EKS-MAM-00194

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00194

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	393.5	7.8E-118	61	294	234

Status

Unreviewed

Ensembl Protein

ENSMMUP00000026429

UniProt Accession

F7GPC1;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000020083	ENSMMUP00000040295	ENSMMUT00000047268
ENSMMUG00000020083	ENSMMUP00000026429	ENSMMUT00000028246
ENSMMUG00000020083	ENSMMUP00000026430	ENSMMUT00000028247

Organism

Macaca mulatta

Functional Description

Protein Length

570

Protein Sequence
(FASTA)

MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NVSQVGRVWP SSYRALISAF SRLTRLDDFT 60

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 120

VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 180

NCLIKRDENG YSAVVADFGL AEKIPDVSMG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 240

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNVISLLLP 300

RLECNVKTFC GKMLLLFVMT SESNRLNYSS GLLEKAPGVK RLSSLDDKIP HKSPCPRRTI 360

WLSRSQSDIF SRKPSRTVSV LDPYYQPRDG AARTPKVNPF SARQDLKGGK IKFFDLPSKS 420

VISLVFDLDA PGPGTMPLAD WQEPLAPPIR RWRSLPGSPE FLHQEACPFV GREESLSDGP 480

PPRLSSLKYR VKEIPPFRAS ALPAAQAHEA MDCSSLQEEN GFGSRPQGTS PCPVGASEEM 540

EVEEERPAGS TPVTFSTSGI GLQTQGKQDG 570

Nucleotide Sequence
(FASTA)

ATGGATCGGA GCAAACGGAA TTCAATTGCA GGTTTTCCTC CACGTGTGGA GCGTCTTGAA 60

GAGTTTGAAG GAGGTGGTGG AGGAGATGGA AATGTGAGCC AGGTGGGAAG AGTTTGGCCA 120

TCTTCGTATC GAGCTCTTAT AAGTGCCTTT TCCAGACTGA CGCGTTTGGA TGATTTCACC 180

TGTGAAAAAA TAGGGTCTGG CTTCTTCTCT GAAGTGTTCA AGGTACGACA CCGAGCTTCT 240

GGTCAGGTGA TGGCTCTTAA GATGAACACG TTGAGCAGTA ACCGGGCAAA CATGCTGAAA 300

GAAGTACAGC TCATGAATAG ACTCTCCCAT CCCAACATCC TTAGGTTCAT GGGTGTGTGT 360

GTTCATCAAG GACAATTGCA TGCACTTACA GAGTATATCA ACTCCGGGAA CCTGGAACAG 420

TTGCTAGACA GTAACCTGCA TTTGCCTTGG ACTGTGAGGG TAAAACTGGC CTATGACATA 480

GCAGTGGGCC TCAGCTACCT TCACTTCAAA GGCATTTTTC ATCGGGACCT CACATCTAAG 540

AACTGCCTGA TAAAGAGGGA TGAGAATGGT TACTCTGCAG TGGTAGCTGA CTTTGGCCTG 600

GCTGAGAAGA TCCCCGATGT CAGCATGGGG AGTGAGAAGT TGGCCGTGGT GGGTTCCCCA 660

TTCTGGATGG CACCTGAGGT TCTCCGAGAT GAGCCCTATA ACGAAAAGGC AGATGTGTTC 720

TCTTATGGTA TCATCCTCTG CGAGATCATC GCCCGCATCC AGGCCGATCC GGACTATCTT 780

CCCCGCACAG AGAATTTCGG GCTGGACTAT GATGCCTTCC AGCACATGGT AGGAGACTGT 840

CCTCCAGACT TTCTGCAGCT TACCTTCAAC TGCTGTAATG TGATTTCGCT CTTGTTGCCC 900

AGACTGGAGT GCAATGTGAA AACATTCTGT GGTAAAATGC TGCTTCTATT TGTCATGACT 960

AGTGAGAGTA ACAGACTTAA TTATTCTTCA GGACTCTTGG AGAAAGCACC TGGGGTGAAG 1020

CGACTAAGCT CACTGGATGA CAAGATCCCC CACAAATCAC CATGCCCAAG ACGTACCATC 1080

TGGCTGTCTC GAAGCCAGTC AGACATCTTT TCGCGTAAGC CCTCACGTAC AGTGAGCGTC 1140

TTGGACCCAT ACTACCAGCC ACGAGATGGT GCTGCCCGCA CCCCCAAAGT CAACCCTTTT 1200

AGTGCTCGCC AGGACCTCAA GGGAGGCAAG ATCAAGTTTT TTGACCTGCC CAGCAAGTCT 1260

GTCATCTCTC TGGTATTTGA CCTGGATGCA CCAGGGCCTG GAACTATGCC CCTGGCTGAC 1320

TGGCAGGAGC CCCTGGCCCC ACCTATTCGC CGGTGGCGTT CCTTGCCTGG TTCGCCTGAG 1380

TTCTTGCATC AGGAGGCTTG TCCATTTGTG GGCCGGGAAG AATCGCTATC TGATGGGCCC 1440

CCACCACGCC TAAGTAGTCT CAAGTACAGA GTTAAAGAGA TCCCACCATT CCGGGCATCT 1500

GCCCTACCAG CTGCTCAAGC CCATGAGGCT ATGGACTGCT CCAGTCTCCA GGAAGAAAAC 1560

GGTTTTGGGT CCAGGCCCCA GGGGACCAGT CCATGCCCTG TGGGTGCTTC TGAGGAGATG 1620

GAGGTAGAAG AAGAAAGGCC AGCAGGCTCA ACTCCAGTCA CCTTTTCCAC CTCAGGCATA 1680

GGCCTGCAAA CCCAGGGAAA GCAGGATGGG TGA 1713

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+n+lkev+l+++l+hpn+l+f+G

Q: 61    CEKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMG  118

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi++G+l++ll+s+ +lpwt+rv+la+dia+Glsylh+kgi+hrdl+

Q: 119   VCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT  178

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s+vvadfGla          ek+++++++  +++l+vvGsP+wmaPe

Q: 179   SKNCLIKRdenGYSAVVADFGLA----------EKIPDVSMG--SEKLAVVGSPFWMAPE  226

         *******9887899*********..........9****9999..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f

Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPPDF  284

         *************************************************.999.******

S: 241   lklavvccdl  250

         l+l+++cc++

Q: 285   LQLTFNCCNV  294

         ********96

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 60

VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 120

NCLIKRDENG YSAVVADFGL AEKIPDVSMG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNV 234

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013