EKS-MAM-00171
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00171
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC439.01.2E-131151405255
StatusUnreviewed
Ensembl ProteinENSMMUP00000036322
UniProt AccessionF7HC75;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCQ
Gene Synonyms/Alias PRKCQ; EGK_19438;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000020776ENSMMUP00000027347ENSMMUT00000029226
ENSMMUG00000020776ENSMMUP00000036323ENSMMUT00000043326
ENSMMUG00000020776ENSMMUP00000036322ENSMMUT00000043325
OrganismMacaca mulatta
Functional Description
Protein Length477
Protein Sequence
(FASTA)
SLLPCLLSLP TIIPMKIVIQ RDSLPPKKLS YSLIACGMNV HHRCQTKVAN LCGINQKLMA 60
EALAMIESTQ QARCLRDTEQ IFREGPVEIG LPCSTKNEAR PPCLPTPGKR EPQGISWESP 120
LDEVDKMCHL PEPELNKERP SLQMKLKIED FILHKMLGKG SFGKVFLAEF KKTNQFFAIK 180
ALKKDVVLMD DDVECTMVEK RVLSLAWEHP FLTHMFCTFQ TKENLFFVME YLNGGDLMYH 240
IQSCHKFDLS RATFYAAEII LGLQFLHSKG IVYRDLKLDN ILLDKDGHIK IADFGMCKEN 300
MLGDAKTNTF CGTPDYIAPE ILLGQRYNHS VDWWSFGVLL YEMLIGQSPF HGQDEEELFH 360
SIRMDNPFYP RWLEKEAKDL LVKLFVREPE KRLGVRGDIR QHPLFREINW EELERKEIDP 420
PFRPKVKSPY DCSNFDKEFL NEKPRLSFAD RALINSMDQN MFRNFSFMNP GMERLIS 477
Nucleotide Sequence
(FASTA)
AGCCTTTTAC CCTGCCTTCT CTCTCTCCCC ACGATAATTC CTATGAAAAT AGTCATCCAG 60
AGGGACTCTT TGCCCCCCAA GAAATTGAGT TACAGCCTGA TAGCATGTGG CATGAATGTA 120
CATCACAGAT GCCAGACGAA GGTGGCCAAC CTTTGTGGCA TAAACCAGAA GCTAATGGCT 180
GAAGCACTGG CCATGATTGA GAGCACTCAA CAGGCTCGCT GCTTGAGAGA TACTGAACAG 240
ATCTTCAGAG AAGGTCCGGT TGAAATTGGT CTCCCATGCT CCACCAAAAA TGAAGCAAGG 300
CCACCATGTT TACCAACACC AGGAAAACGA GAGCCTCAGG GCATCTCCTG GGAGTCTCCG 360
TTGGATGAGG TGGATAAAAT GTGCCATCTT CCGGAACCTG AACTGAACAA AGAAAGACCA 420
TCTCTGCAGA TGAAACTAAA AATTGAGGAT TTTATCTTGC ACAAAATGTT GGGGAAAGGC 480
AGTTTTGGCA AGGTCTTCCT GGCAGAATTC AAGAAAACCA ATCAATTTTT CGCCATAAAG 540
GCCTTAAAGA AAGATGTGGT CTTGATGGAC GATGATGTTG AGTGCACGAT GGTAGAGAAG 600
AGAGTTCTTT CCTTGGCCTG GGAGCATCCG TTTCTGACGC ACATGTTTTG TACGTTCCAG 660
ACCAAGGAAA ACCTCTTTTT TGTGATGGAG TACCTCAACG GAGGGGACTT AATGTACCAC 720
ATCCAAAGCT GCCACAAGTT CGACCTTTCC AGAGCGACGT TTTATGCTGC TGAAATCATT 780
CTTGGTCTGC AGTTCCTTCA TTCCAAAGGA ATCGTCTACA GGGACCTGAA GCTAGATAAC 840
ATCCTATTAG ACAAAGATGG ACATATCAAG ATTGCGGATT TTGGAATGTG CAAGGAGAAC 900
ATGTTAGGAG ATGCCAAGAC GAATACCTTC TGTGGGACAC CCGACTATAT CGCCCCGGAG 960
ATCTTGCTGG GTCAGAGATA CAACCACTCT GTGGACTGGT GGTCCTTCGG GGTTCTCCTT 1020
TACGAGATGC TGATTGGCCA GTCGCCTTTC CACGGGCAGG ACGAGGAGGA GCTCTTCCAC 1080
TCCATCCGCA TGGACAATCC CTTTTACCCA CGGTGGCTGG AGAAGGAGGC AAAGGATCTT 1140
CTGGTGAAGC TCTTTGTGCG AGAACCTGAG AAGAGGCTGG GCGTGAGGGG AGATATCCGC 1200
CAGCACCCTT TGTTTCGAGA GATCAACTGG GAGGAACTTG AACGGAAGGA GATTGACCCA 1260
CCATTCCGGC CGAAAGTGAA ATCACCATAT GACTGCAGCA ATTTCGACAA AGAATTCTTA 1320
AATGAGAAGC CTCGGCTGTC ATTCGCCGAC AGAGCGCTGA TCAACAGCAT GGACCAGAAC 1380
ATGTTCAGAA ACTTTTCCTT CATGAACCCC GGGATGGAGC GGCTGATATC CTGA 1434
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f l+k+lGkGsfgkv+lae kkt++++aik lkkdvvl+dddve+t+vekrvl+la+++p
Q: 151   FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP  210
         7899********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+++f++fqt+++lffv+ey+nGGdlm+hiq+++k++ +ra+fyaaeiil+l+flh+kg
Q: 211   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG  270
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         i+yrdlkldn+lld++Ghik+adfG+cke++l +++t+tfcGtPdyiaPeil +++y++s
Q: 271   IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQRYNHS  330
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l+kea+++l +l+ ++pe
Q: 331   VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE  390
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  di++h++f
Q: 391   KRLGV--RG--DIRQHPLF  405
         *****..55..89999987
Domain Sequence
(FASTA)
FILHKMLGKG SFGKVFLAEF KKTNQFFAIK ALKKDVVLMD DDVECTMVEK RVLSLAWEHP 60
FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQSCHKFDLS RATFYAAEII LGLQFLHSKG 120
IVYRDLKLDN ILLDKDGHIK IADFGMCKEN MLGDAKTNTF CGTPDYIAPE ILLGQRYNHS 180
VDWWSFGVLL YEMLIGQSPF HGQDEEELFH SIRMDNPFYP RWLEKEAKDL LVKLFVREPE 240
KRLGVRGDIR QHPLF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>
EKS-BOT-00175
EKS-CAJ-00177
EKS-CAF-00182
EKS-EQC-00171
EKS-GOG-00174
EKS-HOS-00181
EKS-MUP-00179
EKS-NOL-00167
EKS-ORC-00162
EKS-PAT-00165
EKS-POA-00168
EKS-SAH-00167
EKS-TAR-00228
Gene Ontology
GO:0005737; C:cytoplasm
GO:0001772; C:immunological synapse
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
GO:0006509; P:membrane protein ectodomain proteolysis
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0070233; P:negative regulation of T cell apoptotic process
GO:0032740; P:positive regulation of interleukin-17 production
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process
GO:0032753; P:positive regulation of interleukin-4 production
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0042102; P:positive regulation of T cell proliferation
GO:2000318; P:positive regulation of T-helper 17 type immune response
GO:2000570; P:positive regulation of T-helper 2 cell activation
GO:0090330; P:regulation of platelet aggregation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013