCACGCCC CTGCACAGAG CCCAGGCCTG 1680
CACGGCGTTG CAGCTGGCAG CCGGGAGGGC CGGAGCCTGC TGGAGGAGGT GCTAGAACAG 1740
CAGAGGCTGC TCCAGTTACA GCACCATCCG GCCGCTGCGC CCGGCTGCTC ACAGGCCGCC 1800
CAGCCAGCCC CGGCCCAGTT TGTGATCGCC CCCTGTGATG GCCCCGGGGC TGCCCCGCTC 1860
CCCAGCACCC TCCTCATGTC GGGGCTCCCG CTGCTGCAGC CCCCACTCCT GCAGACCGGC 1920
GTCTCCCCAG TGGCCTCGGC GGCGCAGCTC CTGGACACAC ACCTGCACAT TGGTGCCGGC 1980
CCCACCACCC TCCCCGCTGC GCCCCCACCA CGCCTGGCAA GGCTGGCCCC AGGTTGTGAG 2040
CCCCTGGGGC TGCTGCAGGG GGACTGTGAG ATGGAGGACC TGACGCCCTG CCCCCTGGGG 2100
ACCTTTGTCC TGGTGCAGTG A 2121
Domain Profile
S: 52    lkklkhpniikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsav  111
         +k l+hp+iikl++v+etk++ly+v+e+a++ge+fdy++++g+l+e+eark f q++sav
Q: 1     MKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAV  60
         799*********************************************************
S: 112   kYlhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkg  171
         +Y+h+++ivHrDlK+eNllld +++ik+aDFG++n++k+g+ l+t+cGsppYaaPe+++g
Q: 61    EYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEG  120
         ************************************************************
S: 172   kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrk  231
         k+Yegp++D+WslGvvLy+lv+g+lPfd++nl +l++++l+g+++ip+ +s+++esL+r+
Q: 121   KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRR  180
         ************************************************************
S: 232   lLvvdpekRatieeilkhewl  252
         +Lvvdp++R+ti +i++h+w+
Q: 181   MLVVDPARRITIAQIRQHRWM  201
         ********************8
Domain Sequence
(FASTA)
MKLLNHPHII KLYQVMETKD MLYIVTEFAK NGEMFDYLTS NGHLSENEAR KKFWQILSAV 60
EYCHDHHIVH RDLKTENLLL DGNMDIKLAD FGFGNFYKSG EPLSTWCGSP PYAAPEVFEG 120
KEYEGPQLDI WSLGVVLYVL VCGSLPFDGP NLPTLRQRVL EGRFRIPFFM SQDCESLIRR 180
MLVVDPARRI TIAQIRQHRW M 201
KeywordATP-binding; Kinase; Nucleotide-binding; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00224
EKS-ANC-00233
EKS-BOT-00240
EKS-CAJ-00248
EKS-CAF-00251
EKS-CAP-00267
EKS-DAR-00558
EKS-DIO-00009
EKS-EQC-00237
EKS-FEC-00227
EKS-GAM-00143
EKS-GAG-00202
EKS-GAA-00297
EKS-GOG-00241
EKS-HOS-00253
EKS-ICT-00229
EKS-LAC-00268
EKS-LOA-00237
EKS-MEG-00189
EKS-MIM-00009
EKS-MOD-00243
EKS-MUM-00249
EKS-MYL-00243
EKS-NOL-00225
EKS-OCP-00018
EKS-ORN-00311
EKS-ORA-00212
EKS-ORL-00296
EKS-OTG-00249
EKS-PAT-00232
EKS-PES-00216
EKS-POA-00238
EKS-PTV-00026
EKS-RAN-00240
EKS-SAH-00227
EKS-TAG-00259
EKS-TAR-00306
EKS-TEN-00305
EKS-XIM-00305
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0008140; F:cAMP response element binding protein binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0072333; P:anoikis by p53 class mediator
GO:0055007; P:cardiac muscle cell differentiation
GO:0007243; P:intracellular protein kinase cascade
GO:0032792; P:negative regulation of CREB transcription factor activity
GO:0045721; P:negative regulation of gluconeogenesis
GO:0010868; P:negative regulation of triglyceride biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0007346; P:regulation of mitotic cell cycle
GO:0010830; P:regulation of myotube differentiation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
SM00165; UBA; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013