EKS-MAM-00430

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00430

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	359.2	2.4E-107	2	242	241

Status

Unreviewed

Ensembl Protein

ENSMMUP00000027852

UniProt Accession

H9EV28;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase ULK2;

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000021156	ENSMMUP00000027852	ENSMMUT00000029760

Organism

Macaca mulatta

Functional Description

Protein Length

1007

Protein Sequence
(FASTA)

QKTDWEVAIK SINKKNLSKS QILLGKEIKI LKELQHENIV ALYDVQELPN SVFLVMEYCN 60

GGDLADYLQA KGTLSEDTIR VFLHQIAAAM RILHSKGIIH RDLKPQNILL SYANRRKSSV 120

SGIRIKIADF GFARYLHSNM MAATLCGSPM YMAPEVIMSQ HYDAKADLWS IGTVIYQCLV 180

GKPPFQANSP QDLRMFYEKN RSLMPSIPRE TSPYLANLLL GLLQRNQKDR MDFEAFFSHP 240

FLEQVPVKKS CPVPVPVYSG SVSGSSCGSS PSCRFASPPS LPDMQHIQEE NLSSPPLGPP 300

NYLQVSKDSA STSSKNSSCD TDDFVLVPHN ISSDHSYDMP LGTAGRRASN EFLVCGGQCQ 360

PTVSPHSETA PIPVPTQIRN YQRIEQNLTS TASSGTNVHG SPRSAVVRRS NTSPMGFLRL 420

GSCSPVPADT AQTVGRRLST GSSRPYSPSP LVGTIPEQFS QCCCGHPQGH DSRSRNSSGS 480

PVPQAQSPQS LLLGARLQSA PTLTDIYQNK QKLRKQHSDP VCPTHAGAGY SYSPQPSRPG 540

SLGTSPTKHL GSSPRSSDWF FKTPLPTIIG SPTKTTAPFK IPKTQASSNL LALVTRHGPA 600

EEQSKDGNEP RECAHCLLVQ GSERQRAEQQ SKAVFGRSVS TGKLSDQQGK TPIGGHQGST 660

DSLNTERPMD IAPAGACGIV LAPPAGIAAS SRAVLFTVGS PPHSAVAPTC THMLLRARTT 720

SVGPSNSGGS LCAVSGRVCV GSPPGPGFGS SPPGAEAAPS LRYVPYGASP PSLEGLITFE 780

APELPEETLM EREHTDTLRH LNVMLMFTEC VLDLTAVRGG NPELCTSAVS LYQIQESVVV 840

DQISQLSKDW GRVEQLVLYM KAAQLLAASL HLAKAQIKSG KLSPSTAVKQ VVKNLNERYK 900

FCITMCKKLT EKLNRFFSDK QRFIDEINSV TAEKLIYNCA VEMVQSAALD EMFQQTEDIV 960

YRYHKAALLL EGLTKILQDP ADIENVHKYK CSIERRLSAL CHSTATV 1007

Nucleotide Sequence
(FASTA)

CAGAAAACTG ATTGGGAGGT AGCTATTAAA AGTATTAATA AAAAGAACTT GTCAAAATCA 60

CAAATACTGC TTGGAAAGGA AATTAAAATC TTAAAGGAAC TTCAGCATGA AAATATTGTA 120

GCACTCTATG ATGTTCAGGA ATTACCCAAC TCTGTCTTTT TGGTGATGGA GTATTGCAAT 180

GGTGGAGACC TCGCAGATTA TTTGCAAGCA AAAGGAACTC TCAGTGAAGA TACCATCAGA 240

GTGTTTCTGC ATCAGATTGC TGCTGCCATG CGAATCCTGC ACAGCAAAGG AATCATCCAC 300

AGAGATCTCA AACCACAGAA CATCTTGCTG TCCTATGCTA ATCGCAGAAA ATCAAGTGTC 360

AGTGGTATTC GCATCAAAAT AGCGGATTTT GGTTTTGCTC GTTACCTACA TAGTAACATG 420

ATGGCTGCAA CACTGTGTGG ATCCCCCATG TATATGGCTC CTGAGGTTAT TATGTCTCAA 480

CATTATGATG CTAAGGCTGA CTTGTGGAGC ATAGGAACAG TGATATACCA ATGCCTAGTT 540

GGAAAACCAC CTTTTCAGGC CAATAGTCCT CAAGACTTAA GGATGTTTTA TGAAAAAAAC 600

AGGAGCTTAA TGCCTAGTAT TCCCAGAGAA ACATCACCTT ATTTGGCTAA TCTCCTTTTG 660

GGTTTGCTTC AGAGAAACCA AAAAGATAGA ATGGACTTTG AAGCATTTTT TAGCCATCCT 720

TTTCTTGAGC AAGTTCCAGT AAAAAAATCT TGCCCAGTTC CAGTGCCCGT GTATTCTGGT 780

TCTGTCTCTG GAAGCTCCTG TGGCAGCTCT CCATCTTGTC GTTTTGCTTC TCCACCATCC 840

CTTCCAGATA TGCAGCATAT TCAGGAAGAA AACTTATCTT CCCCACCATT GGGTCCTCCC 900

AACTATCTAC AAGTTTCCAA AGATTCTGCC AGTACTAGTA GCAAGAATTC TTCTTGTGAC 960

ACGGATGACT TTGTTTTGGT GCCACACAAC ATCTCGTCAG ACCACTCATA TGATATGCCA 1020

TTGGGGACTG CTGGCAGGCG TGCTTCAAAT GAGTTCTTGG TGTGTGGAGG GCAGTGTCAG 1080

CCTACCGTGT CACCTCACAG TGAAACAGCA CCAATTCCAG TACCTACTCA AATAAGGAAT 1140

TATCAGCGCA TAGAGCAGAA TCTTACATCT ACTGCCAGCT CAGGCACAAA TGTACATGGT 1200

TCTCCAAGAT CTGCAGTGGT GCGAAGGTCC AACACCAGCC CCATGGGCTT CCTCCGGCTG 1260

GGATCATGCT CCCCGGTGCC AGCAGACACA GCACAGACAG TTGGACGAAG GCTCTCCACT 1320

GGGTCTTCTA GGCCTTACTC ACCTTCCCCT TTGGTTGGTA CCATTCCTGA GCAATTCAGT 1380

CAGTGCTGCT GTGGGCATCC TCAGGGCCAT GACTCCAGGA GTAGAAACTC CTCAGGTTCT 1440

CCAGTGCCAC AAGCTCAGTC ACCACAGTCC CTCTTATTGG GTGCTAGACT GCAGAGCGCC 1500

CCCACCCTCA CTGACATCTA TCAGAACAAG CAGAAGCTCA GAAAGCAGCA CTCTGACCCC 1560

GTGTGCCCAA CCCATGCTGG GGCTGGGTAC AGCTACTCAC CTCAGCCCAG CCGGCCTGGC 1620

AGCCTTGGAA CTTCTCCCAC CAAGCACTTG GGGTCCTCTC CACGGAGTTC TGACTGGTTC 1680

TTTAAAACTC CTTTGCCAAC AATCATTGGC TCTCCTACTA AGACCACAGC TCCTTTCAAA 1740

ATCCCTAAAA CGCAAGCATC TTCCAACCTG TTAGCCTTGG TTACTCGTCA TGGGCCTGCT 1800

GAAGAACAAT CCAAAGATGG GAATGAACCA CGGGAATGTG CCCATTGCCT CTTAGTGCAA 1860

GGAAGTGAGA GGCAGCGGGC TGAGCAGCAG AGCAAGGCAG TGTTTGGCAG ATCTGTCAGT 1920

ACTGGGAAGT TATCAGATCA ACAAGGAAAG ACTCCTATAG GTGGACATCA GGGCAGCACA 1980

GACAGTTTAA ATACAGAACG ACCAATGGAT ATAGCTCCAG CAGGAGCCTG TGGTATTGTT 2040

CTGGCACCTC CTGCAGGTAT AGCTGCAAGT TCCAGGGCTG TCCTCTTCAC TGTAGGGTCT 2100

CCTCCACACA GTGCAGTAGC CCCCACTTGT ACCCACATGC TCCTTCGAGC AAGAACAACC 2160

TCAGTGGGGC CTAGCAACTC GGGGGGCTCT CTGTGTGCCG TGAGTGGCCG CGTGTGTGTG 2220

GGGTCCCCGC CTGGCCCAGG CTTCGGCTCT TCCCCTCCAG GAGCAGAGGC AGCTCCCAGC 2280

CTGAGATACG TGCCTTACGG TGCTTCACCC CCCAGCCTGG AGGGGCTCAT CACCTTTGAA 2340

GCCCCTGAAC TGCCGGAGGA GACGCTGATG GAGCGGGAAC ACACGGACAC CTTACGCCAT 2400

CTGAATGTGA TGCTGATGTT CACTGAATGT GTGCTGGACC TGACAGCCGT GAGGGGAGGA 2460

AACCCTGAGC TGTGCACATC TGCTGTGTCC TTGTACCAGA TCCAGGAGAG TGTGGTGGTG 2520

GACCAGATCA GTCAGCTGAG CAAAGACTGG GGGCGGGTGG AGCAGCTGGT GTTGTACATG 2580

AAAGCAGCAC AGCTGCTTGC GGCTTCTCTG CATCTTGCCA AAGCCCAGAT CAAGTCCGGG 2640

AAACTGAGCC CATCCACAGC AGTGAAACAA GTTGTCAAAA ATCTGAACGA ACGATATAAA 2700

TTCTGCATCA CCATGTGCAA GAAACTTACA GAAAAGCTGA ATCGATTCTT CTCTGACAAA 2760

CAGAGGTTTA TTGATGAAAT CAACAGTGTG ACTGCAGAGA AACTCATCTA TAATTGTGCT 2820

GTAGAAATGG TTCAGTCTGC AGCCCTTGAT GAGATGTTTC AGCAGACCGA AGATATTGTT 2880

TATCGCTATC ATAAGGCAGC CCTTCTTTTG GAAGGCCTAA CTAAGATTCT ACAGGACCCT 2940

GCAGATATTG AAAATGTACA TAAATATAAA TGTAGTATTG AGAGAAGACT GTCGGCGCTC 3000

TGCCATAGCA CCGCAACCGT GTGA 3024

Domain Profile

S: 23    ktsqvvAikvvekkklkkslenlekeikilkelkhenivalldveetskevylvmeycag  82

         kt+++vAik+++kk+l+ks+  l keikilkel+henival+dv+e  ++v+lvmeyc+g

Q: 2     KTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNG  61

         7899********************************************************

S: 83    gdLakllkqkkeLsedtvreflqqlasalkaLhskkivhrDlkPqniLlsyadakk.elk  141

         gdLa++l++k++Lsedt+r+fl+q+a+a+++Lhsk+i+hrDlkPqniLlsya+++k +++

Q: 62    GDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKsSVS  121

         *****************************************************99989**

S: 142   kvtlkladFglarvlkeesmaatlkGsplYmaPEvvkeqqydakaDlWSiGtilyellvG  201

          +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++q+ydakaDlWSiGt++y++lvG

Q: 122   GIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVG  181

         ************************************************************

S: 202   kpPfaaesiseLvekiekndvleppipkeisselkdllqsLLqrdpkkRisfeelfahpf  261

         kpPf+a+s+++L++++ekn++l+p+ip+e+s+ l++ll +LLqr++k+R++fe +f+hpf

Q: 182   KPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPF  241

         ***********************************************************9

S: 262   l  262

Q: 242   L  242

Domain Sequence
(FASTA)

KTDWEVAIKS INKKNLSKSQ ILLGKEIKIL KELQHENIVA LYDVQELPNS VFLVMEYCNG 60

GDLADYLQAK GTLSEDTIRV FLHQIAAAMR ILHSKGIIHR DLKPQNILLS YANRRKSSVS 120

GIRIKIADFG FARYLHSNMM AATLCGSPMY MAPEVIMSQH YDAKADLWSI GTVIYQCLVG 180

KPPFQANSPQ DLRMFYEKNR SLMPSIPRET SPYLANLLLG LLQRNQKDRM DFEAFFSHPF 240

L 241

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0034045	; C:pre-autophagosomal structure membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048675	; P:axon extension
GO:0048671	; P:negative regulation of collateral sprouting
GO:0046777	; P:protein autophosphorylation
GO:0010506	; P:regulation of autophagy
GO:0042594	; P:response to starvation
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR016237	; Ser/Thr_kin_STPK_Ulk-1/2.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013