EKS-MAM-00366
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00366
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.41.1E-134276525250
StatusUnreviewed
Ensembl ProteinENSMMUP00000026506
UniProt AccessionF7FWN4;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000020131ENSMMUP00000026506ENSMMUT00000028324
ENSMMUG00000020131ENSMMUP00000026505ENSMMUT00000028323
OrganismMacaca mulatta
Functional Description
Protein Length542
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRRSLEP AENAHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTRNL 120
SVDGGDWWLA HSLSTGQTGY IPSNYVAPSD SIQAEEWYFG KITRRESERL LLNAENPRGT 180
FLVRESETTK GAYCLSVSDF DNAKGLNVKH YKIRKLDSGG FYITSRTQFN SLQQLVAYYS 240
KHADGLCHRL TTVCPTSKPQ TQGLAKDAWE IPRESLRLEV KLGQGCFGEV WMGTWNGTTR 300
VAIKTLKPGT MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM SKGSLLDFLK 360
GETGKYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLVCK VADFGLARLI 420
EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL LTELTTKGRV PYPGMVNREV 480
LDQVERGYRM PCPPECPESL HDLMCQCWRK EPEERPTFEY LQAFLEDYFT STEPQYQPGE 540
NL 542
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAGC GGCGCCGCAG CCTGGAGCCC 60
GCCGAGAACG CGCATGGCGC TGGCGGGGGC GCTTTCCCCG CCTCCCAGAC CCCCAGCAAG 120
CCAGCCTCGG CCGACGGCCA CCGCGGCCCC AGCGCGGCCT TCGCCCCCGC GGCCGCCGAG 180
CCCAAGCTGT TCGGAGGCTT CAACTCCTCG GACACCGTCA CCTCCCCGCA GAGGGCGGGC 240
CCGCTGGCCG GTGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC TAGGACGGAG 300
ACAGACCTGT CCTTCAAGAA AGGCGAGCGG CTCCAGATTG TCAACAACAC GAGGAACCTG 360
TCTGTGGATG GGGGAGACTG GTGGCTGGCC CACTCGCTCA GCACGGGACA GACAGGCTAC 420
ATTCCCAGCA ACTACGTGGC GCCCTCCGAC TCCATCCAGG CCGAGGAGTG GTATTTTGGC 480
AAGATCACCA GACGGGAGTC AGAGCGGTTA CTGCTCAATG CAGAGAACCC GAGAGGGACC 540
TTCCTCGTGC GAGAAAGTGA GACCACAAAA GGTGCCTACT GCCTCTCAGT GTCCGACTTC 600
GACAACGCCA AGGGCCTCAA CGTGAAGCAC TACAAGATCC GCAAGCTGGA CAGCGGCGGC 660
TTCTACATCA CCTCCCGCAC CCAGTTCAAC AGCCTGCAGC AGCTGGTGGC CTACTACTCC 720
AAACACGCCG ATGGCCTGTG CCACCGCCTC ACCACTGTGT GCCCCACATC CAAGCCTCAG 780
ACTCAGGGCC TGGCCAAGGA TGCCTGGGAG ATCCCTCGGG AGTCGCTGCG GCTGGAGGTC 840
AAGCTGGGCC AGGGCTGCTT TGGCGAGGTG TGGATGGGGA CCTGGAACGG CACTACCAGG 900
GTGGCCATCA AAACCCTGAA GCCTGGCACG ATGTCTCCAG AGGCCTTCCT GCAGGAGGCC 960
CAGGTCATGA AGAAGCTGAG GCATGAGAAG CTGGTGCAGT TGTATGCTGT GGTTTCGGAG 1020
GAGCCCATTT ACATCGTCAC AGAGTACATG AGCAAGGGGA GTTTGCTGGA CTTTCTCAAG 1080
GGGGAGACGG GCAAGTACCT GCGGCTACCT CAGCTGGTGG ACATGGCTGC TCAGATCGCC 1140
TCAGGCATGG CATACGTGGA GCGGATGAAC TACGTCCACC GGGATCTTCG TGCAGCCAAC 1200
ATCCTGGTGG GAGAGAACCT GGTGTGCAAA GTGGCTGACT TCGGGCTGGC TCGGCTCATC 1260
GAAGACAATG AGTACACGGC CCGGCAAGGT GCCAAATTCC CCATCAAGTG GACAGCTCCG 1320
GAAGCTGCCC TGTATGGCCG CTTCACCATC AAGTCGGACG TGTGGTCCTT TGGGATCCTG 1380
CTGACTGAGC TCACCACAAA GGGACGGGTG CCCTACCCTG GGATGGTGAA CCGCGAGGTG 1440
CTGGACCAGG TGGAACGGGG CTACCGGATG CCCTGCCCAC CGGAGTGTCC CGAGTCCCTG 1500
CACGACCTCA TGTGCCAGTG CTGGCGGAAG GAGCCTGAGG AGCGGCCCAC CTTCGAGTAC 1560
CTGCAGGCCT TCCTGGAGGA CTACTTCACG TCCACCGAGC CCCAGTACCA GCCCGGGGAG 1620
AACCTCTAG 1629
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 276   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  335
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 336   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  394
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 395   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  454
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 455   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  514
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 515   RPTFEYLQAFL  525
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013