EKS-MAM-00008
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00008
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph487.31.3E-146635892258
StatusUnreviewed
Ensembl ProteinENSMMUP00000027314
UniProt AccessionF7HEL6;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000020754ENSMMUP00000027314ENSMMUT00000029192
OrganismMacaca mulatta
Functional Description
Protein Length1005
Protein Sequence
(FASTA)
MAPARGRLPP ALWVVTAAAA AATCVSAARG EVNLLDTSTI HGDWGWLTYP AHGWDSINEV 60
DESFQPIHTY QVCNVMSPNQ NNWLRTSWVP RDGARRVYAE IKFTLRDCNS MPGVLGTCKE 120
TFNLYYLESD RDLGASTQES QFLKIDTIAA DESFTGADLG VRRLKLNTEV RGVGPLSKRG 180
FYLAFQDIGA CLAILSLRIY YKKCPAMVRN LAAFSEAVTG ADSSSLVEVR GQCVRHSEER 240
DTPKMYCSAE GEWLVPIGKC VCSAGYEERR DACVACELGF YKSAPGDQLC ARCPPHSHSA 300
APAAQACHCD LSYYRAALDP PSSACTRPPS APVNLISSVN GTSVTLEWAP PLDPGGRSDV 360
TYNAVCRRCP WALSRCEACG SGTRFVPQQT SLVQASLLVA NLLAHMNYSF WIEAVNGVSD 420
LSPEPRRAAV VNITTNQAAP SQVVVIRQER AGQTSVSLLW QEPEQPNGII LEYEIKYYEK 480
DKEMQSYSTL KAVTTRATVS GLKPGTRYVF QVRARTSAGC GRFSQAMEVE TGKPRPRYDT 540
RTIVWICLTL ITGLVVLLLL LICKKRHCGY SKAFQDSDEE KMHYQNGQAP PPVFLPLHHP 600
PGKLPEPQFY AEPHTYEEPG RAGRSFTREI EASRIHIEKI IGSGESGEVC YGRLQVPGQR 660
DVPVAIKALK AGYTERQRRD FLSEASIMGQ FDHPNIIRLE GVVTRGRLAM IVTEYMENGS 720
LDAFLRTHDG QFTIMQLVGM LRGVGAGMRY LSDLGYVHRD LAARNVLVDS NLVCKVSDFG 780
LSRVLEDDPD AAYTTTGGKI PIRWTAPEAI AFRTFSSASD VWSFGVVMWE VLAYGERPYW 840
NMTNRDVISS VEEGYRLPAP MGCPRALHQL MLDCWHKDRA QRPRFSQIVS VLDALIRSPE 900
SLRATATVSR CPPPAFARSC FDLRGGSGGG GGLTVGDWLD SIRMGRYRDH FAAGGYSSLG 960
MVLRMNAQDV RALGITLMGH QKKILGSIQT MRAQLTSTQG PRRHL 1005
Nucleotide Sequence
(FASTA)
ATGGCCCCCG CCCGGGGCCG CCTGCCCCCC GCGCTCTGGG TCGTCACGGC CGCGGCGGCG 60
GCGGCCACCT GCGTGTCCGC GGCGCGCGGC GAAGTGAATT TGCTGGACAC ATCGACCATC 120
CACGGGGACT GGGGCTGGCT CACGTATCCG GCTCATGGTT GGGACTCCAT CAACGAGGTG 180
GACGAGTCCT TCCAGCCCAT CCACACGTAC CAGGTGTGCA ATGTCATGAG CCCCAACCAG 240
AACAACTGGC TGCGCACGAG CTGGGTCCCC CGCGACGGCG CCCGGCGCGT CTATGCCGAG 300
ATCAAGTTTA CCCTGCGCGA CTGCAACAGC ATGCCCGGCG TGCTGGGCAC CTGCAAGGAG 360
ACCTTCAACC TCTACTACCT GGAGTCGGAC CGCGACCTGG GGGCCAGCAC ACAAGAAAGC 420
CAGTTCCTCA AAATCGACAC CATTGCGGCC GACGAGAGCT TCACAGGTGC CGACCTTGGT 480
GTGCGGCGTC TCAAGCTCAA CACGGAGGTG CGCGGTGTGG GTCCCCTCAG CAAGCGCGGC 540
TTCTACCTGG CCTTCCAGGA CATCGGTGCC TGCCTGGCCA TCCTCTCTCT CCGCATCTAC 600
TATAAGAAGT GCCCCGCCAT GGTGCGCAAT CTGGCTGCCT TCTCGGAGGC AGTGACGGGG 660
GCTGACTCTT CCTCACTGGT GGAGGTGCGG GGCCAGTGCG TGCGGCACTC GGAGGAGCGG 720
GACACGCCCA AGATGTACTG CAGTGCGGAG GGCGAGTGGC TGGTGCCCAT CGGCAAATGT 780
GTGTGCAGTG CCGGCTACGA GGAGCGGCGG GATGCCTGTG TGGCCTGTGA GCTGGGCTTC 840
TACAAGTCAG CCCCTGGGGA CCAGCTGTGT GCCCGCTGCC CTCCCCACAG CCACTCCGCA 900
GCTCCAGCCG CCCAAGCCTG CCACTGTGAC CTCAGCTACT ACCGCGCAGC CCTGGACCCG 960
CCGTCCTCAG CCTGCACCCG GCCGCCCTCG GCACCAGTGA ACCTCATCTC CAGTGTGAAT 1020
GGGACATCGG TGACTCTGGA GTGGGCCCCT CCCCTGGACC CAGGTGGCCG CAGTGACGTC 1080
ACCTACAACG CCGTGTGCCG CCGCTGCCCC TGGGCCCTGA GCCGCTGCGA GGCGTGTGGG 1140
AGCGGCACCC GCTTTGTGCC CCAGCAGACA AGCCTGGTGC AGGCCAGCCT GCTGGTGGCC 1200
AACCTGCTGG CCCACATGAA CTACTCCTTC TGGATCGAGG CCGTCAATGG CGTGTCCGAC 1260
CTGAGCCCCG AGCCCCGCCG GGCCGCCGTG GTCAACATCA CCACGAACCA GGCAGCCCCG 1320
TCCCAGGTGG TGGTGATCCG GCAAGAGCGG GCAGGGCAGA CCAGCGTCTC GCTACTGTGG 1380
CAGGAGCCTG AGCAGCCCAA CGGCATCATC CTGGAGTATG AGATCAAGTA CTACGAGAAG 1440
GACAAGGAGA TGCAGAGCTA CTCCACCCTC AAGGCCGTCA CCACCAGAGC CACCGTCTCC 1500
GGCCTCAAGC CAGGCACGCG CTATGTGTTC CAGGTCCGAG CCCGCACCTC AGCAGGCTGT 1560
GGCCGCTTCA GCCAGGCCAT GGAGGTGGAG ACTGGGAAAC CCCGGCCCCG CTATGACACC 1620
AGGACCATTG TCTGGATCTG CCTGACTCTC ATCACGGGCC TGGTGGTGCT TCTGCTCCTG 1680
CTTATCTGCA AGAAGAGGCA CTGTGGCTAC AGCAAGGCCT TCCAGGACTC GGACGAGGAG 1740
AAGATGCACT ATCAGAATGG ACAGGCACCC CCACCTGTCT TCCTACCCCT GCATCACCCC 1800
CCGGGAAAGC TCCCAGAGCC CCAGTTCTAC GCGGAACCCC ACACCTACGA GGAGCCGGGC 1860
CGGGCCGGCC GCAGTTTCAC CCGGGAGATC GAGGCCTCTA GGATCCACAT CGAGAAAATC 1920
ATCGGCTCTG GAGAGTCCGG GGAAGTCTGC TATGGGAGGC TGCAGGTGCC AGGGCAGCGG 1980
GATGTGCCCG TGGCCATCAA GGCCCTCAAA GCCGGCTACA CGGAGAGACA GCGGCGGGAC 2040
TTCCTGAGTG AGGCGTCCAT CATGGGGCAA TTCGACCACC CCAACATTAT CCGCCTCGAG 2100
GGTGTCGTCA CCCGCGGCCG CCTGGCAATG ATCGTGACGG AGTACATGGA GAACGGCTCT 2160
CTGGACGCCT TCCTGAGGAC CCACGATGGG CAATTCACCA TCATGCAGCT GGTGGGCATG 2220
CTCAGAGGAG TGGGTGCCGG CATGCGCTAC CTCTCAGACC TGGGCTACGT CCACCGAGAC 2280
CTGGCCGCCC GCAACGTCCT GGTTGACAGC AACCTGGTCT GCAAGGTGTC TGACTTCGGA 2340
CTCTCACGGG TGCTAGAGGA CGACCCGGAT GCTGCCTACA CCACCACGGG CGGGAAGATC 2400
CCCATCCGCT GGACAGCCCC AGAGGCCATC GCCTTCCGCA CCTTCTCCTC GGCCAGCGAC 2460
GTGTGGAGCT TCGGTGTGGT CATGTGGGAG GTGCTGGCCT ACGGGGAGCG GCCCTACTGG 2520
AACATGACCA ACCGGGATGT CATCAGCTCC GTGGAGGAGG GGTACCGCCT GCCCGCACCC 2580
ATGGGCTGCC CCCGCGCCCT GCACCAGCTC ATGCTTGACT GCTGGCACAA GGACCGGGCG 2640
CAGCGGCCTC GCTTCTCCCA GATTGTCAGT GTCCTCGACG CGCTGATCCG CAGCCCGGAG 2700
AGTCTCAGGG CCACCGCCAC TGTCAGCAGG TGCCCACCCC CTGCCTTCGC CCGGAGCTGC 2760
TTTGACCTCC GAGGGGGCAG CGGTGGCGGC GGGGGCCTCA CTGTGGGGGA CTGGCTGGAC 2820
TCCATCCGCA TGGGCCGGTA CCGAGACCAC TTCGCTGCGG GCGGCTACTC CTCTCTGGGC 2880
ATGGTGCTAC GCATGAACGC ACAAGACGTG CGTGCCCTGG GCATCACCCT CATGGGTCAC 2940
CAGAAGAAGA TCCTGGGCAG CATTCAGACC ATGCGGGCCC AGCTGACCAG CACCCAGGGG 3000
CCCCGCCGGC ACCTCTGA 3018
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+Ge Gevc Grl++pg+r+++vaik+lkag+te+qrrdflseasi+Gqfdhp
Q: 635   IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHP  694
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ld+flr++dgqft++qlvgmlrG+++gm+ylsd+
Q: 695   NIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDL  754
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lv+snlvckvsdfGlsrvledd++aaytt+ggkipirwtapeaia+r+
Q: 755   GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT  814
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+sasdvws+G+v+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc
Q: 815   FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPRALHQLMLDC  874
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         w+kdra+rp+f+qivs+l
Q: 875   WHKDRAQRPRFSQIVSVL  892
         ***************985
Domain Sequence
(FASTA)
IHIEKIIGSG ESGEVCYGRL QVPGQRDVPV AIKALKAGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGRLAMIVTE YMENGSLDAF LRTHDGQFTI MQLVGMLRGV GAGMRYLSDL 120
GYVHRDLAAR NVLVDSNLVC KVSDFGLSRV LEDDPDAAYT TTGGKIPIRW TAPEAIAFRT 180
FSSASDVWSF GVVMWEVLAY GERPYWNMTN RDVISSVEEG YRLPAPMGCP RALHQLMLDC 240
WHKDRAQRPR FSQIVSVL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-ORL-00016
EKS-OTG-00011
EKS-PAT-00013
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043005; C:neuron projection
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007411; P:axon guidance
GO:0016322; P:neuron remodeling
GO:0043410; P:positive regulation of MAPK cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777; P:protein autophosphorylation
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0006929; P:substrate-dependent cell migration
KEGG
mcc:708378;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013