EKS-MAM-00005

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00005

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	513.5	1.3E-154	619	878	260

Status

Unreviewed

Ensembl Protein

ENSMMUP00000028101

UniProt Accession

F7DM27;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB1

Gene Synonyms/Alias

EPHB1; EGK_12084;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000021334	ENSMMUP00000028101	ENSMMUT00000030026
ENSMMUG00000021334	ENSMMUP00000028102	ENSMMUT00000030027

Organism

Macaca mulatta

Functional Description

Protein Length

984

Protein Sequence
(FASTA)

MALDCLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV 60

CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV 120

IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY 180

GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC 240

NGDGEWMVPI GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPAEASPI 300

CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC 360

KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP 420

QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN 480

SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP 540

LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY 600

EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK 660

QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ 720

LVGMLRGIAA GMKYLAEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS 780

SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD 840

YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ 900

PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGVTLAG 960

HQKKILNSIH SMRVQMSQSP TAMA 984

Nucleotide Sequence
(FASTA)

ATGGCCCTGG ATTGTCTGCT ACTGCTCCTC CTGGCTTCCG CAGTGGCCGC GATGGAAGAA 60

ACGTTAATGG ACACCAGAAC GGCTACTGCA GAGCTGGGCT GGACGGCCAA TCCTGCATCA 120

GGGTGGGAAG AAGTCAGTGG CTATGATGAA AACCTGAACA CCATCCGCAC CTACCAGGTG 180

TGCAATGTCT TCGAGCCCAA CCAGAACAAT TGGCTGCTCA CCACCTTCAT CAACCGGCGG 240

GGGGCCCATC GCATCTACAC AGAGATGCGC TTCACTGTGA GAGACTGCAG CAGCCTCCCT 300

AATGTCCCAG GATCCTGCAA GGAGACCTTC AACTTGTATT ACTATGAGAC TGACTCTGTC 360

ATTGCCACCA AGAAGTCGGC CTTCTGGTCT GAGGCCCCCT ACCTCAAAGT AGACACCATT 420

GCTGCAGATG AGAGCTTCTC CCAGGTGGAC TTTGGGGGAA GGCTGATGAA GGTAAACACA 480

GAAGTCAGGA GCTTTGGGCC TCTTACTCGG AATGGTTTTT ACCTCGCTTT TCAGGATTAT 540

GGAGCCTGTA TGTCTCTTCT TTCTGTCCGT GTCTTCTTCA AAAAGTGTCC CAGCATTGTG 600

CAAAATTTTG CAGTGTTTCC AGAGACCATG ACGGGGGCAG AGAGCACATC TCTGGTGATT 660

GCTCGGGGCA CATGCATCCC CAACGCAGAG GAAGTGGACG TGCCCATCAA ACTCTACTGC 720

AACGGGGATG GGGAATGGAT GGTGCCCATT GGGCGATGCA CCTGCAAGCC TGGCTATGAG 780

CCTGAGAACA GCGTGGCATG CAAGGCCTGC CCTGCAGGGA CATTCAAGGC CAGCCAGGAA 840

GCTGAGGGCT GCTCCCACTG CCCCTCCAAC AGCCGCTCCC CTGCAGAGGC GTCTCCCATC 900

TGCACCTGTC GGACTGGTTA TTACCGAGCG GACTTTGACC CTCCAGAAGT GGCATGCACT 960

AGTGTCCCAT CAGGTCCCCG CAATGTTATC TCCATCGTCA ATGAGACATC CATCATTCTG 1020

GAGTGGCACC CTCCAAGGGA GACAGGTGGG CGGGATGATG TGACCTACAA CATCATCTGC 1080

AAAAAGTGCC GGGCAGACCG CCGGAGCTGC TCCCGCTGTG ACGACAATGT GGAGTTTGTG 1140

CCCAGGCAGC TGGGCCTGAC TGAGTGTCGT GTCTCCATCA GCAGCCTGTG GGCTCACACC 1200

CCCTACACCT TTGACATCCA GGCCATCAAT GGAGTCTCCA GCAAGAGTCC CTTTCCCCCA 1260

CAGCATGTCT CTGTCAACAT CACCACAAAC CAAGCCGCCC CCTCCACCGT TCCCATCATG 1320

CACCAAGTCA GTGCCACTAT GAGGAGCATC ACCTTGTCAT GGCCACAGCC GGAGCAGCCC 1380

AATGGCATCA TCCTGGACTA TGAGATCCGG TACTATGAGA AGGAACACAA TGAGTTCAAC 1440

TCCTCCATGG CCAGGAGTCA GACCAACACA GCAAGGATTG ATGGGCTGCG GCCTGGCATG 1500

GTATATGTGG TACAGGTGCG CGCCCGCACT GTTGCTGGCT ACGGCAAGTT CAGTGGCAAG 1560

ATGTGCTTCC AAACTCTGAC GGATGATGAT TACAAGTCAG AGCTGAGGGA GCAGCTGCCC 1620

CTGATTGCTG GCTCGGCAGC GGCCGGCGTC GTGTTCGTTG TGTCCTTGGT GGCCATCTCT 1680

ATCGTCTGTA GCAGGAAACG GGCTTATAGC AAAGAGGCTG TGTACAGCGA TAAGCTCCAG 1740

CATTACAGCA CAGGCCGAGG CTCCCCAGGG ATGAAGATCT ACATTGACCC CTTCACTTAT 1800

GAGGATCCCA ACGAAGCTGT CCGGGAGTTC GCCAAGGAGA TTGATGTATC TTTCGTGAAA 1860

ATTGAAGAGG TCATCGGAGC AGGGGAGTTT GGAGAAGTGT ACAAGGGGCG TTTGAAACTG 1920

CCAGGCAAGA GGGAAATCTA TGTGGCCATC AAGACCCTGA AGGCAGGGTA CTCGGAGAAG 1980

CAGCGTCGGG ACTTCCTGAG TGAGGCAAGC ATCATGGGCC AGTTCGACCA TCCCAACATC 2040

ATTCGCCTGG AGGGTGTGGT CACCAAGAGT CGGCCTGTCA TGATCATCAC AGAGTTCATG 2100

GAGAATGGTG CATTGGATTC TTTCCTCAGG CAAAATGATG GGCAGTTCAC CGTGATCCAG 2160

CTTGTGGGTA TGCTCAGGGG CATCGCTGCT GGCATGAAGT ACCTGGCCGA GATGAATTAT 2220

GTGCACCGGG ACCTGGCTGC TAGGAACATT CTGGTCAACA GTAACCTGGT GTGCAAGGTG 2280

TCCGACTTTG GCCTCTCCCG CTACCTCCAG GATGACACCT CAGATCCCAC CTACACCAGC 2340

TCCTTGGGAG GGAAGATCCC CGTGAGATGG ACAGCTCCAG AGGCCATCGC CTACCGCAAG 2400

TTCACTTCAG CCAGCGACGT TTGGAGCTAT GGGATTGTCA TGTGGGAAGT CATGTCATTT 2460

GGAGAGAGAC CCTACTGGGA TATGTCCAAC CAAGATGTCA TCAATGCCAT CGAGCAGGAC 2520

TACCGGCTGC CCCCACCCAT GGACTGTCCA GCTGCTCTAC ACCAGCTCAT GCTGGACTGT 2580

TGGCAGAAGG ACCGGAACAG CCGGCCCCGC TTTGCAGAGA TTGTCAACAC CCTAGACAAG 2640

ATGATCCGGA ACCCGGCAAG TCTCAAGACT GTGGCAACCA TCACCGCTGT GCCTTCCCAG 2700

CCCCTGCTCG ACCGCTCCAT CCCAGACTTC ACGGCCTTTA CCACCGTGGA TGACTGGCTC 2760

AGCGCCATCA AAATGGTCCA GTACAGGGAC AGCTTCCTCA CTGCTGGCTT CACCTCCCTC 2820

CAGCTGGTCA CCCAGATGAC ATCAGAAGAC CTCCTGAGAA TAGGGGTCAC CTTAGCAGGC 2880

CATCAGAAGA AGATCCTGAA CAGCATTCAT TCTATGAGGG TCCAGATGAG TCAGTCACCA 2940

ACAGCAATGG CATGA 2955

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp

Q: 619   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  678

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvtks+pvmi+te+mengaldsflr++dgqftviqlvgmlrGia+gmkyl++m

Q: 679   NIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM  738

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay

Q: 739   NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  798

         *******************************99999*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml

Q: 799   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  858

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcwqkdr++rp+f++iv++l

Q: 859   DCWQKDRNSRPRFAEIVNTL  878

         *****************975

Domain Sequence
(FASTA)

VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60

NIIRLEGVVT KSRPVMIITE FMENGALDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLAEM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRY LQDDTSDPTY TSSLGGKIPV RWTAPEAIAY 180

RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240

DCWQKDRNSR PRFAEIVNTL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0031901	; C:early endosome membrane
GO:0005887	; C:integral to plasma membrane
GO:0045121	; C:membrane raft
GO:0005524	; F:ATP binding
GO:0008046	; F:axon guidance receptor activity
GO:0005005	; F:transmembrane-ephrin receptor activity
GO:0001525	; P:angiogenesis
GO:0048593	; P:camera-type eye morphogenesis
GO:0031589	; P:cell-substrate adhesion
GO:0021952	; P:central nervous system projection neuron axonogenesis
GO:0060997	; P:dendritic spine morphogenesis
GO:0050965	; P:detection of temperature stimulus involved in sensory perception of pain
GO:0030010	; P:establishment of cell polarity
GO:0061351	; P:neural precursor cell proliferation
GO:0021631	; P:optic nerve morphogenesis
GO:0051965	; P:positive regulation of synapse assembly
GO:0070372	; P:regulation of ERK1 and ERK2 cascade
GO:0046328	; P:regulation of JNK cascade
GO:0031290	; P:retinal ganglion cell axon guidance

KEGG

mcc:717211

;

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013