EKS-MAM-00456

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00456

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	509.4	4.1E-153	26	310	285

Status

Unreviewed

Ensembl Protein

ENSMMUP00000026707

UniProt Accession

F6WX07;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000020294	ENSMMUP00000026707	ENSMMUT00000028545

Organism

Macaca mulatta

Functional Description

Protein Length

621

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDRSIRELV TQMIHREPDK 300

RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 360

DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNNEEIDEVT HPNGNYDTVE LQALHEMVQQ 540

KVVTLLSDPE NIVKQTLMEN GITRLCVFFG RQKANDVLLS HMITFLNDKN DWHLRGAFFD 600

SIVGVAAYVG WQSSSILKPL L 621

Nucleotide Sequence
(FASTA)

ATGGGAAATC AGCTTGCTGG CATTGCTCCC TCCCAGATCC TTTCTGTAGA GAGTTATTTT 60

TCAGATATTC ATGACTTTGA ATATGATAAA AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 120

GCTCGAGCCA AGCACCGAGA AGGCCTGGTC GTTGTGAAGG TTTTTGCAAT TCAGGATCCC 180

ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTAATTCT 240

GCACAGAACT GTCTACCTTT CCAAAAAGCA TCAGAAAAAG CATCTGAGAA AGCAGCTATG 300

CTCTTTAGGC AGTACGTGCG AGACAATCTC TATGATCGTA TCAGTACCCG TCCATTCTTG 360

AATAACATTG AGAAGCGCTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 420

AAATCTGGAG TTCGTCATGG AGACATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAT 480

TGGGTTCTTC TAACTGATTT TGCCAGTTTT AAGCCCACTT ATCTTCCAGA AGACAACCCG 540

GCAGATTTCA ATTATTTCTT TGACACATCA CGGAGGAGAA CTTGTTATAT TGCTCCTGAA 600

CGTTTTGTTG ATGGTGGGAT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCAACT 660

CCACTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGAG AGCAATGGAC 720

ATCTTTTCAG CAGGTTGTGT GATAGCTGAG CTTTTTACAG AAGGTGTACC ATTATTTGAT 780

CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CATTTTTTCC CTGAACAAGT GCTAAATAAA 840

ATTGAAGATC GCAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 900

CGTTTAGAGG CAGAAGATTA CTTAAAACAG CAGCGTGGCA ACGCCTTTCC TGAAATATTT 960

TACACTTTCC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACGTTTCT TTCTGCAGAT 1020

GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 1080

GATCTGCCAG AAAAAGCCGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTATCT 1140

GTTATAACAT CCTGCCTACA GACCCTTAAA TACTGTGATT CCAAATTAGC TGCTTTGGAA 1200

CTTATTCTTC ATTTGGCTCC AAGATTAAGT GTTGAAATTC TTTTGGATCG GATTACTCCA 1260

TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCCAGGGTGA GGGCCGAAGC CTTGAGGACG 1320

TTGACCAAAG TTCTTGCTCT CGTCAAAGAG GTTCCTCGTA ATGATATCAA TATTTATCCG 1380

GAATACATTC TGCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT CGTTAGACTA 1440

GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTT TGAGATTCCT GGAATTAGTA 1500

CAGTTAAAAA ATCTTAATAT GGAAAATGAC CCCAATAATG AAGAAATAGA TGAAGTTACA 1560

CATCCAAATG GAAATTATGA CACAGTAGAG CTCCAAGCCT TACATGAAAT GGTCCAGCAG 1620

AAAGTTGTTA CTTTGCTAAG TGATCCTGAA AATATTGTAA AACAAACCTT GATGGAAAAT 1680

GGAATAACAC GGCTGTGTGT ATTCTTTGGA CGTCAGAAAG CCAATGATGT TTTGTTGTCC 1740

CACATGATTA CTTTCCTAAA TGATAAGAAT GATTGGCATC TACGTGGAGC ATTTTTTGAT 1800

AGTATAGTTG GTGTTGCTGC CTATGTTGGC TGGCAAAGCT CCTCAATTCT CAAGCCCCTG 1860

CTG 1863

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKASEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         *******999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         ++++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GMFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied+++r+lv+q+i++ep+kr++aed+lk+

Q: 266   AYRNGHFFPEQVLNKIEDRSIRELVTQMIHREPDKRLEAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLNSAQNCL 60

PFQKASEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GMFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGHFFPE QVLNKIEDRS IRELVTQMIH REPDKRLEAE DYLKQ 285

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005770	; C:late endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013