EPS-MAM-00076

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00076

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2A	419.6	2.6E-126	51	243	193

Status

Unreviewed

Ensembl Protein

ENSMMUP00000027404

UniProt Accession

F7HSM1;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP2CB

Gene Synonyms/Alias

PPP2CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000020819	ENSMMUP00000027404	ENSMMUT00000029290

Organism

Macaca mulatta

Functional Description

Protein Length

309

Protein Sequence
(FASTA)

MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60

QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES 120

RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180

RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240

HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300

TRRTPDYFL 309

Nucleotide Sequence
(FASTA)

ATGGACGACA AGGCGTTTAC CAAGGAGCTG GACCAGTGGG TCGAGCAGCT GAACGAGTGT 60

AAGCAGCTGA ACGAGAACCA AGTGCGGACG CTGTGCGAGA AGGCAAAGGA AATTTTAACA 120

AAAGAATCAA ATGTGCAAGA GGTTCGTTGC CCTGTTACTG TCTGTGGAGA TGTGCATGGT 180

CAATTTCATG ATCTTATGGA ACTCTTTAGA ATTGGTGGAA AATCACCAGA TACAAACTAC 240

TTATTCATGG GTGACTATGT AGACAGAGGA TATTATTCAG TGGAGACTGT GACTCTTCTT 300

GTAGCATTAA AGGTGCGTTA TCCAGAACGC ATTACAATAT TGAGAGGAAA TCACGAAAGC 360

CGACAAATTA CCCAAGTATA TGGCTTTTAT GATGAATGTC TGCGAAAGTA TGGGAATGCC 420

AACGTTTGGA AATATTTTAC AGATCTTTTT GATTATCTTC CACTTACAGC TTTAGTAGAT 480

GGACAGATAT TCTGCCTCCA TGGTGGCCTC TCTCCATCCA TAGACACACT GGATCATATA 540

AGAGCCCTGG ATCGCTTACA GGAAGTTCCA CATGAGGGCC CAATGTGTGA TCTGTTATGG 600

TCAGATCCAG ATGATCGTGG TGGATGGGGT ATTTCACCAC GTGGTGCTGG CTACACATTT 660

GGACAAGACA TTTCTGAAAC CTTTAACCAC GCCAATGGTC TCACACTGGT TTCTCGTGCC 720

CACCAGCTTG TAATGGAGGG ATACAATTGG TGTCATGATC GGAATGTGGT TACTATTTTC 780

AGTGCACCCA ATTACTGTTA CCGTTGTGGG AACCAGGCTG CTATCATGGA ATTAGATGAC 840

ACTTTAAAAT ATTCCTTCCT TCAGTTTGAC CCAGCGCCTC GTCGTGGCGA GCCTCATGTT 900

ACACGGCGCA CCCCAGACTA CTTCCTATAA 930

Domain Profile

S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60

         pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvry+er

Q: 51    PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPER  110

         9***********************************************************

S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120

         itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl

Q: 111   ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL  170

         ************************************************************

S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180

         spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh

Q: 171   SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH  230

         ************************************************************

S: 181   angleliarahql  193

         angl+l++rahql

Q: 231   ANGLTLVSRAHQL  243

         ************8

Domain Sequence
(FASTA)

PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER 60

ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120

SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180

ANGLTLVSRA HQL 193

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0000159	; C:protein phosphatase type 2A complex
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0043066	; P:negative regulation of apoptotic process
GO:0043161	; P:proteasomal ubiquitin-dependent protein catabolic process
GO:0010468	; P:regulation of gene expression
GO:0046677	; P:response to antibiotic
GO:0042542	; P:response to hydrogen peroxide

KEGG

mcc:695118

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013