EKS-MAM-00158
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00158
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb485.65.6E-146426683258
StatusUnreviewed
Ensembl ProteinENSMMUP00000027043
UniProt AccessionF7D8E6;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA6
Gene Synonyms/Alias RPS6KA6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000020532ENSMMUP00000027043ENSMMUT00000028898
OrganismMacaca mulatta
Functional Description
Protein Length745
Protein Sequence
(FASTA)
MLPFAPQDEP WDREMEVFSG GGASSGEVNG LKMVDEPMEE GEADSCHDEG VVKEIPITHH 60
VKEGYEKADP AQFELLKVLG QGSFGKVFLV RKKTGPDAGQ LYAMKVLKKA SLKVRDRVRT 120
KMERDILVEV NHPFIVKLHY AFQTEGKLYL ILDFLRGGDV FTRLSKEVLF TEEDVKFYLA 180
ELALALDHLH QLGIVYRDLK PENILLDEIG HIKLTDFGLS KESVDQEKKA YSFCGTVEYM 240
APEVVNRRGH SQSADWWSYG VLMFEMLTGT LPFQGKDRNE TMNMILKAKL GMPQFLSAEA 300
QSLLRMLFKR NPANRLGSEG VEEIKRHLFF ANIDWDKLYK REVQPPFKPA SGKPDDTFCF 360
DPEFTAKTPK DSPGLPASAN AHQLFKGFSF VATSIAEEYK ITPITSANVL PIVQINGNAA 420
QFGEVYELKE DIGVGSYSVC KRCVHATTNM EFAVKIIDKS KRDPSEEIEI LMRYGQHPNI 480
ITLKDVFDDG RYVYLVTDLM KGGELLDRIL KQKCFSEREA SDILYVISKT VDYLHCQGVV 540
HRDLKPSNIL YMDESASADS IRICDFGFAK QLRGENGLLL TPCYTANFVA PEVLMQQGYD 600
AACDIWSLGV LFYTMLAGYT PFANGPNDTP EEILLRIGNG KFSLSGGNWD NISGGAKDLL 660
SHMLHMDPRQ RYTTEQILKH PWITHRDQLP NDQPKRNDVS HVVKGAMVAT YSALTHKTFQ 720
PVLEPVAASS LAQRRSMKKR TSTGL 745
Nucleotide Sequence
(FASTA)
ATGCTACCAT TCGCTCCTCA GGACGAGCCC TGGGACCGAG AAATGGAAGT GTTCAGCGGC 60
GGCGGCGCGA GCAGCGGCGA GGTAAATGGT CTTAAAATGG TTGATGAGCC AATGGAAGAG 120
GGAGAAGCAG ATTCTTGTCA TGATGAAGGA GTTGTTAAAG AAATCCCTAT TACTCATCAT 180
GTTAAAGAAG GCTATGAGAA AGCAGATCCT GCACAGTTTG AGTTGCTCAA GGTTCTTGGT 240
CAGGGGTCAT TTGGAAAGGT TTTTCTTGTT AGAAAGAAGA CCGGTCCTGA TGCTGGGCAA 300
CTCTATGCAA TGAAGGTGTT AAAAAAAGCC TCTTTAAAAG TTCGAGACAG AGTTCGGACA 360
AAGATGGAGA GGGATATACT GGTGGAAGTA AATCATCCAT TTATTGTCAA ATTGCACTAT 420
GCCTTTCAGA CTGAAGGGAA ACTGTACTTA ATACTGGATT TTCTCAGGGG AGGAGATGTT 480
TTCACAAGAT TATCCAAAGA GGTTCTGTTT ACAGAGGAAG ATGTGAAATT CTACCTCGCA 540
GAACTGGCCC TTGCTTTGGA TCATCTGCAC CAATTAGGAA TTGTTTATAG AGACCTGAAG 600
CCAGAAAACA TTTTGCTTGA TGAAATAGGA CATATCAAAT TAACAGATTT TGGACTCAGC 660
AAGGAGTCAG TAGATCAAGA AAAGAAGGCT TACTCATTTT GTGGTACAGT AGAGTATATG 720
GCTCCTGAAG TAGTAAATAG GAGAGGCCAT TCCCAGAGTG CTGATTGGTG GTCATATGGT 780
GTTCTTATGT TTGAAATGCT TACTGGTACT CTGCCATTTC AAGGTAAAGA CAGAAATGAG 840
ACCATGAATA TGATATTAAA AGCAAAACTT GGAATGCCTC AATTTCTTAG TGCTGAAGCA 900
CAAAGTCTTC TAAGGATGTT ATTCAAAAGG AATCCAGCAA ATAGATTGGG ATCAGAAGGA 960
GTTGAAGAAA TCAAAAGACA TCTGTTTTTT GCAAATATTG ACTGGGATAA GTTATATAAA 1020
AGAGAAGTTC AACCTCCTTT CAAACCTGCT TCTGGAAAAC CAGATGATAC TTTTTGTTTT 1080
GATCCTGAAT TTACTGCAAA AACACCTAAA GATTCTCCTG GTTTGCCAGC CAGTGCAAAC 1140
GCTCATCAGC TCTTCAAAGG ATTCAGCTTT GTTGCAACTT CTATTGCAGA AGAATATAAA 1200
ATCACTCCTA TCACAAGTGC AAATGTATTA CCAATTGTTC AGATAAATGG AAATGCTGCA 1260
CAATTTGGTG AAGTATATGA ATTGAAAGAG GATATTGGTG TTGGCTCCTA TTCTGTTTGC 1320
AAGCGATGCG TACATGCAAC TACCAACATG GAATTTGCAG TGAAGATCAT TGACAAAAGT 1380
AAGCGAGACC CTTCAGAAGA GATTGAAATA CTGATGCGCT ATGGACAACA TCCCAACATT 1440
ATTACTTTGA AGGATGTCTT TGATGATGGT AGATATGTTT ACCTTGTTAC GGATTTAATG 1500
AAAGGAGGAG AGTTACTTGA CCGTATTCTC AAACAAAAAT GTTTCTCGGA ACGGGAGGCT 1560
AGTGATATAC TATATGTAAT AAGTAAGACA GTTGACTATC TTCATTGTCA AGGAGTTGTT 1620
CATCGTGATC TTAAACCTAG TAATATTTTA TACATGGATG AATCAGCCAG TGCAGATTCA 1680
ATCAGGATAT GTGATTTTGG GTTTGCAAAA CAACTTCGAG GAGAAAATGG ACTTCTCTTA 1740
ACTCCATGCT ACACTGCAAA CTTTGTTGCA CCTGAGGTTC TTATGCAACA GGGATATGAT 1800
GCTGCTTGTG ATATCTGGAG TTTAGGAGTC CTTTTTTACA CAATGTTGGC TGGCTACACT 1860
CCATTTGCTA ATGGCCCCAA TGATACTCCT GAAGAGATAC TGCTGCGTAT AGGCAATGGA 1920
AAGTTCTCTT TGAGTGGTGG AAACTGGGAC AATATTTCAG GTGGAGCAAA GGATTTGCTT 1980
TCCCATATGC TTCATATGGA CCCACGTCAG CGGTATACTA CTGAACAAAT ATTAAAGCAC 2040
CCATGGATAA CTCACAGAGA CCAGTTGCCA AATGATCAGC CAAAGAGAAA TGATGTGTCA 2100
CATGTTGTTA AGGGAGCAAT GGTTGCAACA TACTCTGCCC TGACTCACAA GACCTTTCAA 2160
CCAGTCCTAG AGCCTGTAGC TGCTTCAAGC TTAGCCCAGC GACGGAGCAT GAAAAAGCGA 2220
ACATCAACTG GCCTGTAA 2238
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvh++tn+efavkiidkskrd+seeieil+ry+qhpni+tlkd
Q: 426   YELKEDIGVGSYSVCKRCVHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD  485
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v+ddg+yvylv++l+kGGelldri+k+k+fsereas+il++++k+v+ylh+qGvvhrdlk
Q: 486   VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK  545
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des++a+si+i+dfGfak++r engll tpcyt+nfvapevl++qGyd+acd+
Q: 546   PSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDI  605
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslGvl+ytmlaGy+pfangp+dt+eeil +i++GkfslsG++wd++s  akdl+s++l+
Q: 606   WSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISGGAKDLLSHMLH  665
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         +dp++r++ eq+lkh+w+
Q: 666   MDPRQRYTTEQILKHPWI  683
         *****************8
Domain Sequence
(FASTA)
YELKEDIGVG SYSVCKRCVH ATTNMEFAVK IIDKSKRDPS EEIEILMRYG QHPNIITLKD 60
VFDDGRYVYL VTDLMKGGEL LDRILKQKCF SEREASDILY VISKTVDYLH CQGVVHRDLK 120
PSNILYMDES ASADSIRICD FGFAKQLRGE NGLLLTPCYT ANFVAPEVLM QQGYDAACDI 180
WSLGVLFYTM LAGYTPFANG PNDTPEEILL RIGNGKFSLS GGNWDNISGG AKDLLSHMLH 240
MDPRQRYTTE QILKHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00155
EKS-BOT-00162
EKS-CAJ-00164
EKS-DAR-00447
EKS-EQC-00161
EKS-FEC-00152
EKS-GAG-00137
EKS-GOG-00164
EKS-HOS-00168
EKS-LAC-00171
EKS-LOA-00160
EKS-MEG-00127
EKS-MOD-00161
EKS-MUM-00168
EKS-MUP-00166
EKS-MYL-00172
EKS-NOL-00155
EKS-ORN-00200
EKS-ORA-00140
EKS-ORC-00149
EKS-ORL-00190
EKS-OTG-00169
EKS-PAT-00152
EKS-PES-00144
EKS-POA-00159
EKS-RAN-00160
EKS-SAH-00156
EKS-TAG-00189
EKS-TAR-00206
EKS-TEN-00201
EKS-VIP-00077
EKS-XET-00149
EKS-XIM-00194
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007243; P:intracellular protein kinase cascade
KEGG
mcc:710337;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013