EKS-MAM-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	420.4	8.4E-126	71	387	317

Status

Unreviewed

Ensembl Protein

ENSMMUP00000040352

UniProt Accession

F7H7P4;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000020811	ENSMMUP00000040352	ENSMMUT00000047324
ENSMMUG00000020811	ENSMMUP00000027396	ENSMMUT00000029280

Organism

Macaca mulatta

Functional Description

Protein Length

406

Protein Sequence
(FASTA)

TALTPREALK LFKNQLSPYE QSEILGYTEL WFLGLEAKKL DLAPEKFSKT SFDDEQGSYL 60

KVLHDHIAYR YEVLEMIGKG SFGQVAKCLD HKNNELVALK IIRNKKRFHQ QALVELKILE 120

ALRKKDKDNT SNVVHMKDFF YFRNHFCITF ELLGINLYEL MKNNNFQGFS LSIVRRFTLS 180

VLKCLQMLSV EKIIHCDLKP ENIVLYQKGQ VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP 240

EVILGHPYDM AIDMWSLGCI MAELYTGYPL FPGENEVEQL ACIMEVLGLP PAGFIETASR 300

RQTFFVFSKL YPNGCSVLDS LSQAGKIIYL GGLGGSGSRK GMEGMINEGQ SEKNCELDSS 360

LVFGKKASRW EPSLRMTPDQ ALKHAWIHQS RNLKPQPKPQ TLRKSS 406

Nucleotide Sequence
(FASTA)

ACTGCTCTAA CCCCCAGAGA GGCCCTAAAG CTTTTTAAGA ATCAGCTGTC TCCATATGAG 60

CAAAGTGAAA TCCTGGGCTA CACGGAGCTG TGGTTCCTGG GGCTTGAAGC CAAGAAGCTC 120

GACCTGGCTC CTGAGAAATT TAGCAAGACA AGTTTTGATG ATGAGCAAGG CTCCTATCTG 180

AAGGTCCTGC ATGATCACAT TGCCTACCGC TATGAGGTTC TGGAGATGAT CGGGAAGGGG 240

TCCTTTGGAC AGGTGGCCAA GTGCTTGGAT CACAAAAACA ATGAGCTGGT GGCCCTGAAA 300

ATCATCAGGA ACAAGAAGAG ATTTCACCAG CAGGCCCTGG TGGAGCTGAA GATCCTGGAA 360

GCTCTCAGAA AGAAGGACAA AGACAACACC TCCAATGTGG TGCATATGAA GGACTTTTTC 420

TACTTCCGCA ATCACTTCTG CATCACCTTT GAGCTCCTGG GAATCAACTT GTATGAGTTG 480

ATGAAGAATA ACAACTTTCA AGGCTTCAGT CTGTCGATAG TTCGGCGTTT CACTCTCTCT 540

GTTTTGAAGT GCTTGCAAAT GCTTTCTGTA GAGAAAATCA TTCACTGCGA TCTCAAGCCC 600

GAAAATATAG TGCTGTACCA AAAGGGCCAA GTCTCTGTTA AAGTCATTGA CTTTGGATCA 660

AGCTGTTATG AACACCAGAA AGTATACACG TACATCCAAA GCCGGTTCTA CCGATCCCCA 720

GAAGTGATCC TGGGCCACCC GTACGACATG GCCATTGACA TGTGGAGCCT GGGCTGCATC 780

ATGGCAGAGT TGTACACGGG CTACCCCCTG TTCCCCGGGG AGAATGAGGT GGAGCAGCTG 840

GCCTGCATCA TGGAGGTGCT GGGTCTGCCG CCAGCCGGCT TCATTGAGAC GGCCTCCAGG 900

AGACAGACGT TCTTTGTGTT TTCCAAACTC TATCCAAATG GTTGTTCAGT CCTTGACTCC 960

CTTTCCCAGG CTGGTAAGAT AATATACTTA GGTGGCCTAG GTGGCTCAGG CAGTAGGAAG 1020

GGAATGGAGG GAATGATTAA TGAGGGCCAG AGTGAGAAAA ACTGTGAGCT TGATTCTTCT 1080

TTGGTCTTTG GTAAAAAGGC AAGTAGATGG GAACCTTCTC TTCGCATGAC CCCGGACCAG 1140

GCCCTCAAGC ATGCTTGGAT TCATCAGTCT CGGAACCTCA AGCCACAGCC CAAGCCCCAG 1200

ACCCTGAGGA AATCCAGT 1218

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle+igkGsfgqV+k+ld+k++e va+kii+nkkrf++qa  E++iLe+l+kkdk+++

Q: 71    YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALVELKILEALRKKDKDNT  130

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

          nvv+++++f+frnh+c++fell +nLyel+k+n+f+g+sl++vr+++ ++lk+L++L+

Q: 131   SNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSV  190

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNi+l++k++ +vkviDFGss++++qk +ytyiqsrfYr+PE+ilg++yd

Q: 191   EKIIHCDLKPENIVLYQKGQVSVKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHPYD  249

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff...t  237

         +aiDmWSlGc++aEl+tG+pLfpGenev+qla+i+evlglpp+ ++e+a+++++ff   +

Q: 250   MAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIETASRRQTFFvfsK  309

         ********************************************************8544

S: 238   kkeapkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmle  297

          + +   +l + ++  k ++  +   +++++ +++  + g+++k++e  +   + k+  +

Q: 310   LYPNGCSVLDSLSQAGKIIYLGGLGGSGSRKGMEGMINEGQSEKNCELDSSLVFGKKASR  369

         44444455555577777888888889999999***999999999999999899*******

S: 298   ldpakRitpkealkhpfv  315

         ++p+ R+tp++alkh ++

Q: 370   WEPSLRMTPDQALKHAWI  387

         ****************97

Domain Sequence
(FASTA)

YEVLEMIGKG SFGQVAKCLD HKNNELVALK IIRNKKRFHQ QALVELKILE ALRKKDKDNT 60

SNVVHMKDFF YFRNHFCITF ELLGINLYEL MKNNNFQGFS LSIVRRFTLS VLKCLQMLSV 120

EKIIHCDLKP ENIVLYQKGQ VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYDM 180

AIDMWSLGCI MAELYTGYPL FPGENEVEQL ACIMEVLGLP PAGFIETASR RQTFFVFSKL 240

YPNGCSVLDS LSQAGKIIYL GGLGGSGSRK GMEGMINEGQ SEKNCELDSS LVFGKKASRW 300

EPSLRMTPDQ ALKHAWI 317

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013