EKS-MAM-00321

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00321

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	344.9	5.3E-103	20	277	258

Status

Unreviewed

Ensembl Protein

ENSMMUP00000027064

UniProt Accession

F7D279;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K5

Gene Synonyms/Alias

MAP4K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000020550	ENSMMUP00000027064	ENSMMUT00000028919

Organism

Macaca mulatta

Functional Description

Protein Length

845

Protein Sequence
(FASTA)

MEAPLRPAAD ILRRNPQQDY ELVQRVGSGT YGDVYKARNV HTGELAAVKI IKLEPGDDFS 60

LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV 120

CRETLQGLAY LHTKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY 180

WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL 240

KDKTKWSSTF HNFVKIALTK NPKKRPTAER LLTHTFVAQP GLSRALAVEL LDRVNNPDNH 300

AHYTEADDDD FEPHAIIRHT IRSTNRNARA ERTASEINFD KLQFEPPLRK ETEARDEMGL 360

SSDPNFMLQW NPFVDGANTG KLTSKRAVPP PLPPKPRISS YPEDNFPDEE KTSTIKHCPD 420

SENRAPQILR RQSSPSCGPV AETSSIGNGD GISKLMSENT EGSAQAPQLP RKKDKRDFPK 480

PAINGLPPTP KVLMGACFSK VFDGCPLKIN CATSWIHPDT KDQYIIFGTE DGIYTLNLNE 540

LHEATMEQLF PRKCTWLYVI NNTLMSLSGK TFQLYSHNLI ALFEHAKKPG LAAHIQTHRF 600

PDRILPRKFA LTTKIPDTKG CHKCCIVRNP YTGHKYLCGA LQSGIVLLQW YEPMQKFMLI 660

KHFDFPLPSP LNVFEMLVIP EQEYPMVCVA ISKGTESNQV VQFETINLNS ASSWFTEIGA 720

GNQQLDSIHV TQLERDTVLV CLDKFVKIVN LQGKLKSSKK LASELSFDFR IESVVCLQDS 780

VLAFWKHGMQ GKSFKSDEVT QEISDETRVF RLLGSDRVVV LESRPTENPT AHSNLYILAG 840

HENSY 845

Nucleotide Sequence
(FASTA)

ATGGAGGCCC CGCTGCGGCC TGCCGCGGAC ATCCTGAGGC GGAACCCGCA GCAGGACTAC 60

GAGCTTGTCC AGAGGGTCGG CAGCGGCACC TACGGGGACG TCTACAAGGC CAGAAATGTA 120

CACACAGGAG AGTTGGCTGC AGTAAAAATC ATTAAATTGG AGCCTGGAGA TGACTTTTCT 180

TTGATTCAAC AAGAAATATT TATGGTTAAA GAATGTAAAC ATTGTAACAT CGTTGCCTAC 240

TTTGGGAGTT ACCTTAGTCG GGAAAAACTA TGGATTTGTA TGGAATACTG TGGTGGCGGA 300

TCACTTCAAG ATATTTACCA TGTTACTGGA CCATTATCAG AATTGCAAAT AGCCTATGTA 360

TGCAGAGAAA CTTTACAGGG TCTTGCCTAT TTGCATACTA AAGGCAAAAT GCATAGAGAT 420

ATCAAAGGTG CTAATATTTT ATTGACAGAC CATGGCGATG TAAAATTAGC TGACTTTGGT 480

GTGGCTGCAA AAATAACAGC TACCATTGCA AAACGAAAAT CTTTCATTGG CACCCCTTAT 540

TGGATGGCCC CAGAAGTTGC AGCAGTAGAG AAGAATGGTG GCTACAACCA ACTCTGTGAT 600

ATCTGGGCAG TAGGAATAAC AGCAATTGAA CTTGGAGAAC TTCAACCACC TATGTTTGAT 660

CTCCACCCAA TGAGGGCTCT CTTCTTAATG TCAAAAAGTA ATTTTCAACC TCCCAAACTA 720

AAGGACAAAA CAAAATGGTC ATCAACATTC CATAATTTTG TCAAAATAGC ACTAACCAAA 780

AACCCAAAAA AAAGACCAAC TGCTGAAAGA CTTCTGACTC ACACTTTTGT TGCGCAACCA 840

GGTCTCTCTA GAGCCCTAGC GGTTGAACTG TTAGACAGAG TGAACAATCC AGATAATCAT 900

GCACATTACA CTGAAGCAGA TGATGATGAC TTTGAGCCCC ATGCAATCAT TCGTCATACC 960

ATTAGATCTA CAAACAGGAA TGCCAGAGCT GAACGGACAG CTTCAGAAAT AAATTTTGAC 1020

AAATTACAAT TTGAACCTCC TCTGAGAAAA GAAACAGAAG CACGAGATGA AATGGGATTG 1080

TCATCAGACC CAAATTTCAT GTTACAGTGG AATCCTTTTG TTGATGGTGC AAATACTGGC 1140

AAATTAACCT CAAAACGTGC AGTACCACCT CCCCTACCTC CTAAGCCAAG GATAAGCAGT 1200

TACCCTGAAG ACAACTTCCC GGATGAAGAA AAAACATCAA CCATAAAACA TTGTCCTGAT 1260

TCAGAGAACA GAGCTCCCCA AATTCTGAGA AGACAGAGTA GCCCAAGTTG TGGGCCTGTG 1320

GCAGAGACTT CCTCTATTGG AAATGGTGAT GGTATTTCAA AACTGATGAG TGAAAATACA 1380

GAAGGATCAG CACAAGCACC ACAGTTACCA CGAAAAAAAG ACAAACGAGA CTTCCCTAAA 1440

CCAGCCATCA ATGGCCTTCC ACCCACCCCA AAAGTTCTGA TGGGAGCATG CTTTTCAAAA 1500

GTTTTTGATG GCTGTCCTTT GAAAATTAAT TGTGCAACAT CCTGGATACA TCCTGATACA 1560

AAAGATCAGT ACATTATTTT TGGAACTGAA GATGGCATTT ACACACTGAA TCTCAATGAG 1620

CTACATGAAG CAACAATGGA ACAGTTATTT CCACGGAAGT GTACTTGGCT GTATGTTATC 1680

AATAATACTT TAATGTCATT ATCAGGAAAA ACCTTTCAGC TCTACTCTCA CAATCTTATA 1740

GCTTTGTTTG AACATGCCAA AAAACCAGGA TTAGCTGCCC ATATTCAAAC TCACAGGTTT 1800

CCAGACCGCA TACTACCAAG AAAATTCGCT TTAACAACAA AGATTCCTGA TACAAAAGGC 1860

TGCCACAAAT GTTGCATTGT CAGAAACCCT TACACGGGAC ATAAATACCT CTGTGGAGCT 1920

TTACAGTCTG GAATTGTTTT ACTTCAGTGG TATGAGCCAA TGCAGAAATT CATGTTGATA 1980

AAGCACTTTG ATTTTCCTTT GCCAAGTCCT TTGAATGTTT TTGAAATGCT GGTGATACCA 2040

GAACAGGAAT ACCCTATGGT CTGTGTAGCG ATTAGCAAAG GCACTGAATC GAATCAGGTA 2100

GTTCAGTTTG AGACAATCAA TTTGAACTCT GCATCCTCAT GGTTTACAGA AATTGGTGCA 2160

GGTAACCAGC AGTTAGATTC CATTCATGTA ACACAGTTGG AAAGAGATAC CGTTTTAGTG 2220

TGTTTAGACA AATTTGTAAA AATTGTAAAT CTACAAGGAA AATTAAAATC AAGTAAGAAA 2280

CTGGCCTCTG AGTTGAGTTT TGATTTTCGC ATTGAATCTG TAGTATGCCT TCAAGACAGT 2340

GTGTTGGCTT TCTGGAAACA TGGGATGCAG GGTAAAAGCT TCAAGTCAGA TGAGGTTACC 2400

CAGGAGATTT CAGATGAAAC AAGAGTTTTC CGCTTATTAG GATCAGACAG GGTTGTCGTT 2460

TTGGAAAGTA GGCCAACAGA AAATCCTACT GCACACAGCA ATCTCTACAT CTTGGCTGGA 2520

CATGAAAATA GTTACTAA 2538

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yel++++g+G++g+vy+ar+++tgel+a+k+i+le  ++ +++q+ei ++k++kh niv+

Q: 20    YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVA  79

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay++re+l++L+ylH+k+++

Q: 80    YFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHTKGKM  137

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++

Q: 138   HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQ  197

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GItaiel e +pP++dl+p++al++++k++  ppklk+k+k+s++f++fv+ +

Q: 198   LCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFVKIA  257

         ********************************9999988*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 258   LTKNPKKRPTAERLLTHTFV  277

         *******************7

Domain Sequence
(FASTA)

YELVQRVGSG TYGDVYKARN VHTGELAAVK IIKLEPGDDF SLIQQEIFMV KECKHCNIVA 60

YFGSYLSREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY VCRETLQGLA YLHTKGKMHR 120

DIKGANILLT DHGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV EKNGGYNQLC 180

DIWAVGITAI ELGELQPPMF DLHPMRALFL MSKSNFQPPK LKDKTKWSST FHNFVKIALT 240

KNPKKRPTAE RLLTHTFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013